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31. 发明授权

US07455646B2 Polymer coated guide wire 有权
标题翻译：聚合物涂层导丝
公开(公告)号：US07455646B2
公开(公告)日：2008-11-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
发明人： Mark T. Richardson , David M. Anderson , Emmanuel C. Biagtan , Lawrence E. Brennan , David H. Burkett , Wayne E. Cornish , Robert C. Esselstein , James Jacobs , Marc M. Jalisi , Daryush P. Mirzaee , Olin J. Palmer , John Schreiner , Kent C. Stalker
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

32. 发明授权

US06524301B1 Guidewire with an intermediate variable stiffness section 有权
标题翻译：导丝具有中间可变刚度部分
公开(公告)号：US06524301B1
公开(公告)日：2003-02-25
申请号：US09748294
申请日：2000-12-21
申请人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
发明人： W. Stan Wilson , Robert C. Esselstein , Wayne E. Cornish , Mark T. Richardson
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133
摘要： The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a “nodding” motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.
摘要翻译：本发明涉及一种用于在患者体内腔内部署医疗装置的导丝，所述导丝具有细长的芯部件，所述细长的芯部件具有中间的芯部分，所述中间纤芯部分包括与所述芯部件的纵向轴线对准的多个连续部分，柔性和刚性的芯段，使得铰接部分在通过患者体内的弯曲血管或其他体腔前进时以不连续的离散方式弯曲。当血管壁上的阻塞物导致导管或其它同轴装置被阻碍时，引导线和中间芯部分可以交替地前进并缩回穿过导管远端的短距离，导致导管末端的“点头”运动，同时导管被推过血管，以避免和绕过血管阻塞。

33. 发明授权

US06352515B1 NiTi alloyed guidewires 有权
标题翻译： NiTi合金导线
公开(公告)号：US06352515B1
公开(公告)日：2002-03-05
申请号：US09459814
申请日：1999-12-13
申请人： David M. Anderson , Wayne E. Cornish , Marc Mehrzad Jalisi , Nancy Nicotra , Mark T. Richardson
发明人： David M. Anderson , Wayne E. Cornish , Marc Mehrzad Jalisi , Nancy Nicotra , Mark T. Richardson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09133 , A61M2025/09141
摘要： The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the same. The device, has proximal and distal ends and includes an elongated high strength proximal portion having proximal and distal ends. The device further includes a distal portion having proximal and distal ends. The distal end of the proximal portion and the proximal end of the distal portion are connected by a connector. The distal portion is formed of a superelastic alloy composition. Preferably, the connector is also formed of the superelastic alloy composition. The superelastic alloy composition includes, in atomic percent, from about 28 to about 52% nickel, from about 48 to about 52% titanium, and up to about 20% of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.
摘要翻译：本发明涉及一种体内装置，优选导丝及其制造方法。该装置具有近端和远端并且包括具有近端和远端的细长的高强度近端部分。该装置还包括具有近端和远端的远侧部分。近端部分的远端和远端部分的近端通过连接器连接。远端部分由超弹性合金组成形成。优选地，连接器也由超弹性合金组合物形成。超弹性合金组成包括原子百分比为约28至约52％的镍，约48至约52％的钛，以及至多一种选自钯，铬，和铪。

34. 发明授权

US08480598B2 Guide wire with soldered multilayer coil member 有权
标题翻译：带有焊接多层线圈构件的导丝
公开(公告)号：US08480598B2
公开(公告)日：2013-07-09
申请号：US12881456
申请日：2010-09-14
申请人： John J. Nelson, III , David H. Burkett , Wayne E. Cornish
发明人： John J. Nelson, III , David H. Burkett , Wayne E. Cornish
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09091 , A61M2025/0915
摘要： A guide wire includes an elongate core section and a flexible member disposed on the distal end, the flexible member including a first wire wound into an inner helical coil in a first direction and a second wire wound into an outer helical coil wrapped about the first helical coil in the opposite direction. The two combined helical coils add stiffness and torque transmission to the guide wire without sacrificing tactile feedback.
摘要翻译：引导线包括细长芯部分和设置在远端上的柔性部件，所述柔性部件包括沿着第一方向缠绕在内螺旋线圈中的第一线，以及缠绕在围绕第一螺旋缠绕的外螺旋线圈的第二线线圈在相反的方向。两个组合的螺旋线圈增加了导丝的刚度和扭矩传递，而不会牺牲触觉反馈。

