专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20140031383A1 METHODS FOR TREATMENT OF MELANOMA 审中-公开
标题翻译：治疗梅毒的方法
公开(公告)号：US20140031383A1
公开(公告)日：2014-01-30
申请号：US13983090
申请日：2012-02-08
申请人： Leonard Zon , Richard M. White
发明人： Leonard Zon , Richard M. White
IPC分类号： A61K31/437 , A61K31/277 , A61K31/42
CPC分类号： A61K31/437 , A01K67/027 , A01K67/0275 , A01K2207/20 , A01K2217/052 , A01K2227/40 , A01K2267/03 , A01K2267/0393 , A61K31/122 , A61K31/167 , A61K31/196 , A61K31/277 , A61K31/42 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/506 , A61K31/517 , A61K31/7105 , A61K45/06 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , A61K2300/00
摘要： The present invention is directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods herein are directed to screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.
摘要翻译：本发明涉及使用二氢乳清酸脱氢酶（DHODH）的抑制剂治疗黑素瘤的方法以及涉及向受试者施用致癌性BRAF抑制剂（例如BRAF（V600E））以及二氢胆酸酯抑制剂的组合疗法脱氢酶（DHODH）。还提供了用于鉴定可用于治疗黑素瘤的化合物的测定。本文的方法涉及筛选在黑素瘤斑马鱼模型中抑制神经嵴祖细胞形成的化合物或试剂。

32. 发明申请

US20120306510A1 Method and System for Assessing Insulation Deterioration in Live Underground Power Cables 有权
标题翻译：现场地下电力电缆绝缘劣化评估方法与系统
公开(公告)号：US20120306510A1
公开(公告)日：2012-12-06
申请号：US13152162
申请日：2011-06-02
申请人： Richard M. White , Igor Paprotny , Augusto Giovanni Gonzalez
发明人： Richard M. White , Igor Paprotny , Augusto Giovanni Gonzalez
IPC分类号： H01H31/12
CPC分类号： G01R31/021 , G01R27/06 , G01R27/16 , G01R31/1272 , H02G1/00 , H02G9/00
摘要： A method for assessing insulation deterioration in a live underground power cable may include, in one embodiment, attaching a coupling device to a live underground power cable and using the coupling device to couple a test signal onto the power cable. The power cable may carry a normal AC power signal at a first frequency, while the test signal may have a second frequency different from the first frequency. The test signal may be detected after it has traveled a distance along the power cable. It may then be analyzed to determine a change in velocity and/or attenuation of the test signal as a function of the normal AC power signal. The severity of water trees in the power cable may be inferred based on the magnitude of the change.
摘要翻译：在一个实施例中，用于评估活地下电力电缆中的绝缘劣化的方法可以包括将耦合装置附接到活地下电力电缆并且使用耦合装置将测试信号耦合到电力电缆上。电力电缆可以以第一频率携带正常的交流电力信号，而测试信号可以具有与第一频率不同的第二频率。在沿着电力电缆行进一段距离之后，可以检测测试信号。然后可以对其进行分析，以确定作为正常AC功率信号的函数的测试信号的速度和/或衰减的变化。电力电缆中水木的严重性可以根据变化的大小来推断。

33. 发明授权

US07935312B2 Microfabricated reactor, process for manufacturing the reactor, and method of amplification 失效
标题翻译：微型反应器，制造反应器的方法和扩增方法
公开(公告)号：US07935312B2
公开(公告)日：2011-05-03
申请号：US11471718
申请日：2006-06-21
申请人： M. Allen Northrup , Richard M. White
发明人： M. Allen Northrup , Richard M. White
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/502707 , B01L7/525 , B01L9/527 , B01L2300/1827 , B01L2400/0406 , B01L2400/0436 , G01N9/24 , G01N11/16
摘要： An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.
摘要翻译：用于微升至微升玻璃样品的操作，反应和检测的集成微加工仪器。该仪器适用于生化反应，特别是基于DNA的反应，如聚合酶链反应，需要热循环，因为仪器固有的小尺寸便于快速循环。仪器的综合性能提供了准确，无污染的处理。仪器可以包括试剂储存器，搅拌器和混合器，加热器，泵以及光学或机电传感器。超声波兰波装置可用作传感器，泵和搅拌器。

34. 发明授权

US5633552A Cantilever pressure transducer 失效
标题翻译：悬臂式压力传感器
公开(公告)号：US5633552A
公开(公告)日：1997-05-27
申请号：US258046
申请日：1994-06-10
申请人： Seung S. Lee , Richard M. White , Albert P. Pisano
发明人： Seung S. Lee , Richard M. White , Albert P. Pisano
IPC分类号： A61B17/00 , A61B17/32 , A61B18/14 , B06B1/06 , H01L41/09 , H04R17/00 , H04R17/08 , H01L41/08
CPC分类号： A61B17/320068 , A61B18/1402 , B06B1/0688 , H01L41/094 , H04R17/00 , H04R17/005 , A61B18/14 , A61B2017/00345 , A61B2017/0088 , A61B2018/00107 , A61B2018/00119 , H04R17/08
摘要： Micromachined cantilever pressure transducers, which work both as microphones and as microspeakers, are disclosed. These devices are made possible by novel methods for producing flat, thin film multilayer or polymeric cantilevers.
摘要翻译：公开了用作麦克风和微型扬声器的微加工悬臂式压力传感器。这些装置可以通过用于生产平面，薄膜多层或聚合悬臂的新方法成为可能。

