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31. 发明授权

US5159637A Speech word recognizing apparatus using information indicative of the relative significance of speech features 失效
标题翻译：使用指示语音特征的相对重要性的信息的语音字识别装置
公开(公告)号：US5159637A
公开(公告)日：1992-10-27
申请号：US821861
申请日：1992-01-16
申请人： Makoto Okazaki , Koji Eto
发明人： Makoto Okazaki , Koji Eto
IPC分类号： H04M1/27
CPC分类号： H04M1/271
摘要： An isolated speech word recognizer for recognizing an input pattern as one of a plurality of known patterns, comprising a similarity information storing unit for storing similarity information representing the degree of significance of a feature in each of the known patterns for recognizing thereof, and a most similar pattern determining unit for determining one of the plurality of known patterns as the most similar pattern to the input pattern by the use of the similarity information, whereby the recognition performance is improved.
摘要翻译：一种用于将输入图案识别为多个已知图案之一的隔离语音字识别器，包括相似度信息存储单元，用于存储表示每个已知图案中的特征的重要程度的相似度信息，用于识别，以及最多相似图案确定单元，用于通过使用相似度信息来将多个已知图案中的一个确定为与输入图案最相似的图案，由此提高了识别性能。

32. 发明授权

US09492508B2 Parathyroid hormone analogs and uses thereof 有权
标题翻译：甲状旁腺激素类似物及其用途
公开(公告)号：US09492508B2
公开(公告)日：2016-11-15
申请号：US13697249
申请日：2011-05-12
申请人： Thomas J. Gardella , John T. Potts, Jr. , Harald Jueppner , Makoto Okazaki
发明人： Thomas J. Gardella , John T. Potts, Jr. , Harald Jueppner , Makoto Okazaki
IPC分类号： A61K38/29 , C07K14/635
CPC分类号： A61K38/29 , C07K14/635
摘要： Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed.
摘要翻译：公开了在体外和体内证明在PTH受体具有长效活性的两个PTH类似物配体SP-PTH-AAK和Aib-SP-PTH-AAK。因此，这些多肽特别可用于治疗需要长效活性的疾病，如甲状旁腺功能减退。还公开了制备类似物多肽的方法。

33. 发明授权

US07038983B2 Data reproduction apparatus having a variable synchronization detection window 失效
标题翻译：具有可变同步检测窗口的数据再现装置
公开(公告)号：US07038983B2
公开(公告)日：2006-05-02
申请号：US09980202
申请日：2001-03-27
申请人： Yasushi Ueda , Toru Aoki , Makoto Okazaki , Nobuaki Noguchi
发明人： Yasushi Ueda , Toru Aoki , Makoto Okazaki , Nobuaki Noguchi
IPC分类号： G11B7/00
CPC分类号： G11B20/14 , G11B20/00 , G11B20/1403 , G11B20/18 , G11B20/1803 , G11B27/3027 , G11B2020/10916 , G11B2220/216 , G11B2220/2562 , G11B2220/2575
摘要： A fast synchronization pull-in and an optimum error correction are achieved in a reproduction apparatus for reproducing data recorded on a recording medium even in the case where the quality of input data involving a seek or defect is low. A seek amount detection block 190 is provided, a seek change signal 201 is generated, and the width of a synchronization detection window pulse 161 and a correction algorithm in a correction block 230 are modified.
摘要翻译：即使在涉及搜索或缺陷的输入数据的质量低的情况下，也可以在用于再现记录在记录介质上的数据的再现装置中实现快速同步拉入和最佳的纠错。提供寻道量检测块190，生成寻道改变信号201，并修正校正块230中的同步检测窗脉冲161的宽度和校正算法。

34. 发明授权

US07035183B2 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 失效
公开(公告)号：US07035183B2
公开(公告)日：2006-04-25
申请号：US10651033
申请日：2003-08-29
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B15/52
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.

