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31. 发明申请

US20080010026A1 Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof 有权
标题翻译：具有新催化功能的L-鼠李糖异构酶的基因序列及其应用
公开(公告)号：US20080010026A1
公开(公告)日：2008-01-10
申请号：US11714887
申请日：2007-03-07
申请人： Ken Izumori , Goro Takada , Masaaki Tokuda
发明人： Ken Izumori , Goro Takada , Masaaki Tokuda
IPC分类号： G06F19/00
CPC分类号： C12N9/90 , C12P19/02 , C12P19/24 , C12Y503/01014
摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.
摘要翻译：在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的。编码以下蛋白质（a）或（b）的DNA。上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。包含SEQ ID NO：2所示的氨基酸序列的蛋白质。一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

32. 发明申请

US20050053507A1 Scroll compressor 审中-公开
标题翻译：涡旋压缩机
公开(公告)号：US20050053507A1
公开(公告)日：2005-03-10
申请号：US10914644
申请日：2004-08-10
申请人： Makoto Takeuchi , Tetsuzo Ukai , Masaaki Tokuda
发明人： Makoto Takeuchi , Tetsuzo Ukai , Masaaki Tokuda
IPC分类号： F04C18/02 , F04C28/26 , F01C1/02 , F01C1/063 , F04C18/00
CPC分类号： F04C28/26 , F04C18/0215 , F04C18/0261 , F04C18/0276 , F04C18/088
摘要： A scroll compressor includes a first scroll and a second scroll. The first scroll has a step portion that separates an elevated portion and a recessed portion of a surface of the first scroll. A spiral wall of the second scroll has a step that separates an elevated portion and a recessed portion of the wall. A first bypass hole is provided in the elevated portion of the surface of the first scroll. A second bypass hole is provided in the recessed portion of the surface of the first scroll. The second bypass hole is within 360 degrees toward a center of the spiral of the first scroll from an outer end of the spiral. The first bypass hole is within 360 degrees from the second bypass hole toward the center of the spiral.
摘要翻译：涡旋压缩机包括第一涡旋件和第二涡旋件。第一涡旋件具有分离第一涡旋件的表面的升高部分和凹部的台阶部分。第二涡卷的螺旋壁具有分隔壁的升高部分和凹陷部分的台阶。第一旁通孔设置在第一涡旋盘的表面的升高部分中。第二旁通孔设置在第一涡旋盘的表面的凹部中。第二旁通孔从螺旋的外端朝向第一涡旋盘的螺旋的中心360度内。第一旁通孔与第二旁通孔朝向螺旋中心360度以内。

33. 发明授权

US08881523B2 Waste heat utilization device for internal combustion engine 有权
标题翻译：内燃机废热利用装置
公开(公告)号：US08881523B2
公开(公告)日：2014-11-11
申请号：US13061513
申请日：2009-08-25
申请人： Junichiro Kasuya , Tetsuya Nakano , Tomohiko Saito , Masaaki Tokuda , Satoshi Ogiwara
发明人： Junichiro Kasuya , Tetsuya Nakano , Tomohiko Saito , Masaaki Tokuda , Satoshi Ogiwara
IPC分类号： F01K23/10 , F01K23/06 , F01K25/00 , F02B27/00 , F02B27/02 , F01N5/02 , F01K13/02 , F01P9/06 , F02G5/04 , F01K25/08 , F01P7/16
CPC分类号： F02G5/04 , F01K13/02 , F01K23/065 , F01N5/02 , F01N2240/02 , F01P7/162 , F01P9/06 , F01P2050/24 , F02G2260/00 , Y02E20/14 , Y02T10/16 , Y02T10/166
摘要： A Rankine cycle (6) of a waste heat utilization device includes a circulation path (7) for circulating a working fluid therethrough, an evaporator (12) for causing heat to transfer from cooling water delivered from an internal combustion engine (2) to the working fluid to evaporate the working fluid, a superheater (10) for causing heat to transfer from the cooling water delivered from an exhaust gas heat exchanger (8) to the working fluid delivered from the evaporator to superheat the working fluid, an expander (22) for expanding the working fluid delivered from the superheater to produce driving force, a condenser (24) for condensing the working fluid delivered from the expander, and a pump (28) for feeding the working fluid delivered from the condenser to the evaporator. The evaporator, the superheater, the expander, the condenser and the pump are successively inserted in the working fluid circulation path.
摘要翻译：废热利用装置的兰金循环（6）具有循环路径（7），用于使工作流体循环通过其中，用于使热量从内燃机（2）输送的冷却水转移到工作流体以蒸发工作流体;一个过热器（10），用于使热量从从排气热交换器（8）输送的冷却水转移到从蒸发器输送的工作流体以使工作流体过热;膨胀器（22）），用于膨胀从过热器输送的工作流体以产生驱动力;冷凝器（24），用于冷凝从膨胀器输送的工作流体;以及泵（28），用于将从冷凝器输送的工作流体供给到蒸发器。蒸发器，过热器，膨胀机，冷凝器和泵依次插入工作流体循环路径。

