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31. 发明授权

US5180836A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US5180836A
公开(公告)日：1993-01-19
申请号：US786392
申请日：1991-11-01
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： C07D233/84 , C07D235/28
CPC分类号： C07D233/84 , C07D235/28
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.
摘要翻译：公开了具有下式的新的咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或者R 1和R 2结合形成杂环; R3，R4，R5和R6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基或氟取代的 - 烷氧基，或R3与R2结合形成杂环; R8和R9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基，氟取代的 - 烷氧基或芳基，或R8和R9组合形成脂环 ; R 7是，其中R 8和R 9不组合，其中R 8和R 9结合，可以具有取代基的烷基，可以具有取代基的芳基，可以具有取代基的芳基或含硫杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

32. 发明授权

US5082943A Novel imidazole derivatives 失效
标题翻译：新咪唑衍生物
公开(公告)号：US5082943A
公开(公告)日：1992-01-21
申请号：US658424
申请日：1991-02-20
申请人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
发明人： Susumu Okabe , Mitsuo Masaki , Tomio Yamakawa , Hitoshi Matsukura , Yutaka Nomura
IPC分类号： A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/47 , A61P1/04 , C07D233/84 , C07D233/86 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/28 , C07D401/12
CPC分类号： C07D235/28 , C07D233/84
摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

33. 发明授权

US4596803A Piperazine derivatives and a medicine containing the same 失效
标题翻译：哌嗪衍生物和含有其的药物
公开(公告)号：US4596803A
公开(公告)日：1986-06-24
申请号：US587545
申请日：1984-03-08
申请人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
发明人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
IPC分类号： C07D295/10 , A61K31/495 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , C07D213/74 , C07D213/75 , C07D239/42 , C07D295/18 , C07D295/185 , C07D303/48 , C07D405/12 , C07D405/14
CPC分类号： C07D303/48 , Y02P20/55
摘要： A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.
摘要翻译：公开了具有下式的化合物，其中R 1是氢原子，或具有1至4个碳原子的直链或支链烷基，R 2是具有1至4个碳原子的直链或支链烷基，其中n为0〜3的整数， + TR ，或其药学上可接受的盐。还公开了制备该化合物的方法和含有该化合物的药物。这种药物有效地用于抑制心肌梗死。

34. 发明授权

US4507297A Piperazine derivatives and a medicine containing the same 失效
公开(公告)号：US4507297A
公开(公告)日：1985-03-26
申请号：US361506
申请日：1982-03-25
申请人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
发明人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
IPC分类号： C07D295/10 , A61K31/495 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , C07D213/74 , C07D213/75 , C07D239/42 , C07D295/18 , C07D295/185 , C07D303/48 , C07D405/12
CPC分类号： C07D303/48 , Y02P20/55
摘要： A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.

35. 发明授权

US4339378A N-Acylcarnosine aluminum salts 失效
标题翻译： N-酰基肌氨酸铝盐
公开(公告)号：US4339378A
公开(公告)日：1982-07-13
申请号：US194841
申请日：1980-10-07
申请人： Mitsuo Masaki , Toru Yamanaka , Taketoshi Kinoshita
发明人： Mitsuo Masaki , Toru Yamanaka , Taketoshi Kinoshita
IPC分类号： A61K31/415 , A61P1/04 , A61P1/14 , C07D233/54 , C07D233/64 , C07C103/52 , A61K37/02
CPC分类号： C07D233/64 , Y10S514/927
摘要： An N-acylcarnosine aluminum salt of the formula, ##STR1## Wherein R represents a lower alkyl group or a phenyl group, and n is an integer of 2 to 3 is effective for use as a digestive ulcer-remedying or anti-ulcer agent.
摘要翻译：下式的N-酰基肌氨酸铝盐，其中R表示低级烷基或苯基，n为2〜3的整数，可用作消化性溃疡补救剂或抗溃疡剂。

36. 发明授权

US4009168A Pyridinethiol-tin compound and process for the preparation of the same 失效
标题翻译：吡啶硫醇 - 锡化合物及其制备方法
公开(公告)号：US4009168A
公开(公告)日：1977-02-22
申请号：US440382
申请日：1974-02-07
申请人： Mitsuo Masaki , Satoshi Matsunami , Jyunichiro Kita , Toshikazu Hayashi
发明人： Mitsuo Masaki , Satoshi Matsunami , Jyunichiro Kita , Toshikazu Hayashi
IPC分类号： C08K5/00 , B01J31/00 , C07B61/00 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , C07F7/00 , C07F7/22 , C08K5/37 , C08K5/57 , C08L23/00 , C08L101/00
CPC分类号： C07D213/70 , C07D213/80 , C07D213/85 , C07D213/89 , C07F7/003 , C08K5/36 , C08K5/37
摘要： Pyridinethiol-tin compounds having the formula of RS-SnX.sub.2 -SR' in which R and R' are groups derived from unsubstituted or substituted pyridines or unsubstituted or substituted pyridine N-oxides. A process for the preparation of the same is also discosed. The compounds are stabilizers for polyolefins.
摘要翻译：具有式RS-SnX2-SR'的吡啶硫醚锡化合物，其中R和R'是衍生自未取代或取代的吡啶或未取代或取代的吡啶N-氧化物的基团。还提出了其制备方法。这些化合物是聚烯烃的稳定剂。

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