35. 发明申请

US20050199779A1 Temperature control apparatus 失效
标题翻译：温度控制装置
公开(公告)号：US20050199779A1
公开(公告)日：2005-09-15
申请号：US11076230
申请日：2005-03-10
申请人： Nobuaki Noguchi , Yasushi Ueda , Toru Aoki , Makoto Okazaki
发明人： Nobuaki Noguchi , Yasushi Ueda , Toru Aoki , Makoto Okazaki
IPC分类号： G01J1/32
CPC分类号： G01J5/061 , G01J5/20 , G01J5/52 , G01J2005/062 , G01J2005/066 , H01S5/02415 , H01S5/06804 , H01S5/06825
摘要： A temperature control apparatus comprises a light-emitting device, a light-emitting device controller, a Peltier device for controlling the temperature of the light-emitting device to a target temperature, a temperature detector for the light-emitting device, a first reference voltage holding unit for holding a voltage corresponding to the target temperature, a reference voltage controller for outputting a holding signal and a switching signal, a second reference voltage holding unit for holding the output voltage of the temperature detector on the basis of the holding signal, a reference voltage switching unit for selecting either the output of the first reference voltage holding unit or the output of the second reference voltage holding unit as a reference voltage, and a Peltier controller for controlling the Peltier device so as to minimize a difference between the output voltage of the temperature detector and the output voltage of the reference voltage switching unit.
摘要翻译：温度控制装置包括发光装置，发光装置控制器，用于将发光装置的温度控制为目标温度的珀耳帖装置，用于发光装置的温度检测器，第一参考电压用于保持与目标温度相对应的电压的保持单元，用于输出保持信号和开关信号的参考电压控制器，用于基于保持信号保持温度检测器的输出电压的第二参考电压保持单元，参考电压切换单元，用于选择第一参考电压保持单元的输出或第二参考电压保持单元的输出作为参考电压;以及珀耳帖控制器，用于控制珀耳帖装置，以便最小化输出电压的温度检测器和参考电压开关单元的输出电压。

36. 发明申请

US20050122866A1 Optical disc recording and reproduction apparatus having automatic gate signal generation modes 失效
标题翻译：具有自动门信号生成模式的光盘记录和再现设备
公开(公告)号：US20050122866A1
公开(公告)日：2005-06-09
申请号：US11035272
申请日：2005-01-14
申请人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
发明人： Yukio Iijima , Nobuaki Minakuchi , Hidemi Takahashi , Yasushi Ueda , Makoto Okazaki
IPC分类号： G11B7/00 , G11B7/0037 , G11B7/004 , G11B7/005 , G11B7/007 , G11B19/04 , G11B19/12 , G11B20/10 , G11B20/14 , G11B27/19 , G11B27/30 , G11B5/09
CPC分类号： G11B19/04 , G11B7/0037 , G11B7/0053 , G11B7/00745 , G11B19/122 , G11B20/10 , G11B20/10009 , G11B20/10222 , G11B20/1403 , G11B20/1426 , G11B27/19 , G11B27/24 , G11B27/3027 , G11B2020/10888 , G11B2020/1269 , G11B2020/1274 , G11B2220/20 , G11B2220/2537
摘要： An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要翻译：一种用于通过使用光盘作为记录介质来记录和从光盘再现数据的光盘记录和再现装置，包括模拟处理装置，包括用于对从光盘读取的信号进行二值化的二值化单元，以及用于控制在光盘中记录和再现信号的伺服单元; 同步时钟发生装置，用于产生与从光盘读取的信号同步的同步时钟信号; 地址检测装置，用于基于从光盘读取的信号检测表示光盘上的物理位置的地址信息，并且当检测到地址信息时，输出指示地址信息的信号和指示已经检测到地址的信号 ; 用于将光盘的扇区计数值保持为记录单位的扇区计数器，并根据同步时钟信号和从地址检测装置输出的信号来更新扇区计数值; 以及门信号产生切换装置，用于根据表示地址已经被信号的信号，基于扇区计数器中保存的扇区计数值和从模拟处理装置获得的信息，产生控制模拟处理装置的信号从地址检测装置输出。

37. 发明授权

US5578708A Bone-associated transcription control factor-like protein 失效
标题翻译：骨相关转录调控因子样蛋白
公开(公告)号：US5578708A
公开(公告)日：1996-11-26
申请号：US208108
申请日：1994-03-08
申请人： Makoto Okazaki , Sunao Takeshita , Shinji Kawai , Reiko Kikuno , Egon Amann
发明人： Makoto Okazaki , Sunao Takeshita , Shinji Kawai , Reiko Kikuno , Egon Amann
IPC分类号： A61K38/00 , A61K39/395 , A61K49/00 , A61P3/00 , A61P19/10 , A61P43/00 , C07K14/47 , C07K14/51 , C07K16/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/08 , G01N33/50 , G01N33/53
CPC分类号： C07K14/51 , C07K14/4702 , A61K38/00 , C07K2319/02
摘要： Bone-associated proteins derived from bone of mammals, including mice and human beings, named OSF-6. The protein is the novel natural type mammal protein, which can play an important role in bone formation, and belongs to a group of transcription control factors.OSF-6 can be used as a therapeutic agent for bone metabolic diseases, and also as a diagnostic agent for bone metabolic diseases, since it may demonstrate a high organ specificity to bone.
摘要翻译：衍生自哺乳动物骨骼的骨相关蛋白，包括小鼠和人类，称为OSF-6。该蛋白是新型天然型哺乳动物蛋白，可在骨形成中起重要作用，属于一组转录调控因子。 OSF-6可用作骨代谢疾病的治疗剂，也可用作骨代谢疾病的诊断剂，因为它可能对骨骼具有高的器官特异性。

