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31. 发明授权

US06269250B1 Method and apparatus for controlling transmit power thresholds based on classification of wireless communication subscribers 有权
公开(公告)号：US06269250B1
公开(公告)日：2001-07-31
申请号：US09480474
申请日：2000-01-10
申请人： Paul E. Bender , Noam A. Ziv
发明人： Paul E. Bender , Noam A. Ziv
IPC分类号： H04B7185
CPC分类号： H04W52/283 , H04W52/367
摘要： The present invention provides a method and apparatus for allowing a base station or base station controller to adjust transmissions to fixed location subscribers in closed-loop communication systems. In a closed-loop communication system, a base station exchanges signals with both fixed location and mobile user stations. When a user or subscriber initially registers with the base station, the base station determines a status of this subscriber based on, for example, an electronic serial number transmitted to the base station. The base station compares the electronic serial number to a database (Home Location Register) which determines whether the user corresponds to a fixed station or a mobile station. If the user is a fixed station, then the base station lowers nominal and minimum power level thresholds. Based on the lowered thresholds, the base station thereafter transmits forward link signals to the fixed station at a lower power level. As a result, the base station can increase its capacity due to the lower overall power rate.

32. 发明授权

US5978413A Method and system for processing a plurality of multiple access transmissions 失效
标题翻译：用于处理多个多址传输的方法和系统
公开(公告)号：US5978413A
公开(公告)日：1999-11-02
申请号：US518217
申请日：1995-08-28
申请人： Paul E. Bender
发明人： Paul E. Bender
IPC分类号： H04B1/7107 , H04B7/26 , H04Q7/34 , H04Q7/36 , H04B7/216
CPC分类号： H04B1/71075
摘要： A method and system incorporating the use of interference cancellation during synchronized demodulation of a code division multiple access (CDMA) signal is described. A wireless communications receiver uses synchronized demodulation techniques to estimate the data contained in multiple orthogonal sub-channels of multiple CDMA signals. In response to these estimates an ideal waveform is constructed for each CDMA signal. These ideal waveforms are subtracted from the original signal received to form an interference-cancelled version of the original signal which is used when demodulating individual orthogonal sub-channels.
摘要翻译：描述了在码分多址（CDMA）信号的同步解调期间并入使用干扰消除的方法和系统。无线通信接收机使用同步解调技术来估计包含在多个CDMA信号的多个正交子信道中的数据。响应于这些估计，为每个CDMA信号构造一个理想波形。从接收的原始信号中减去这些理想波形，以形成在解调各个正交子信道时使用的原始信号的干扰消除版本。

33. 发明授权

US5892098A 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds 失效
标题翻译： 3,3-（二取代的）环己烷-1-酮单体和相关化合物
公开(公告)号：US5892098A
公开(公告)日：1999-04-06
申请号：US624546
申请日：1997-04-15
申请人： Siegfried B. Christensen, IV , Joseph M. Karpinski , M. Dominic Ryan , Paul E. Bender
发明人： Siegfried B. Christensen, IV , Joseph M. Karpinski , M. Dominic Ryan , Paul E. Bender
IPC分类号： C07D271/06 , A61K31/41 , A61K31/4245 , A61P11/00 , C07B57/00 , C07C45/67 , C07C45/68 , C07C45/78 , C07C49/753 , C07C59/90 , C07C65/40 , C07C69/738 , C07C69/76 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/76 , C07C255/56 , C07C311/08 , C07D271/10 , C07D285/12
CPC分类号： C07D271/10 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/76 , C07C255/56 , C07C311/08 , C07C45/673 , C07C45/68 , C07C45/78 , C07C49/753 , C07C65/40 , C07C69/738 , C07C69/76 , C07D285/12
摘要： This invention relates to derivatives of 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds which are useful for treating allergic and inflammatory diseases.
摘要翻译： PCT No.PCT / US95 / 16710 Sec。 371日期1997年04月15日 102（e）日期1997年4月15日PCT 1995年12月21日PCT PCT。 WO96 / 20158 PCT出版物日期1996年7月4日本发明涉及可用于治疗过敏性和炎性疾病的3,3-（二取代的）环己烷-1-酮单体和相关化合物的衍生物。