35. 发明授权

US08480597B2 Color coded guide wire and methods of making same 有权
标题翻译：彩色导丝及其制作方法
公开(公告)号：US08480597B2
公开(公告)日：2013-07-09
申请号：US12880465
申请日：2010-09-13
申请人： Wayne E. Cornish , Travis R. Yribarren , Carl P. Frick , Jessica M. Saenz , Emmanuel C. Biagtan , Pablito Buan , David H. Burkett , John J. Nelson, III , Robert J. Peralta , Michelle E. Alexander , Arthur R. Tyre , John A. Simpson
发明人： Wayne E. Cornish , Travis R. Yribarren , Carl P. Frick , Jessica M. Saenz , Emmanuel C. Biagtan , Pablito Buan , David H. Burkett , John J. Nelson, III , Robert J. Peralta , Michelle E. Alexander , Arthur R. Tyre , John A. Simpson
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/0008 , A61M2025/09108 , A61M2025/09133 , Y10T29/49815 , Y10T29/49826 , Y10T29/49885 , Y10T156/10
摘要： A color coding is applied to medical guide wires by coloring portions of the guide wire to distinguish similar guide wires and guide wire portions from a particular manufacturer. The metallic elongate core can be colored using various methods such as electrochemical processes, sputtering, electroplating, and laser inducing microstructures to alter the surface characteristics of the elongate metallic core. Alternatively, the outer layer of the guide wire can be color coded by using non-standard colors or by introducing a colored band on the guide wire.
摘要翻译：通过着色引导线的部分来将医疗引导线上的颜色编码应用于将特定制造商的类似导丝和导丝部分区分开。金属细长芯可以使用诸如电化学工艺，溅射，电镀和激光诱导微结构的各种方法着色，以改变细长金属芯的表面特性。或者，引导线的外层可以通过使用非标准颜色进行颜色编码，或者通过在导丝上引入彩色带。

36. 发明授权

US08029530B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US08029530B2
公开(公告)日：2011-10-04
申请号：US12904001
申请日：2010-10-13
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

37. 发明授权

US06464650B2 Guidewire with smoothly tapered segment 有权
标题翻译：导丝平滑锥形
公开(公告)号：US06464650B2
公开(公告)日：2002-10-15
申请号：US09224451
申请日：1998-12-31
申请人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
发明人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for intraluminal advancement of a medical device within a patient which has an elongate core member with a flexible body member disposed on a distal section thereof. In one embodiment, the distal section of the elongate core member has at least one flexible segment with at least one pair of opposed tapered or parallel faces. Preferably the flexible segment with the tapered or parallel faces is disposed at the distal end of the elongate core and forms a shapable segment.
摘要翻译：一种用于管腔内推进医疗装置的导丝，其具有细长的芯部件，其具有设置在其远端部分上的柔性主体部件。在一个实施例中，细长芯部件的远端部分具有至少一个具有至少一对相对的锥形或平行面的柔性部分。优选地，具有锥形或平行面的柔性段设置在细长芯的远端并形成可成形段。

