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31. 发明授权

US5034517A Process for producing 2,6-dideoxy-2-fluoro-L-talopyranose 失效
标题翻译：制备2,6-二脱氧-2-氟-L-吡喃葡萄糖的方法
公开(公告)号：US5034517A
公开(公告)日：1991-07-23
申请号：US488871
申请日：1990-03-06
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Yasushi Takagi
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Yasushi Takagi
IPC分类号： A61K31/70 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , C07H1/00 , C07H5/02 , C07H13/04 , C07H13/06 , C07H15/04 , C07H15/252
CPC分类号： C07H5/02 , C07H13/04 , C07H15/04 , Y02P20/55
摘要： 2,6-Dideoxy-2-fluoro-L-talopyranose and 1-substituted derivatives thereof, including methyl 2,6-dideoxy-2-fluoro-L-talopyranoside and 3,4-di-O-protected-2,6-dideoxy-2-fluoro-L-talopyranosyl halides, are now provided and these new compounds are useful as intermediates for use in the synthesis of new compounds having antitumor activity, especially 7-O-(2,6-dideoxy-2-fluoro-.alpha.-L-talopyranosyl) daunomycinone or -adriamycinone. 2,6-Dideoxy-2-fluoro-L-talopyranose shows antibacterial activity. 2,6-Dideoxy-fluoro-L-talopyranose and the 1-substituted derivatives thereof may be produced by a multi-stage process starting from L-fucose.
摘要翻译： 2,6-二脱氧-2-氟-L-吡喃葡萄糖及其1-取代衍生物，包括2,6-二脱氧-2-氟-L-吡喃葡萄糖苷和3,4-二-O-保护的2,6-二现在提供二脱氧-2-氟-L-吡喃葡萄糖基卤化物，这些新化合物可用作合成具有抗肿瘤活性的新化合物的中间体，特别是7-O-（2,6-二脱氧-2-氟 - α-L-吡喃葡萄糖基）道诺霉素或阿霉素酮。 2,6-二脱氧-2-氟-L-吡喃葡萄糖显示出抗菌活性。 2,6-二脱氧 - 氟-L-吡喃葡萄糖及其1-取代衍生物可以通过从L-岩藻糖开始的多阶段方法制备。

32. 发明申请

US20110162948A1 KEY SWITCH STRUCTURE 有权
标题翻译：钥匙开关结构
公开(公告)号：US20110162948A1
公开(公告)日：2011-07-07
申请号：US13061979
申请日：2010-06-04
申请人： Yasushi Takagi
发明人： Yasushi Takagi
IPC分类号： H01H13/14
CPC分类号： H01H3/125 , H01H2223/002
摘要： Provided is a key switch structure wherein a membrane sheet (7) having a movable contact point (7e) and a stationary contact point (7d) is provided between a housing (5), which supports a key top (1) so as to allow the key top to be pushed downward and a base plate (8). The movable contact point (7e) is brought into contact with the stationary contact point (7d) by a downward push to the key top (1), so that a switch is closed. In the key switch structure, the inside of a device's main body is completely shielded from outside air, and water is completely prevented from entering the inside of the device's main body. A plate (6) provided with a plurality of attachment holes (6g) corresponding to fixing pins (5f) of the housing (5) is provided on the membrane sheet (7), so that the fixing pins (5f) are secured in the attachment holes (6g) of the plate (6).
摘要翻译：提供了一种键开关结构，其中具有可移动触点（7e）和固定触点（7d）的膜片（7）设置在支撑键顶（1）的壳体（5）之间，以允许顶部向下推，底板（8）。可动触点（7e）通过向下按压到键顶（1）而与固定触点（7d）接触，从而使开关闭合。在钥匙开关结构中，装置主体的内部完全被外部空气遮蔽，完全防止水进入装置主体内部。设置有与壳体（5）的固定销（5f）相对应的多个安装孔（6g）的板（6）设置在膜片（7）上，使得固定销（5f）固定在板（6）的安装孔（6g）。

