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31. 发明申请

WO03041653A3 CYTOTOXIC AGENTS 审中-公开
标题翻译： CYTOTOXIC代理
公开(公告)号：WO03041653A3
公开(公告)日：2003-07-10
申请号：PCT/US0236604
申请日：2002-11-14
申请人： UNIV RUTGERS , LAVOIE EDMOND J , RUCHELMAN ALEXANDER L , SINGH SUDHIR KUMAR , RAY ABHIJIT , LIU LEROY FONG
发明人： LAVOIE EDMOND J , RUCHELMAN ALEXANDER L , SINGH SUDHIR KUMAR , RAY ABHIJIT , LIU LEROY FONG
IPC分类号： A61K31/503 , A61P35/00 , C07D487/14 , C07D491/14 , C07D237/26 , A61K31/4355 , A61K31/4741 , A61K31/5025 , C07D491/147 , C07D491/153 , C07D491/22
CPC分类号： C07D491/14 , C07D491/147 , C07D491/22 , C12N5/0693 , C12N2501/06 , C12N2501/999
摘要： The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
摘要翻译：本发明提供了本发明化合物，其包含本发明化合物的药物组合物，用于制备本发明化合物的方法，用于制备本发明化合物的中间体，以及用于治疗癌症和其它拓扑异构酶介导的病症的治疗方法。

32. 发明申请

WO2010042638A2 HPMA - DOCETAXEL OR GEMCITABINE CONJUGATES AND USES THEREFORE 审中-公开
标题翻译： HPMA - 多西他赛或吉西他滨结合物及其用途
公开(公告)号：WO2010042638A2
公开(公告)日：2010-04-15
申请号：PCT/US2009059869
申请日：2009-10-07
申请人： LEE YOUNG BOK , AHN CHANG HO , KIM DEOG JOONG , GHANDEHARI HAMIDREZA , RAY ABHIJIT , NAN ANJAN
发明人： LEE YOUNG BOK , AHN CHANG HO , KIM DEOG JOONG , GHANDEHARI HAMIDREZA , RAY ABHIJIT , NAN ANJAN
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/551 , A61K47/58 , A61K47/64 , A61K47/65
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
摘要翻译：公开了通过将吉西他滨或多西他赛与水溶性聚合物如N-2-羟丙基甲基丙烯酰胺（HPMA）缀合形成的吉西他滨和多西他赛的水溶性组合物。还公开了使用本发明组合物治疗癌症的方法。

33. 发明专利

BR112013006929A2 composto de fórmula i, composição farmacêutica, processo para preparar os compostos de fórmula 9, 16, 20, 27 e 30 未知
公开(公告)号：BR112013006929A2
公开(公告)日：2016-07-12
申请号：BR112013006929
申请日：2011-09-26
申请人： RANBAXY LAB LTD
发明人： RAUF ABDUL REHMAN ABDUL , RAY ABHIJIT , CLIFFE IAN A , SATTIGERI JITENDRA , KHERA MANOJ KUMAR , YADAV NEERAJ KUMAR , BHATNAGAR PRADIP KUMAR , SRIVASTAVA PUNIT , DASTIDAR SUNANDA GHOSH
IPC分类号： A61K31/325 , A61K31/192 , A61P11/00 , A61P19/02 , A61P35/00 , C07C309/60 , C07C321/28 , C07C333/08
摘要： composto de fórmula i, composição farmacêutica, processo para preparar os compostos de fórmula 9, 16, 20, 27 e 30. a presente invenção refere-se a certos derivados de ácido sulfona acéticos como inibidor de mmp e processos para sua sintase. a invenção também se refere a composições farmacológicas contendo os compostos da presente invenção e métodos para tratar asma, artrite reumatóide, copd, rinite, osteoartrite, artrite psoriática, psoríase, fibrose pulmonar, inflamação pulmonar, síndrome do desconforto respiratório agudo, periodontite, esclerose múltipla, gengivite, ateroesclerose, secura ocular, proliferação neoíntima que leva a restenose e falha isquêmica cardíaca, derrame, doença renal, metástase tumoral e outros distúrbios inflamatórios caracterizados por superexpressão e superativação de uma matriz de metaloproteinase usando os compostos.

34. 发明专利

CO6680674A2 Inhibidores de la metalproteinasa de matriz 未知
公开(公告)号：CO6680674A2
公开(公告)日：2013-05-31
申请号：CO13040146
申请日：2013-02-28
申请人： RANBAXY LAB LTD
发明人： KHERA MANJO KUMAR , SATTIGERI JITENDRA , SATTIGERI VISWAJANANI , YADAV NEERAJ KUMAR , KUMAR KEWAL , RAUF ADBUL REHMAN , CLIFFE IAN ANTHONY , BHATNAGAR PRADIP , RAY ABHIJIT , SRIVASTAVA PUNIT KUMAR , DASTIDAR SUNANDA GHOSH
IPC分类号： C07D253/08 , A61K31/536 , A61P29/00 , A61P37/02 , A61P37/08
摘要： La presente invención se relaciona con ciertos derivados de ácido hidroxipropiónico y los procesos para la síntesis de los mismos. La invención también se relaciona con composiciones farmacológicas que contienen los compuestos de a presente invención, y métodos para el tratamiento de asma, artritis reumatoidea, COPD, rinitis, osteoartritis, artritis psoriásica, psoriasis, fibrosis pulmonar, inflamación pulmonar, síndrome de dificultad respiratoria aguda, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, ojo seco, proliferación neointimal, que conduce a la restenosis y a la insuficiencia cardíaca isquémica, ataque apopléjico, enfermedades renales, metástasis tumoral, y otros desórdenes inflamatorios caracterizados por la sobre-expresión y la sobre-activación de una metaloproteinasa de matriz utilizando los compuestos.