35. 发明授权

US5617020A Microelectromechanical-based power meter 失效
标题翻译：微机电功率计
公开(公告)号：US5617020A
公开(公告)日：1997-04-01
申请号：US487292
申请日：1995-06-07
申请人： Gregory A. Campbell , Richard M. White
发明人： Gregory A. Campbell , Richard M. White
IPC分类号： G01R15/16 , G01R21/06 , G01R21/133 , G01R11/32
CPC分类号： G01R21/133 , G01R15/165 , G01R21/06
摘要： A self-excited microelectromechanical device is described. The device includes a resonating structure, such as a cantilever, which responds to a physical phenomenon by generating an induced variable frequency voltage signal corresponding to the physical phenomenon. Self-excitation circuitry connected to the cantilever processes the induced variable frequency voltage signal and produces a variable frequency voltage signal in a resonant pass band of interest that is applied to the cantilever to augment the effect of the physical phenomenon on the cantilever. An exemplary use of the device is as a power meter. In this context, the cantilever responds to the electric field associated with a power signal on a metered line. The cantilever transforms the voltage signal of the electric field into a corresponding frequency signal. The noise-immune frequency signal can be readily processed to reconstruct the power signals carried by the power line.
摘要翻译：描述了一种自激式微机电装置。该装置包括诸如悬臂的谐振结构，其通过产生对应于物理现象的感应可变频率电压信号来响应物理现象。连接到悬臂的自激电路处理感应的可变频率电压信号，并在感兴趣的谐振通带中产生可变频率电压信号，该信号被施加到悬臂上以增加悬臂上的物理现象的影响。该装置的示例性用途是作为功率计。在这种情况下，悬臂响应与计量线上的功率信号相关联的电场。悬臂将电场的电压信号转换成相应的频率信号。可以容易地对噪声免疫频率信号进行处理以重建由电力线承载的功率信号。

36. 发明授权

US5450752A Ultrasonic position sensor for measuring movement of an object 失效
标题翻译：用于测量物体运动的超声波位置传感器
公开(公告)号：US5450752A
公开(公告)日：1995-09-19
申请号：US902713
申请日：1992-06-23
申请人： Richard M. White , Stuart Wenzel
发明人： Richard M. White , Stuart Wenzel
IPC分类号： G01D5/48 , G01H9/00 , G01S11/12 , G01S11/14 , G10K15/04 , H03B5/30 , G01B11/14
CPC分类号： G01D5/48 , G01H9/00 , G01S11/12 , G01S11/14 , G10K15/046 , A61B5/0066
摘要： A position sensor for measuring the distance from a first position to a second position. The sensor may include an elastic wave generator, an acoustical path over which the elastic wave passes, and a transducer to which the wave passes. A measurement loop includes the acoustical path, and has electrical and optical elements. The electrical elements may compare the phases of the transducer signals from which the change in position between the first and second positions are determined. Alternatively, the measurement loop may comprise a feedback loop to produce oscillations and an output frequency. A frequency counter is included in the feedback loop to measure frequency.
摘要翻译：一种用于测量从第一位置到第二位置的距离的位置传感器。传感器可以包括弹性波发生器，弹性波穿过的声道和波通过的换能器。测量回路包括声道，并具有电光元件。电气元件可以比较确定第一和第二位置之间的位置变化的换能器信号的相位。或者，测量回路可以包括产生振荡和输出频率的反馈回路。反馈回路中包含频率计数器以测量频率。