33. 发明申请

US20050135788A1 Image encoder and recorder 审中-公开
标题翻译：图像编码器和录像机
公开(公告)号：US20050135788A1
公开(公告)日：2005-06-23
申请号：US10920980
申请日：2004-08-18
申请人： Hiromasa Fujii , Yasushi Takagi , Yuji Sato
发明人： Hiromasa Fujii , Yasushi Takagi , Yuji Sato
IPC分类号： H04N5/915 , H04N7/18 , H04N19/102 , H04N19/115 , H04N19/134 , H04N19/157 , H04N19/172 , H04N19/189 , H04N19/50 , H04N19/503 , H04N7/26
CPC分类号： H04N19/31 , H04N19/179
摘要： A recording apparatus is provided in which, when image signals are inputted from a plurality of channels and compressed and encoded before being recorded on a medium, the slow-varying-image signals are improved in their quality even if the numbers of bits for the image signals are decreased and they are recorded on the medium for a long time. The image signals inputted are converted into a single-channel image signal, sorted to be a group of a certain number of frames for each channel, and compressed and encoded for each group of a certain number of frames. When an image quality is fixed, the number of bits for the reference image at the encoding time is kept constant, but the number of bits for the difference image at that time is changed.
摘要翻译：提供了一种记录装置，其中当图像信号从多个通道输入并在被记录在介质上之前进行压缩和编码时，即使图像的比特数量，慢变化图像信号也提高了其质量信号减少，并且它们被长时间地记录在介质上。输入的图像信号被转换为单通道图像信号，被分类为每个通道的一定数量的帧的组，并且对于一组数量的帧的每个组进行压缩和编码。当图像质量固定时，编码时的参考图像的位数保持不变，但是此时的差分图像的比特数改变。

34. 发明授权

US06378342B1 Electric washer-dryer 失效
公开(公告)号：US06378342B1
公开(公告)日：2002-04-30
申请号：US09852277
申请日：2001-05-10
申请人： Masami Fukumoto , Junichi Morinaka , Yasushi Takagi , Shinichi Matsuda
发明人： Masami Fukumoto , Junichi Morinaka , Yasushi Takagi , Shinichi Matsuda
IPC分类号： D06F2500
CPC分类号： D06F25/00
摘要： A washer-dryer has an improved efficiency of drying; namely, the drying time is shortened and the unevenness of drying is alleviated. Furthermore, vibration during operations, especially during spin-drying, is reduced. An inner tub of approximately cylindrical shape rotating around a substantially vertical axis and for receiving a wash load is housed in an outer tub. The inner tub is provided with freely rotatable agitating means at the bottom part for agitating the wash load. A motor rotates the inner tub or the agitating means. The air to be supplied through a hot air supply channel into the inner tub is heated by heating means, which air is advanced by a drying air blower into the inner tub. Control means controls each of the washing, rinsing, spin-drying and drying processes by controlling respective operations of the motor, the heating means, the drying air blower, etc. During the drying process, a wash load is agitated by the agitating means, and exposed to the air heated by the heating means and blown by the drying air blower against the washing staying within the inner tub. The washing is thus removed of humidity and dried.

