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31. 发明专利

JP2007077104A Vascular endothelial growth factor inhibitor 审中-公开
标题翻译：血管内皮生长因子抑制剂
公开(公告)号：JP2007077104A
公开(公告)日：2007-03-29
申请号：JP2005269646
申请日：2005-09-16
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HASEGAWA KIYOTAKA , INOMATA SHINJI , UMISHIO KENICHI
IPC分类号： A61K36/00 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/96 , A61K36/18 , A61K36/73 , A61K36/899 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , A61Q1/12
摘要： PROBLEM TO BE SOLVED: To provide a VEGF (vascular endothelial growth factor) expression inhibitor characterized as comprising one or a plurality of kinds of crude drug extracts selected from the group consisting of crude drugs Coix extract, Chlorella Extract and Tormentilla Extract as an active ingredient. SOLUTION: The VEGF expression inhibitor is characterized as comprising the one or plurality of kinds of crude drug extracts selected from the group consisting of the Coix extract, the Chlorella Extract and the Tormentilla Extract as the active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供VEGF（血管内皮生长因子）表达抑制剂，其特征在于包含一种或多种选自以下的生药药物提取物：生药物ix ix提取物，小球藻提取物和Tormentilla提取物作为活性成分。解决方案：VEGF表达抑制剂的特征在于包含一种或多种选自由ix ix提取物，小球藻提取物和Tormentilla提取物组成的组的生药提取物作为活性成分。版权所有（C）2007，JPO＆INPIT

32. 发明专利

JP2005298441A Skin care preparation for bleaching 审中-公开
标题翻译：皮肤护理准备漂白
公开(公告)号：JP2005298441A
公开(公告)日：2005-10-27
申请号：JP2004120121
申请日：2004-04-15
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： OCHIAI NOBUHIKO , YAGI EIICHIRO , AITSU YOKO , UMISHIO KENICHI , HATAO MASATO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a skin care preparation for bleaching that controls melanogenesis, prevents and ameliorates pigmentation after suntan, stains, freckles, liver spots, etc., by including a plant extract having high safety as a bleaching agent.
SOLUTION: The skin care preparation for bleaching comprises an extract of Commiphora abyssinica of the genes Commiphora of family Burseraceae. The skin care preparation for bleaching comprises an extract of Cautleya spicata of the genus Cautleya of the family Cannaceae.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过包括具有高安全性的植物提取物作为漂白剂，获得控制黑色素生成的漂白护肤品，防止和改善晒黑，斑点，雀斑，肝斑等后的色素沉着。解决方案：用于漂白的皮肤护理制剂包括枸杞科的Commiphora基因的提取物。用于漂白的皮肤护理制剂包括蒿科科学家的Cautleya属的Cautleya spicata的提取物。版权所有（C）2006，JPO＆NCIPI

33. 发明专利

JP2005075812A Plasmin specific activity inhibitor 审中-公开
标题翻译： PLASMIN特异性活性抑制剂
公开(公告)号：JP2005075812A
公开(公告)日：2005-03-24
申请号：JP2003311417
申请日：2003-09-03
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HIBINO TOSHIHIKO , UMISHIO KENICHI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/04 , A61K8/97 , A61K36/18 , A61K36/23 , A61K36/48 , A61P17/16 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q19/00 , A61K35/78 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To provide a plasmin specific activity inhibitor, inhibiting only the activity of plasmin and not inhibiting trypsin activity. SOLUTION: This plasmin specific activity inhibitor contains 1 kind or ≥2 kinds of plants selected from Petroselium crispum, Thea sinensis, Cinnamomum cassia Blume, Vitis vinipera L., Guevina avellana Mol and Sophorae radix, or solvent extracted materials of the plants. The inhibitor can be used as a preparation for improving various diseases in which the change of plasmin activity is observed, and especially for skin diseases such as contact dermatitis, psoriasis, pemphigus vulgaris, congenital varicella, etc., where the changes of plasmin activities are recognized in affected parts. The inhibitor is preferably used for the preparation inhibiting only the activity of plasmin and not the activity of trypsin. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供纤溶酶比活性抑制剂，仅抑制纤溶酶的活性而不抑制胰蛋白酶活性。解决方案：该纤维蛋白溶酶比活性抑制剂含有1种或2种以上的植物，分别选自石斛，中华Cin藜，桂皮，葡萄a，葛根和苦参，或植物溶剂提取物。抑制剂可用作改善观察到纤溶酶活性变化的各种疾病的制剂，特别是对于皮肤疾病如接触性皮炎，牛皮癣，寻常型天疱疮，先天性水痘等，其中纤维蛋白溶酶活性的变化是在受影响的部位承认。抑制剂优选用于抑制纤维蛋白溶酶活性而不是胰蛋白酶活性的制剂。版权所有（C）2005，JPO＆NCIPI