38. 发明申请

US20120065622A1 COLOR CODED GUIDE WIRE AND METHODS OF MAKING SAME 有权
标题翻译：彩色编码指南及其制作方法
公开(公告)号：US20120065622A1
公开(公告)日：2012-03-15
申请号：US12880465
申请日：2010-09-13
申请人： Wayne E. Cornish , Travis R. Yribarren , Carl P. Frick , Jessica M. Saenz , Emmanuel C. Biagtan , Pablito Buan , David H. Burkett , John J. Nelson, III , Robert J. Peralta , Michelle E. Alexander , Arthur R. Tyre , John A. Simpson
发明人： Wayne E. Cornish , Travis R. Yribarren , Carl P. Frick , Jessica M. Saenz , Emmanuel C. Biagtan , Pablito Buan , David H. Burkett , John J. Nelson, III , Robert J. Peralta , Michelle E. Alexander , Arthur R. Tyre , John A. Simpson
IPC分类号： A61M25/09 , B05D3/14 , B05D3/10
CPC分类号： A61M25/09 , A61M2025/0008 , A61M2025/09108 , A61M2025/09133 , Y10T29/49815 , Y10T29/49826 , Y10T29/49885 , Y10T156/10
摘要： A color coding is applied to medical guide wires by coloring portions of the guide wire to distinguish similar guide wires and guide wire portions from a particular manufacturer. The metallic elongate core can be colored using various methods such as electrochemical processes, sputtering, electroplating, and laser inducing microstructures to alter the surface characteristics of the elongate metallic core. Alternatively, the outer layer of the guide wire can be color coded by using non-standard colors or by introducing a colored band on the guide wire.
摘要翻译：通过着色引导线的部分来将医疗引导线上的颜色编码应用于将特定制造商的类似导丝和导丝部分区分开。金属细长芯可以使用诸如电化学工艺，溅射，电镀和激光诱导微结构的各种方法着色，以改变细长金属芯的表面特性。或者，引导线的外层可以通过使用非标准颜色进行颜色编码，或者通过在导丝上引入彩色带。

39. 发明授权

US08100837B1 Superelastic guidewire with locally altered properties 有权
标题翻译：具有局部改变特性的超弹性导丝
公开(公告)号：US08100837B1
公开(公告)日：2012-01-24
申请号：US09746144
申请日：2000-12-21
申请人： Wayne E. Cornish , Sharon Wong
发明人： Wayne E. Cornish , Sharon Wong
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108 , A61M2025/09141 , A61M2025/0915 , A61M2025/09175
摘要： A guidewire formed at least in part of a superelastic member with a section having one or more altered properties including physical and mechanical properties. Preferably, the section of altered property has reduced superelasticity with respect to the remainder of the superelastic member. The invention also comprises method of manufacturing such guidewires wherein a section of the superelastic member is isolated and treated to change one or more of the properties. The treatment may be alloying with a diffusable element or isolating one or more sections to work and heat treat to decrease superelasticity relative to the rest of the member. The section having one or more altered properties is preferably a distal portion of the member, for example about the most distal 3 cm.
摘要翻译：至少部分由超弹性构件形成的导丝，其具有包括物理和机械性质的一个或多个改变的特性的区段。优选地，改变的性质的部分相对于超弹性构件的其余部分具有降低的超弹性。本发明还包括制造这种导丝的方法，其中超弹性构件的一部分被分离和处理以改变一种或多种性质。处理可以是与可扩散元件合金化或隔离一个或多个部分以进行加工和热处理以降低相对于其余部件的超弹性。具有一个或多个改变的性质的区段优选地是构件的远侧部分，例如约3cm的最远端。

40. 发明授权

US06669652B2 Guidewire with tapered distal coil 有权
公开(公告)号：US06669652B2
公开(公告)日：2003-12-30
申请号：US09748089
申请日：2000-12-21
申请人： David M. Anderson , Emmanuel C. Biagtan , Wayne E. Cornish , Sharon Y. Wong
发明人： David M. Anderson , Emmanuel C. Biagtan , Wayne E. Cornish , Sharon Y. Wong
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09175
摘要： A guidewire having a flexible coil with a tapered distal tip. Preferably, the flexible coil has a polymer coating at least at its tapered distal portion. The polymer coating may comprise polyurethanes or other suitable polymers. The guidewires of the invention provide desirable performance characteristics, particularly when used to cross relatively tight lesions such as chronic total occlusions.

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