34. 发明授权

US08748589B2 Complex crystalline sugar comprising D-psicose and D-allose and process for production of the same 有权
标题翻译：复合结晶糖，包括D-灵敏蛋白和D-丙氨酸及其制备方法
公开(公告)号：US08748589B2
公开(公告)日：2014-06-10
申请号：US11817774
申请日：2006-03-03
申请人： Ken Izumori , Masaaki Tokuda , Goro Takata , Kenji Morimoto
发明人： Ken Izumori , Masaaki Tokuda , Goro Takata , Kenji Morimoto
IPC分类号： C07H1/00
CPC分类号： C12P19/02 , C12P19/24
摘要： A complex crystalline sugar comprising D-psicose and D-allose and a method for producing the same are disclosed. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.
摘要翻译：公开了一种复合结晶糖，其包含D-木糖和D-阿洛糖及其制备方法。糖中D-灵糖和D-阿洛糖的组成比为约1:1至1:4。一种制备复合结晶糖的方法，该复合结晶糖包括D-木糖和D-阿洛糖，该方法包括由含有D-木糖和对 - 阿洛糖的糖溶液制备包含D-灵敏蛋白和D-阿洛糖的复合结晶糖并收集复合结晶糖糖。用于生产复合结晶糖的糖溶液的溶剂是水或水和乙醇的混合物。通过包括使D-灵芝糖与L-鼠李糖异构酶反应以将D-灵芝蛋白转化为D-丙氨酸的方法产生含有D-灵敏蛋白和D-阿洛糖的糖溶液。 L-鼠李糖异构酶衍生自属于假单胞菌（Strepomonas stutzeri）的菌株（IPOD FERM BP-08593）。

35. 发明申请

US20130344008A1 NONCARIOUS MATERIAL AND ANTICARIOUS AGENT CONTAINING RARE SUGAR 有权
标题翻译：非常重的材料和含有稀有糖的强力剂
公开(公告)号：US20130344008A1
公开(公告)日：2013-12-26
申请号：US13369780
申请日：2012-02-09
申请人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
发明人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
IPC分类号： A61K8/60 , A61Q11/00
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
摘要翻译：为了提供用于预防牙周疾病的组合物（牙周病的预防剂），该组合物具有优异的抑制性，对于长期使用是安全和稳定的并且对风味的影响较小。通过将选自D-木糖，D-山梨糖和D-塔格糖的D-形式的稀有糖混合制备的非致龋物质，L型果糖中的稀有糖，选自L-果糖，L- 灵长类和L-塔格糖，或作为稀有糖衍生物的甘醇，单独或组合使用。包含D-灵糖蛋白，D-山梨糖，D-塔格糖，L-果糖，L-灵巧蛋白和/或L-塔格糖的抑制剂。与儿茶素组合使用的抑菌剂。

