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31. 发明申请

US20120115182A1 MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA 有权
标题翻译：大分子诊断分析
公开(公告)号：US20120115182A1
公开(公告)日：2012-05-10
申请号：US13322363
申请日：2010-07-14
申请人： Thomas Maier
发明人： Thomas Maier
IPC分类号： C12Q1/04
CPC分类号： C12Q1/24 , C12Q1/04 , G01N33/6851 , G01N2560/00 , G01N2570/00 , G01N2800/26
摘要： The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour.
摘要翻译：本发明主要涉及血流感染（败血病）血液培养物中病原体的质谱鉴定。本发明提供了一种在血培养瓶中比较短暂的培养后，将微生物病原体与血液分离的方法，其中没有任何干扰的人类蛋白质或血液颗粒如红细胞和白细胞的任何残留部分，并且可直接通过其蛋白质谱的质谱测定来鉴定。该方法基于使用相对较强的表面活性剂通过溶解弱细胞膜和血液颗粒的大部分内部结构来破坏血液颗粒; 尽管在MALDI和质谱测量所需的其他电离过程中，表面活性剂被认为是强电离抑制剂。该方法允许通过离心或过滤以其纯形式获得未知的病原体，并根据物种或亚种的分类级别进行鉴定。通过特殊措施可以解决高水平白细胞DNA的问题。在充分培养后，质谱实验室的鉴定只需半小时。

32. 发明申请

US20110012016A1 SPECTROPHOTOMETRIC IDENTIFICATION OF MICROBE SUBSPECIES 有权
标题翻译：微量元素的分光光度鉴定
公开(公告)号：US20110012016A1
公开(公告)日：2011-01-20
申请号：US12834504
申请日：2010-07-12
申请人： Thomas Maier , Markus Kostrzewa
发明人： Thomas Maier , Markus Kostrzewa
IPC分类号： B01D59/44
CPC分类号： G01N33/6848 , C12Q1/04 , G01N2560/00 , G06F19/24
摘要： A dual-stage method is provided for identifying a microbe by, for example, its species or its subspecies. The method includes measuring a mass spectrum of the microbe using a mass spectrometer, calculating indicators for similarities between reference mass spectra in a library and the measured mass spectrum, selecting a group of reference mass spectra similar to the measured mass spectrum, determining a distinguishing weight for each mass signal of the reference mass spectra in the group, where the distinguishing weights emphasize differences between the reference mass spectra in the group, and calculating indicators for similarities between the reference mass spectra in the group and the measured mass spectrum as a function of the distinguishing weights.
摘要翻译：提供了用于通过例如其物种或其亚种鉴定微生物的双阶段方法。该方法包括使用质谱仪测量微生物的质谱，计算文库中参考质谱与测量质谱之间的相似性的指标，选择与测得的质谱相似的一组参考质谱，确定鉴别重量对于组中参考质谱的每个质量信号，其中区分权重强调组中参考质谱之间的差异，并且计算组中参考质谱与测量质谱之间的相似性的指标，作为区别权重。

33. 发明申请

US20090026995A1 Reliable Monitoring of the Speed in Coordinate Measuring Appliances 有权
标题翻译：可靠的监测坐标测量设备的速度
公开(公告)号：US20090026995A1
公开(公告)日：2009-01-29
申请号：US12280625
申请日：2007-02-16
申请人： Peter Uhl , Gunter Grupp , Thomas Maier
发明人： Peter Uhl , Gunter Grupp , Thomas Maier
IPC分类号： G05B23/02
CPC分类号： G01B21/04 , G05B2219/42318
摘要： In a method for reliably monitoring the speed of a moveable coordinate measuring device, a first value of the speed is calculated from measured values of the coordinate measurement system. The measured values contain information on positions of the coordinate measuring device. The measured values are further used to determine the coordinates of a measurement object. A second value of the speed is ascertained from measurement signals of at least one additional movement sensor. The measurement signals can also be used for controlling a drive device of the coordinate measuring device. A fault signal can be generated if the first value and/or the second value deviate from one another, from a predetermined value and/or a limit value according to a predefined criterion.
摘要翻译：在可靠地监视可移动坐标测量装置的速度的方法中，根据坐标测量系统的测量值来计算速度的第一值。测量值包含关于坐标测量装置位置的信息。测量值进一步用于确定测量对象的坐标。速度的第二值由至少一个额外的运动传感器的测量信号确定。测量信号也可用于控制坐标测量装置的驱动装置。如果第一值和/或第二值根据预定标准从预定值和/或极限值彼此偏离，则可以产生故障信号。

