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31. 发明专利

AU2006276119A1 Focused droplet nebulizer for evaporative light scattering detector 未知
公开(公告)号：AU2006276119A1
公开(公告)日：2007-02-08
申请号：AU2006276119
申请日：2006-07-21
申请人： UNIV MISSOURI
发明人： LARSON DAVID W , XU ZHI
IPC分类号： A61M11/00
摘要： A focused droplet nebulizer of the invention produces substantially uniform droplets of a predetermined size. Droplets are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a drift tube. A piezo membrane micro pump acts in response to an electrical control signal to force a droplet out of the outlet orifice. The nebulizer can operate at frequencies permitting a stream of individual droplets of the predetermined size to be sent along the substantially non-divergent path in the drift tube in a preferred embodiment ELSD device.

32. 发明专利

CA2593967A1 ULTRASENSITIVE SPECTROPHOTOMETER 未知
公开(公告)号：CA2593967A1
公开(公告)日：2006-07-20
申请号：CA2593967
申请日：2006-01-11
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI
IPC分类号： G01J3/42 , G01J3/427
摘要： The invention concerns measurements in which light interacts with matter to generate light intensity changes, and spectrophotometer devices of the invention provide ultrasensitive measurements. Light source noise in these measurements can be reduced in accordance with the invention. Exemplary embodiments of the invention use sealed housings lacking an internal light source. In some embodiments a substantially solid thermally conductive housing is used. Other embodiments include particular reflection based sample and reference cells. One embodiment includes a prism including an interaction surface, a detector, a lens that focuses a prism beam output onto the detector, and a closed interaction volume for delivering gas or liquid to the interaction surface. Another embodiment replaces a prism with a reflective surface. Another embodiment replaces a prism with a scattering matte surface. Aspects of the invention identify noise-contributing components in spectrophotometry and realize noise levels very near the shot noise limit.

33. 发明专利

BRPI0818177A2 Componentes para dispositivo óptico 未知
公开(公告)号：BRPI0818177A2
公开(公告)日：2022-01-18
申请号：BRPI0818177
申请日：2008-10-03
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G01N21/00
摘要： componentes para dispositivo óptico. as modalidades da invenção referem-se a um aparelho incluindo uma fonte de luz para gerar uma pluralidade de feixes de luz com cada da pluralidade de feixes de luz tendo uma diferente faixa de comprimento de onda. o aparelho também inclui um funil de luz para direcionar a pluralidade de feixes de luz para a área-alvo, uma abertura para direcionar a pluralidade de emissões de feixes de luz da área-alvo para uma lente, a lente configurada para coletar as emissões de feixes de luz da área-alvo. adicionalmente, o aparelho inclui um detector que tem uma pluralidade de dispositivos sensores de luz, cada um configurado para detectar um feixe de luz e configurado para gerar um sinal de saída indicativo de uma intensidade de luz detectada e um processador para determinar as características do sangue como uma função de cada sinal de saída gerado.

34. 发明专利

CA2789658C OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE 未知
公开(公告)号：CA2789658C
公开(公告)日：2017-11-07
申请号：CA2789658
申请日：2010-03-23
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G02B19/00 , A61B5/1455 , G01J3/12 , G01N21/01 , G02B27/00
摘要： An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto- conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.

35. 发明专利

CA2789658A1 OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE 未知
公开(公告)号：CA2789658A1
公开(公告)日：2010-10-07
申请号：CA2789658
申请日：2010-03-23
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00
摘要： An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto- conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.

36. 发明专利

AU2006203529B2 Light scattering detector 未知
公开(公告)号：AU2006203529B2
公开(公告)日：2009-11-26
申请号：AU2006203529
申请日：2006-08-16
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI
IPC分类号： G01N30/74 , B01D15/08 , G01N15/14 , G01N21/00 , G01N21/03 , G01N21/53 , G01N30/84
摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

37. 发明专利

AU2003228434A1 ULTRASENSITIVE SPECTROPHOTOMETER 未知
公开(公告)号：AU2003228434A1
公开(公告)日：2003-11-17
申请号：AU2003228434
申请日：2003-04-04
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI , GARVER WAYNE
IPC分类号： G01J3/02 , G01J3/28 , G01J3/42 , G01N21/27 , G01J3/427
摘要： The invention concerns improvements in spectrophotometry. Aspects of the invention may be used independently or together to increase the sensitivity of spectrophotometry. One aspect of the invention is a spectrophotometer detection circuit. In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing with a hollowed portion defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments. Many noise sources would not normally be considered in conventional spectrophotometry because the magnitude of particular noise sources dominates device performance.

38. 发明专利

CA2484130A1 ULTRASENSITIVE SPECTROPHOTOMETER 未知
公开(公告)号：CA2484130A1
公开(公告)日：2003-11-13
申请号：CA2484130
申请日：2003-04-04
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI , GARVER WAYNE
IPC分类号： G01J3/02 , G01J3/28 , G01J3/42 , G01N21/27 , G01J3/427
摘要： One aspect of the invention is a spectrophotometer detection circuit (189, 934, 1031). In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing (112, 900, 1000) and optical system components to promote equilibrium. Another preferre d embodiment has a unitary solid metal housing (900, 1000) with a hollowed portion (900a, 1000a) defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments.

39. 发明专利

CA2700996C OPTICAL DEVICE COMPONENTS 未知
公开(公告)号：CA2700996C
公开(公告)日：2016-12-13
申请号：CA2700996
申请日：2008-10-03
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G01J3/12 , A61B5/1455 , G01J3/10 , G01J3/18 , G01J3/26 , G01J3/28
摘要： Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.

40. 发明专利

BRPI0909825A2 método e sistemas para detecção não-invasiva de glicose sanguíneo utilizando dados espectrais de um ou mais componentes que não a glicose 未知
公开(公告)号：BRPI0909825A2
公开(公告)日：2015-10-06
申请号：BRPI0909825
申请日：2009-03-20
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00

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