34. 发明授权

US5863926A 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds 失效
标题翻译： 4,4-（二取代的）环己烷-1-羧酸酯单体和相关化合物
公开(公告)号：US5863926A
公开(公告)日：1999-01-26
申请号：US860401
申请日：1997-10-06
申请人： Siegfried B. Christensen, IV , Joseph M. Karpinski , M. Dominic Ryan , Paul E. Bender
发明人： Siegfried B. Christensen, IV , Joseph M. Karpinski , M. Dominic Ryan , Paul E. Bender
IPC分类号： A61K31/41 , A61K31/433 , A61K31/44 , A61P11/00 , A61P37/00 , A61P43/00 , C07C62/34 , C07C62/36 , C07C69/734 , C07C69/738 , C07C69/757 , C07D213/55 , C07D213/57 , C07D239/42 , C07D271/06 , C07D271/10 , C07D271/107 , C07D285/12 , A61K31/435 , A61K31/19
CPC分类号： C07D239/42 , C07C62/34 , C07C62/36 , C07C69/734 , C07C69/738 , C07D213/55 , C07D271/06 , C07D271/107 , C07D285/12
摘要： The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
摘要翻译： PCT No.PCT / US95 / 16857 Sec。 371日期：1997年10月6日 102（e）日期1997年10月6日PCT 1995年12月21日PCT PCT。公开号WO96 / 19990 日期：1996年7月4日本发明涉及新的4,4-（二取代）环己烷-1-羧酸酯单体及其相关化合物，含有这些化合物的药物组合物及其在治疗过敏性和炎性疾病中的用途以及抑制肿瘤生成坏死因子（TNF）。

35. 发明授权

US5475870A Apparatus and method for adding and removing a base station from a cellular communications system 失效
标题翻译：用于从蜂窝通信系统添加和移除基站的设备和方法
公开(公告)号：US5475870A
公开(公告)日：1995-12-12
申请号：US304730
申请日：1994-09-12
申请人： Lindsay A. Weaver, Jr. , Paul E. Bender
发明人： Lindsay A. Weaver, Jr. , Paul E. Bender
IPC分类号： H04B7/005 , H04B7/26 , H04W16/06 , H04W36/18 , H04W52/40 , H04W52/52 , H04B17/00
CPC分类号： H04W16/06 , H04B7/2628 , H04W52/40 , H04W52/52 , H04W36/18 , Y02B60/50
摘要： An apparatus and method for adding and removing a target base station from a network of base stations, which includes base stations adjacent the target base station. The apparatus is comprised of two attenuators: a first for setting an artificial receive noise power level and a second for setting a transmit level. The transmit level determines the forward link coverage area of the base station. The artificial noise level sets the reverse link coverage area of the base station. When a base station is added, initially the transmit power is low and the artificial receive noise power is high such that the forward and reverse link coverage areas are collocated in close proximity to the base station. As the base station blossoms into full operation, the artificial receive noise power is decreased and the transmit level is increased such that the two coverage areas of the base station remain balanced as the coverage areas expand. When a base station is to be removed from a system, the same attenuators are used to wilt the two coverage areas in unison as the power level transmitted from the base station decreases.
摘要翻译：一种用于从包括与所述目标基站相邻的基站的基站网络中添加和去除目标基站的装置和方法。该装置包括两个衰减器：第一个用于设置人造接收噪声功率电平，另一个用于设置发射电平。发送电平确定基站的前向链路覆盖区域。人造噪声电平设置基站的反向链路覆盖区域。当添加基站时，最初的发射功率低，并且人为接收噪声功率较高，使得前向链路覆盖区域和反向链路覆盖区域在基站附近并置。随着基站开始全面运行，人造接收噪声功率降低，发射等级增加，使得基站的两个覆盖区域随着覆盖区域的扩大而保持平衡。当要从系统中移除基站时，由于从基站传输的功率电平减小，所以使用相同的衰减器来一致地使两个覆盖区域下降。