37. 发明授权

US5212988A Plate-mode ultrasonic structure including a gel 失效
标题翻译：板状超声波结构包括凝胶
公开(公告)号：US5212988A
公开(公告)日：1993-05-25
申请号：US775631
申请日：1991-10-10
申请人： Richard M. White , Stuart W. Wenzel , Benedict J. Costello
发明人： Richard M. White , Stuart W. Wenzel , Benedict J. Costello
IPC分类号： B01L3/00 , G01H13/00 , G01H17/00 , G01L9/00 , G01N29/02 , G01P15/08 , G10K11/36 , H03H9/42
CPC分类号： G01N29/2437 , B01L3/5027 , G01H13/00 , G01H17/00 , G01L9/0025 , G01N29/022 , G01P15/08 , G10K11/36 , H03H9/42 , B01L2300/0663 , B01L2300/1827 , B01L2400/0421 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/02827 , G01N2291/02854 , G01N2291/0427
摘要： An ultrasonic structure which has a thin planar sheet of material forming a Lamb wave propagation medium The propagation medium is coated with a gel. The structure may also include a Lamb wave generator for generating Lamb waves in the propagation medium and an output device for producing an electrical signal representative of the propagation characteristics of the Lamb waves propagating along the propagation medium. A measuring device can be included to measure selected characteristics of the output electrical signal. The propagation medium has some physical characteristics that are determined by the value of a measurand acting on the medium and the determined physical characteristics determine the propagation characteristics of the Lamb waves which are propagated along the medium. When the sensor is acted on by a measurand to determine the physical characteristics of the propagation medium, the characteristics of the electrical signal are also determined. The measuring device measures the electrical signal and provides an indication of the measurand value.
摘要翻译：具有形成兰姆波传播介质的薄平板材料的超声波结构传播介质用凝胶涂覆。该结构还可以包括用于在传播介质中产生兰姆波的兰姆波发生器和用于产生表示沿着传播介质传播的兰姆波传播特性的电信号的输出装置。可以包括测量装置来测量输出电信号的选定特性。传播介质具有由作用在介质上的被测量的值确定的一些物理特性，并且所确定的物理特性确定沿着介质传播的兰姆波的传播特性。当传感器被被测量作用以确定传播介质的物理特性时，也确定电信号的特性。测量设备测量电信号并提供被测量值的指示。

38. 发明授权

US5006749A Method and apparatus for using ultrasonic energy for moving microminiature elements 失效
标题翻译：使用超声能量移动微型元件的方法和装置
公开(公告)号：US5006749A
公开(公告)日：1991-04-09
申请号：US416532
申请日：1989-10-03
申请人： Richard M. White
发明人： Richard M. White
IPC分类号： B01L3/00 , B81B3/00 , H01L41/09
CPC分类号： H02N2/028 , B01L3/502792 , H02N2/08 , H02N2/16 , B01L2400/0439 , B01L2400/0496
摘要： A micromotor device for moving a micro-miniature element along a predetermined path comprises a membrane supported on a substrate having an upper planar surface for supporting the element to be moved and a lower surface. An ultrasonic transducer attached to one membrane surface is supplied with electrical power to produce ultrasonic energy and thereby cause a flexural wave action in the membrane. The membrane may be comprised of a layer of piezoelectric material in one embodiment or an electrically insulating amorphous material which utilizes an electrostriction phenomenon in another embodiment. The generated flexural wave action produces linear movement of one or more microelements on a membrane for a variety of applications. Control of the moving elements may be maintained using a linear position sensor which includes a circuit for producing feedback control signals.
摘要翻译：用于沿着预定路径移动微型微型元件的微电机装置包括支撑在具有用于支撑待移动元件的上平面的基板上的膜和下表面。连接到一个膜表面的超声波换能器被供给电力以产生超声能量，从而在膜中引起弯曲波动作用。在一个实施例中，膜可以由一层压电材料构成，或者在另一个实施例中使用电致伸缩现象的电绝缘非晶材料。所产生的弯曲波作用产生一种或多种微量元素在膜上的线性运动，用于各种应用。可以使用包括用于产生反馈控制信号的电路的线性位置传感器来维持运动元件的控制。

39. 发明授权

US4200472A Solar power system and high efficiency photovoltaic cells used therein 失效
标题翻译：太阳能发电系统及其中使用的高效光伏电池
公开(公告)号：US4200472A
公开(公告)日：1980-04-29
申请号：US912724
申请日：1978-06-05
申请人： Terry I. Chappell , Richard M. White
发明人： Terry I. Chappell , Richard M. White
IPC分类号： H01L27/142 , H01L31/042 , H01L31/052 , H01L31/06
CPC分类号： H01L31/052 , H01L31/047 , H01L31/0547 , Y02E10/52
摘要： A solar power system including a movable platform for tracking the sun, a radiation concentrator, and a plurality of photovoltaic cell modules positioned on the platform for receiving concentrated solar radiation. The module includes a heat dissipation housing which supports a silicon cell across an open end of the housing. A heat transfer block physically engages the silicon cell and a metallic sponge and wick is attached to the heat transfer block and depends therefrom into the housing. The housing is partially filled with liquid to facilitate heat removal. The silicon cells are processed by preferential etching to form V grooves which define a plurality of diode elements having generally trapezoidal cross-sections. The elements may be serially interconnected by metallization on the V groove surfaces. The physical configurations of the elements and the use of antireflective coatings on surfaces of the elements result in high efficiency cells.
摘要翻译：包括用于跟踪太阳的可移动平台的太阳能发电系统，辐射集中器和位于平台上用于接收集中的太阳辐射的多个光伏电池模块。该模块包括散热壳体，该壳体在壳体的开口端部支撑硅电池。传热块物理地接合硅电池，并且金属海绵和灯芯附接到传热块并且从而进入壳体。壳体部分地装有液体以便于除热。通过优先蚀刻处理硅电池以形成限定多个具有大致梯形横截面的二极管元件的V沟槽。这些元件可以通过V槽表面上的金属化来串联。元件的物理结构和在元件表面上使用抗反射涂层导致高效率的电池。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式