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31. 发明授权

US07960562B2 Propane-1,3-dione derivative or salt thereof 有权
标题翻译：丙烷-1,3-二酮衍生物或其盐
公开(公告)号：US07960562B2
公开(公告)日：2011-06-14
申请号：US11887384
申请日：2006-03-30
申请人： Masaaki Hirano , Isao Kinoyama , Shunichiro Matsumoto , Eiji Kawaminami , Kei Ohnuki , Hirofumi Yamamoto , Kazuhiko Osoda , Tatsuhisa Takahashi , Takashi Shin , Takanori Koike , Itsuro Shimada , Hiroyuki Hisamichi , Toshiyuki Kusayama
发明人： Masaaki Hirano , Isao Kinoyama , Shunichiro Matsumoto , Eiji Kawaminami , Kei Ohnuki , Hirofumi Yamamoto , Kazuhiko Osoda , Tatsuhisa Takahashi , Takashi Shin , Takanori Koike , Itsuro Shimada , Hiroyuki Hisamichi , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D235/12 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14
摘要： It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by —SO2—R3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone-dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.
摘要翻译：旨在提供可用作GnRH受体拮抗剂的化合物。本发明人进一步研究了丙烷-1,3-二酮衍生物。结果证实，在具有2-（1,3-二氢-2H-苯并咪唑）的丙烷-1,3-二酮衍生物中具有被-SO 2 -R 3表示的基团取代的苯环或噻吩环的化合物 -2-亚基）具有优异的GnRH受体拮抗作用，完成了本发明。因为本发明的化合物具有强的GnRH受体拮抗作用，因此可用于治疗性激素依赖性疾病，特别是GnRH相关疾病。此外，由于本发明的化合物在人体中具有优异的代谢稳定性，药物相互作用少，因此作为上述疾病的药物具有优选的特性。

32. 发明申请

US20110085768A1 OPTICAL FIBER AND METHOD OF MANUFACTURING OPTICAL FIBER 有权
标题翻译：光纤和制造光纤的方法
公开(公告)号：US20110085768A1
公开(公告)日：2011-04-14
申请号：US12903798
申请日：2010-10-13
申请人： Tetsuya Nakanishi , Masaaki Hirano , Tetsuya Haruna , Maki Ikechi
发明人： Tetsuya Nakanishi , Masaaki Hirano , Tetsuya Haruna , Maki Ikechi
IPC分类号： G02B6/44 , G02B6/02
CPC分类号： C03B37/02727 , C03B2203/19 , C03B2203/222 , G02B6/02 , G02B6/02366 , G02B6/03627 , G02B6/0365 , G02B6/03694
摘要： An optical fiber having excellent strength that can be manufactured at low cost, as well as a method for making such optical fiber, is provided. An optical fiber 1 is a silica-based optical fiber comprising a core 11, an optical cladding 12 surrounding the core 11, and a jacketing region 13 surrounding the optical cladding 12 and having a uniform composition throughout from the internal circumference to the outer circumference. A compressive strained layer having a residual compressive stress is provided at the outermost circumference of the jacketing region 13.
摘要翻译：提供了具有可以低成本制造的优异强度的光纤以及制造这种光纤的方法。光纤1是包括芯11，围绕芯11的光学包层12和围绕光学包层12并且具有从内周到外周均匀组成的护套区域13的二氧化硅基光纤。在护套区域13的最外周设有具有残余压应力的压应变层。

33. 发明授权

US07787730B2 Optical fiber and broadband light source 有权
标题翻译：光纤和宽带光源
公开(公告)号：US07787730B2
公开(公告)日：2010-08-31
申请号：US11922783
申请日：2007-03-12
申请人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
发明人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
IPC分类号： G02B6/02
CPC分类号： G02B6/03627 , G02B6/02028 , G02B6/02242 , G02B6/02257 , G02B6/02271 , G02F1/3532 , G02F2001/3528
摘要： An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area of 12 μm2 or less at the central wavelength, outputs supercontinuum light having a wavelength bandwidth expanded to 1000 nm or more.
摘要翻译：可以产生具有更宽带宽的SC光的光纤和宽带光源。宽带光源1配备有种子光源11和光纤12.种子光源11输出在1500nm至1650nm的波长范围内的中心波长的光。光纤12输出来自种子光源的光输出的结果的超连续光。在中心波长处具有在1300nm至1500nm的波长范围内的零色散波长和12μm2或更小的有效面积的光纤12输出具有扩展至1000nm以上的波长带宽的超连续光。

