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31. 发明授权

US07874992B2 Method for continuous baroreflex sensitivity measurement 有权
标题翻译：连续压力反射灵敏度测量方法
公开(公告)号：US07874992B2
公开(公告)日：2011-01-25
申请号：US11343635
申请日：2006-01-31
申请人： Yong K. Cho , Tommy D. Bennett
发明人： Yong K. Cho , Tommy D. Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0816 , A61B5/7285 , A61N1/3627 , A61N1/36521 , A61N1/368
摘要： A medical device and method for determining baroreflex sensitivity (BRS) based on one or more respiration cycles. The BRS determination may be performed continuously based on measurements of heart rate, blood pressure, and respiration cycles.
摘要翻译：一种用于根据一个或多个呼吸周期来确定压力反射灵敏度（BRS）的医疗装置和方法。可以基于心率，血压和呼吸周期的测量来连续进行BRS测定。

32. 发明授权

US07766826B2 Multi-level averaging scheme for acquiring hemodynamic data 有权
标题翻译：用于获取血液动力学数据的多级平均方案
公开(公告)号：US07766826B2
公开(公告)日：2010-08-03
申请号：US10723364
申请日：2003-11-26
申请人： Brian B. Lee , Tommy D. Bennett
发明人： Brian B. Lee , Tommy D. Bennett
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/04325 , A61B5/145 , A61B5/14532 , G06F19/00
摘要： A system and method for storing and processing physiological data in a medical recording device that allows continuous data collection and storage of such data in multiple time-resolved levels are provided. The method includes: sampling one or more physiological signals at a selected sampling rate; deriving physiological parameter values from the sampled signal; storing the parameter values as they are determined in a temporary memory buffer for a predetermined storage interval; determining a statistical aspect of the stored parameter values upon expiration of the storage interval; and writing the statistical aspect to a long-term memory buffer. A number of long-term memory buffers may be designated for storing a statistical aspect of a physiological parameter at uniquely different time resolutions. The resolution of each long-term memory buffer is determined by the storage interval defined for an associated temporary memory buffer, which stores parameter values from which statistical aspects are computed.
摘要翻译：提供一种在医疗记录装置中存储和处理生理数据的系统和方法，其允许以多个时间分辨级别连续数据收集和存储这些数据。该方法包括：以选定的采样速率对一个或多个生理信号进行采样; 从采样信号中得到生理参数值; 将其在临时存储器缓冲器中确定的参数值存储在预定的存储间隔中; 在所述存储间隔期满时确定所存储的参数值的统计方面; 并将统计方面写入长期内存缓冲区。可以指定多个长期记忆缓冲器用于以独特的不同时间分辨率存储生理参数的统计方面。每个长期存储器缓冲器的分辨率由为关联的临时存储器缓冲器定义的存储间隔确定，其存储从其计算统计方面的参数值。

33. 发明申请

US20100114230A1 Method and Apparatus to Detect Ischemia With A Pressure Sensor 有权
标题翻译：用压力传感器检测缺血的方法和装置
公开(公告)号：US20100114230A1
公开(公告)日：2010-05-06
申请号：US12263423
申请日：2008-10-31
申请人： Sarah A. Audit , James K. Carney , William J. Combs , Tommy D. Bennett , Barbro M.L. Kjellstrom
发明人： Sarah A. Audit , James K. Carney , William J. Combs , Tommy D. Bennett , Barbro M.L. Kjellstrom
IPC分类号： A61N1/365
CPC分类号： A61B5/02055 , A61B5/0215 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61N1/36514 , A61N1/36564 , A61N1/37258
摘要： The present disclosure provides an apparatus and method of detecting ischemia with a pressure sensor. The method can include obtaining a pressure signal and determining a pressure rate of change. The method can also include identifying at least one of impaired relaxation and impaired contractility in order to detect ischemia.
摘要翻译：本公开提供了利用压力传感器检测缺血的装置和方法。该方法可以包括获得压力信号并确定压力变化率。该方法还可以包括鉴定减轻的松弛和受损的收缩力中的至少一种以便检测缺血。

34. 发明申请

US20100076325A1 METHOD AND APPARATUS FOR DETERMINING RESPIRATORY EFFORT IN A MEDICAL DEVICE 有权
标题翻译：用于确定医疗装置中呼吸道作用的方法和装置
公开(公告)号：US20100076325A1
公开(公告)日：2010-03-25
申请号：US12262320
申请日：2008-10-31
申请人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
发明人： Yong K. Cho , Tommy D. Bennett , Mark K. Erickson , Maneesh Shrivastav , Saul E. Greenhut , Karen J. Kleckner , Charles P. Sperling , Robert A. Corey
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A method of determining respiratory effort in a medical device in which pressure signals are sensed to generate corresponding sample points, an inspiration and an expiration are detected in response to the sensed pressure signals, a breath is detected in response to the detected inspiration and the detected expiration, and the respiratory effort is determined in response to the detected breath.
摘要翻译：一种在医疗装置中确定呼吸力的方法，其中响应于检测到的压力信号检测压力信号以产生相应的采样点，吸气和呼气，响应于检测到的吸气和检测到的呼吸被检测到呼吸到期，并且响应于检测到的呼吸来确定呼吸努力。

35. 发明申请

US20100056885A1 IMPLANTABLE BIOSENSOR DEVICES FOR MONITORING CARDIAC MARKER MOLECULES 审中-公开
标题翻译：用于监测心脏标记分子的可植入生物传感器装置
公开(公告)号：US20100056885A1
公开(公告)日：2010-03-04
申请号：US12612133
申请日：2009-11-04
申请人： Ven Manda , Tommy D. Bennett , Zhongping Yang
发明人： Ven Manda , Tommy D. Bennett , Zhongping Yang
IPC分类号： A61B5/145
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61N1/36514
摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.
摘要翻译：公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

