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31. 发明授权

US3943694A Divers' fluid-tight watch comprising an electric circuit 失效
标题翻译：潜水员{3 {0流体密封手表，包括电路
公开(公告)号：US3943694A
公开(公告)日：1976-03-16
申请号：US497942
申请日：1974-08-16
申请人： Peter Hofer
发明人： Peter Hofer
IPC分类号： G04C19/02 , G04G11/00 , G04G19/00 , G04C21/16 , G04B19/30
CPC分类号： G04G19/00 , G04C19/02 , G04G11/00
摘要： An arrangement for indicating elapsed time is disclosed that is particularly useful in marine timepieces, divers' wristwatches and the like. The arrangement utilizes a light-emitting member which, upon the lapsing of a predetermined time is energized to give visual indication to the wearer of the elapsed time. A mechanical switching structure is described that is controlled by the movement of the timepiece and which upon closure causes the light emitting member to be energized. An electronic circuit is provided which causes the light emitting member to flash when energized.
摘要翻译：公开了用于指示经过时间的布置，其特别适用于海洋钟表，潜水手表等。该布置使用发光构件，其在预定时间的经过通电以向穿戴者给出经过时间的视觉指示。描述了由钟表的运动控制的机械开关结构，并且在闭合时使得发光构件被通电。提供了一种电子电路，其使得发光部件在通电时闪光。

32. 发明授权

US08658130B2 Agricultural compositions 有权
标题翻译：农作物
公开(公告)号：US08658130B2
公开(公告)日：2014-02-25
申请号：US13201249
申请日：2010-02-04
申请人： Hans-Georg Mainx , Peter Hofer
发明人： Hans-Georg Mainx , Peter Hofer
IPC分类号： A61K36/14 , A61K51/00
CPC分类号： A01N25/30 , A01N25/04 , A01N47/22 , A01N33/22 , A01N43/12 , A01N43/653 , A01N57/20 , A01N2300/00
摘要： Suggested are agrochemical compositions, comprising (a) biocides, and (b) alkoxylation products of di- and/or oligosaccharide esters.
摘要翻译：建议的是农药组合物，其包含（a）杀生物剂和（b）二糖和/或寡糖酯的烷氧基化产物。

33. 发明申请

US20110294667A1 Agricultural Compositions 有权
标题翻译：农业组合
公开(公告)号：US20110294667A1
公开(公告)日：2011-12-01
申请号：US13201249
申请日：2010-02-04
申请人： Hans-Georg Mainx , Peter Hofer
发明人： Hans-Georg Mainx , Peter Hofer
IPC分类号： A01N57/20 , A01N43/653 , A01P13/00 , A01N43/08 , A01P3/00 , A01P7/04 , A01N33/22 , A01N47/22
CPC分类号： A01N25/30 , A01N25/04 , A01N47/22 , A01N33/22 , A01N43/12 , A01N43/653 , A01N57/20 , A01N2300/00
摘要： Suggested are agrochemical compositions, comprising (a) biocides, and (b) alkoxylation products of di- and/or oligosaccharide esters.
摘要翻译：建议的是农药组合物，其包含（a）杀生物剂和（b）二糖和/或寡糖酯的烷氧基化产物。

34. 发明授权

US06365606B1 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity 失效
标题翻译：具有增强的磷酸二酯酶IV抑制活性的6,5-稠合芳环体系
公开(公告)号：US06365606B1
公开(公告)日：2002-04-02
申请号：US09506624
申请日：2000-02-18
申请人： David Cavalla , Peter Hofer , Andre Gehrig , Peter Wintergerst , Mark Chasin
发明人： David Cavalla , Peter Hofer , Andre Gehrig , Peter Wintergerst , Mark Chasin
IPC分类号： A61K314402
CPC分类号： C07D263/56 , C07D413/06 , C07D417/06
摘要： Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition compared to theophylline or rolipram, with improved selectivity with regard to, e.g., PDE V inhibition. The present invention includes compounds of Formula I: wherein the substituents are as disclosed herein.
摘要翻译：公开了作为有效的PDE IV抑制剂的新型化合物。与茶碱或咯利普兰相比，该化合物具有改善的PDE IV抑制作用，具有关于例如PDE V抑制的改善的选择性。本发明包括式I的化合物：其中取代基如本文所公开。

