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31. 发明申请

US20070287735A1 Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases 有权
标题翻译：用于治疗和预防正痘病毒感染和相关疾病的化学品，组合物和方法
公开(公告)号：US20070287735A1
公开(公告)日：2007-12-13
申请号：US11785998
申请日：2007-04-23
申请人： Robert Jordan , Thomas Bailey , Susan Rippin , Dongcheng Dai
发明人： Robert Jordan , Thomas Bailey , Susan Rippin , Dongcheng Dai
IPC分类号： A61K31/403 , A61K31/4439 , A61P31/12 , C07D209/56 , C07D401/12
CPC分类号： C07D209/56 , A61K9/1623 , A61K9/1652
摘要： Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
摘要翻译：使用二，三和四环酰肼衍生物及其类似物的方法，以及含有它们的药物组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。

32. 发明申请

US20070281949A1 Substituted pyrazolopyrimidines 有权
标题翻译：取代的吡唑并嘧啶
公开(公告)号：US20070281949A1
公开(公告)日：2007-12-06
申请号：US11803320
申请日：2007-05-14
申请人： Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
发明人： Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
IPC分类号： A61K31/519 , A61K31/517 , C07D487/02 , C07D403/02
CPC分类号： C07D401/14 , C07D403/04 , C07D487/04
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译：本发明涉及化学组成，其制备方法和组合物的用途。特别地，本发明涉及包含式（I）的取代的杂双环嘧啶的组合物：其中R 1，R 2，R 3， R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 以及它们在治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病中的用途。更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。

33. 发明申请

US20060157282A1 Managed pressure drilling 有权
公开(公告)号：US20060157282A1
公开(公告)日：2006-07-20
申请号：US11254993
申请日：2005-10-20
申请人： Frederick Tilton , David Haugen , Kevin Smith , David Brunnert , Thomas Bailey , Tom Fuller , Roy Rooyakkers , Ram Bansal , Graham Skinner
发明人： Frederick Tilton , David Haugen , Kevin Smith , David Brunnert , Thomas Bailey , Tom Fuller , Roy Rooyakkers , Ram Bansal , Graham Skinner
IPC分类号： E21B21/00
CPC分类号： E21B21/08 , E21B4/02 , E21B21/00 , E21B21/14 , E21B33/14 , E21B2021/006
摘要： Embodiments of the present invention include methods and apparatus for dynamically controlling pressure within a wellbore while forming the wellbore. In one aspect, one or more pressure control apparatus are used to maintain desired pressure within the wellbore while drilling the wellbore. In another aspect, pressure is dynamically controlled while drilling using foam to maintain a substantially homogenous foam flow regime within the wellbore annulus for carrying cuttings from the wellbore.

34. 发明申请

US20060144622A1 Rotating control head radial seal protection and leak detection systems 有权
标题翻译：旋转控制头径向密封保护和泄漏检测系统
公开(公告)号：US20060144622A1
公开(公告)日：2006-07-06
申请号：US11366078
申请日：2006-03-02
申请人： Thomas Bailey , James Chambers , Don Hannegan , Mark Gravouia
发明人： Thomas Bailey , James Chambers , Don Hannegan , Mark Gravouia
IPC分类号： E21B17/10
CPC分类号： E21B33/085 , E21B36/001 , E21B47/10 , F16J15/324 , F16K41/046
摘要： A system and method for reducing repairs to radial seals used in a rotating control head used while drilling is disclosed. Also, a system and method to detect leaks in the rotating control head and a latching system to latch the rotating control head to a housing is disclosed.
摘要翻译：公开了一种用于减少在钻孔时使用的旋转控制头中使用的径向密封维修的系统和方法。此外，公开了一种用于检测旋转控制头中的泄漏的系统和方法，以及用于将旋转控制头锁定到壳体的闩锁系统。

