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31. 发明授权

US06503227B1 Guide wire brake 失效
标题翻译：导丝制动
公开(公告)号：US06503227B1
公开(公告)日：2003-01-07
申请号：US09624429
申请日：2000-07-24
申请人： Zihong Guo , Verivada Chandrasekaran
发明人： Zihong Guo , Verivada Chandrasekaran
IPC分类号： A61B1700
CPC分类号： A61B17/320758 , A61B2017/00469 , A61B2017/22049 , A61B2017/22075
摘要： An improved guide wire brake that is particularly suited to ablative rotational atherectomy devices is disclosed. The guide wire brake ensures that a guide wire is prevented from rotating or moving axially prior to activation of a primary mover such as a turbine. In one embodiment a pressure relief valve delays the activation of the prime mover on start up, and a check valve delays the release of the guide wire brake on shut down. In a second embodiment the guide wire brake is serially connected to the prime mover such that the prime mover is not connected to the pressurized gas source until after the guide wire brake is engaged. In a third embodiment a guide wire is disposed through a flexible tube within a rigid cylinder that is serially connected to the prime mover, such that when pressurized gas is provided to the prime mover the flexible tube will collapse on the guide wire, to prevent guide wire movement. In a fourth embodiment a mechanical brake, in a single action, engages the guide wire prior to opening a flow path between the pressurized gas source and the prime mover. Methods for manually bypassing the guide wire brake are also disclosed.
摘要翻译：公开了一种特别适用于消融性旋切体切除装置的改进的导丝线制动器。引导线制动器确保在诸如涡轮机的初级动子的启动之前防止导丝旋转或轴向移动。在一个实施例中，减压阀在启动时延迟原动机的启动，并且止回阀在关闭时延迟引导线制动器的释放。在第二实施例中，引导线制动器串联连接到原动机，使得原动机不连接到加压气体源，直到在引导线制动器接合之后。在第三实施例中，引导线通过柔性管道设置在刚性圆柱体内，该刚性圆柱体串联连接到原动机，使得当加压气体被提供给原动机时，柔性管将在引导线上塌陷，以防止引导电线运动。在第四实施例中，在打开加压气体源和原动机之间的流动路径之前，在一个动作中的机械制动器接合导丝。还公开了手动绕过导丝线制动器的方法。

32. 发明授权

US06394956B1 RF ablation and ultrasound catheter for crossing chronic total occlusions 有权
标题翻译：射频消融和超声导管横穿慢性全闭塞
公开(公告)号：US06394956B1
公开(公告)日：2002-05-28
申请号：US09514970
申请日：2000-02-29
申请人： Chandru V. Chandrasekaran , Zihong Guo , Anthony J. Pantages , Donald Masters , Ryan Kaveckis
发明人： Chandru V. Chandrasekaran , Zihong Guo , Anthony J. Pantages , Donald Masters , Ryan Kaveckis
IPC分类号： A61B800
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445 , A61B18/1492 , A61B2017/003 , A61B2018/00208 , A61B2018/00351 , A61B2018/0041 , A61B2018/00541 , A61B2018/144 , A61B2018/1861 , A61B2090/3782 , A61F9/0079
摘要： A combination catheter includes an ultrasound transducer and RF ablation electrode. The ultrasound transducer transmits ultrasound signals into and receives echo signals from a vessel. The echo signals are processed and used to produce an image of the tissue surrounding the catheter. A driveshaft rotates the ultrasound transducer to obtain a 360° view of the vessel wall. At the distal end of the driveshaft is an electrode. An RF generator is electrically coupled to the driveshaft to deliver RF energy to the electrode at the distal end of the driveshaft to ablate occluding material in the vessel. The electrode may have a variety of tip shapes including concave, roughened, or expandable configurations, depending on the size of the vessel and composition of the occluding material to be ablated. Alternatively, the RF ablation energy may be delivered to a guidewire that is used to route the ultrasound catheter through a patient's vasculature. Finally, a steerable catheter can be used to further position the ultrasound catheter and ablation electrode in the vessel.
摘要翻译：组合导管包括超声换能器和RF消融电极。超声波传感器将超声波信号发送到容器中并从容器接收回波信号。回波信号被处理并用于产生围绕导管的组织的图像。驱动轴旋转超声换能器以获得血管壁的360°视图。在驱动轴的远端是电极。 RF发生器电耦合到驱动轴以将RF能量传递到驱动轴的远端处的电极以消除容器中的封闭材料。取决于容器的尺寸和待烧蚀的封闭材料的组成，电极可以具有各种尖端形状，包括凹形，粗糙化或可膨胀构型。或者，RF消融能量可以被递送到用于将超声导管穿过患者脉管系统的引导线。最后，可以使用可导向的导管将超声波导管和消融电极进一步放置在容器中。

33. 发明授权

US06210408B1 Guide wire system for RF recanalization of vascular blockages 失效
公开(公告)号：US06210408B1
公开(公告)日：2001-04-03
申请号：US09256977
申请日：1999-02-24
申请人： Verivada Chandrasekaran , Zihong Guo , Brooke Qin Ren , Byron Fedie
发明人： Verivada Chandrasekaran , Zihong Guo , Brooke Qin Ren , Byron Fedie
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/22038 , A61B2017/22094 , A61B2018/00214 , A61B2018/00261 , A61B2018/00279 , A61B2018/00285 , A61B2018/0041 , A61B2018/00422 , A61B2018/00625 , A61B2018/1213 , A61B2018/1253 , A61B2018/1435 , A61B2018/144 , A61M25/09 , A61M25/10 , A61M2025/1047
摘要： A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process. The ablative guide wire includes a distal ablation tip having a non-traumatic structure and at least one discontinuous feature for creating high current densities for more efficient tissue ablation.