35. 发明授权

US06282928B1 Electric washer-dryer 有权
标题翻译：电动洗衣机 - 烘干机
公开(公告)号：US06282928B1
公开(公告)日：2001-09-04
申请号：US09266599
申请日：1999-03-11
申请人： Masami Fukumoto , Junichi Morinaka , Yasushi Takagi , Shinichi Matsuda
发明人： Masami Fukumoto , Junichi Morinaka , Yasushi Takagi , Shinichi Matsuda
IPC分类号： D06F2500
CPC分类号： D06F25/00
摘要： A washer-dryer having an improved efficiency of drying up; namely, the drying time is shortened and the unevenness of drying is alleviated. Furthermore, vibration during operations, especially during spin-drying, is reduced. An inner tub of approximately cylindrical shape rotating around a substantially vertical axis and receives a washing is housed in an outer tub. The inner tub is provided with freely rotatable agitating means at the bottom part for agitating the washing. A motor rotates the inner tub or the agitating means. The air to be supplied through a hot air supply channel into the inner tub is heated by heating means, which air is advanced by a drying air blower into the inner tub. Control means controls each of the washing, rinsing, spin-drying and drying processes by controlling respective operations of the motor, the heating means, the drying air blower, etc. During the drying process, a washing is agitated by the agitating means, and exposed to the air heated by the heating means and blown by the drying air blower against the washing staying within the inner tub. The washing is thus deprived of humidity and dried.
摘要翻译：具有改善的干燥效率的洗涤干燥器; 即干燥时间缩短，干燥不均匀性降低。此外，操作期间的振动，特别是在旋转干燥期间的振动减小。围绕基本上垂直的轴线旋转并接收洗涤的大致圆筒形的内桶容纳在外桶中。内桶在底部设置有可自由旋转的搅拌装置，用于搅拌洗涤。电动机使内桶或搅拌装置旋转。通过热空气供应通道供入内桶的空气由加热装置加热，空气通过干燥空气鼓风机进入内桶。控制装置通过控制电动机，加热装置，干燥鼓风机等的各个操作来控制洗涤，漂洗，旋转干燥和干燥过程。在干燥过程中，通过搅拌装置搅拌洗涤，暴露于由加热装置加热的空气中，并被干燥空气鼓风机吹扫而抵靠内桶内的洗涤物。因此洗涤物被剥去湿气并干燥。

36. 发明授权

US6094220A Image pickup apparatus with image extracting unit 失效
标题翻译：具有图像提取单元的图像拾取装置
公开(公告)号：US6094220A
公开(公告)日：2000-07-25
申请号：US797084
申请日：1997-02-10
申请人： Norihiko Nakano , Ryuji Nishimura , Yasushi Takagi
发明人： Norihiko Nakano , Ryuji Nishimura , Yasushi Takagi
IPC分类号： H04N9/04 , H04N9/73 , H04N9/74
CPC分类号： H04N9/735 , H04N9/045
摘要： An image pickup apparatus including an image extracting unit and performing an image extraction process and automatic feedback control of white balance for executing image extraction with high accuracy by performing the image extraction process and automatic white balance control with reference to each other.
摘要翻译：一种图像拾取装置，包括图像提取单元，并且通过执行图像提取处理和自动白平衡控制来执行图像提取处理和用于执行高精度的图像提取的白平衡的自动反馈控制。

37. 发明授权

US6075135A 3,4-di-O,N-Protected-4-amino-2,4,6-trideoxy-2-fluoro-L-manno-pyranosyl halide and a process for its preparation 失效
标题翻译： 3,4-二-O，N-保护的-4-氨基-2,4,6-三脱氧-2-氟-L-壬烷 - 吡喃糖基卤化物及其制备方法
公开(公告)号：US6075135A
公开(公告)日：2000-06-13
申请号：US282200
申请日：1999-03-31
申请人： Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi
发明人： Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/244 , C07H15/252 , C07H1/00 , C07H5/00
CPC分类号： C07H15/252 , C07H15/244 , Y02P20/55
摘要： 7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-.alpha.-L-mannopyranosyl)-daunomycinone or -adriamycinone is now synthesized as a daunomycinone or adriamycinone derivative having the general formula ##STR1## wherein R is a hydrogen atom or hydroxyl group. These novel compounds according to this invention exhibit excellent antitumor activities and have a high solubility in water, and hence they are useful as an antitumor agent.
摘要翻译：现在，合成7-O-（4-氨基-2,4,6-三脱氧-2-氟-α-L-吡喃甘露糖基） - 日诺霉素酮或阿曲达霉素，作为具有通式的道诺霉素酮或阿霉素酮衍生物，其中R是氢原子或羟基。根据本发明的这些新化合物表现出优异的抗肿瘤活性，并且在水中的溶解度高，因此它们可用作抗肿瘤剂。