35. 发明专利

RS52232B 5-PHENYL-PENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES 未知
公开(公告)号：RS52232B
公开(公告)日：2012-10-31
申请号：RSP20120174
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , SATTIGERI VISWAJANANI JITENDRA , KHERA MANOJ KUMAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VOLETI SREEDHARA RAO
IPC分类号： C07D249/18 , A61P11/06 , C07D207/40 , C07D209/12 , C07D209/48 , C07D211/88 , C07D213/64 , C07D237/32 , C07D239/54 , C07D239/96 , C07D263/58 , C07D265/28 , C07D401/10 , C07D403/10 , C07D471/04
摘要： The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rχ, —NHC(═O)OR4, —NHSO2R4, C(═Y)NR4R5, C(═O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C═O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(═O)NR4R5, O-acyl, NH2, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rx, —NHC(═O)OR4, —NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

37. 发明专利

AT542804T 未知
公开(公告)号：AT542804T
公开(公告)日：2012-02-15
申请号：AT06727254
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA , SATTIGERI VISWAJANANI , KHERA MANOJ , VOLETI SREEDHARA , RAY ABHIJIT , DASTIDAR SUNANDA
IPC分类号： C07D249/18 , C07D209/12 , C07D209/48 , C07D211/88 , C07D213/64 , C07D237/32 , C07D239/54 , C07D265/28
摘要： The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rχ, —NHC(═O)OR4, —NHSO2R4, C(═Y)NR4R5, C(═O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C═O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(═O)NR4R5, O-acyl, NH2, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rx, —NHC(═O)OR4, —NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

38. 发明专利

DE602006016430D1 PHOSPHODIESTERASEINHIBITOREN AUF AZOLBASIS 未知
公开(公告)号：DE602006016430D1
公开(公告)日：2010-10-07
申请号：DE602006016430
申请日：2006-05-03
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA , BALACHANDRAN SARALA , MUTHUKAMA NAGARAJAN MALAYAMMAN KOVIL ST , RAY ABHIJIT , DASTIDAR SUNANDA GHOSE , RAMAIAH RAGHU
IPC分类号： C07D413/12 , A61K31/4439 , A61P11/00 , A61P31/00

39. 发明专利

EA013539B1 ПРОИЗВОДНЫЕ 5-ФЕНИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ МАТРИЧНОЙ МЕТАЛЛОПРОТЕИНАЗЫ ДЛЯ ЛЕЧЕНИЯ АСТМЫ И ДРУГИХ ЗАБОЛЕВАНИЙ 未知
公开(公告)号：EA013539B1
公开(公告)日：2010-06-30
申请号：EA200701768
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , SATTIGERI VISWAJANANI JITENDRA , KHERA MANOJ KUMAR , VOLETI SREEDHARA RAO , RAY ABHIJIT , DASTIDAR SUNANDA G
IPC分类号： C07D249/18 , A61P11/06 , C07D207/40 , C07D209/12 , C07D209/48 , C07D211/88 , C07D213/64 , C07D237/32 , C07D239/54 , C07D239/96 , C07D263/58 , C07D265/28 , C07D401/10 , C07D403/10 , C07D471/04
摘要： Настоящееизобретениеотноситсяк соединениямструктурнойформулы (I), где n имеетзначениеот 1 до 5; Rпредставляетсобойнеобязательнозамещенныйалкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, алкокси, арилокси, алкенилоксиилиалкинилокси; Rпредставляетсобойалкенил, алкинил, арил, гетероциклил, гетероарил, циклоалкил, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, C(=Y)NRR, C(=O)OR(где Y представляетсобойатомкислородаилисеры), OR, -OC(=O)NRR, О-ацил, S(O)R, -SON(R), циано, амидиноилигуанидино (где Rпредставляетсобойалкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, гетероарилалкил, гетероциклилалкилилициклоалкилалкили m имеетзначение 0-2; Rпредставляетсобойводородили R; Rпредставляетсобой Rили -SON(R)и Rпредставляетсобойводород, алкил, циклоалкил, аралкил, гетероарилалкил, гетероциклилалкилилициклоалкилалкил); Rпредставляетсобойводород, фтор, алкил, циклоалкилалкилилиаралкил; АпредставляетсобойОН, OR, -OC(=O)NRR, О-ацил, NH, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, ик способамихполучения. Настоящееизобретениетакжеотноситсяк фармакологическимкомпозициям, содержащимсоединениянастоящегоизобретения, ик способамлеченияастмы, ревматоидногоартрита, COPD, ринита, остеоартрита, псориатическогоартрита, псориаза, легочногофиброза, воспалениялегких, острогореспираторногодистрессовогосиндрома, периодонтита, рассеянногосклероза, гингивита, атеросклероза, неоинтимальнойпролиферации, котораяприводитк рестенозуи ишемическойсердечнойнедостаточности, инсульта, почечныхзаболеваний, опухолевыхметастази другихвоспалительныхзаболеваний, характеризующихсясверхэкспрессиейи сверхактивациейматричнойметаллопротеиназы, спомощьюэтихсоединений.

40. 发明专利

CA2735956A1 PHOSPHODIESTARASE INHIBITORS 未知
公开(公告)号：CA2735956A1
公开(公告)日：2010-04-29
申请号：CA2735956
申请日：2009-09-19
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , CHANDRAKANT KAKADE GANESH , JAIN TARUN , VOLETI SREEDHARA RAO , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： C07D471/04 , A61P11/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4 /PDE type 7 inhibitors are provided.

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