34. 发明申请

US20070232596A1 Benzothienopyridines for Use as Inhibitors of Eg5 Kinesin 有权
标题翻译：苯并噻吩类作为Eg5驱动蛋白的抑制剂
公开(公告)号：US20070232596A1
公开(公告)日：2007-10-04
申请号：US11659738
申请日：2005-08-17
申请人： Matthias Vennemann , Thomas Baer , Gudrun Groegor , Jurgen Braunger , Petra Gimmnich , Thomas Maier , Heike Rothfels
发明人： Matthias Vennemann , Thomas Baer , Gudrun Groegor , Jurgen Braunger , Petra Gimmnich , Thomas Maier , Heike Rothfels
IPC分类号： A61K31/4523 , A61K31/5377 , A61K31/541 , C07D417/14 , C07D419/14
CPC分类号： C07D471/14 , C07D495/14
摘要： Compounds of the formula (1) in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.
摘要翻译：其中R1，R2，R3，R4和X具有说明书中所示含义的式（1）化合物是具有Eg5抑制，抗增殖和/或凋亡诱导活性的新型有效化合物。

35. 发明申请

US20050084507A1 Liquid preparations and surfactant/solvent systems 审中-公开
标题翻译：液体制剂和表面活性剂/溶剂体系
公开(公告)号：US20050084507A1
公开(公告)日：2005-04-21
申请号：US10985606
申请日：2004-11-10
申请人： Jochen Wurtz , Thomas Maier , Gerhard Schnabel , Gerhard Johann
发明人： Jochen Wurtz , Thomas Maier , Gerhard Schnabel , Gerhard Johann
IPC分类号： B01F17/12 , A01N25/02 , A01N25/04 , A01N25/30 , A01N39/04 , A01N43/12 , A01N43/76 , A01N47/22 , A01N47/38 , A01N53/08 , B01F17/14 , B01F17/38 , B01F17/40 , B01F17/42 , A61K9/00
CPC分类号： A01N25/30 , A01N25/02 , A01N47/22 , A01N43/12 , A01N37/38 , A01N47/38 , A01N53/00
摘要： Surfactant/solvent systems for liquid organic formulations (preparations) which comprise one or more aromatic-based surfactants and one or more completely esterified organic phosphates and/or phosphonates which are as polar as possible, but are at the same time water-insoluble or soluble in water to 5 g/l, as solvents, are suitable to be used for the preparation of emulsifiable concentrates and corresponding liquid preparations derived therefrom, such as aqueous spray mixtures.
摘要翻译：含有一种或多种芳族基表面活性剂和一种或多种完全酯化的有机磷酸盐和/或膦酸盐的液体有机配方（制剂）的表面活性剂/溶剂系统，它们尽可能极性，但同时是不溶于水或不溶的在水中至5g / l，作为溶剂适合用于制备可乳化浓缩物和由其衍生的相应的液体制剂，例如水性喷雾混合物。

36. 发明授权

US06872690B2 Herbicidal 2-alkynyl-pyri (mi) dines 失效
标题翻译：除草2-炔基 - 吡啶（mi）餐
公开(公告)号：US06872690B2
公开(公告)日：2005-03-29
申请号：US10087066
申请日：2002-03-01
申请人： Thomas Maier
发明人： Thomas Maier
IPC分类号： C07D213/64 , A01N43/40 , A01N43/56 , A01N47/02 , A01N55/00 , C07D213/643 , C07D213/68 , C07D213/69 , C07D213/70 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/08
CPC分类号： C07D213/643 , A01N43/40 , A01N43/56 , A01N55/00 , C07D213/68 , C07D213/69 , C07D213/70 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/0812
摘要： The invention relates method of combating undesired plant growth at a locus, comprising application to the locus of an effective amount of at least one compound of formula (I): wherein R1, R3, A, X, Z and m have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and to novel compounds of formula I as well as to herbicidal compositions containing such compounds as active ingredients.
摘要翻译：本发明涉及在一个场所防治不想要的植物生长的方法，其包括将有效量的至少一种式（I）化合物施用于所述场所：其中R 1，R 3，A，X，Z和 m具有权利要求1中给出的含义及其农学上可接受的盐或N-氧化物，以及式I的新化合物以及含有这些化合物作为活性成分的除草组合物。

37. 发明授权

US06534447B1 Herbicidal pyridine compounds 失效
标题翻译：除草吡啶化合物
公开(公告)号：US06534447B1
公开(公告)日：2003-03-18
申请号：US09708921
申请日：2000-11-08
申请人： Stefan Scheiblich , Thomas Maier , Helmut Baltruschat
发明人： Stefan Scheiblich , Thomas Maier , Helmut Baltruschat
IPC分类号： C07D21396
CPC分类号： C07D213/69 , A01N43/40 , A01N43/56 , C07D213/84 , C07D239/52 , C07D239/56 , C07D241/18 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The invention relates to novel compounds of formula I: wherein E, A, X1, X2, X3, Z, m, x and y have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredients.
摘要翻译：本发明涉及式I的新化合物：其中E，A，X 1，X 2，X 3，Z，m，x和y具有权利要求1中给出的含义及其农艺学上可接受的盐或N-氧化物，含有这些化合物作为活性成分的组合物。