34. 发明授权

US07340137B2 Optical fiber and optical module 有权
标题翻译：光纤和光模块
公开(公告)号：US07340137B2
公开(公告)日：2008-03-04
申请号：US11586004
申请日：2006-10-25
申请人： Takemi Hasegawa , Masaaki Hirano
发明人： Takemi Hasegawa , Masaaki Hirano
IPC分类号： G02B6/02
CPC分类号： G02B6/03694 , G02B6/02028 , G02B6/0281 , H01S3/06716 , H01S3/302
摘要： An optical fiber capable of effectively suppressing stimulated Brillouin scattering, and an optical module including the fiber are provided. The fiber includes a core region, and a cladding region having a refractive index lower than that of the core region and an acoustic velocity higher than that of the core region. An effective area of the fiber is 5λ2 or less at at least one light wavelength λ. The ratio ΔA/ΔO of an acoustic relative refractive index ratio ΔA and an optical relative refractive index ratio ΔO is 25 or more. The optical module includes the optical fiber, a light source that outputs first light having a wavelength λ1, and a multiplexer that receives the first light and second light having a wavelength λ2 and that multiplexes and couples the first light and the second light to the optical fiber.
摘要翻译：提供能够有效地抑制受激布里渊散射的光纤，以及包括该光纤的光学模块。纤维包括芯区域和折射率低于核心区域的折射率的包层区域，并且声速比芯区域高。纤维的有效面积在至少一个光波长λ为5λ2以下。声学相对折射率比ΔA和光学相对折射率ΔA的比值ΔA为25以上。光学模块包括光纤，输出具有波长λ1的第一光的光源，以及接收第一光的多路复用器和具有波长λ2的第二光并且将第一光和第二光复用并耦合到光纤。

35. 发明申请

US20070283721A1 Method Of Producing An Optical Fiber Preform 有权
标题翻译：制造光纤预制件的方法
公开(公告)号：US20070283721A1
公开(公告)日：2007-12-13
申请号：US11665600
申请日：2005-10-20
申请人： Tetsuya Nakanishi , Masaaki Hirano
发明人： Tetsuya Nakanishi , Masaaki Hirano
IPC分类号： C03B37/018
CPC分类号： C03B37/01823 , C03B2207/66 , Y02P40/57
摘要： Glass can be synthesized and deposited at a high rate by the inside CVD method using a plasma burner in a manner such that unconsolidated portions or bubbles are little generated. The method includes a step of depositing a glass film on the inner wall surface of a starting pipe. In a first aspect, temperature the pipe is controlled not to exceed (1800+100×d)° C., a temperature of (1100+100×d)° C. or higher being continued for 20 seconds or more at each point of the pipe, where d (mm) represents the wall thickness of the pipe. In a second aspect, the burner includes at least two inlets and has an inner diameter of 80 mm or more, and the deposition step is performed in the relationship, 150 mm/s
摘要翻译：可以通过使用等离子体燃烧器的内部CVD方法以高速率合成和沉积玻璃，使得很少产生未固化的部分或气泡。该方法包括在起始管的内壁表面上沉积玻璃膜的步骤。在第一方面，管道的温度控制不超过（1800 + 100×d）℃，（1100 + 100×d）℃或更高的温度在管道的每个点处持续20秒以上，其中 d（mm）表示管道的壁厚。在第二方面，燃烧器包括至少两个入口并且具有80mm或更大的内径，并且沉积步骤以150mm / s（引入燃烧器的气体的总流量） /（燃烧器的截面积）<600 mm / s。

36. 发明申请

US20070258717A1 Optical device and wavelength conversion method and optical fiber suitable for them 审中-公开
标题翻译：光器件和波长转换方法以及适合它们的光纤
公开(公告)号：US20070258717A1
公开(公告)日：2007-11-08
申请号：US11797212
申请日：2007-05-01
申请人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno , Masato Tanaka
发明人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno , Masato Tanaka
IPC分类号： H04J14/02
CPC分类号： G02F1/395 , G02B6/02028 , G02B6/02242 , G02B6/02252 , G02B6/02266 , G02B6/02285 , G02B6/03627 , G02B6/03644 , G02B6/0365 , G02B6/03666
摘要： An optical device and wavelength conversion method can selectively perform wavelength conversion of a probe lightwave. An optical fiber is suitable for them. The device 1 comprises (a) a pump light source 12 for outputting a pump lightwave having a wavelength of λpump and (b) an optical fiber 11 that guides the pump lightwave and a probe lightwave having a wavelength of λprobe and generates through a nonlinear optical phenomenon an idler lightwave having a newly produced wavelength of λidler that is in accordance with the wavelength λprobe. The wavelength λprobe dependence of the efficiency of the wavelength conversion has a main band including the wavelength λpump and a subband distinct from the main band. The probe lightwave included in the subband is guided in the optical fiber 11 to generate in it the idler lightwave having the wavelength λidler that is in accordance with the wavelength λprobe.
摘要翻译：光学器件和波长转换方法可以选择性地执行探针光波的波长转换。光纤适合它们。装置1包括：（a）泵浦光源12，用于输出具有波长λλ泵的泵浦光波;以及（b）引导泵浦光波的光纤11和具有波长的探针光波的λ＆lt;探针＆lt;＆gt;并且通过非线性光学现象产生具有根据波长λ探针。波长转换效率的波长λ> probe has has has has has has has。。。。。。。。。。。。。。。。。。。。。。。。。。。。。包括在子带中的探测光波在光纤11中被引导，以在其中产生具有与波长λ探针的波长相匹配的波长λ惰性的惰性光波。