34. 发明专利

JP2003063944A Skin care preparation and melanogenesis inhibitor 审中-公开
标题翻译：皮肤护理制剂和造血剂抑制剂
公开(公告)号：JP2003063944A
公开(公告)日：2003-03-05
申请号：JP2001258067
申请日：2001-08-28
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： UMISHIO KENICHI , OTA MASAHIRO , KOBAYASHI KOJI , OTA NAOMI , AOKI HIROFUMI , IFUKU OUJI
IPC分类号： A61K8/00 , A61K8/30 , A61K8/49 , A61K8/96 , A61K8/97 , A61K31/015 , A61K31/122 , A61K31/336 , A61K31/343 , A61K36/24 , A61K36/47 , A61P17/16 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a skin care preparation having a good effect on melanogenesis inhibition and an excellent skin whitening effect, and provide an agent for inhibiting melanogenesis. SOLUTION: The skin care preparation has diterpene having, as a basic structure, a jatrophane skeleton (I) or a cyclojatrophane skeleton (II). In formulas (I) and (II), an oxo group is bonded to 7-th position and a bonding of carbons between 5-6 positions and/or 8-9 positions are each preferably a double bond.
摘要翻译：要解决的问题：提供对黑素生成抑制和良好的皮肤美白效果具有良好效果的护肤制剂，并提供抑制黑素生成的药剂。解决方案：皮肤护理制剂具有作为基本结构的营养不良骨架（I）或环丙烷骨架（II）的二萜。在式（I）和（II）中，氧代基键合到第七位，碳原子在5-6位和/或8-9位之间的键合各自优选为双键。

35. 发明专利

JP2011148730A Anti-aging agent 审中-公开
标题翻译：抗衰老剂
公开(公告)号：JP2011148730A
公开(公告)日：2011-08-04
申请号：JP2010010904
申请日：2010-01-21
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： UMISHIO KENICHI , TSUNENAGA MAKOTO
IPC分类号： A61K8/97 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an anti-aging agent which can promote the proliferation of fibroblast to promote the production of extracellular matrixes such as collagen and elastin, can prevent and inhibit the aging of skins, and can restore the damages of skins, and to provide a fibroblast proliferation promoter. SOLUTION: The anti-aging agent contains an extract of Buckleya henryi in Santalaceae. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可以促进成纤维细胞增殖以促进细胞外基质如胶原和弹性蛋白的生成的抗老化剂，可以防止和抑制皮肤的老化，并且可以恢复损伤皮肤，并提供成纤维细胞增殖启动子。
解决方案：抗老化剂含有马齿苋科的Buckleya henryi提取物。版权所有（C）2011，JPO＆INPIT

36. 发明专利

JP2009280613A Plasmin specific activity inhibitor 审中-公开
标题翻译： PLASMIN特异性活性抑制剂
公开(公告)号：JP2009280613A
公开(公告)日：2009-12-03
申请号：JP2009199147
申请日：2009-08-31
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HIBINO TOSHIHIKO , UMISHIO KENICHI
IPC分类号： A61K36/18 , A61K8/97 , A61K36/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a plasmin specific activity inhibitor which especially specifically inhibits only the activity of plasmin and does not inhibit the activity of trypsin.
SOLUTION: Provided is the plasmin specific activity inhibitor which does not inhibit the activity of the trypsin and comprises a Cinnamomum cassia Blume solvent extract. The plasmin specific activity inhibitor is applied to pharmaceutical preparations for improving various diseases in which the changes in the activity of the plasmin are recognized. Especially, the plasmin specific activity inhibitor is applied to pharmaceutical preparations for improving skin diseases such as contact dermatitis, psoriasis, pemphigus vulgaris, and congenital chicken pox in whose disease sites the changes in the activity of plasmin are recognized. The plasmin specific activity inhibitor is preferably used for pharmaceutical preparations which inhibit the activity of only the plasmin and does not inhibit the activity of trypsin.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供特异性仅抑制纤溶酶活性且不抑制胰蛋白酶活性的纤溶酶比活性抑制剂。解决方案：提供不抑制胰蛋白酶活性的纤溶酶比活性抑制剂，其包含肉桂薄荷溶剂提取物。将纤溶酶比活性抑制剂应用于改善各种疾病的药物制剂，其中可以认识到纤溶酶活性的变化。特别地，纤维蛋白溶酶比活性抑制剂被应用于改善皮肤疾病的药物制剂，例如接触性皮炎，牛皮癣，寻常型天疱疮和先天性水痘，其疾病部位认识到纤溶酶活性的变化。纤溶酶比活性抑制剂优选用于抑制纤维蛋白溶酶活性且不抑制胰蛋白酶活性的药物制剂。版权所有（C）2010，JPO＆INPIT