36. 发明授权

US07632234B2 Implantable biosensor devices for monitoring cardiac marker molecules 失效
标题翻译：用于监测心脏标志物分子的可植入生物传感器装置
公开(公告)号：US07632234B2
公开(公告)日：2009-12-15
申请号：US10652837
申请日：2003-08-29
申请人： Ven Manda , Tommy D. Bennett , Zhongping Yang
发明人： Ven Manda , Tommy D. Bennett , Zhongping Yang
IPC分类号： A61B5/02
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61N1/36514
摘要： An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.
摘要翻译：公开了一种用于确定患者心脏标志物水平的可植入生物传感器系统，以帮助诊断，确定心血管疾病的严重性和管理。该传感器包括纳米线传感器元件，其具有连接到纳米线换能器的生物识别元件，该纳米线传感器特异性地结合正被测量的心脏标志物。每个传感器元件与防止传感器元件与周围环境相互作用的保护构件相关联。在选择的时间，保护构件可以被禁用，从而允许传感器元件开始感测活体内的信号。

37. 发明申请

US20090171220A1 METHODS FOR DETECTING AND MONITORING SLEEP DISORDERED BREATHING USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗器械检测和监测睡眠障碍性呼吸的方法
公开(公告)号：US20090171220A1
公开(公告)日：2009-07-02
申请号：US12346290
申请日：2008-12-30
申请人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
发明人： Yong Kyun Cho , Tommy D. Bennett , Barbro M. Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

38. 发明授权

US07470233B2 Method and apparatus for muscle function measurement 有权
标题翻译：肌肉功能测量的方法和装置
公开(公告)号：US07470233B2
公开(公告)日：2008-12-30
申请号：US11043819
申请日：2005-01-26
申请人： Mustafa Karamanoglu , Vincent E. Splett , Tommy D. Bennett
发明人： Mustafa Karamanoglu , Vincent E. Splett , Tommy D. Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译：本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。瞬时刚度比E / E（t）以1 /秒为单位，与强键形成速率有关，并受肌肉纤维钙处理性能和细胞内钙浓度的影响。因此，从E / E（t）得到的指数提供肌肉肌力状态的量度。

39. 发明授权

US5626623A Method and apparatus for optimizing pacemaker AV delay 失效
标题翻译：用于优化起搏器AV延迟的方法和装置
公开(公告)号：US5626623A
公开(公告)日：1997-05-06
申请号：US640434
申请日：1996-04-30
申请人： Robert S. Kieval , Tommy D. Bennett
发明人： Robert S. Kieval , Tommy D. Bennett
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368 , A61N1/36
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/7239 , A61N1/36564 , A61N1/3682
摘要： In a dual chamber cardiac pacemaker, a method and apparatus for determining an atrioventricular (AV) delay interval to maintain optimal left heart AV mechanical synchrony and function. When the intrinsic or paced atrial heart rate is stable, test AV delay intervals are selected and delivered as right ventricular absolute blood pressures (RVP) are measured at the opening of the pulmonary valve. The opening of the pulmonary valve is determined by the peak rate of change in the RVP (dP/dt) following depolarization of the right ventricle. The test AV delay interval providing the lowest amplitude RVP at the peak dP/dt, indicating the lowest pulmonary blood pressure, is selected as the optimal AV delay. The system may be fully contained in an implanted pacemaker system including a right ventricular absolute blood pressure sensor and automatically invoked to determine the optimum AV delay for the prevailing atrial heart rate at any time, or may be invoked at a predetermined time of day or may be invoked by a programmed-in command. The system may also be employed on a temporary basis in conjunction with an implanted dual chamber pacemaker and an external pacemaker programmer with a temporary absolute blood pressure sensor to provide the blood pressure signals.
摘要翻译：在双室心脏起搏器中，一种用于确定房室（AV）延迟间隔以维持最佳左心脏AV机械同步和功能的方法和装置。当内在或节奏的心房心率稳定时，在肺动脉瓣的开口处测量右心室绝对血压（RVP），选择并递送测试AV延迟间隔。肺动脉瓣的开放由右心室去极化后的RVP（dP / dt）的峰值变化速率决定。选择峰值dP / dt处的最低振幅RVP的测试AV延迟间隔，表示最低的肺血压，作为最佳的AV延迟。该系统可以完全包含在包括右心室绝对血压传感器的植入式起搏器系统中，并且自动调用以在任何时间确定主要心房心率的最佳AV延迟，或者可以在一天的预定时间被调用由编入命令调用。该系统还可以临时使用植入的双室起搏器和具有临时绝对血压传感器的外部起搏器编程器来提供血压信号。

40. 发明授权

US09399091B2 System and method to regulate ultrafiltration 有权
标题翻译：调节超滤的系统和方法
公开(公告)号：US09399091B2
公开(公告)日：2016-07-26
申请号：US12571127
申请日：2009-09-30
申请人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
发明人： Daniel C. Sigg , Sarah Anne Audet , Tommy D. Bennett , Dwight H. Warkentin
IPC分类号： A61M37/00 , A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3403 , A61M1/16 , A61M1/34 , A61M1/3406 , A61M1/341 , A61M1/36 , A61M1/3669 , A61M2205/18 , A61M2205/33 , A61M2205/3334 , A61M2205/3344 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/20 , A61M2230/201 , A61M2230/30 , A61M2230/65
摘要： A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.
摘要翻译：包括生理传感器和超滤单元的医疗装置系统感测患者的生理信号，并使用生理信号计算患者的流体状况测量。根据响应于流体状态测量而建立的治疗递送控制参数将超滤治疗递送给患者。

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