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31. 发明授权

US08841319B2 Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management 有权
标题翻译：在白血病管理中使用3-（吲哚基） - 或3-（azaindolyl）-4-芳基马来酰亚胺衍生物
公开(公告)号：US08841319B2
公开(公告)日：2014-09-23
申请号：US12746630
申请日：2008-12-04
申请人： Gerd Dannhardt , Thomas Fischer , Florian Heidel
发明人： Gerd Dannhardt , Thomas Fischer , Florian Heidel
IPC分类号： A61K31/40 , A61K31/44
CPC分类号： A61K31/404 , A61K31/437
摘要： The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected from C1-C6-alkyl, C1-C6-alkoxy, phenyl, OH, halogen, NH2, C1-C6-alkylamino, di-C1-C6-alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S, or heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S, a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for the prevention or treatment of leukemia.
摘要翻译：本发明涉及其中R 1为H，C 1 -C 6 - 烷基，苯基-C 1 -C 4烷基或苯基的式（I）化合物的用途，R 2为被2或3个C1- C6烷氧基，R3是可带有一个或两个独立地选自C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，苯基，OH，卤素，NH 2，C 1 -C 6 - 烷基氨基，含有1或2个独立地选自O，N和S的杂原子的5或6个环原子的杂芳基，或具有5或6个含1或2个独立地选自O，N，和S，其生理上可接受的盐，或式（I）化合物或其盐的溶剂化物，用于预防或治疗白血病。

32. 发明申请

US20140202246A1 Sensor With a Single Electrical Carrier Means 有权
标题翻译：传感器具有单个电气载体装置
公开(公告)号：US20140202246A1
公开(公告)日：2014-07-24
申请号：US14240503
申请日：2012-08-24
申请人： Thomas Fischer , Stefan Günthner , Dietmar Huber , Jakob Schillinger
发明人： Thomas Fischer , Stefan Günthner , Dietmar Huber , Jakob Schillinger
IPC分类号： G01P15/08
CPC分类号： G01P1/023 , B81C1/0023 , H01L23/49575 , H01L24/16 , H01L24/48 , H01L24/49 , H01L2224/13101 , H01L2224/13147 , H01L2224/16245 , H01L2224/48091 , H01L2224/48137 , H01L2224/48247 , H01L2224/49171 , H01L2224/49175 , H01L2924/00014 , H01L2924/1461 , H01L2924/181 , H05K3/284 , H05K2201/10674 , H05K2201/10924 , H01L2224/48227 , H01L2924/00 , H01L2224/45099 , H01L2924/00012
摘要： A sensor having at least one sensor element (1), at least one signal processing element (2), and a housing (7) which has at least one fastening means. An electrical interface is provided for electrically connecting the sensor. The sensor has an electrically and mechanically connecting carrier means (4) on which the at least one sensor element (1) and the signal processing element (2) are arranged and are electrically connected to the carrier means. The carrier means (4) is also at least electrically connected to the electrical interface.
摘要翻译：具有至少一个传感器元件（1），至少一个信号处理元件（2）和具有至少一个紧固装置的壳体（7）的传感器。提供用于电连接传感器的电接口。传感器具有电气和机械连接的载体装置（4），其上安置有至少一个传感器元件（1）和信号处理元件（2）并且电连接到载体装置。载体装置（4）至少电连接到电接口。

33. 发明授权

US08569073B2 Test element having combined control and calibration zone 有权
标题翻译：具有组合控制和校准区域的测试元件
公开(公告)号：US08569073B2
公开(公告)日：2013-10-29
申请号：US13132624
申请日：2009-12-02
申请人： Thomas Fischer
发明人： Thomas Fischer
IPC分类号： G01N33/558 , G01N33/544 , G01N33/545
CPC分类号： G01N33/558
摘要： A test element, for example in the form of an immunological test strip functioning according to the sandwich principle, for the fluorophoric detection of one or more analytes in a sample comprising an analyte detection zone and a combined control and calibration zone. The combined control and calibration zone include a fluorophore and binding partners for the specific binding of reagents labelled with a fluorophore. Furthermore, the invention concerns a method for calibrating an analyte-specific measurement signal, a method for determining the concentration of an analyte in a sample and the use of the test element for calibrating a signal generated in the analyte detection zone of a test element.
摘要翻译：测试元件，例如以根据夹心原理起作用的免疫测试条形式，用于在包含分析物检测区域和组合的控制和校准区域的样品中的一种或多种分析物的荧光检测。组合的对照和校准区包括用荧光团标记的试剂的特异性结合的荧光团和结合配偶体。此外，本发明涉及校准分析物特异性测量信号的方法，用于确定样品中分析物的浓度的方法以及用于校准在测试元件的分析物检测区域中产生的信号的测试元件的使用。

