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31. 发明申请

US20110319969A1 ELECTRIC MODULATION OF SYMPATHETIC NERVOUS SYSTEM 有权
公开(公告)号：US20110319969A1
公开(公告)日：2011-12-29
申请号：US13230525
申请日：2011-09-12
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61N1/36
CPC分类号： A61N1/36085 , A61N1/36007 , A61N1/36017 , A61N1/36071
摘要： A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.

32. 发明授权

US07951183B2 Medical procedure 有权
标题翻译：医疗程序
公开(公告)号：US07951183B2
公开(公告)日：2011-05-31
申请号：US12152160
申请日：2008-05-13
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/12
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0288 , A61F2007/126
摘要： The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35° C., more preferably 32±2° C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37° C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35° C. using the heat transfer element.
摘要翻译：使用血管内冷却元件诱导与医疗过程相关的体温过低。根据本发明的第一方面，进行冠状动脉旁路手术，其中患者的血液与患者的肺充氧，并且使用患者的心脏或使用体内泵循环血液。该方法优选包括：（a）将热传递元件定位在患者的血管中; （b）使用传热元件将患者的身体冷却至小于35℃，更优选32±2℃; 和（c）在动脉血液供应和冠状动脉之间形成流体连通的移植物。优选在形成流体连通移植物的步骤之后，使用传热元件将患者的身体加热至约37℃。根据本发明的另一方面，在患者处于有意识或半自觉状态时提供低温医疗程序，其包括（a）向患者施用β-阻断药物; （b）将传热元件输送到患者的血管; 和（c）使用传热元件将患者或患者体内的区域冷却至小于35℃。

33. 发明申请

US20100049063A1 DEVICES AND METHODS FOR ACCELEROMETER-BASED CHARACTERIZATION OF CARDIAC FUNCTION AND IDENTIFICATION OF LV TARGET PACING ZONES 失效
标题翻译：用于基于加速度计的心脏功能特征和LV目标区域识别的装置和方法
公开(公告)号：US20100049063A1
公开(公告)日：2010-02-25
申请号：US12396420
申请日：2009-03-02
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61B5/02
CPC分类号： A61B5/02 , A61B5/0456 , A61B2562/0219 , A61B2562/028 , A61N1/056 , A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N2001/0585
摘要： Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and uses this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non-implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system (“IAD”) includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG.
摘要翻译：根据本发明的系统采用加速度传感器来表征位移和振动LV运动，并且使用该运动数据来表征用于分析LV功能的LV循环的不同相位。系统可以使用加速度传感器来识别LV或RV中的目标起搏区域或区域，通过将相对于QRS的运动迟发性区域，或等容性收缩或二尖瓣闭合定位，或通过起搏区域和测量LV功能来定位响应起搏。系统还提供用于测量LV运动和表征LV功能的可植入或不可植入的加速度传感器装置。可植入心肌加速度感测系统（“IAD”）包括至少一个加速度传感器，数据采集和处理装置以及电磁（例如RF）通信装置。 IAD可以集成到CRT设备的起搏引线中，并且可独立于CRT IPG进行操作。