35. 发明申请

US20060031349A1 Method and system for providing a dynamic mailing list 审中-公开
标题翻译：提供动态邮件列表的方法和系统
公开(公告)号：US20060031349A1
公开(公告)日：2006-02-09
申请号：US11117142
申请日：2005-04-28
申请人： Thomas Bailey , Christopher Jenkins , Jonathan Roberts , Kieran Scott
发明人： Thomas Bailey , Christopher Jenkins , Jonathan Roberts , Kieran Scott
IPC分类号： G06F15/16
CPC分类号： H04L51/14
摘要： A method and system for providing a dynamic mailing list are described. The method includes creating a calendar event and creating a dynamic mailing list with a reference to the event. Clients are added to the dynamic mailing list in accordance with a client's status with regard to the event. Access is allowed to the dynamic mailing list by clients in accordance with a client's status with regard to the event. Access to the dynamic mailing list allows a client to send a message to the clients on the dynamic mailing list. A message addressed to the dynamic mailing list is received and forwarded to the clients on the dynamic mailing list. The method and system also include storing messages sent to clients on the dynamic mailing list and sending stored messages to a client added to the dynamic mailing list after the stored messages have been originally sent.
摘要翻译：描述了一种用于提供动态邮件列表的方法和系统。该方法包括创建一个日历事件，并创建一个动态邮件列表，并引用该事件。根据客户关于事件的状态，将客户端添加到动态邮件列表中。根据客户关于事件的状态，客户可以访问动态邮件列表。访问动态邮件列表允许客户端在动态邮件列表中向客户端发送消息。接收到动态邮件列表的消息，并将其转发到动态邮件列表中的客户端。所述方法和系统还包括将存储在动态邮件列表上的客户端的消息存储在存储的消息最初发送之后，将存储的消息发送到添加到动态邮件列表的客户端。

36. 发明申请

US20050241833A1 Solid rubber packer for a rotating control device 有权
标题翻译：用于旋转控制装置的固体橡胶封隔器
公开(公告)号：US20050241833A1
公开(公告)日：2005-11-03
申请号：US11123329
申请日：2005-05-06
申请人： Thomas Bailey , James Chambers , Mark Gravouia
发明人： Thomas Bailey , James Chambers , Mark Gravouia
IPC分类号： E21B33/08 , E21B33/06
CPC分类号： F16J15/3224 , E21B33/085 , F16J15/025 , F16J15/3208 , F16J15/3216 , F16J15/3236
摘要： A seal assembly for use with a rotating control head is provided. The seal assembly includes a rotatable member and a cavity formed between the rotatable member and a tubular radially inwardly disposed from the rotatable member. The cavity having a first surface and a second surface. The seal assembly further includes a seal member having a first end and a second end disposed between the first surface and the second surface of the cavity and sealable with the tubular between the first and the second ends due to deformation of the seal member.
摘要翻译：提供了一种用于旋转控制头的密封组件。密封组件包括可旋转构件和形成在可旋转构件和从可旋转构件径向向内布置的管状物之间的空腔。空腔具有第一表面和第二表面。密封组件还包括密封构件，密封构件具有第一端和设置在空腔的第一表面和第二表面之间的第二端，并且由于密封构件的变形而可与第一和第二端之间的管状物密封。

37. 发明申请

US20050118260A1 Method and apparatus for making a tablet product 审中-公开
标题翻译：制造片剂产品的方法和装置
公开(公告)号：US20050118260A1
公开(公告)日：2005-06-02
申请号：US10509466
申请日：2003-04-03
申请人： Thomas Bailey , Jeremy Baker , Roger Self , Raymond Scherzer , Alan Wilson
发明人： Thomas Bailey , Jeremy Baker , Roger Self , Raymond Scherzer , Alan Wilson
IPC分类号： B30B11/08 , B30B15/30 , A61K9/20 , D04H1/00
CPC分类号： B30B15/304 , B30B11/08
摘要： There is provided a method of forming a tablet product. The method comprises closing off a perforation in a perforated plate; directing powder into said closed-off perforation by the sweeping action of a first director blade spaced from said perforated plate; compacting the powder to form a tablet; and transferring the so-formed tablet from the closed-off perforation. The method is characterized by relative rotary motion of the perforated plate and said first director blade. Suitable apparatus is also provided.
摘要翻译：提供了形成片剂产品的方法。该方法包括关闭多孔板中的穿孔; 通过与所述多孔板间隔开的第一导向器叶片的扫掠作用将粉末引导到所述封闭穿孔中; 压粉以形成片剂; 并将如此形成的片剂从封闭的穿孔转移。该方法的特征在于多孔板和所述第一导向叶片的相对旋转运动。还提供了合适的装置。

