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31. 发明授权

US5852006A N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds 失效
标题翻译： N-氨基烷基取代的含氮六元杂环化合物
公开(公告)号：US5852006A
公开(公告)日：1998-12-22
申请号：US725247
申请日：1996-10-04
申请人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
发明人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
IPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D413/06 , C07D265/30 , A61K31/535 , A61K31/54 , C07D279/12
CPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D413/06
摘要： Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R.sup.1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.2 is a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.3 and R.sup.4 represent hydrogen, alkyl, aralkyl or aryl; or R.sup.3 and R.sup.4 are combined to form one of substituted or unsubstituted 5- to 7-membered heterocyclic groups; X is oxygen, sulfur or imino; Y is oxygen or sulfur; Z is --CH.sub.2 --, --CO-- or --CS--; m is an integer of 0-4; n is an integer of 0-4; r is 0 or 1; and p and q represent an integer of 0-5 provided that p plus q is 1-5.
摘要翻译：公开了对治疗排尿困难有效的下式的新的亚烷基二胺衍生物：其中R 1是氢，烷基或取代或未取代的苯基，萘基或芳族杂环基; R2是取代或未取代的苯基，萘基或芳族杂环基; R3和R4代表氢，烷基，芳烷基或芳基; 或R 3和R 4组合以形成取代或未取代的5至7元杂环基团之一; X是氧，硫或亚氨基; Y是氧或硫; Z是-CH 2 - ， - CO-或-CS-; m为0-4的整数; n是0-4的整数; r为0或1; p和q表示0〜5的整数，只要p + q为1-5。

32. 发明授权

US5843992A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US5843992A
公开(公告)日：1998-12-01
申请号：US930509
申请日：1997-09-29
申请人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
发明人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinic acid derivative having the following formula: ##STR1## �wherein R.sup.1 is hydrogen, alkyl, aryl, or aralkyl; each of R.sup.2 and R.sup.3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR.sup.4 --; and R.sup.4 is hydrogen, alkyl, or aralkyl! is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.
摘要翻译： PCT No.PCT / JP96 / 00889 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1996年4月1日PCT公布。出版物WO96 / 30354 日期：1996年10月3日具有下式的环氧琥珀酸衍生物：其中R 1是氢，烷基，芳基或芳烷基; R2和R3各自独立地为芳基，芳烷基或烷基; X是-O-或-NR4-; 和R4是氢，烷基或芳烷基]可用于预防和治疗骨质疏松症，恶性高钙血症和佩吉特综合征等骨疾病，并且还可用于治疗组织蛋白酶L活性异常增强的骨关节炎和类风湿性关节炎，并且还可用作治疗组织蛋白酶B和L参与的疾病的药物，例如肌营养不良和肌肉萎缩。

33. 发明授权

US5180836A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US5180836A
公开(公告)日：1993-01-19
申请号：US786392
申请日：1991-11-01
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： C07D233/84 , C07D235/28
CPC分类号： C07D233/84 , C07D235/28
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.
摘要翻译：公开了具有下式的新的咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或者R 1和R 2结合形成杂环; R3，R4，R5和R6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基或氟取代的 - 烷氧基，或R3与R2结合形成杂环; R8和R9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基，氟取代的 - 烷氧基或芳基，或R8和R9组合形成脂环 ; R 7是，其中R 8和R 9不组合，其中R 8和R 9结合，可以具有取代基的烷基，可以具有取代基的芳基，可以具有取代基的芳基或含硫杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

34. 发明授权

US5082943A Novel imidazole derivatives 失效
标题翻译：新咪唑衍生物
公开(公告)号：US5082943A
公开(公告)日：1992-01-21
申请号：US658424
申请日：1991-02-20
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/47 , A61P1/04 , C07D233/84 , C07D233/86 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/28 , C07D401/12
CPC分类号： C07D235/28 , C07D233/84
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

35. 发明授权

US4339378A N-Acylcarnosine aluminum salts 失效
标题翻译： N-酰基肌氨酸铝盐
公开(公告)号：US4339378A
公开(公告)日：1982-07-13
申请号：US194841
申请日：1980-10-07
申请人： Mitsuo Masaki , Toru Yamanaka , Taketoshi Kinoshita
发明人： Mitsuo Masaki , Toru Yamanaka , Taketoshi Kinoshita
IPC分类号： A61K31/415 , A61P1/04 , A61P1/14 , C07D233/54 , C07D233/64 , C07C103/52 , A61K37/02
CPC分类号： C07D233/64 , Y10S514/927
摘要： An N-acylcarnosine aluminum salt of the formula, ##STR1## Wherein R represents a lower alkyl group or a phenyl group, and n is an integer of 2 to 3 is effective for use as a digestive ulcer-remedying or anti-ulcer agent.
摘要翻译：下式的N-酰基肌氨酸铝盐，其中R表示低级烷基或苯基，n为2〜3的整数，可用作消化性溃疡补救剂或抗溃疡剂。

36. 发明授权

US4009168A Pyridinethiol-tin compound and process for the preparation of the same 失效
标题翻译：吡啶硫醇 - 锡化合物及其制备方法
公开(公告)号：US4009168A
公开(公告)日：1977-02-22
申请号：US440382
申请日：1974-02-07
申请人： Mitsuo Masaki , Satoshi Matsunami , Jyunichiro Kita , Toshikazu Hayashi
发明人： Mitsuo Masaki , Satoshi Matsunami , Jyunichiro Kita , Toshikazu Hayashi
IPC分类号： C08K5/00 , B01J31/00 , C07B61/00 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , C07F7/00 , C07F7/22 , C08K5/37 , C08K5/57 , C08L23/00 , C08L101/00
CPC分类号： C07D213/70 , C07D213/80 , C07D213/85 , C07D213/89 , C07F7/003 , C08K5/36 , C08K5/37
摘要： Pyridinethiol-tin compounds having the formula of RS-SnX.sub.2 -SR' in which R and R' are groups derived from unsubstituted or substituted pyridines or unsubstituted or substituted pyridine N-oxides. A process for the preparation of the same is also discosed. The compounds are stabilizers for polyolefins.
摘要翻译：具有式RS-SnX2-SR'的吡啶硫醚锡化合物，其中R和R'是衍生自未取代或取代的吡啶或未取代或取代的吡啶N-氧化物的基团。还提出了其制备方法。这些化合物是聚烯烃的稳定剂。

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