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31. 发明申请

US20110009919A1 METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
标题翻译：使用噪声共振方法来提高实际和有效的传输
公开(公告)号：US20110009919A1
公开(公告)日：2011-01-13
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.
摘要翻译：提供了向患者提供治疗的方法。在一种方法中，患者具有应用亚阈值生物电刺激的神经元。该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。在另一种方法中，患者具有应用超临界生物电刺激的神经元。该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

32. 发明申请

US20090082835A1 Apparatus and Methods For Charging An Implanted Medical Device Power Source 有权
标题翻译：一种植入式医疗器械电源充电装置及方法
公开(公告)号：US20090082835A1
公开(公告)日：2009-03-26
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

33. 发明申请

US20050143789A1 Methods and systems for stimulating a peripheral nerve to treat chronic pain 审中-公开
标题翻译：刺激周围神经治疗慢性疼痛的方法和系统
公开(公告)号：US20050143789A1
公开(公告)日：2005-06-30
申请号：US11067111
申请日：2005-02-25
申请人： Todd Whitehurst , Kristen Jaax
发明人： Todd Whitehurst , Kristen Jaax
IPC分类号： A61N1/05 , A61N1/08 , A61N1/18 , A61N1/34
CPC分类号： A61N1/36071 , A61N1/08
摘要： Methods of treating chronic pain within a patient include applying at least one stimulus to a peripheral nerve within the patient with an implanted system control unit in accordance with one or more stimulation parameters. The stimulus is configured to treat the chronic pain. Systems for treating chronic pain within a patient include a system control unit configured to apply a stimulus to a peripheral nerve within the patient in accordance with one or more stimulation parameters. The system control unit is implanted within the patient and the stimulus is configured to treat the chronic pain.
摘要翻译：治疗患者的慢性疼痛的方法包括根据一个或多个刺激参数，用植入的系统控制单元对患者内的周围神经施加至少一种刺激。刺激被配置为治疗慢性疼痛。用于治疗患者中的慢性疼痛的系统包括系统控制单元，其被配置为根据一个或多个刺激参数对患者内的周围神经施加刺激。将系统控制单元植入患者体内，并且将刺激配置为治疗慢性疼痛。

34. 发明申请

US20060235484A1 Stimulation of a stimulation site within the neck or head 有权
标题翻译：刺激颈部或头部刺激部位
公开(公告)号：US20060235484A1
公开(公告)日：2006-10-19
申请号：US11259176
申请日：2005-10-25
申请人： Kristen Jaax , Todd Whitehurst
发明人： Kristen Jaax , Todd Whitehurst
IPC分类号： A61N1/34
CPC分类号： A61N1/3787 , A61N1/0534 , A61N1/36071 , A61N1/37211 , A61N2001/0582
摘要： Methods of applying a stimulus to a stimulation site within the neck or head of a patient include implanting a distal portion of one or more leads adjacent to the stimulation site, forming a loop with a proximal portion of the one or more leads, and securing the distal and proximal portions of the one or more leads to one or more securing sites with one or more securing devices. The distal portion of the one or more leads includes a number of electrodes disposed thereon that are configured to deliver the stimulus to the stimulation site. Systems for applying a stimulus to a stimulation site within the neck or head of a patient include one or more leads having a number of electrodes disposed on a distal portion thereof and one or more securing devices configured to secure the one or more leads to one or more securing sites. The distal portion of the one or more leads is implanted adjacent to the stimulation site and the electrodes are configured to deliver the stimulus to the stimulation site. The proximal portion of the one or more leads is formed in a loop.
摘要翻译：将刺激施加到患者的颈部或头部内的刺激部位的方法包括将邻近刺激部位的一个或多个引线的远端部分植入，形成具有一个或多个引线的近端部分的环，一个或多个引线的远端和近端部分具有一个或多个固定装置的一个或多个固定位置。一个或多个引线的远端部分包括布置在其上的多个电极，其被配置为将刺激传递到刺激部位。将刺激施加到患者的颈部或头部内的刺激部位的系统包括一个或多个引线，其具有设置在其远端部分上的多个电极，以及一个或多个固定装置，其被配置成将一个或多个引线固定到一个或多个引线更多的安全网站。一个或多个引线的远端部分被邻近刺激部位植入，并且电极构造成将刺激递送到刺激部位。一个或多个引线的近端部分形成为环形。

35. 发明申请

US20050049651A1 Treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion 失效
标题翻译：通过电脑刺激和/或药物输注治疗情绪和/或焦虑症
公开(公告)号：US20050049651A1
公开(公告)日：2005-03-03
申请号：US10925519
申请日：2004-08-24
申请人： Todd Whitehurst , Kristen Jaax
发明人： Todd Whitehurst , Kristen Jaax
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36096 , A61M5/172 , A61M5/1723 , A61N1/37205 , A61N1/3787
摘要： A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：用于将一种或多种刺激性药物引入和/或施加电刺激以治疗情绪和/或焦虑症的系统和方法使用可植入系统控制单元（SCU），特别是可植入信号/脉冲发生器（IPG）或微刺激器在电刺激的情况下具有一个或多个电极，以及在药物输注的情况下具有一个或多个导管的可植入泵。在需要电刺激和药物刺激的情况下，使用一个或多个SCU。或者，优选地，当需要时，SCU提供电刺激和一种或多种刺激性药物。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。

36. 发明申请

US20050240229A1 Methods and systems for stimulation as a therapy for erectile dysfunction 审中-公开
标题翻译：刺激作为勃起功能障碍治疗的方法和系统
公开(公告)号：US20050240229A1
公开(公告)日：2005-10-27
申请号：US11141443
申请日：2005-05-31
申请人： Tood Whitehurst , James McGivern , Kristen Jaax , James Makous
发明人： Tood Whitehurst , James McGivern , Kristen Jaax , James Makous
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37211 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： Systems and methods for stimulating tissue affecting the penis to treat erectile dysfunction may include stimulation using at least one implantable system control unit (SCU).
摘要翻译：刺激影响阴茎治疗勃起功能障碍的组织的系统和方法可以包括使用至少一个可植入系统控制单元（SCU）的刺激。

37. 发明授权

US08315707B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08315707B2
公开(公告)日：2012-11-20
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , Andrew DiGiore
发明人： Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

38. 发明申请

US20120179222A1 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMMODATION TO ELECTRICAL STIMULATION 有权
标题翻译：用于避免，反转和管理神经病学接受电刺激的系统和方法
公开(公告)号：US20120179222A1
公开(公告)日：2012-07-12
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , DIGIORE ANDREW
发明人： Kristen Jaax , DIGIORE ANDREW
IPC分类号： A61N1/36
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

39. 发明授权

US09345878B2 System and method for compensating for shifting of neurostimulation leads in a patient 有权
标题翻译：用于补偿患者神经刺激导线移位的系统和方法
公开(公告)号：US09345878B2
公开(公告)日：2016-05-24
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

40. 发明申请

US20100331922A1 SYSTEM AND METHOD FOR COMPENSATING FOR SHIFTING OF NEUROSTIMULATION LEADS IN A PATIENT 有权
标题翻译：用于补偿患者神经细胞发生突变的系统和方法
公开(公告)号：US20100331922A1
公开(公告)日：2010-12-30
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

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