37. 发明专利

JP2007084508A New vascular endothelial growth factor expression inhibitor 审中-公开
标题翻译：新型血管内皮生长因子表达抑制剂
公开(公告)号：JP2007084508A
公开(公告)日：2007-04-05
申请号：JP2005277870
申请日：2005-09-26
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HASEGAWA KIYOTAKA , INOMATA SHINJI , UMISHIO KENICHI
IPC分类号： A61K36/18 , A61K8/00 , A61K8/96 , A61K36/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a new vascular endothelial growth factor expression inhibitor.
SOLUTION: This anti-aging agent, angiogenesis inhibitor, or vascular endothelial growth factor expression inhibitor comprises one or two galenicals selected from the group consisting of Mukurossi Peel Extract and Hazelnut Extract.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供新的血管内皮生长因子表达抑制剂。解决方案：该抗老化剂，血管生成抑制剂或血管内皮生长因子表达抑制剂包含选自Mukurossi皮提取物和榛子提取物的一种或两种盖仑制品。版权所有（C）2007，JPO＆INPIT

38. 发明专利

JP2007077113A Neovascularization inhibitor 审中-公开
标题翻译：新生血管抑制剂
公开(公告)号：JP2007077113A
公开(公告)日：2007-03-29
申请号：JP2005270179
申请日：2005-09-16
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HASEGAWA KIYOTAKA , INOMATA SHINJI , UMISHIO KENICHI
IPC分类号： A61K36/18 , A61K8/00 , A61K8/96 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a neovascularization inhibitor or a VEGF (vascular endothelial growth factor) expression inhibitor characterized as comprising a crude drug Linden Extract as an active ingredient. SOLUTION: The neovascularization inhibitor and the VEGF expression inhibitor are characterized as comprising the Linden Extract as the active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供新生血管形成抑制剂或VEGF（血管内皮生长因子）表达抑制剂，其特征在于包含生药林登提取物作为活性成分。解决方案：新生血管形成抑制剂和VEGF表达抑制剂的特征在于包含林丹提取物作为活性成分。版权所有（C）2007，JPO＆INPIT

39. 发明专利

JP2006265141A Skin-whitening agent 审中-公开
标题翻译：皮肤白化剂
公开(公告)号：JP2006265141A
公开(公告)日：2006-10-05
申请号：JP2005083979
申请日：2005-03-23
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： YAGI EIICHIRO , OTA NAOMI , FUJIWARA RUMIKO , UMISHIO KENICHI
IPC分类号： A61K8/00 , A61K8/96 , A61Q19/00 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a skin-whitening agent that has excellent skin-whitening action and develops excellent effects on the sedimentation of the pigment after the sunburn and brightening freckles, liver spots or the like and whitening skin.
SOLUTION: The skin-whitening agent comprises solvent-extracted products selected from Eryngium plant, Sterculia villosa Roxb. ex. Smith, Litsea plant and Pterocarpus plants.
COPYRIGHT: (C)2007,JPO&INPIT

40. 发明专利

JP2006193504A Skin whitening agent 有权
标题翻译：皮肤白化剂
公开(公告)号：JP2006193504A
公开(公告)日：2006-07-27
申请号：JP2005193348
申请日：2005-07-01
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： UMISHIO KENICHI , MAEDA KAZUHISA , KOBAYASHI KOJI
IPC分类号： A61K8/96 , A61K8/00 , A61Q1/12 , A61Q19/00 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a skin whitening agent that has excellent skin-whitening action and has excellent hypochromic and bleaching effects on the pigmentation after sunburn, stains, freckles, liver spots and the like.
SOLUTION: The skin whitening agent includes the extract from a plant, Elephantopus mollis H.B. & K. belonging to Compositae.
COPYRIGHT: (C)2006,JPO&NCIPI

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