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31. 发明专利

CA2789658C OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE 未知
公开(公告)号：CA2789658C
公开(公告)日：2017-11-07
申请号：CA2789658
申请日：2010-03-23
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G02B19/00 , A61B5/1455 , G01J3/12 , G01N21/01 , G02B27/00
摘要： An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto- conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.

32. 发明专利

CA2789658A1 OPTICAL SPECTROSCOPY DEVICE FOR NON-INVASIVE BLOOD GLUCOSE DETECTION AND ASSOCIATED METHOD OF USE 未知
公开(公告)号：CA2789658A1
公开(公告)日：2010-10-07
申请号：CA2789658
申请日：2010-03-23
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00
摘要： An apparatus for concentrating light and associated method of use is disclosed. This apparatus includes a first outer wall having an anterior end, a posterior end, an inner surface and an outer surface, the inner surface defining an interior portion, the interior portion having an anterior end and a posterior end, and a light source disposed within the interior portion. The first outer wall has an opening in the posterior end, the opening having an opening diameter. The interior portion has a substantially frusto- conical shape and has a cross-sectional diameter at the opening equal to the opening diameter and a second cross-sectional diameter near the anterior end that is less than the opening diameter and the inner surface is photo-reflective. The light passes through a sample through an aperture and a collector lens or a second outer wall. A transmission diffraction grating may be utilized.

33. 发明专利

AU2006203529B2 Light scattering detector 未知
公开(公告)号：AU2006203529B2
公开(公告)日：2009-11-26
申请号：AU2006203529
申请日：2006-08-16
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI
IPC分类号： G01N30/74 , B01D15/08 , G01N15/14 , G01N21/00 , G01N21/03 , G01N21/53 , G01N30/84
摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

34. 发明专利

CA2671380A1 LIQUID CHROMATOGRAPHY DETECTOR AND FLOW CONTROLLER THEREFOR 未知
公开(公告)号：CA2671380A1
公开(公告)日：2008-06-12
申请号：CA2671380
申请日：2007-12-06
申请人： UNIV MISSOURI , GRACE W R & CO
发明人： ANDERSON JAMES M , BOSE RAKESH , XU ZHI
IPC分类号： G01N1/00
摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control c hannel portion in communication with the inlet portion, and an outlet portio n in communication with said control channel portion. The control channel po rtion has a cross-sectional area smaller than a cross-sectional area of a dr ift tube of the liquid chromatography detector for channeling the flow of dr oplets through the smaller cross-sectional area. The flow controller is shap ed and sized to reduce pressure fluctuations and turbulence in the droplet s tream of the liquid chromatography detector.

35. 发明专利

AU2003228434A1 ULTRASENSITIVE SPECTROPHOTOMETER 未知
公开(公告)号：AU2003228434A1
公开(公告)日：2003-11-17
申请号：AU2003228434
申请日：2003-04-04
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI , GARVER WAYNE
IPC分类号： G01J3/02 , G01J3/28 , G01J3/42 , G01N21/27 , G01J3/427
摘要： The invention concerns improvements in spectrophotometry. Aspects of the invention may be used independently or together to increase the sensitivity of spectrophotometry. One aspect of the invention is a spectrophotometer detection circuit. In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing with a hollowed portion defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments. Many noise sources would not normally be considered in conventional spectrophotometry because the magnitude of particular noise sources dominates device performance.

36. 发明专利

CA2484130A1 ULTRASENSITIVE SPECTROPHOTOMETER 未知
公开(公告)号：CA2484130A1
公开(公告)日：2003-11-13
申请号：CA2484130
申请日：2003-04-04
申请人： UNIV MISSOURI
发明人： LARSEN DAVID W , XU ZHI , GARVER WAYNE
IPC分类号： G01J3/02 , G01J3/28 , G01J3/42 , G01N21/27 , G01J3/427
摘要： One aspect of the invention is a spectrophotometer detection circuit (189, 934, 1031). In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing (112, 900, 1000) and optical system components to promote equilibrium. Another preferre d embodiment has a unitary solid metal housing (900, 1000) with a hollowed portion (900a, 1000a) defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments.

37. 发明专利

CA2700996C OPTICAL DEVICE COMPONENTS 未知
公开(公告)号：CA2700996C
公开(公告)日：2016-12-13
申请号：CA2700996
申请日：2008-10-03
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G01J3/12 , A61B5/1455 , G01J3/10 , G01J3/18 , G01J3/26 , G01J3/28
摘要： Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.

38. 发明专利

BRPI0909825A2 método e sistemas para detecção não-invasiva de glicose sanguíneo utilizando dados espectrais de um ou mais componentes que não a glicose 未知
公开(公告)号：BRPI0909825A2
公开(公告)日：2015-10-06
申请号：BRPI0909825
申请日：2009-03-20
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00

39. 发明专利

BRPI0816925A2 Componentes de dispositivo óptico 未知
公开(公告)号：BRPI0816925A2
公开(公告)日：2015-03-17
申请号：BRPI0816925
申请日：2008-09-12
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： A61B5/00

40. 发明专利

BRPI0719924A2 未知
公开(公告)号：BRPI0719924A2
公开(公告)日：2014-03-04
申请号：BRPI0719924
申请日：2007-12-06
申请人： UNIV MISSOURI
发明人： XU ZHI
IPC分类号： G01N11/04
摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector

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