36. 发明授权

US5449686A Compounds useful for treating allergic or inflammatory diseases 失效
标题翻译：可用于治疗过敏性或炎性疾病的化合物
公开(公告)号：US5449686A
公开(公告)日：1995-09-12
申请号：US313095
申请日：1994-09-29
申请人： Siegfried B. Christensen, IV , Paul E. Bender , Cornelia J. Forster
发明人： Siegfried B. Christensen, IV , Paul E. Bender , Cornelia J. Forster
IPC分类号： C07D295/00 , A61K31/12 , A61K31/24 , A61K31/275 , A61K31/33 , A61P11/06 , A61P29/00 , A61P37/08 , C07C45/44 , C07C45/51 , C07C45/71 , C07C47/47 , C07C47/575 , C07C49/603 , C07C49/613 , C07C49/753 , C07C49/757 , C07C233/56 , C07C235/82 , C07C251/42 , C07C255/46 , C07C255/54 , C07C255/64 , C07D213/00 , C07D215/00 , C07D233/00 , C07D239/00 , C07D257/00 , C07D261/00 , C07D263/00 , C07D277/00 , C07D307/00 , C07D309/00 , C07F7/08
CPC分类号： C07C255/46 , C07C233/56 , C07C235/82 , C07C45/44 , C07C45/515 , C07C45/71 , C07C47/47 , C07C47/575 , C07C49/753 , C07C49/757 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要： Novel cyclohexanes of Formulas (I) and (II) ##STR1## are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.
摘要翻译：式（I）和（II）的新型环己烷在本文中描述。它们抑制肿瘤坏死因子的产生，可用于治疗由TNF产生介导或加重的疾病状态; 这些化合物也可用于调节或抑制磷酸二酯酶V的酶促或催化活性。

37. 发明授权

US5317019A Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages 失效
标题翻译：单核细胞和/或巨噬细胞抑制白细胞介素-1和肿瘤坏死因子的产生
公开(公告)号：US5317019A
公开(公告)日：1994-05-31
申请号：US809484
申请日：1991-12-12
申请人： Paul E. Bender , Don E. Griswold , Nabil Hanna , John C. Lee , Bartholomew J. Votta , Philip L. Simon , Alison M. Badger , Klaus M. Esser
发明人： Paul E. Bender , Don E. Griswold , Nabil Hanna , John C. Lee , Bartholomew J. Votta , Philip L. Simon , Alison M. Badger , Klaus M. Esser
IPC分类号： A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/54 , A61K31/55 , A61P29/00 , A61P43/00 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A01N43/40
CPC分类号： C07D471/04 , A61K31/44 , C07D487/04 , C07D513/04
摘要： A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead atom wherein said second ring may also contain sulfur, oxygen or an additional nitrogen atom, and may contain additional unsaturation.This invention relates to a method of inhibiting the production of Tumor Necrosis Factor (TNF) by monocytes or macrophages in a human in need thereof which comprises administering to such mammal an effective, TNF production inhibiting amount of a compound of Formula (I) as described herein. The compounds of Formula (II) are generally described as diaryl-substituted imidazole fused to a second heterocyclic ring containing a nitrogen bridgehead wherein said ring may also contain sulfur, oxygen, or an additional nitrogen atom, and may contain additional unsaturation.
摘要翻译： PCT No.PCT / US90 / 03367 Sec。 371日期1991年12月12日 102（e）1991年12月12日授权PCT于1990年6月13日提交.1。一种在有需要的人中抑制单核细胞和/或巨噬细胞产生白细胞介素-1的方法，其包括给予这样一种有效的，与含有氮桥头原子的第二杂环稠合的二芳基取代的咪唑的白细胞介素-1产生抑制量，其中所述第二环还可以含有硫，氧或另外的氮原子，并且可以含有额外的不饱和度。本发明涉及在有需要的人中抑制单核细胞或巨噬细胞产生肿瘤坏死因子（TNF）的方法，该方法包括向所述哺乳动物施用有效的TNF产生抑制量的如上所述的式（I）化合物这里。式（II）的化合物通常被描述为与包含氮桥头堡的第二杂环稠合的二芳基取代的咪唑，其中所述环还可以含有硫，氧或另外的氮原子，并且可以含有额外的不饱和度。

