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    • 32. 发明授权
    • System and method for controlling ignition timing for vehicular internal
combustion engine
    • 用于控制车用内燃机点火正时的系统和方法
    • US4966117A
    • 1990-10-30
    • US330343
    • 1989-03-28
    • Yoshihisa Kawamura
    • Yoshihisa Kawamura
    • F02P5/15F02P5/145F02P5/152F02P5/153
    • F02P5/1455F02P5/152Y02T10/46
    • A system and method for controlling an ignition timing for a vehicular internal combustion engine are disclosed in which a feedback correction quantity for the ignition timing value is calculated on the basis of a result of detection of at least one of an occurrence of engine knocking and a position at which a combustion pressure becomes maximum and the feedback correction quantity is added to a basic ignition timing angle value based on engine operating conditions to determine a final ignition timing angle value. The feedback correction quantity is limited by a limit value set so as to be varied with the increase of a vehicle speed when the feedback correction quantity is advanced toward an advance angle value. The limit value is retarded when the vehicle speed is low, thus suppressing a combustion noise. On the other hand, the limit value is advanced when the vehicle speed is high, thus achieving the engine output torque and fuel economy.
    • 公开了一种用于控制车辆内燃机的点火正时的系统和方法,其中基于发动机爆震的发生和发动机的发生中的至少一个的结果来计算点火正时值的反馈校正量 燃烧压力变得最大的位置,并且基于发动机操作条件将反馈校正量添加到基本点火正时角度值,以确定最终点火正时角度值。 反馈校正量受限于设定的限制值的限制,随着反馈校正量向前进角度值的前进而随着车速的增加而变化。 当车速低时,限制值被延迟,从而抑制燃烧噪声。 另一方面,当车速高时极限值提前,从而实现发动机输出扭矩和燃油经济性。
    • 33. 发明授权
    • System for controlling a fuel injection quantity and method therefor
    • 用于控制燃料喷射量的系统及其方法
    • US4901699A
    • 1990-02-20
    • US216041
    • 1988-07-07
    • Hiromichi MiwaMasaaki UchidaYoshihisa Kawamura
    • Hiromichi MiwaMasaaki UchidaYoshihisa Kawamura
    • F02D41/10F02D35/02F02D41/00F02D41/04F02D41/18F02D41/34F02D45/00
    • F02D35/023F02D41/008F02D41/045F02D41/10
    • A system and method for controlling a fuel injection quantity for an internal combustion engine are disclosed in which upon start of the engine acceleration, a quantity corresponding to an air quantity sucked into an engine cylinder (for example, a pressure in an intake air passage downstream of a throttle valve) is detected, an indicated mean effective pressure (P.sub.i) is detected, gains and phases of both detected values are matched with each other, respectively, so that an expected value of the indicated mean effective pressure is derived from the detected value of the air quantity corresponding quantity, a deviation between the expected value and detected value of the indicated mean effective pressure is derived, a correction quantity for a basic injection quantity at the time of an acceleration of a vehicle through the engine is derived on the basis of the deviation, and a fuel injection quantity outputted from a fuel injection valve is determined on the basis of the corrected fuel injection quantity.
    • 公开了一种用于控制内燃机的燃料喷射量的系统和方法,其中在发动机加速开始时,对应于吸入发动机气缸的空气量的量(例如,进气通道下游的压力 检测到指示的平均有效压力(Pi),两个检测值的增益和相位分别相互匹配,使得从检测到的平均有效压力的期望值得到 导出空气量对应量的值,得出所指示的平均有效压力的预期值和检测值之间的偏差,在车辆通过发动机加速时的基本喷射量的校正量在 基于校正燃料i来确定从燃料喷射阀输出的燃料喷射量 喷射量
    • 34. 发明授权
    • Adjusting system for crank angle sensor
    • 曲柄角传感器调整系统
    • US4413508A
    • 1983-11-08
    • US300101
    • 1981-09-08
    • Yoshihisa KawamuraSeishi Yasuhara
    • Yoshihisa KawamuraSeishi Yasuhara
    • F02B1/04F02B77/08F02D41/34F02D45/00F02F7/00F02P5/02F02P5/15F02P7/077G01M15/00
    • F02D41/009F02B77/087F02P7/0775F02B1/04F02D41/0097F02F7/006
    • An adjusting system for crank angle sensor signal comprises a crank angle sensor, a timing detector and an adjusting unit including an output control device. The crank angle sensor is associated with an engine crankshaft and produces first and second signals. The first signal is indicative of a predetermined crankshaft position for each engine cylinder and the second signal is indicative of rotation of the engine crankshaft through a unit angle. These signals are used for controlling fuel injection timing or spark timing. The timing detector measures the difference between an actual value and a target value with respect to a desired timing, which timing is, for example, fuel injection timing, spark timing, or a predetermined crankshaft position for each engine cylinder. The output control device is provided at a safe place away from various engine rotational parts and is manually operable to change its output as a correction value. The adjusting unit is adapted to adjust the first signal in response to the output of the output control device to make the actual value coincide with the target value so that the first signal is electrically adjusted safely and efficiently without moving the crank angle sensor itself to attain optimal fuel injection timing or spark timing.