37. 发明申请

US20070147755A1 Optical fiber and optical module 有权
标题翻译：光纤和光模块
公开(公告)号：US20070147755A1
公开(公告)日：2007-06-28
申请号：US11586004
申请日：2006-10-25
申请人： Takemi Hasegawa , Masaaki Hirano
发明人： Takemi Hasegawa , Masaaki Hirano
IPC分类号： G02B6/02
CPC分类号： G02B6/03694 , G02B6/02028 , G02B6/0281 , H01S3/06716 , H01S3/302
摘要： An optical fiber capable of effectively suppressing stimulated Brillouin scattering, and an optical module including the fiber are provided. The fiber includes a core region, and a cladding region having a refractive index lower than that of the core region and an acoustic velocity higher than that of the core region. An effective area of the fiber is 5λ2 or less at at least one light wavelength λ. The ratio ΔA/ΔO of an acoustic relative refractive index ratio ΔA and an optical relative refractive index ratio ΔO is 25 or more. The optical module includes the optical fiber, a light source that outputs first light having a wavelength λ1, and a multiplexer that receives the first light and second light having a wavelength λ2 and that multiplexes and couples the first light and the second light to the optical fiber.
摘要翻译：提供能够有效地抑制受激布里渊散射的光纤，以及包括该光纤的光学模块。纤维包括芯区域和折射率低于核心区域的折射率的包层区域，并且声速比芯区域高。纤维的有效面积在至少一个光波长λ为5λ2以下。声学相对折射率比ΔΔA和光学相对折射率ΔA的比值ΔA/ΔA/ / SUB>为25以上。光学模块包括光纤，输出具有波长λ1的第一光的光源，以及接收第一光的多路复用器和具有波长λ2的第二光并且将第一光和第二光复用并耦合到光纤。

38. 发明申请

US20070047962A1 Optical fiber and optical device using the same 有权
标题翻译：光纤和光学器件使用相同
公开(公告)号：US20070047962A1
公开(公告)日：2007-03-01
申请号：US11483979
申请日：2006-07-11
申请人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
发明人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
IPC分类号： H04B10/12
CPC分类号： G02B6/03666 , G02B6/02028 , G02B6/02242 , G02B6/02257 , G02B6/02271 , G02B6/0228 , G02B6/0281 , G02B6/03627 , G02B6/03644 , G02F1/365 , G02F2001/3528
摘要： This invention relates to an optical fiber and others having a structure for efficiently generating SC light while realizing high nonlinearity over a wide band. The optical fiber has at least a center core region, and an outside cladding region having a refractive index lower than that of the center core region and provided on an outer periphery of the center core region. The optical fiber has, as characteristics to light of a wavelength λ1 in a wavelength range of 1520 nm to 1620 nm, a chromatic dispersion of −2 ps/nm/km to +2 ps/nm/km, a dispersion slope of −0.009 ps/nm2/km to +0.009 ps/nm2/km, and a fourth-order dispersion of −1.8×10−4 ps/nm3/km to +1.8×10−4 ps/nm3/km.
摘要翻译：本发明涉及一种具有用于在宽带上实现高非线性的同时有效地产生SC光的结构的光纤等。该光纤至少具有中心纤芯区域和折射率低于中心纤芯区域的折射率的外包层区域，并且设置在中心纤芯区域的外周。在1520nm至1620nm的波长范围内，作为波长λ1的光的特性，光纤具有-2ps / nm / km至+ 2ps / nm / km的色散，色散斜率为 - 0.009ps / nm 2 / km至+0.009ps / nm 2 / km，第四阶色散为-1.8×10 -4 / ps / nm 3 / km至+ 1.8×10 -4 ps / nm 3 / km。

39. 发明申请

US20050267110A1 Propane-1, 3-dione derivative 有权
标题翻译：丙烷-1,3-二酮衍生物
公开(公告)号：US20050267110A1
公开(公告)日：2005-12-01
申请号：US11155595
申请日：2005-06-20
申请人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
发明人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61P5/24 , A61P35/00 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/53 , A61K31/385 , A61K31/423
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
摘要翻译：本发明提供含有丙-1,3-二酮衍生物作为活性成分，特别是GnRH受体拮抗剂的药物组合物。此外，提供具有GnRH拮抗作用的丙烷-1,3-二酮衍生物。

40. 发明授权

US06960591B2 Propane-1,3-dione derivative 有权
标题翻译：丙烷-1,3-二酮衍生物
公开(公告)号：US06960591B2
公开(公告)日：2005-11-01
申请号：US10311688
申请日：2001-07-04
申请人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
发明人： Masaaki Hirano , Eiji Kawaminami , Akira Toyoshima , Hiroyuki Moritomo , Norio Seki , Ryutaro Wakayama , Minoru Okada , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61P5/24 , A61P35/00 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D235/06 , C07D235/12 , C07D277/64 , C07D277/84 , C07D339/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
摘要翻译：本发明提供含有丙-1,3-二酮衍生物作为活性成分，特别是GnRH受体拮抗剂的药物组合物。此外，提供具有GnRH拮抗作用的丙烷-1,3-二酮衍生物。

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