34. 发明申请

US20090318899A1 METHOD AND DEVICE FOR LIPOSUCTION 审中-公开
标题翻译：用于排泄的方法和装置
公开(公告)号：US20090318899A1
公开(公告)日：2009-12-24
申请号：US12338941
申请日：2008-12-18
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61M1/00
CPC分类号： A61M1/0084 , A61B17/3203 , A61M1/0058 , A61M2202/08
摘要： Systems and methods for liposuction are disclosed that use a lipid-emulsifying fluid to produce fluid jet disruption and Venturi pumping of fat tissue. The device includes a flexible or rigid probe with an inlet lumen and an outlet lumen. The inlet lumen is in fluid communication with a pump capable of producing high pressures, e.g., 250-3500 psi. The pump is in fluid communication with a volume of a liquid such as sterile saline that may or may not contain a fat emulsifier. At the end of the inlet lumen is a conical constriction or a port that accelerates the emulsification fluid to high velocities. The high velocity jet stream creates a low pressure area that draws the fat tissue into proximity with the jet stream. The jet stream directly and through turbulent vortices breaks up the fat cells. The lipid of the fat cells is subsequently emulsified by the emulsification fluid.
摘要翻译：公开了用于吸脂的系统和方法，其使用脂质 - 乳化液来产生流体喷射干扰和文丘里泵送脂肪组织。该装置包括具有入口腔和出口腔的柔性或刚性探针。入口腔与能够产生高压（例如250-3500psi）的泵流体连通。泵与一定体积的液体流体连通，例如无菌盐水，其可以含有或不含有脂肪乳化剂。在入口管腔的末端是锥形收缩或将乳化液加速到高速度的端口。高速喷射流产生低压区域，其将脂肪组织吸引到喷射流附近。喷射流直接和通过湍流涡流分解脂肪细胞。脂肪细胞的脂质随后被乳化液乳化。

35. 发明授权

US07211106B2 Selective organ cooling apparatus and method 有权
公开(公告)号：US07211106B2
公开(公告)日：2007-05-01
申请号：US10763542
申请日：2004-01-23
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

36. 发明授权

US07101386B2 Patient temperature regulation method and apparatus 失效
公开(公告)号：US07101386B2
公开(公告)日：2006-09-05
申请号：US10219735
申请日：2002-08-15
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A device and method for providing body cooling. The cooling device applies cooling to blood flowing in a vena cavae that is then distributed throughout the body. The cooling can be assisted by use of thermoregulatory drugs or warming devices to prevent shivering and vasoconstriction.

37. 发明授权

US06887262B2 Selective organ cooling apparatus and method 有权
标题翻译：选择性器官冷却装置及方法
公开(公告)号：US06887262B2
公开(公告)日：2005-05-03
申请号：US10251124
申请日：2002-09-19
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12 , A61M25/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： A selective organ heat transfer device with deep irregularities in a turbulence-inducing exterior surface. The device can have a plurality of elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects adjacent elongated, articulated segments. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：湍流诱导外表面具有深度不规则的选择性器官传热装置。该装置可以具有多个细长的关节节段，每个节段具有引起湍流的外表面。柔性接头连接相邻的细长铰接段。内腔设置在传热段内。内腔能够将加压的工作流体输送到传热元件的远端。

38. 发明授权

US06869440B2 Method and apparatus for patient temperature control employing administration of anti-shivering agents 有权
公开(公告)号：US06869440B2
公开(公告)日：2005-03-22
申请号：US10216405
申请日：2002-08-09
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/00 , A61F7/02 , A61F7/12 , A61M25/00
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0288 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient's body or a selected portion thereof. In particular, strategies for providing cooling while reducing shivering are disclosed, including administration of various drugs and drug combinations.

39. 发明授权

US06843800B1 Patient temperature regulation method and apparatus 失效
标题翻译：患者温度调节方法和装置
公开(公告)号：US06843800B1
公开(公告)日：2005-01-18
申请号：US09373112
申请日：1999-08-11
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/08 , A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12 , A61K31/05 , A61K31/4168 , A61K31/4174 , A61K31/451 , A61K33/06 , A61M1/36 , A61P43/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A device and method for providing body cooling. The cooling device applies cooling to blood flowing in a vena cavae that is then distributed throughout the body. The cooling can be assisted by use of thermoregulatory drugs or warming devices to prevent shivering and vasoconstriction.
摘要翻译：一种用于提供身体冷却的装置和方法。冷却装置对流过腔静脉的血液进行冷却，然后分布在整个身体内。冷却可以通过使用调温药物或加温装置来辅助，以防止发抖和血管收缩。

40. 发明授权

US06695873B2 Inflatable catheter for selective organ heating and cooling and method of using the same 有权
公开(公告)号：US06695873B2
公开(公告)日：2004-02-24
申请号：US10095753
申请日：2002-03-11
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

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