36. 发明授权

US08496915B2 Noncarious material and anticarious agent containing rare sugar 有权
标题翻译：含有稀有糖的不规则材料和抗菌剂
公开(公告)号：US08496915B2
公开(公告)日：2013-07-30
申请号：US12514182
申请日：2007-03-27
申请人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
发明人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
IPC分类号： A61K8/60 , A61Q11/00 , A23L1/22 , A23L2/60
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor.Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
摘要翻译：目的：提供一种用于预防牙周病（牙周病的预防剂）的组合物，该组合物具有优异的抑制性，对于长时间使用是安全和稳定的并且对风味的影响较小。解决方法：通过将选自D-木糖，D-山梨糖和D-塔格糖的D-形式的稀有糖混合制备的非致龋材料，L型的稀有糖选自L- 果糖，L-灵巧蛋白和L-塔格糖，或作为稀有糖衍生物的全醇，单独或组合使用。包含D-灵糖蛋白，D-山梨糖，D-塔格糖，L-果糖，L-灵巧蛋白和/或L-塔格糖的抑制剂。与儿茶素组合使用的抑菌剂。

37. 发明申请

US20120111003A1 Waste Heat Utilization Device for Internal Combustion Engine 有权
标题翻译：内燃机废热利用装置
公开(公告)号：US20120111003A1
公开(公告)日：2012-05-10
申请号：US13061513
申请日：2009-08-25
申请人： Junichiro Kasuya , Tetsuya Nakano , Tomohiko Saito , Masaaki Tokuda , Satoshi Ogiwara
发明人： Junichiro Kasuya , Tetsuya Nakano , Tomohiko Saito , Masaaki Tokuda , Satoshi Ogiwara
IPC分类号： F02G5/04 , F01N5/02 , F01K23/10
CPC分类号： F02G5/04 , F01K13/02 , F01K23/065 , F01N5/02 , F01N2240/02 , F01P7/162 , F01P9/06 , F01P2050/24 , F02G2260/00 , Y02E20/14 , Y02T10/16 , Y02T10/166
摘要： A Rankine cycle (6) of a waste heat utilization device includes a circulation path (7) for circulating a working fluid therethrough, an evaporator (12) for causing heat to transfer from cooling water delivered from an internal combustion engine (2) to the working fluid to evaporate the working fluid, a superheater (10) for causing heat to transfer from the cooling water delivered from an exhaust gas heat exchanger (8) to the working fluid delivered from the evaporator to superheat the working fluid, an expander (22) for expanding the working fluid delivered from the superheater to produce driving force, a condenser (24) for condensing the working fluid delivered from the expander, and a pump (28) for feeding the working fluid delivered from the condenser to the evaporator. The evaporator, the superheater, the expander, the condenser and the pump are successively inserted in the working fluid circulation path.
摘要翻译：余热利用装置的兰金循环（6）具有循环路径（7），用于使工作流体循环通过其中，用于使热量从内燃机（2）输送的冷却水转移到工作流体以蒸发工作流体;一个过热器（10），用于使热量从从排气热交换器（8）输送的冷却水转移到从蒸发器输送的工作流体以使工作流体过热;膨胀器（22）），用于膨胀从过热器输送的工作流体以产生驱动力;冷凝器（24），用于冷凝从膨胀器输送的工作流体;以及泵（28），用于将从冷凝器输送的工作流体供给到蒸发器。蒸发器，过热器，膨胀机，冷凝器和泵依次插入工作流体循环路径。