38. 发明授权

US09022117B2 Section mill and method for abandoning a wellbore 有权
标题翻译：用于抛弃井眼的分段磨机和方法
公开(公告)号：US09022117B2
公开(公告)日：2015-05-05
申请号：US13047658
申请日：2011-03-14
申请人： Richard Segura , Thomas Bailey , David J. Brunnert , Ram K. Bansal , Andrew Antoine
发明人： Richard Segura , Thomas Bailey , David J. Brunnert , Ram K. Bansal , Andrew Antoine
IPC分类号： E21B29/00
CPC分类号： E21B29/005 , E21B29/002
摘要： A method for milling a tubular cemented in a wellbore includes deploying a bottomhole assembly (BHA) into the wellbore through the tubular, the BHA comprising a window mill; and extending arms of the window mill and radially cutting through the tubular, thereby forming a window through the tubular, wherein a body portion of each window mill arm engages and stabilizes from an inner surface of the tubular after a blade portion of each window mill arm cuts through the tubular.
摘要翻译：用于研磨在井眼中胶结的管状物的方法包括通过管状物将井底组件（BHA）部署到井筒中，BHA包括窗口磨; 并且延伸所述窗玻璃的臂并且径向地切割穿过所述管状物，从而形成通过所述管状物的窗口，其中每个窗口磨机臂的主体部分在每个窗口磨机臂的刀片部分之后从所述管状物的内表面接合并稳定穿过管子。

39. 发明申请

US20130118132A1 MACHINE AND METHOD FOR PHARMACEUTICAL AND PHARMACEUTICAL-LIKE PRODUCT ASSEMBLY 有权
标题翻译：用于药物和药物类产品组装的机器和方法
公开(公告)号：US20130118132A1
公开(公告)日：2013-05-16
申请号：US13738640
申请日：2013-01-10
申请人： Thomas Bailey , Ronnie Benditt , Brewerton Nigel , Steven D. Finkelmeier , Robert Glinecke , Martini Luigi , Paul Simmons
发明人： Thomas Bailey , Ronnie Benditt , Brewerton Nigel , Steven D. Finkelmeier , Robert Glinecke , Martini Luigi , Paul Simmons
IPC分类号： B65B1/04
CPC分类号： B65B1/04 , A61J3/06 , A61J3/10 , Y10T156/10
摘要： A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final project. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product.
摘要翻译：提供了用于组装多个独立形成的固体组分的方法和装置，从而形成用于药物或药物样产品的单一递送载体。可以通过多个杂志将固体成分保持并供给至装置。推杆等可用于定位每个固体组分。在通过粘合液体连接部件的情况下，设置喷雾器，压缩销等将粘合液体的部件压在一起形成最终的工程。铆钉或其他连接结构也可以通过每个固体组分中的孔使用和驱动以形成最终产品。

40. 发明授权

US08354414B2 Substituted bicyclic pyrimidines 有权
标题翻译：取代的双环嘧啶
公开(公告)号：US08354414B2
公开(公告)日：2013-01-15
申请号：US12939527
申请日：2010-11-04
申请人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号： C07D239/70 , C07D471/04 , A61K31/517 , A61K31/519 , C07D239/72 , C07D239/84 , C07D239/78 , C07D487/04
CPC分类号： C07D401/14 , C07D403/04 , C07D487/04
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译：本发明涉及化学组成，其制备方法和组合物的用途。特别地，本发明涉及包含式（I）的取代杂双环嘧啶的组合物：其中R 1，R 2，R 3，R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病的用途。更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。

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