35. 发明授权

US06248746B1 3-(arylalkyl) xanthines 失效
标题翻译： 3-（芳烷基）黄嘌呤
公开(公告)号：US06248746B1
公开(公告)日：2001-06-19
申请号：US09227057
申请日：1999-01-07
申请人： Mark Chasin , David J. Cavalla , Peter Hofer
发明人： Mark Chasin , David J. Cavalla , Peter Hofer
IPC分类号： A61K3152
CPC分类号： A61K31/522 , C07D473/04 , C07D473/06
摘要： With the above and other objects in view, the present invention comprises compounds having the general formula (I): wherein: R1 is a C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl or cycloalkynyl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or cycloalkynyl is optionally substituted with hydroxy, C1-5 alkoxy, C3-5 cycloalkoxy, halogen, oxo, carbamido, hydroxycarbamido, oximido, C1-5 alkyloximido, C3-5 cycloalkyloximido, C1-5 acyloximido or C3-5 cycloacyloximido; Q is methylene or ethylene; R3 is aryl or heteroaryl wherein said aryl or heteroaryl has one to three substituents selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, cycloalkynyl, C3-5 alkylene, C3-5 cycloalkylene, haloC1-6 alkyl, haloC1-6 cycloalkyl, hydroxy, C1-5 alkoxy, C3-5 cycloalkoxy, C1-2 alkylenedioxy, C1-6 acyl, C3-6 cycloacyl, C1-6 acyloxy, C3-6 cycloacyloxy, halogen, nitro or cyano; R8 is C1-5 alkyl or C3-5 cycloalkyl, optionally substituted by hydroxy, C1-5 alkyloxy, C3-5 cycloalkyloxy, C1-5 acyloxy, C3-5 cycloacyloxy or halogen; and methods of using the compounds of formula I for treatment of patients who can benefit from a modification of PDE IV levels in their bodies.
摘要翻译：考虑到上述和其它目的，本发明包括具有通式（I）的化合物：其中：R 1是C 2-8烷基，C 2-8烯基，C 2-8炔基，C 3-8环烷基，C 3-8 环烯基或环炔基，其中所述烷基，烯基，炔基，环烷基，环烯基或环炔基任选被羟基，C 1-5烷氧基，C 3-5环烷氧基，卤素，氧代，氨基甲酰基，羟基氨基甲酰基，肟基，C 1-5烷基酰氧基， 5环烷酰肟基，C1-5酰氧亚氨基或C3-5环亚胺酰脒; Q是亚甲基或亚乙基; R 3是芳基或杂芳基，其中所述芳基或杂芳基具有一至三个选自C 1-6烷基，C 2-6烯基， C2-6炔基，C3-6环烷基，C3-6环烯基，环炔基，C3-5亚烷基，C3-5亚环烷基，卤代C 1-6烷基，卤代C 1-6环烷基，羟基，C 1-5烷氧基，C 3-5环烷氧基，C 1 -2亚烷基二氧基，C1-6酰基，C3-6环酰基，C1-6酰氧基，C3-6环酰氧基，卤素，硝基或氰基; R8是C1-5烷基或C3-5环任选地被羟基，C 1-5烷氧基，C 3-5烃环氧基，C 1-5酰氧基，C 3-5环芳氧基或卤素取代的烷基;以及使用式I化合物治疗可从PDE修饰中受益的患者的方法 IV级别在他们的身体。

