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31. 发明申请

US20070173645A1 Process for the preparation of biphosphonic acids 失效
标题翻译：制备双膦酸的方法
公开(公告)号：US20070173645A1
公开(公告)日：2007-07-26
申请号：US11655027
申请日：2007-01-18
申请人： Subba Reddy Danda , Narayan K.A.S.S. Garimella , Srinivasa Rao V.N Divvela , Ramesh Dandala , Sivakumaran Meenakshisunderam
发明人： Subba Reddy Danda , Narayan K.A.S.S. Garimella , Srinivasa Rao V.N Divvela , Ramesh Dandala , Sivakumaran Meenakshisunderam
IPC分类号： C07F9/6506 , C07F9/28 , C07F9/58
CPC分类号： C07F9/3873 , C07F9/386 , C07F9/58 , C07F9/6506 , C07F9/6561
摘要： An improved process for bisphosphonylation of acids, substituted acids to obtain compounds with the formula using phosphorus trihalide, phosphorus acid, in presence of phenolic compounds as diluent/solvent.
摘要翻译：在酚类化合物作为稀释剂/溶剂的存在下，改进了酸，取代酸的双膦酰化，得到具有下式的化合物的方法：磷三卤化磷，磷酸。

32. 发明授权

US11077103B2 Naloxegol oxalate and solid dispersion thereof 有权
公开(公告)号：US11077103B2
公开(公告)日：2021-08-03
申请号：US16462856
申请日：2017-11-22
申请人： AUROBINDO PHARMA LIMITED , Rama Shankar , Nimesh Chandra Misra , Siva Rama Kasibabu Velegula , Suresh Chapala , Sivakumaran Meenakshisunderam
发明人： Rama Shankar , Nimesh Chandra Misra , Siva Rama Kasibabu Velegula , Suresh Chapala , Sivakumaran Meenakshisunderam
IPC分类号： A61K31/485
摘要： The present invention relates to solid dispersion of Naloxegol oxalate. Further, the present invention relates to an improved process for Naloxegol oxalate and intermediates thereof.

33. 发明申请

US20150157618A1 Stabilized pharmaceutical compositions of dabigatran and process for preparation thereof 审中-公开
标题翻译：稳定的达比加群的药物组合物及其制备方法
公开(公告)号：US20150157618A1
公开(公告)日：2015-06-11
申请号：US14544126
申请日：2014-11-26
申请人： Chandrashekhar Kandi , Nagaprasad Vishnubhotla , Sreekanth Manikonda , Anil Kumar Reddy , Sivakumaran Meenakshisunderam , Arjuna Rao Panchada
发明人： Chandrashekhar Kandi , Nagaprasad Vishnubhotla , Sreekanth Manikonda , Anil Kumar Reddy , Sivakumaran Meenakshisunderam , Arjuna Rao Panchada
IPC分类号： A61K31/4439 , A61K9/48 , A61K9/20
CPC分类号： A61K31/4439 , A61K9/1652 , A61K9/1676 , A61K9/2013 , A61K9/2077 , A61K9/4808 , A61K9/4858
摘要： Stabilized pharmaceutical compositions comprising a thrombin inhibitor as an active agent(s), process of preparation and method of using the same are provided. The present invention also relates to stabilized pharmaceutical compositions comprising dabigatran etexilate, or pharmaceutically acceptable salts, esters, hydrates and solvates thereof, process of preparation and method of using the same.
摘要翻译：提供了包含凝血酶抑制剂作为活性剂的稳定化药物组合物，其制备方法及其使用方法。本发明还涉及包含达比加群酯或其药学上可接受的盐，酯，水合物和溶剂合物的稳定的药物组合物，其制备方法及其使用方法。

34. 发明申请

US20150141520A1 Stabilized pharmaceutical compositions of fingolimod and process for preparation thereof 审中-公开
标题翻译：芬戈莫德的稳定药物组合物及其制备方法
公开(公告)号：US20150141520A1
公开(公告)日：2015-05-21
申请号：US14544040
申请日：2014-11-18
申请人： Chandrasekhar Kandi , Nagaprasad Vishnubhotla , Asif Anwar , Krishnakumar Chegonda , Sivakumaran Meenakshisunderam
发明人： Chandrasekhar Kandi , Nagaprasad Vishnubhotla , Asif Anwar , Krishnakumar Chegonda , Sivakumaran Meenakshisunderam
IPC分类号： A61K31/137 , A61K47/14 , A61K47/12 , A61K47/02
CPC分类号： A61K31/137 , A61K9/1611 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/4866
摘要： Stabilized pharmaceutical compositions comprising a S1P receptor modulator as an active agent(s), process of preparation and method of using the same are provided. The present invention also relates to stabilized pharmaceutical compositions comprising fingolimod, or pharmaceutically acceptable salts, esters, hydrates and solvates thereof, process of preparation and method of using the same.
摘要翻译：提供了包含作为活性剂的S1P受体调节剂的稳定化药物组合物，其制备方法及其使用方法。本发明还涉及包含芬戈莫德或其药学上可接受的盐，酯，水合物和溶剂合物的稳定化药物组合物，其制备方法及其使用方法。

