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31. 发明授权

US07087646B2 Composition for external application 有权
标题翻译：组合外部应用
公开(公告)号：US07087646B2
公开(公告)日：2006-08-08
申请号：US10082115
申请日：2002-02-26
申请人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
发明人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
IPC分类号： A01N37/18 , A61K6/00 , C07C233/00
CPC分类号： A61Q5/00 , A61K8/42 , A61Q5/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/007
摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译：本发明涉及外用的组合物，保湿剂和皮肤屏障功能增强剂，其各自含有下式（1）表示的二酰胺衍生物：（其中，R 1a和R“ SUP> 1b相同或不同，分别表示C 1-13烃基，R 2a和R 2b均为相同或不同，并且各自表示二价C 1-6 - 烃基，R 3相同或不同，并且各自表示二价C 2-6 烃基，n表示1〜100）。外用组合物，保湿剂和皮肤屏障功能增强剂基本上提高了角质层的保水能力和阻隔功能，具有优异的混溶性和混合稳定性，可以以低成本高效制备。

32. 发明申请

US20050049308A1 Apolipoprotein D degradation inhibitor 有权
标题翻译：载脂蛋白D降解抑制剂
公开(公告)号：US20050049308A1
公开(公告)日：2005-03-03
申请号：US10899155
申请日：2004-07-27
申请人： Shunichi Akiba , Katsutoshi Ara , Hiroshi Kusuoku , Yoshinori Nishizawa
发明人： Shunichi Akiba , Katsutoshi Ara , Hiroshi Kusuoku , Yoshinori Nishizawa
IPC分类号： A61P25/00 , A61K31/19 , A61K31/202 , A61P25/18 , A61P25/28 , A61P43/00
CPC分类号： A61K31/202
摘要： The invention contemplates drugs useful for maintenance or promotion at sites of regenerating nerves and for prevention or treatment of pathological conditions caused by denaturation or cell damage in the nervous system. Thus, the invention provides an apolipoprotein D degradation inhibitor containing lauric acid or oleic acid as an active ingredient.
摘要翻译：本发明考虑了用于在再生神经的部位进行维持或促进的药物和用于预防或治疗由神经系统变性或细胞损伤引起的病理状况的药物。因此，本发明提供含有月桂酸或油酸作为活性成分的载脂蛋白D降解抑制剂。

33. 发明授权

US06685953B1 External preparation compositions 有权
标题翻译：外用制剂组合物
公开(公告)号：US06685953B1
公开(公告)日：2004-02-03
申请号：US09926270
申请日：2001-10-04
申请人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
发明人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
IPC分类号： A61K3116
CPC分类号： C07C233/20 , A61K8/42 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C233/18
摘要： The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译：本发明涉及含有下式（1）表示的二酰胺衍生物的皮肤病学制剂：其中，R 1表示可被一个或多个羟基取代的具有1至22个碳原子的直链或支链烃基和/或烷氧基，R 2表示具有1至12个碳原子的直链或支链二价烃基，R 3表示具有1至42个碳原子的直链或支链二价烃基）。该二酰胺衍生物（1）能够从根本上提高角质层的保水能力和阻隔功能，混溶性和混合稳定性优异，可以低成本有效地制备。

34. 发明授权

US06278539B1 Optical modulation apparatus and method of controlling 有权
标题翻译：光调制装置及光调制器的方法
公开(公告)号：US06278539B1
公开(公告)日：2001-08-21
申请号：US09348166
申请日：1999-07-07
申请人： Hiroki Ooi , Hiroshi Nakamoto , George Ishikawa , Takuji Yamamoto , Yoshinori Nishizawa
发明人： Hiroki Ooi , Hiroshi Nakamoto , George Ishikawa , Takuji Yamamoto , Yoshinori Nishizawa
IPC分类号： G02B2600
CPC分类号： G02F1/0123 , G02F2203/21
摘要： An optical modulator having a voltage—optical output characteristic in which optical output varies periodically with respect to a voltage value of an electrical drive signal is driven by a modulator driving voltage signal, which has an amplitude of 2·V&pgr; between two light-emission culminations or two light extinction culminations of the voltage—optical output characteristic. A low-frequency superimposing unit superimposes a prescribed low-frequency signal on the modulator driving voltage signal, and an operating-point controller controls the operating point of the optical modulator by detecting operating-point drift of the optical modulator based upon the low-frequency signal component contained in an optical signal output from the optical modulator and controlling the bias voltage of the optical modulator in dependence upon the drift of the operating point of the optical modulator.
摘要翻译：一种具有电压 - 光输出特性的光调制器，其中光输出相对于电驱动信号的电压值周期性变化，由调制器驱动电压信号驱动，该调制器驱动电压信号在两个发光峰值之间具有2.Vpi的幅度或电压 - 光输出特性的两个光消光结束。低频叠加单元将规定的低频信号叠加在调制器驱动电压信号上，工作点控制器通过基于低频来检测光调制器的工作点漂移来控制光调制器的工作点信号分量包含在从光调制器输出的光信号中，并且根据光调制器的工作点的漂移来控制光调制器的偏置电压。