36. 发明授权

US6090816A Aryl thioxanthines 失效
标题翻译：芳基硫代黄嘌呤
公开(公告)号：US6090816A
公开(公告)日：2000-07-18
申请号：US911549
申请日：1997-08-14
申请人： David John Cavalla , Mark Chasin , Peter Hofer
发明人： David John Cavalla , Mark Chasin , Peter Hofer
IPC分类号： A61K31/52 , A61K31/522 , A61P11/06 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , A61P37/08 , A61P43/00 , C07D473/18 , C07D473/22 , A61K473/22
CPC分类号： C07D473/18 , C07D473/22
摘要： Disclosed are compounds having the formulae: ##STR1## wherein: Q.sub.3,Q.sub.6a,Q.sub.6b and Q.sub.8 are independently a bond, C.sub.1-8 alkylene, C.sub.2-8 alkenylene and C.sub.2-6 alkynylene, andR.sub.3, R.sub.6a, R.sub.6b, and R.sub.8 are independently hydrogen, aryl or heteroaryl, optionally substituted by halogen, hydroxy, alkoxy, nitro, cyano and carboxy, provided that:Q.sub.3 R.sub.3 is not hydrogen or methyl in formulae (I) or (II); and at least one of R.sub.3 and R.sub.8 is aryl or heteroaryl in formula (I).The compounds are effective PDE IV inhibitors and possess improved PDE IV inhibition and improved selectivity with regard to PDE III inhibition.
摘要翻译：公开了具有下式的化合物：其中：Q 3，Q 6a，Q 6b和Q 8独立地是键，C 1-8亚烷基，C 2-8亚烯基和C 2-6亚炔基，R 3，R 6a，R 6b和R 8独立地是氢，任选被卤素，羟基，烷氧基，硝基，氰基和羧基取代的杂芳基，条件是：式（I）或（II）中的Q3R 3不是氢或甲基; 并且R 3和R 8中的至少一个是式（I）中的芳基或杂芳基。这些化合物是有效的PDE IV抑制剂，并具有改善的PDE IV抑制和改善PDE III抑制的选择性。

37. 发明授权

US6040447A Purine compounds having PDE IV inhibitory activity and methods of synthesis 有权
标题翻译：具有PDE IV抑制活性的嘌呤化合物和合成方法
公开(公告)号：US6040447A
公开(公告)日：2000-03-21
申请号：US209922
申请日：1998-12-10
申请人： David J. Cavalla , Mark Chasin , Peter Hofer
发明人： David J. Cavalla , Mark Chasin , Peter Hofer
IPC分类号： A61K31/52 , A61K31/53 , A61P11/00 , A61P11/06 , A61P25/24 , A61P25/28 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/18 , A61P37/04 , A61P37/08 , A61P43/00 , C07D471/04 , C07D473/30 , C07D473/34 , C07D487/04 , C07D239/42 , C07D239/48
CPC分类号： C07D473/30 , C07D473/34
摘要： The present invention comprises a method of synthesizing compounds having the formula (I): ##STR1## wherein: Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.8 are defined herein, which comprises the steps of(a) reacting a compound of the formula (II) ##STR2## wherein Q is a halogen, with an effective amount of a compound selected from the group consisting of an acid anhydride or an acid halide; to form a compound of the formula (III) ##STR3## b) transforming the 6-halo group of said compound (III) to an amine by displacement with ammonia to form compound (IV) ##STR4## (c) reacting said compound (IV) with a base to cause cyclization to a 6-halo intermediate, said 6-halo group is then transformed to an amine by displacement with an amine to form compound (V) ##STR5## (d) reacting said compound (V) with an effective amount of compound (VI) ##STR6## wherein X is a halogen; to form the compound of formula (I).
摘要翻译：本发明包括合成具有式（I）的化合物的方法：其中：Z，R1，R2，R3，R4和R8如本文所定义，其包括以下步骤：（a）使式（II）其中Q是卤素，有效量的选自酸酐或酰卤的化合物; （III）的化合物b）通过用氨置换而将所述化合物（III）的6-卤代基转化成胺，以形成化合物（IV）（c）使所述化合物（IV）与碱反应导致环化成6-卤代中间体，然后用胺置换将6-卤代基转化成胺，形成化合物（Ⅴ）（d）使所述化合物（Ⅴ）与有效量的化合物（Ⅵ）反应，其中 X是卤素; 以形成式（I）的化合物。