35. 发明申请

US20150141376A1 Pharmaceutical compositions of anti-viral compounds and process for preparation thereof 审中-公开
标题翻译：抗病毒化合物的药物组合物及其制备方法
公开(公告)号：US20150141376A1
公开(公告)日：2015-05-21
申请号：US14544041
申请日：2014-11-18
申请人： Chandrashekhar Kandi , Nagaprasad Vishnubhotla , Asif Anwar , Krishna Kumar Chegonda , Sivakumaran Meenakshisunderam
发明人： Chandrashekhar Kandi , Nagaprasad Vishnubhotla , Asif Anwar , Krishna Kumar Chegonda , Sivakumaran Meenakshisunderam
IPC分类号： A61K9/20 , A61K31/506 , A61K31/675 , A61K31/536
CPC分类号： A61K9/2027 , A61K9/2018 , A61K31/506 , A61K31/513 , A61K31/536 , A61K31/675 , A61K2300/00
摘要： Pharmaceutical compositions of anti-viral compounds, process for preparation and method of using the same are provided. Particularly, the present invention relates to chemically stable pharmaceutical compositions of efavirenz, emtricitabine and tenofovir disoproxil fumarate with optionally one or more pharmaceutically acceptable excipients, process for preparation and method for the treatment or prevention of the symptoms or effects of an HIV infection in an infected patient.
摘要翻译：提供了抗病毒化合物的药物组合物，制备方法及其使用方法。特别地，本发明涉及依法韦仑，恩曲他滨和替诺福韦地索普西富马酸与任选的一种或多种药学上可接受的赋形剂的化学稳定的药物组合物，其制备方法和用于治疗或预防感染HIV感染的症状或效果的方法患者。

36. 发明授权

US08981109B2 Process for the preparation of valsartan 有权
标题翻译：制备缬沙坦的方法
公开(公告)号：US08981109B2
公开(公告)日：2015-03-17
申请号：US13261552
申请日：2011-06-24
申请人： Raveendra Reddy Chinta , Gangadhara Bhima Shankar Nangi , Mahendar Reddy Nayini , Somappa Somannavar Yallapa , Shankar Reddy Budidet , Islam Aminul , Sivakumaran Meenakshisunderam
发明人： Raveendra Reddy Chinta , Gangadhara Bhima Shankar Nangi , Mahendar Reddy Nayini , Somappa Somannavar Yallapa , Shankar Reddy Budidet , Islam Aminul , Sivakumaran Meenakshisunderam
IPC分类号： C07D257/04
CPC分类号： C07D257/04
摘要： The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4′-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2′-(2-tributyltintetrazol-5-yl)-(1,1′-biphenyl)-4-yl]methyl]-(L)-valine methyl ester of formula (VHIb) free from thermal degradation impurity (Villa); (v) hydrolyzing the compound of formula (VHIb) in the presence of alkaline conditions to produce Valsartan (I).
摘要翻译：本发明涉及制备基本上不含式（Ia），（Ib）和（Ic）杂质的纯缬沙坦（I）的方法，其包括：（i）将2-（4'-溴甲基苯基）（II）的苄腈与式（V）的L-缬氨酸甲酯盐酸盐在碱的存在下在溶剂中反应，得到N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸（VI）的甲酯; （ii）用酸处理步骤（i）的化合物VI，然后用碱处理以产生基本上不含式（VIa）的二聚杂质的纯化合物VI; （ⅲ）在碱的存在下使式（Ⅵ）的纯的化合物与正戊酰氯反应，得到纯的N-戊酰基-N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸甲酯（VII）基本上不含式（VIIa）的烯烃杂质; （ⅳ）使式（Ⅶ）化合物与三烷基氯化锡和金属叠氮化物在溶剂中在回流温度下反应，得到N-（1-氧代戊基）-N - [[2' - （2-三丁基四唑-5-基） - （1,1'-联苯基）-4-基]甲基] - （L））不含热降解杂质的式（VHIb）的缬氨酸甲酯（Villa）; （v）在碱性条件存在下水解式（VHIb）化合物以制备缬沙坦（I）。