38. 发明授权

US5134150A Inhibition of the 5-lipoxygenase pathway 失效
标题翻译：抑制5-脂氧合酶途径
公开(公告)号：US5134150A
公开(公告)日：1992-07-28
申请号：US445581
申请日：1989-12-04
申请人： Paul E. Bender , John G. Gleason , Don E. Griswold , Nabil Hanna , Ivan Lantos , Kazys A. Razgaitis , Henry M. Sarau , Susan C. Shilcrat
发明人： Paul E. Bender , John G. Gleason , Don E. Griswold , Nabil Hanna , Ivan Lantos , Kazys A. Razgaitis , Henry M. Sarau , Susan C. Shilcrat
IPC分类号： C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D487/04 , C07D513/04
摘要： A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl- substituted imidazole fused to a thiazole pyrrolidine, thiazide or piperidine ring to such animal.
摘要翻译：一种在有需要的动物中抑制5-脂肪氧合酶途径的方法，其包括将有效的5-脂氧合酶途径抑制量与噻唑吡咯烷，噻嗪类或哌啶环稠合的二芳基取代的咪唑给予动物。

39. 发明授权

US5008390A Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines 失效
标题翻译：用于制备6-苯基-2,3-二氢咪唑并[2,1-b] - 噻唑和相应的噻嗪的化合物
公开(公告)号：US5008390A
公开(公告)日：1991-04-16
申请号：US266728
申请日：1988-11-03
申请人： Paul E. Bender , Ivan Lantos , Michael A. McGuire , Lendon N. Pridgen , Herbert B. Winicov
发明人： Paul E. Bender , Ivan Lantos , Michael A. McGuire , Lendon N. Pridgen , Herbert B. Winicov
IPC分类号： C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D487/04 , C07D513/04
摘要： 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazoles and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.
摘要翻译： 6-芳基-2,3-二氢咪唑并[2,1-b]噻唑和相应的噻嗪直接或以格氏试剂的形式作为亲核试剂与N-酰基吡啶鎓盐作为新的6-芳基-5-（N - 酰基-1,4-二氢-4-吡啶基）-2,3-二氢咪唑并[2,1-b]噻唑和相应的噻嗪。这些被氧化得到相应的吡啶基取代的咪唑并[2,1-b]噻唑和噻嗪，它们作为花生四烯酸代谢的5-脂氧合酶途径的抑制剂是有活性的。

40. 发明授权

US4751310A Inhibition of the 5-lipoxygenase pathway 失效
标题翻译：抑制5-脂氧合酶途径
公开(公告)号：US4751310A
公开(公告)日：1988-06-14
申请号：US092010
申请日：1987-09-22
申请人： Paul E. Bender , Nabil Hanna
发明人： Paul E. Bender , Nabil Hanna
IPC分类号： C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D471/04 , C07D487/04 , C07D513/04 , C07D211/32 , C07D295/10 , C07D401/06
CPC分类号： C07D471/04 , C07D207/22 , C07D211/72 , C07D277/18 , C07D279/06 , C07D487/04 , C07D513/04
摘要： Compounds having the formula ##STR1## wherein n is 0 or 1, R.sup.2 through R.sup.9 are H or C.sub.1-2 alkyl, and X is pyridyl or mono- or disubstituted phenyl are useful in the preparation of the compounds which inhibit the 5-lipoxygenase pathway.
摘要翻译：具有式“IMAGE”的化合物，其中n为0或1，R2至R9为H或C1-2烷基，X为吡啶基或单取代或二取代的苯基，可用于制备抑制5-脂氧合酶途径的化合物。

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