38. 发明授权

US5069542A Contact lens 失效
标题翻译：隐形眼镜
公开(公告)号：US5069542A
公开(公告)日：1991-12-03
申请号：US186674
申请日：1988-04-21
申请人： Peter Hofer , Ulrich Muller , Manfred Barenz , Horst Schafer , Wolfgang Muller-Lierheim
发明人： Peter Hofer , Ulrich Muller , Manfred Barenz , Horst Schafer , Wolfgang Muller-Lierheim
IPC分类号： G02C7/04
CPC分类号： G02C7/04
摘要： A contact lens has an elliptical inside surface with a numerical eccentricity of 0.2 to 0.5 and a zenith radius of curvature of 8.0 to 8.4 mm. The inside surface preferably has a peripheral, circularly cross sectioned bevelled zone. As a soft contact lens, it has these dimensions when fully hydrated and preferably consists of a copolymer comprising of 50% to 90% hydroxyethyl-methacrylate (HEMA) by weight, 2% to 20% one or more unsaturated carboxylic acids, 2% to 20% one or more base monomers, 5% to 25% aliphatic acrylate or methacrylate, and 0.1% to 1% of a dialkylene-glycol-dimethacrylate cross-linker.

39. 发明授权

US5026250A Apparatus for singularizing stacked portions of books and the like 失效
标题翻译：用于将书籍的堆叠部分单数化的装置等
公开(公告)号：US5026250A
公开(公告)日：1991-06-25
申请号：US462810
申请日：1990-01-10
申请人： Peter Hofer
发明人： Peter Hofer
IPC分类号： B65H1/30 , B65G59/06 , B65H3/24 , B65H3/56
CPC分类号： B65G59/068
摘要： Apparatus for singularizing successive stacks of a series of stacks consisting of superimposed groups of sheets has a transporting unit which advances successive stacks of the series in a horizontal plane against a barrier which intercepts each but the lowermost group of the oncoming stack. An endless conveyor with one or more pushers is provided to advance successive lowermost groups of an intercepted stack through and beyond a clearance between the barrier and a stationary table of the transporting unit. The width of such clearance exceeds the height of a single group but is less than the combined height of two superimposed groups. The width of the clearance and the extent to which the pusher or pushers can extend above the horizontal plane are adjustable. The apparatus further comprises a gate which is pivotable behind an intercepted stack to a position in which it prevents advancement of a fresh stack toward the table and can bias each but the lowermost group of an intercepted stack against the barrier, and a raised position in which the conveyor of the transporting unit is free to deliver a fresh stack toward and into engagement with the barrier. The barrier is adjustable toward and away from the gate.
摘要翻译：用于将由叠加的片组组成的一系列堆叠的连续堆叠单个化的装置具有传送单元，该传送单元将水平平面中的串联的连续堆叠抵靠拦截即将到来的堆叠中的每个但最下面的组的屏障。提供具有一个或多个推动器的环形传送带，用于使所拦截的堆叠的连续最下面的组通过并超过所述屏障和所述传送单元的静止台之间的间隙。这种间隙的宽度超过单个组的高度，但小于两个重叠组的组合高度。间隙的宽度以及推动器或推动器可以在水平面上方延伸的程度是可调节的。该装置还包括一个门，该门可以在被拦截的堆叠之后枢转到一个位置，在该位置，防止一个新的堆栈朝向桌子前进，并且可以将拦截的堆叠的每个而不是最低的一组抵靠着屏障偏置，输送单元的输送机可自由地向隔板输送一个新的叠层并与该屏障接合。屏障可以朝向和远离门调节。

40. 发明授权

US4925847A 6-thioxanthines 失效
标题翻译： 6-硫代黄嘌呤
公开(公告)号：US4925847A
公开(公告)日：1990-05-15
申请号：US78545
申请日：1987-07-28
申请人： Peter Hofer
发明人： Peter Hofer
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , C07D473/22
CPC分类号： C07D473/22
摘要： A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.3 is a C.sub.2 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group and R.sub.8 is a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group provided that when R.sub.3 is an ethyl, n-propyl or n-butyl group, R.sub.8 is a C.sub.3 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group.These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.
摘要翻译：通式I的6-硫代黄嘌呤或其药学上可接受的盐，其中R 3为C 2至C 6烷基，C 3至C 7环烷基或C 4至C 8环烷基烷基，R 8为C 1至C 6烷基， C3至C7环烷基或C4至C8环烷基烷基，条件是当R3为乙基，正丙基或正丁基时，R 8为C 3至C 6烷基，C 3至C 7环烷基或C 4至C 8环烷基烷基。这些3,8-二取代-6-硫代黄嘌呤具有增强的支气管扩张剂活性。

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