35. 发明授权

US5876703A Flavanonol derivatives and hair-nourishing, hair-growing compositions containing the derivatives 失效
标题翻译：含有衍生物的黄酮醇衍生物和滋养滋养的发丝组合物
公开(公告)号：US5876703A
公开(公告)日：1999-03-02
申请号：US889327
申请日：1997-07-08
申请人： Susumu Ichinose , Yoshinori Nishizawa , Atsushi Ohuchi , Hideshi Kidena , Mitsuyuki Hotta
发明人： Susumu Ichinose , Yoshinori Nishizawa , Atsushi Ohuchi , Hideshi Kidena , Mitsuyuki Hotta
IPC分类号： A61K8/49 , A61K36/282 , A61K36/31 , A61K36/539 , A61K36/736 , A61K36/752 , A61K36/87 , A61Q7/00 , C07D311/32 , C07D311/62 , A61K7/06 , A61K7/075
CPC分类号： C07D311/62 , A61K8/498 , A61Q7/00 , C07D311/32 , Y10S514/889
摘要： The present invention relates to flavanonol derivatives represented by formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group, and each of R.sup.2 and R.sup.3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkoxyl group which may have a substituent, a hydroxyl group, a cyano group, or a halogen atom), as well as to hair-nourishing and hair-growing compositions containing the derivatives. The compounds accelerate differentiation and proliferation of hair matrix cells, thereby exhibiting remarkable hair-nourishing and hair-growing effects.
摘要翻译：本发明涉及由式（1）表示的黄烷醇衍生物：其中R1表示烷基，R2和R3各自表示氢原子，可以具有取代基的烷基，烷氧基可以具有取代基的基团，羟基，氰基或卤素原子），以及含有该衍生物的发育滋养和发育组合物。这些化合物促进毛发基质细胞的分化和增殖，从而表现出显着的滋养和发育的作用。

36. 发明授权

US5720945A 1,3-butanediol thioglycollate isomer mixture and permanent waving composition comprising same 失效
标题翻译： 1,3-丁二醇硫代乙醇酸异构体混合物和包含其的永久挥发组合物
公开(公告)号：US5720945A
公开(公告)日：1998-02-24
申请号：US620024
申请日：1996-03-21
申请人： Akira Kiyomine , Yukihiro Kondo , Kenichi Morita , Shinobu Nagase , Koichi Nakamura , Yoshinori Nishizawa , Bernd Nocker , Hitoshi Sakaguchi , Hiroyuki Suzuki
发明人： Akira Kiyomine , Yukihiro Kondo , Kenichi Morita , Shinobu Nagase , Koichi Nakamura , Yoshinori Nishizawa , Bernd Nocker , Hitoshi Sakaguchi , Hiroyuki Suzuki
IPC分类号： A61K8/46 , A61Q5/04 , C07C323/52 , A61K7/09 , A61K7/07
CPC分类号： A61Q5/04 , A61K8/46
摘要： The object of the invention is a new isomer mixture of 3-hydroxybutyl monothioglycollate and 3-hydroxy-1-methyl propyl monothioglycollate in a weight proportion of about 1.5:1 to 4:1, preferably about 2:1 to about 3:1, comprising less than 5%, preferably less than 2% by wt., of 1,3-butanediol thioglycollate, and its use as the sole or main reducing agent in compositions for permanent waving of human hair. The compositions have reduced smell, good waving properties and an extremely low sensitizing potential on human skin.
摘要翻译：本发明的目的是重量比为约1.5:1至4:1，优选约2:1至约3:1的3-羟基丁基一硫代乙醇酸酯和3-羟基-1-甲基丙基一硫代乙醇酸酯的新异构体混合物，包含小于5重量％，优选小于2重量％的1,3-丁二醇巯基乙酸酯，以及其作为人类头发永久挥发组合物中唯一或主要还原剂的用途。组合物具有降低的气味，良好的挥发性能和对人体皮肤极度敏感的潜力。

37. 发明授权

US5702691A Flavanonol derivatives and hair-nourishing, hair growing compositions containing the derivatives 失效
标题翻译：黄烷醇衍生物和滋养滋养的含有衍生物的发丝组合物
公开(公告)号：US5702691A
公开(公告)日：1997-12-30
申请号：US682568
申请日：1996-09-16
申请人： Susumu Ichinose , Yoshinori Nishizawa , Atsushi Ohuchi , Hideshi Kidena , Mitsuyuki Hotta
发明人： Susumu Ichinose , Yoshinori Nishizawa , Atsushi Ohuchi , Hideshi Kidena , Mitsuyuki Hotta
IPC分类号： A61K8/49 , A61K36/282 , A61K36/31 , A61K36/539 , A61K36/736 , A61K36/752 , A61K36/87 , A61Q7/00 , C07D311/32 , C07D311/62 , A61K7/06
CPC分类号： C07D311/62 , A61K8/498 , A61Q7/00 , C07D311/32 , Y10S514/889
摘要： The present invention relates to flavanonol derivatives represented by formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group, and each of R.sup.2 and R.sup.3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkoxyl group which may have a substituent, a hydroxyl group, a cyano group, or a halogen atom), as well as to hair-nourishing and hair-growing compositions containing the derivatives. The compounds accelerate differentiation and proliferation of hair matrix cells, thereby exhibiting remarkable hair-nourishing and hair-growing effects.
摘要翻译： PCT No.PCT / JP95 / 02433 Sec。 371日期1996年9月16日 102（e）日期1996年9月16日PCT提交1995年11月29日PCT公布。 WO96 / 16956 PCT公开号日期：1996年6月6日本发明涉及式（1）表示的黄烷醇衍生物：＆lt; IMAGE＆gt; R2和R3各自表示氢原子，可以具有取代基的烷基，可以具有取代基的烷氧基，羟基，氰基或卤素原子），以及含有该衍生物的发育滋养组合物和发丝组合物。这些化合物促进毛发基质细胞的分化和增殖，从而表现出显着的滋养和发育的作用。

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