34. 发明授权

US08567261B2 Device and method for checking the leak tightness of caps on medical hollow bodies 有权
标题翻译：用于检查医用空心体盖帽密封性的装置和方法
公开(公告)号：US08567261B2
公开(公告)日：2013-10-29
申请号：US12999579
申请日：2009-06-18
申请人： Thomas Fischer , Manfred Simader , Günter Kavallar
发明人： Thomas Fischer , Manfred Simader , Günter Kavallar
IPC分类号： G01L3/00 , G01L3/02 , G01L5/24 , G01L3/14
CPC分类号： B67B3/261
摘要： A device for checking the seal-tightness of closure caps on medical hollow bodies has a drive, a retaining element for the hollow body, and a retaining device for the closure cap. The retaining device is pivotably supported relative to the retaining element. The device further includes a sensor for the relative rotation of the retaining device with respect to the retaining element. A torque may be applied to the closure cap by the drive, the retaining element, and the retaining device. A hollow body and a closure cap are gripped by the retaining device and the retaining element from the same side, as viewed along the longitudinal axis of a hollow body.
摘要翻译：用于检查医疗空心体上的封盖的密封性的装置具有驱动装置，用于中空体的保持元件和用于封闭帽的保持装置。保持装置相对于保持元件可枢转地支撑。该装置还包括用于保持装置相对于保持元件相对旋转的传感器。可以通过驱动器，保持元件和保持装置将扭矩施加到封闭盖。当中空体和中空体的纵向轴线观察时，空心体和闭合帽由保持装置和保持元件从同一侧夹持。

35. 发明申请

US20130277797A1 Coil and Method of Manufacturing a Coil 有权
公开(公告)号：US20130277797A1
公开(公告)日：2013-10-24
申请号：US13452669
申请日：2012-04-20
申请人： Markus Menath , Thomas Fischer , Hermann Wendt
发明人： Markus Menath , Thomas Fischer , Hermann Wendt
IPC分类号： H01L21/76 , H01L27/04
CPC分类号： H01L28/10 , H01F17/0006 , H01F17/02 , H01F41/042 , H01L21/0274 , H01L21/76804 , H01L21/76816 , H01L21/76877 , H01L23/5227 , H01L23/5283 , H01L23/64 , H01L27/08 , H01L2224/48095 , H01L2224/48137 , Y10T29/4902 , H01L2924/00014
摘要： A method for manufacturing an electronic device and an electronic device are disclosed. In an embodiment the method comprises forming an opening in an isolation layer, isotropically etching the opening thereby forming an extended opening with curved sidewalls, and forming a conductive material in the opening.

36. 发明申请

US20130236150A1 CONNECTION BOX FOR GLASS FIBER CABLES 有权
标题翻译：玻璃纤维电缆连接盒
公开(公告)号：US20130236150A1
公开(公告)日：2013-09-12
申请号：US13582968
申请日：2011-01-10
申请人： Pia Kopf , Ulrich Hetzer , Thomas Fischer
发明人： Pia Kopf , Ulrich Hetzer , Thomas Fischer
IPC分类号： G02B6/44
CPC分类号： G02B6/4401 , G02B6/0008 , G02B6/4439 , G02B6/4441 , G02B6/4446 , G02B6/4447 , G02B6/4454
摘要： The invention relates to a connecting box (1) for glass fiber cables, comprising a housing which is formed from at least two parts and has a lower part and a cover (2), with at least one holder (20) for a coupling (30) for holding glass fiber plugs being arranged within the housing, wherein the holder (20) is in the form of a double frame which comprises two first vertical struts (21) and two second vertical struts (22), with the second struts (22) being arranged closely to a front face (5, 40) of the cover (2) and of the lower part (3), and with the coupling (30) optionally being latchable to the first or the second struts (21, 22).
摘要翻译：本发明涉及一种用于玻璃纤维电缆的连接盒（1），包括由至少两个部分形成并具有下部和外壳（2）的壳体，其具有至少一个用于联接的保持器（20） 30），其中所述玻璃纤维塞被布置在所述壳体内，其中所述保持器（20）为双框架的形式，其包括两个第一垂直支柱（21）和两个第二垂直支柱（22），所述第二支柱 22）紧密地布置在所述盖（2）和所述下部（3）的前表面（5,40）上，并且所述联接件（30）可选地可闩锁到所述第一或第二支柱（21,22））。

