专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07078493B1 Antibodies to human tumor necrosis factor receptor-like genes 失效
标题翻译：人类肿瘤坏死因子受体样基因的抗体
公开(公告)号：US07078493B1
公开(公告)日：2006-07-18
申请号：US09526437
申请日：2000-03-15
申请人： John M. Greene , Robert D. Fleischmann , Jian Ni
发明人： John M. Greene , Robert D. Fleischmann , Jian Ni
IPC分类号： C07K16/00 , G01N33/53
CPC分类号： C07K16/2878 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/6893 , G01N2800/32 , Y02A50/58
摘要： The present inventors have discovered novel receptors in the Tumor Necrosis Factor (TNF) receptor family. In particular, receptors having homology to the type 2 TNF receptor (TNF-RII) are provided. Isolated nucleic acid molecules are also provided encoding the novel receptors of the present invention. Receptor polypeptides are further provided as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：本发明人已经在肿瘤坏死因子（TNF）受体家族中发现了新的受体。特别地，提供了与2型TNF受体（TNF-RII）具有同源性的受体。也提供编码本发明的新受体的分离的核酸分子。进一步提供受体多肽，载体，宿主细胞和用于制备它们的重组方法。

32. 发明授权

US06602984B1 Human elastase IV 失效
标题翻译：人弹性蛋白酶IV
公开(公告)号：US06602984B1
公开(公告)日：2003-08-05
申请号：US09613822
申请日：2000-07-11
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C07K14435
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：人弹性蛋白酶IV多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法，并且用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常和改善血清脂蛋白公开了代谢。还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

33. 发明授权

US6107075A Human elastase IV 失效
公开(公告)号：US6107075A
公开(公告)日：2000-08-22
申请号：US199793
申请日：1998-11-25
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/04 , C07H21/04 , C07K16/40 , C12N1/21 , C12N9/64 , C12N9/66 , C12N9/99 , C12N15/12 , C12N15/57 , C12Q1/68 , C12R1/19 , C12Q1/37 , C12N15/63 , C12N15/85
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

34. 发明授权

US5710035A Human elastase IV 失效
标题翻译：人弹性蛋白酶IV
公开(公告)号：US5710035A
公开(公告)日：1998-01-20
申请号：US270584
申请日：1994-07-05
申请人： John M. Greene , Mark D. Adams
发明人： John M. Greene , Mark D. Adams
IPC分类号： C12N15/09 , A61K38/00 , A61K38/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P3/06 , A61P9/10 , A61P9/14 , A61P29/00 , A61P31/04 , C07H21/04 , C07K16/40 , C12N1/21 , C12N9/64 , C12N9/66 , C12N9/99 , C12N15/12 , C12N15/57 , C12Q1/68 , C12R1/19 , C12N1/18 , C12N1/20 , C12N5/10 , C12N15/63
CPC分类号： C12N9/6424 , A61K38/00
摘要： Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration.
摘要翻译：人弹性蛋白酶IV多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法，并且用于治疗目的，例如恢复动脉壁的弹性，改善血清脂质异常和改善血清脂蛋白公开了代谢。还公开了针对这种多肽的拮抗剂/抑制剂及其在治疗炎症，关节炎等中的用途。类风湿关节炎和骨关节炎，脓毒性休克，胰腺炎和限制溃疡组织损伤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式