37. 发明授权

US08106188B2 Process for preparing olanzapine form I 失效
标题翻译：奥氮平制备方法Ⅰ
公开(公告)号：US08106188B2
公开(公告)日：2012-01-31
申请号：US12227819
申请日：2006-06-01
申请人： Uttam Kumar Ray , Sreenivasa Rao Pathuri , Sivakumaran Meenakshisunderam
发明人： Uttam Kumar Ray , Sreenivasa Rao Pathuri , Sivakumaran Meenakshisunderam
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： An improved for preparing Olanzapine Form I of Formula 1 in the presence of one solvent or a mixture of solvents.
摘要翻译：改进了在一种溶剂或溶剂混合物存在下制备式1的奥氮平I型。

38. 发明申请

US20110196032A1 Pharmaceutical Dosage Form of an Antidepressant 审中-公开
标题翻译：抗抑郁药的药物剂型
公开(公告)号：US20110196032A1
公开(公告)日：2011-08-11
申请号：US11920798
申请日：2006-05-18
申请人： Ashish Gogia , Krishna Murthy Vanasi , Sivakumaran Meenakshisunderam
发明人： Ashish Gogia , Krishna Murthy Vanasi , Sivakumaran Meenakshisunderam
IPC分类号： A61K31/343 , C07D307/06 , B32B5/00 , A61P25/24
CPC分类号： A61K9/2077 , A61K9/2018 , A61K9/2054 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K31/343 , Y10T428/2982
摘要： The present invention relates to pharmaceutical dosage forms of an antidepressant. More particularly, the present invention relates to pharmaceutical dosage forms of Escitalopram oxalate. The present invention also relates to a process for the preparation of pharmaceutical dosage forms of Escitalopram oxalate.
摘要翻译：本发明涉及抗抑郁药的药物剂型。更具体地，本发明涉及草酸艾司西酞普兰的药物剂型。本发明还涉及一种制备草酸依西普仑的药物剂型的方法。

39. 发明申请

US20080085892A1 Liquid dosage form of acetaminophen 审中-公开
标题翻译：对乙酰氨基酚的液体剂型
公开(公告)号：US20080085892A1
公开(公告)日：2008-04-10
申请号：US11897765
申请日：2007-08-31
申请人： Sangeetha Kandeepan , Krishna Bhavanasi , Venkata Ram Mohan Rao Visinigiri , Nagaprasad Vishnubhotla , Sivakumaran Meenakshisunderam
发明人： Sangeetha Kandeepan , Krishna Bhavanasi , Venkata Ram Mohan Rao Visinigiri , Nagaprasad Vishnubhotla , Sivakumaran Meenakshisunderam
IPC分类号： A61K31/5415 , A61K31/075 , A61K31/135 , A61K31/164 , A61K31/192 , A61P43/00 , A61K31/4355 , A61K31/44 , A61K31/4427
CPC分类号： A61K31/075 , A61K31/135 , A61K31/164 , A61K31/192 , A61K31/4355 , A61K31/44 , A61K31/4427 , A61K31/5415
摘要： The present invention relates to a liquid dosage form comprising pharmaceutically insoluble and unpleasant active drug and liquid excipient base. In particular, the invention relates to a liquid dosage form comprising Acetaminophen and liquid excipient base as a solubilizer.
摘要翻译：本发明涉及包含药物不溶性和不愉快的活性药物和液体赋形剂基质的液体剂型。特别地，本发明涉及包含对乙酰氨基酚和液体赋形剂基质作为增溶剂的液体剂型。

40. 发明授权

US11974996B2 Naloxegol oxalate and solid dispersion thereof 有权
公开(公告)号：US11974996B2
公开(公告)日：2024-05-07
申请号：US17351730
申请日：2021-06-18
申请人： Rama Shankar , Nimesh Chandra Misra , Siva Rama Kasibabu Velugula , Suresh Chapala , Sivakumaran Meenakshisunderam
发明人： Rama Shankar , Nimesh Chandra Misra , Siva Rama Kasibabu Velugula , Suresh Chapala , Sivakumaran Meenakshisunderam
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： The present invention relates to solid dispersion of Naloxegol oxalate. Further, the present invention relates to an improved process for Naloxegol oxalate and intermediates thereof.

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