38. 发明授权

US08071558B2 Application of D-psicose to suppression of abnormal circadian increase in blood glucose level 有权
标题翻译：应用D-psicose抑制血糖水平异常昼夜节律升高
公开(公告)号：US08071558B2
公开(公告)日：2011-12-06
申请号：US11909493
申请日：2006-03-22
申请人： Masaaki Tokuda , Ken Izumori , Tatsuhiro Matsuo , Kenji Morimoto , Kaoru Takekawa
发明人： Masaaki Tokuda , Ken Izumori , Tatsuhiro Matsuo , Kenji Morimoto , Kaoru Takekawa
IPC分类号： A61K31/7004 , A61P3/08
CPC分类号： A23K50/40 , A23K20/163 , A23L27/30 , A23L33/10 , A61K31/7004
摘要： A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.
摘要翻译：提供了一种新的D-psicose的用途（用于抑制日内异常增加血糖水平）。作为活性成分含有D-灵芝蛋白的组合物，用于抑制日内异常增加血浆葡萄糖浓度。组合物是与D-灵芝蛋白和/或其衍生物共混的组合物。该组合物为选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料产品，保健食品和饮料产品，药品和饲料中的形式，并且与D-灵芝蛋白和/或其衍生物作为活性成分组分，用于预防和治疗需要节省胰岛素不足的疾病，改善胰岛素敏感性和改善高血糖症，和/或通过抑制日内异常升高可以改善症状的疾病血浆葡萄糖浓度或通过其抑制如糖尿病，隐匿性糖尿病状态，肥胖症，高血糖症和/或动脉硬化可以预防发作。一种用于抑制血浆葡萄糖浓度异常日增加的方法，包括在给定时间给予D-psicose以抑制全天血浆葡萄糖浓度的异常增加。

39. 发明申请

US20110230659A1 CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMEN FORMATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG 有权
标题翻译：环磷酰胺衍生物，促血管发生剂，促红细胞生成促进剂，神经生长促进剂和药物
公开(公告)号：US20110230659A1
公开(公告)日：2011-09-22
申请号：US13130952
申请日：2009-11-27
申请人： Ikuko Tsukamoto , Ryoji Konishi , Masaaki Tokuda , Yasuo Kubota , Tokumi Maruyama , Hiroaki Kosaka , Junsuke Igarashi
发明人： Ikuko Tsukamoto , Ryoji Konishi , Masaaki Tokuda , Yasuo Kubota , Tokumi Maruyama , Hiroaki Kosaka , Junsuke Igarashi
IPC分类号： C07D473/24 , C07D473/40 , C07D473/18
CPC分类号： C07D473/18 , C07D473/24 , C07D473/34 , C07D473/40
摘要： Provided is a compound having at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumen formation promoting activity, cell migration promoting activity, and neurocyte growth promoting activity, which is a chemically stable low-molecular-weight substance that has high absorbability and can be supplied stably at a low cost because of its low molecular weight. A cyclobutyl purine derivative, a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof according to the present invention is a cyclobutyl purine derivative represented by the following general formula (1), a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof.
摘要翻译：本发明提供一种化学稳定的低分子量物质，其具有选自细胞生长促进活性，血管生成促进活性，管腔形成促进活性，细胞迁移促进活性和神经细胞生长促进活性的至少一种化合物具有高吸收性，由于其低分子量，可以以低成本稳定地供给。根据本发明的环丁基嘌呤衍生物，其互变异构体或立体异构体或其盐，溶剂化物或水合物是由以下通式（1）表示的环丁基嘌呤衍生物，其互变异构体或立体异构体，或其盐，溶剂合物或水合物。

40. 发明申请

US20110112043A1 METHOD OF UTILIZING PHYSIOLOGICAL ACTIVITY OF RARE SACCHARIDE AND COMPOSITION CONTAINING RARE SACCHARIDE 有权
标题翻译：利用稀有酸的生理活性和含有稀土的组合物的方法
公开(公告)号：US20110112043A1
公开(公告)日：2011-05-12
申请号：US13007058
申请日：2011-01-14
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Akram Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A61K31/7004 , A61P35/04 , A61P25/00
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

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