    • 用于曲柄角传感器信号的调节系统包括曲柄角传感器,定时检测器和包括输出控制装置的调节单元。 曲柄角传感器与发动机曲轴相关联,并产生第一和第二信号。 第一信号表示每个发动机气缸的预定曲轴位置,第二信号表示发动机曲轴以单位角度的转动。 这些信号用于控制燃料喷射正时或火花正时。 定时检测器相对于期望的定时测量实际值和目标值之间的差异,该期间例如是燃料喷射正时,火花正时或每个发动机气缸的预定曲轴位置。 输出控制装置设置在远离各种发动机旋转部件的安全的地方,并且可手动地将其输出改变为校正值。 调整单元适于响应于输出控制装置的输出来调整第一信号,以使实际值与目标值一致,使得第一信号被安全有效地电调节,而不移动曲柄角传感器本身以获得 最佳燃油喷射正时或火花正时。
    • 39. 发明授权
    • Determination method of biological component and reagent kit used therefor
    • 用于其的生物成分和试剂盒的测定方法
    • US06867012B2
    • 2005-03-15
    • US09998130
    • 2001-12-03
    • Takahide KishimotoAtsushi SogabeShizuo HattoriMasanori OkaYoshihisa Kawamura
    • Takahide KishimotoAtsushi SogabeShizuo HattoriMasanori OkaYoshihisa Kawamura
    • C12N9/02C12Q1/26C12Q1/32C12Q1/48
    • C12N9/0008C12Q1/26C12Q1/32C12Q1/48Y10S435/975
    • The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method of formaldehyde and biological components, such as creatinine, creatine, and homocysteine, which produces formaldehyde as a reaction intermediate. In addition, the present invention provides a reagent kit for the above-mentioned determination method. The present invention provides a novel determination method of a homocysteine using transferase utilizing homocysteine and other compound as a pair of substrates. Particularly, the present invention provides a determination method of homocysteine which includes bringing betaine-homocysteine methyltransferase and dimethylglycine oxidase into contact with a sample and measuring produced hydrogen peroxide or formaldehyde. Moreover, the present invention provides novel dimethylglycine oxidase stable to thiol compound, which is suitably used for the measurement. The present invention provides a reagent kit used for any of the above-mentioned determination methods of homocysteine.
    • 本发明提供了新的谷胱甘肽依赖性甲醛脱氢酶,其可以通过循环反应定量测定甲醛,以及产生甲醛作为反应中间体的甲醛和生物成分如肌酸酐,肌酸和高半胱氨酸的测定方法。 此外,本发明提供了用于上述确定方法的试剂盒。 本发明提供使用高半胱氨酸和其它化合物作为一对底物的转移酶的同型半胱氨酸的新型测定方法。 特别地,本发明提供了同型半胱氨酸的测定方法,其包括使甜菜碱 - 高半胱氨酸甲基转移酶和二甲基甘氨酸氧化酶与样品接触并测量产生的过氧化氢或甲醛。 此外,本发明提供了适用于测定的硫醇化合物稳定的新型二甲基甘氨酸氧化酶。 本发明提供了用于任何上述同型半胱氨酸测定方法的试剂盒。
    • 40. 发明授权
    • Insitu assay of substance in biological sample using labeled probe
    • 使用标记探针对生物样品中的物质进行原位测定
    • US06455684B1
    • 2002-09-24
    • US09967361
    • 2001-09-28
    • Kazuhiro MatsuiKatsunori IkedaShinichi TeshimaYoshihisa KawamuraKazuko Matsumoto
    • Kazuhiro MatsuiKatsunori IkedaShinichi TeshimaYoshihisa KawamuraKazuko Matsumoto
    • C07H2102
    • G01N33/582G01N2458/40
    • A method for analyzing an objective substance, comprising reacting a labeled probe with an objective substance on a biological sample, said probe comprising a label substance of the formula (I): wherein A1 is an aromatic group, R1 is a hydrogen or —COCH2COCnF2n+1 and n is an integer of 1-6, which is bonded to a probe selected from the group consisting of nucleic acid, nucleic acid binding protein, low molecular ligand and receptor for ligand (except antibody) to give a fluorescent complex, reacting the complex with an objective substance on a biological sample and assaying fluorescence of the resultant fluorescent complex, a labeled nucleic acid probe and a labeled nucleotide. According to the method of the present invention, defects such as hindrance of fluorescence due to contaminant substance, low sensitivity and the like can be resolved, thereby enabling analysis on a tissue.
    • 一种用于分析目标物质的方法,包括使标记的探针与生物样品上的目标物质反应,所述探针包含式(I)的标记物质:其中A1为芳族基团,R1为氢或-COCH2COCnF2n + 1和n是1-6的整数,其与选自核酸,核酸结合蛋白,低分子配体和配体(抗体除外)的受体的探针结合,得到荧光复合物,使 与生物样品上的目标物质复合,并测定所得荧光复合物,标记的核酸探针和标记的核苷酸的荧光。 根据本发明的方法,可以解决诸如由于污染物质引起的荧光阻碍,低灵敏度等的缺陷,从而能够对组织进行分析。