38. 发明授权

US5345559A Bus interface circuit for controlling data transfer 失效
标题翻译：总线接口电路，用于控制数据传输
公开(公告)号：US5345559A
公开(公告)日：1994-09-06
申请号：US730809
申请日：1991-07-29
申请人： Makoto Okazaki , Yuji Shibata , Hisamitsu Tanihira , Yoshiaki Wakimura
发明人： Makoto Okazaki , Yuji Shibata , Hisamitsu Tanihira , Yoshiaki Wakimura
IPC分类号： G06F13/36 , G06F13/40 , G06F13/00
CPC分类号： G06F13/4018
摘要： A transmitter includes a transmitting buffer (21) for temporarily storing the information received from a first bus (11) of N (N is a natural number) bits width and a transmitting input distributer (22) and a transmitting output distributer (23) respectively provided in the input side and output side of the transmitting system buffer (21). A receiver includes a receiving buffer (31) for temporarily storing the information received from the second bus (12) and for sending the information to the first bus (11) and a receiving input distributer (32) and a receiving distributer (33) respectively provided in the input side and output side of the receiving buffer. The transmitting buffer (21) has at least m (m is a natural number) buffers of N bits width. When the second bus (12) has N bits width, the transmitting input distributer (22) sequentially inputs the information sent from the first bus to m buffers and the transmitting output distributer (23) sequentially extracts the information input to the buffers to send to the second bus ( 12). When the second bus (12) has mN bits width, the transmitting input distributer (22) sequentially inputs the information sent from the first bus (11) to m buffers and the transmitting output distributer (23) simultaneously extracts the information into the m buffers to send to the second bus (12).
摘要翻译： PCT No.PCT / JP90 / 01539 Sec。 371日期1991年7月29日发射机包括发送缓冲器（21），用于临时存储从N的第一总线（11）接收的信息（N是自然数）位宽度和分别设置在发送系统缓冲器（21）的输入侧和输出侧的发送输入分配器（22）和发送输出分配器（23）。接收机包括：接收缓冲器（31），用于临时存储从第二总线（12）接收的信息，并分别向第一总线（11）和接收输入分配器（32）和接收分配器（33）发送信息设置在接收缓冲器的输入侧和输出侧。发送缓冲器（21）至少具有N位宽的m（m是自然数）缓冲器。当第二总线（12）具有N位宽度时，发送输入分配器（22）将从第一总线发送的信息顺序地输入到m个缓冲器，并且发送输出分配器（23）依次提取输入到缓冲器的信息以发送到第二巴士（12）。当第二总线（12）具有mN位宽时，发送输入分配器（22）将从第一总线（11）发送的信息顺序地输入到m个缓冲器，并且发送输出分配器（23）同时将信息提取到m个缓冲器发送到第二辆公共汽车（12）。

39. 发明授权

US5151940A Method and apparatus for extracting isolated speech word 失效
标题翻译：提取分离词汇的方法和装置
公开(公告)号：US5151940A
公开(公告)日：1992-09-29
申请号：US622285
申请日：1990-12-07
申请人： Makoto Okazaki , Koji Eto
发明人： Makoto Okazaki , Koji Eto
IPC分类号： G10L11/00 , G10L11/02 , G10L15/00 , G10L15/02 , G10L15/04
CPC分类号： G10L15/00
摘要： An isolated speech word is extracted from an input speech signal. First, the speech signal is divided into a high frequency band signal and a low frequency band signal. Next, the power levels of each of the high and low frequency band signals are independently compared with respective threshold levels. Finally, the front and the end of the speech word are detected from these independent comparisons.

40. 发明授权

US08568737B2 Screening methods using G-protein coupled receptors and related compositions 有权
公开(公告)号：US08568737B2
公开(公告)日：2013-10-29
申请号：US12671429
申请日：2008-08-01
申请人： Thomas J. Gardella , John T. Potts, Jr. , Masaru Shimizu , Fumihiko Ichikawa , Harald Juppner , Makoto Okazaki
发明人： Thomas J. Gardella , John T. Potts, Jr. , Masaru Shimizu , Fumihiko Ichikawa , Harald Juppner , Makoto Okazaki
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： G01N33/56966 , A61K38/00 , A61K49/00 , C07K14/635 , C07K14/723 , G01N33/74 , G01N2333/645 , G01N2333/726
摘要： The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.

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