34. 外观设计

USD983896S1 Oven toy 有权
公开(公告)号：USD983896S1
公开(公告)日：2023-04-18
申请号：US29841112
申请日：2022-06-02
申请人： Zihong Guo
设计人： Zihong Guo

35. 发明授权

US09139351B2 Temperature-stabilized storage systems with flexible connectors 有权
标题翻译：具有柔性连接器的温度稳定存储系统
公开(公告)号：US09139351B2
公开(公告)日：2015-09-22
申请号：US12927981
申请日：2010-11-29
申请人： Fong-Li Chou , Geoffrey F. Deane , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Nathan P. Myhrvold , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Fong-Li Chou , Geoffrey F. Deane , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Nathan P. Myhrvold , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
IPC分类号： B65D1/24 , B65D1/36 , B65D25/04 , B65D57/00 , B65D85/00 , F17C1/00 , F17C3/00 , F17C13/00 , F25D23/00 , A47J39/00 , A47J41/00 , B65D81/38 , A61J1/00 , F28D20/02
CPC分类号： B65D81/3806 , A61J1/00 , A61J2200/40 , F28D20/02
摘要： Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. The flexible connectors include a duct forming an elongated thermal pathway between the exterior of the container and the substantially thermally sealed storage region within the container. The flexible connectors include compression units mated to each end of the duct and a plurality of compression strands connected between the compression units.
摘要翻译：描述了基本上热密封的容器，其包括将容器的外部中的孔与容器内基本上热密封的存储区中的孔接合的柔性连接器。柔性连接器包括在容器的外部和容器内基本上热密封的存储区域之间形成细长的热路径的管道。柔性连接器包括与管道的每个端部配合的压缩单元和连接在压缩单元之间的多个压缩股。

36. 发明申请

US20130319900A1 VESSELS 审中-公开
标题翻译：船只
公开(公告)号：US20130319900A1
公开(公告)日：2013-12-05
申请号：US13485027
申请日：2012-05-31
申请人： Lawrence Morgan Fowler , Zihong Guo , Jenny Hu , John Arthur Ohrt
发明人： Lawrence Morgan Fowler , Zihong Guo , Jenny Hu , John Arthur Ohrt
IPC分类号： B65D21/032 , B29C49/04
CPC分类号： B65D23/102 , B65D1/04 , B65D1/18 , B65D21/0231
摘要： The present disclosure relates to vessels and processes that may be used to fabricate vessels.
摘要翻译：本公开涉及可用于制造血管的血管和过程。

37. 发明申请

US20120315364A1 HEAT STABLE VESSEL 审中-公开
标题翻译：热稳定的船只
公开(公告)号：US20120315364A1
公开(公告)日：2012-12-13
申请号：US13492664
申请日：2012-06-08
申请人： Cary Richard Champlin , Lawrence Morgan Fowler , Zihong Guo , Jenny E. Hu , Ian Fletcher Kent , Ian Murray , Nathan John Pegram , Shannon Weise Stone , Sarah Patricia Walters , Lowell L. Wood, JR. , Ozgur Emek Yildirim , Christopher C. Young
发明人： Cary Richard Champlin , Lawrence Morgan Fowler , Zihong Guo , Jenny E. Hu , Ian Fletcher Kent , Ian Murray , Nathan John Pegram , Shannon Weise Stone , Sarah Patricia Walters , Lowell L. Wood, JR. , Ozgur Emek Yildirim , Christopher C. Young
IPC分类号： A23C3/02
CPC分类号： A23L3/003 , A23C3/023 , A23L3/16
摘要： The present disclosure relates to methods, systems, and devices that may be used to heat treat and store one or more fluids.
摘要翻译：本公开涉及可用于热处理和储存一种或多种流体的方法，系统和装置。

38. 发明授权

US08052604B2 Methods and apparatus for engagement and coupling of an intracavitory imaging and high intensity focused ultrasound probe 有权
标题翻译：腔内成像和高强度聚焦超声探头的接合和耦合的方法和装置
公开(公告)号：US08052604B2
公开(公告)日：2011-11-08
申请号：US11831048
申请日：2007-07-31
申请人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
发明人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔允许流体流过盖子。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

39. 发明申请

US20100213200A1 Temperature-stabilized storage systems 有权
标题翻译：温度稳定的存储系统
公开(公告)号：US20100213200A1
公开(公告)日：2010-08-26
申请号：US12658579
申请日：2010-02-08
申请人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
发明人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K.Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR.
IPC分类号： B65D81/38 , B23P11/00 , B65D79/00
CPC分类号： B65D81/3802 , B65D81/3811 , B65D81/3813 , B65D81/3823 , B65D81/3825 , B65D81/3834 , B65D81/3888 , B65D81/3897 , B65D2203/10 , Y10T29/49826
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.
摘要翻译：基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元存储区域和至少一个储存材料分配器单元，其中所述至少一个储存的材料分配器单元包括一个或多个互锁。

40. 发明申请

US20100144698A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20100144698A1
公开(公告)日：2010-06-10
申请号：US12703610
申请日：2010-02-10
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D205/04 , A61P9/00 , A61P7/00
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

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