38. 发明授权

US06457238B1 Eating utensil 失效
标题翻译：吃饭器具
公开(公告)号：US06457238B1
公开(公告)日：2002-10-01
申请号：US09568347
申请日：2000-05-10
申请人： Michael Maier , Thomas Maier , Thilo Schauer
发明人： Michael Maier , Thomas Maier , Thilo Schauer
IPC分类号： A47G2104
CPC分类号： A47G21/08
摘要： An eating utensil with a spoon shell fastened to a handle enables handicapped people, who have, e.g., only one usable hand, to reduce in size pieces of food, e.g., meat, by cutting into bite-sized pieces. To achieve this, the spoon shell (1, 31) and the handle (6) are of a two-part design. The spoon shell (1) has a first shell part (2) with a first handle shaft (4) and a second shell part (3) with a second handle shaft (5). The respective shell parts (2, 3) and handle shafts (4, 5), which are rigidly connected to one another, are connected to one another by a scissor hinge (7) and can be moved against one another in a scissor-like manner. The shell parts (2, 3) have cutting edges (8, 9) cooperating in a scissor-like manner.
摘要翻译：具有固定在手柄上的勺子壳的餐具使得具有例如仅一只手的残疾人能够通过切割成大小的块来减小食物（例如肉）的大小。为了实现这一点，勺壳（1,31）和手柄（6）是两部分设计的。勺壳（1）具有带有第一手柄轴（4）的第一外壳部分（2）和具有第二手柄轴（5）的第二壳部分（3）。通过剪刀铰链（7）将彼此刚性地连接的各个壳部件（2,3）和手柄轴（4,5）彼此连接，并且可以以类似剪刀的方式相互移动方式。壳体部分（2,3）具有以剪刀状方式配合的切割刃（8,9）。

39. 发明授权

US06420315B1 Herbicidal pyridine compounds 失效
标题翻译：除草吡啶化合物
公开(公告)号：US06420315B1
公开(公告)日：2002-07-16
申请号：US09648886
申请日：2000-08-25
申请人： Stefan Scheiblich , Thomas Maier , Helmut Siegfried Baltruschat , Thomas Hoellmueller
发明人： Stefan Scheiblich , Thomas Maier , Helmut Siegfried Baltruschat , Thomas Hoellmueller
IPC分类号： A01N4340
CPC分类号： C07D213/69 , A01N43/40 , A01N43/56 , C07D401/12 , C07D409/12
摘要： The novel compounds of formula I: wherein R, A, X1, X2, X3, Z and m have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and herbicidal compositions containing such compounds as active ingredients.
摘要翻译：式I的新化合物：其中R，A，X 1，X 2，X 3，Z和m具有权利要求1中给出的含义，及其农艺学上可接受的盐或N-氧化物，以及含有这些化合物作为活性成分的除草组合物。

40. 发明授权

US6162449A Scleroglucans and cosmetic composition containing the new compounds 失效
标题翻译：含有新化合物的硬皮葡聚糖和化妆品组合物
公开(公告)号：US6162449A
公开(公告)日：2000-12-19
申请号：US109414
申请日：1998-07-02
申请人： Thomas Maier , Klaus Huber , Udo Rau , Bernhard Schilling
发明人： Thomas Maier , Klaus Huber , Udo Rau , Bernhard Schilling
IPC分类号： A61K8/72 , A61K8/73 , A61K9/00 , A61Q5/02 , A61Q11/00 , A61Q19/00 , C08B37/00 , C12P19/04 , C12R1/645 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/73 , A61K9/0048 , A61Q11/00 , C08B37/0024 , C12P19/04
摘要： A cosmetic composition is provided comprising:A) a cosmetically acceptable carrier; andB) 0.05 to 3.0 % by weight, based on the weight of the total composition, of a .beta.-1,3-scleroglucan having a three-dimensional crosslinked triple helix structure and having a mean molecular weight of 1.times.10.sup.6 to 12.times.10.sup.6.
摘要翻译：提供了一种化妆品组合物，其包含：A）化妆品可接受的载体; 和B）0.05-3.0重量％，基于总组合物的重量，具有三维交联三螺旋结构且平均分子量为1×10 6至12×10 6的β-1,3-硬葡聚糖。

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