38. 发明授权

US5789386A Fluorine-containing anthracycline derivatives having hydroxyl groups(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof 失效
标题翻译：在其糖部分中具有单或二氨基烷氧基的羟基的含氟蒽环类衍生物
公开(公告)号：US5789386A
公开(公告)日：1998-08-04
申请号：US709297
申请日：1996-09-09
申请人： Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi , Hiromi Sohtome
发明人： Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi , Hiromi Sohtome
IPC分类号： C07H15/252 , A61K31/70 , C07H15/24
CPC分类号： C07H15/252
摘要： To provide novel fluorine-containing anthracycline derivatives having high antitumor activities and a solubility in water, there have now been synthesized a 7-O-(2,6-dideoxy-2-fluoro-3-O- or -4-O- or -3,4-di-O-aminoalkanoyl-.alpha.-L-talopyranosyl)daunomycinone or -adriamycinone of general formula (I) shown below, as well as a 7-O-(3-O- or -4-O- or -3,4-di-O-aminoalkanoyl-2,6-dideoxy-2,6,6,6-tetrafluoro-.alpha.-L-talopyranosyl- or -2,6-dideoxy-6,6,6-trifluoro-.alpha.-L-lyxo-hexopyranosyl)adriamycinone of general formula (II) shown below: General formula (I) ##STR1## General formula (II) ##STR2## wherein either one or both of A.sup.1 and A.sup.2 is or are an .alpha.-amino acid residue or an .omega.-amino acid residue and T denotes a fluorine or hydrogen atom. The novel fluorine-containing anthracycline derivatives of general formulae (I) and (II) are highly active against tumors and soluble in water, and they are useful as antitumor agents administrable in the form of injectable solution.
摘要翻译：为了提供具有高抗肿瘤活性和在水中的溶解性的新型含氟蒽环类衍生物，现在已经合成了7-O-（2,6-二脱氧-2-氟-3-O-或-4-O-或 -3,4-二-O-氨基链烷酰-α-L-吡喃葡萄糖基）道诺霉素酮或下列通式（I）的阿霉素酮，以及7-O-（3-O-或-4-O-或 -3,4-二-O-氨基链烷酰基-2,6-二脱氧-2,6,6,6-四氟-α-L-吡喃木糖基或-2,6-二脱氧-6,6,6-三氟-α （II）的通式（Ⅰ）所示的通式（Ⅰ）所示的通式（Ⅰ）的L-赖氨酸 - 六吡喃糖基）的阿霉素酮：通式（Ⅰ）是α-氨基酸残基或ω-氨基酸残基，T表示氟或氢原子。通式（I）和（II）的新型含氟蒽环类衍生物对肿瘤具有高度活性并且可溶于水，并且它们可用作以可注射溶液形式施用的抗肿瘤剂。

39. 发明授权

US4873225A 1-n-(4-amino-3-fluoro-2-hydroxybutyryl)-kanamycins 失效
标题翻译： 1-正（4-氨基-3-氟-2-羟基丁酰） - 卡那霉素
公开(公告)号：US4873225A
公开(公告)日：1989-10-10
申请号：US158628
申请日：1988-02-22
申请人： Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
发明人： Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236
CPC分类号： C07H15/234
摘要： As new compound are now provided ten compounds, namely 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}kanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxykanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxy-2'-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-kanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3'-deoxykanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3',4'-dideoxykanamycin B; 1-N-{(2R,3R) -4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3'-dideoxy-5-fluorokanamycin B; and 1-N{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3',4'-trideoxy-5-fluorokanamycin B, which are all useful as antibacterial agent in the therapeutic treatment of bacterial infections.

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