37. 发明授权

US08445206B2 Set of oligonucleotide probes as well as methods and uses thereto 有权
标题翻译：一组寡核苷酸探针及其方法和用途
公开(公告)号：US08445206B2
公开(公告)日：2013-05-21
申请号：US13361549
申请日：2012-01-30
申请人： Frank Bergmann , Walter Eberle , Thomas Fischer , Herbert von der Eltz
发明人： Frank Bergmann , Walter Eberle , Thomas Fischer , Herbert von der Eltz
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6841 , C12Q1/6876 , C12Q1/6886 , C12Q2565/1025 , C12Q2563/107
摘要： The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
摘要翻译：本公开内容涉及针对感兴趣的基因组靶序列的（或互补）部分的一组至少100个单链寡核苷酸探针。本公开还涉及使用该组寡核苷酸探针检测感兴趣的基因组靶序列的方法和产生寡核苷酸探针组的方法。此外，本公开涉及包含该组寡核苷酸探针和至少一种另外的组分的试剂盒。

38. 发明授权

US08386715B2 Method and apparatus for tile mapping techniques 有权
标题翻译：瓦片映射技术的方法和装置
公开(公告)号：US08386715B2
公开(公告)日：2013-02-26
申请号：US12627556
申请日：2009-11-30
申请人： Thomas Fischer
发明人： Thomas Fischer
IPC分类号： G06F12/00
CPC分类号： G06F17/30241 , G06F17/30902 , H04L67/2842 , H04L67/2885
摘要： A tile-map caching technique in which it is determined whether a tile object is stored in a first cache that is configured to store a plurality of tile objects associated with a map. It is also determined whether a resource locator associated with the tile object is stored in a second cache, if the tile object is not in the first cache. The tile object is retrieved based on the resource locator if the resource locator is stored in the second cache.
摘要翻译：一种瓦片地图缓存技术，其中确定瓦片对象是否存储在被配置为存储与地图相关联的多个瓦片对象的第一高速缓存中。如果瓦片对象不在第一高速缓存中，则还确定与瓦片对象相关联的资源定位器是否存储在第二高速缓存中。如果资源定位符存储在第二高速缓存中，则基于资源定位器检索瓦片对象。

39. 发明申请

US20130002341A1 INPUT APPARATUS WITH HAPTIC FEEDBACK 有权
标题翻译：输入设备与HAPTIC反馈
公开(公告)号：US20130002341A1
公开(公告)日：2013-01-03
申请号：US13582006
申请日：2011-03-22
申请人： Ferdinand Maier , Thomas Fischer
发明人： Ferdinand Maier , Thomas Fischer
IPC分类号： H03K3/45
CPC分类号： G06F3/03548 , G06F3/0362 , H03K17/97
摘要： The input device has a printed circuit board (5) to which a plurality of coils (L1-L8) has been fitted which, together with a capacitor (C2), each form a frequency-determining element of an oscillator (1). The coils (L1-L8) are arranged so as to be distributed along a path (K), which may also be a circular path. A movable magnet portion (M) can be displaced relative to the printed circuit board (5). At least one further stationary magnet portion (M1-M8) is mounted on the printed circuit board (5), which is opposite the movable magnet portion (M).
摘要翻译：输入装置具有印刷电路板（5），多个线圈（L1-L8）已经被装配到该印刷电路板（5）上，与电容器（C2）一起形成振荡器（1）的频率确定元件。线圈（L1-L8）被布置成沿着也可以是圆形路径的路径（K）分布。可移动磁体部分（M）可以相对于印刷电路板（5）移位。至少一个固定磁体部分（M1-M8）安装在与可移动磁体部分（M）相对的印刷电路板（5）上。

40. 发明授权

US08202490B2 Membranes and methods for coating membranes 有权
标题翻译：膜和膜的涂覆方法
公开(公告)号：US08202490B2
公开(公告)日：2012-06-19
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： B01L3/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

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