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31. 发明申请

WO0173060A9 18221, DUAL SPECIFICITY PHOSPHATASE AND USES THEREOF 审中-公开
标题翻译： 18221，双特异性磷酸酶及其用途
公开(公告)号：WO0173060A9
公开(公告)日：2002-12-19
申请号：PCT/US0109603
申请日：2001-03-22
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E
发明人： MEYERS RACHEL E
IPC分类号： A61K38/00 , C12N9/16 , C12N15/55 , A61K31/7088 , A61K39/395 , C07K16/40 , C12N5/10 , C12Q1/42 , C12Q1/68 , G01N33/68
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 18221 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18221 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18221 gene has been introduced or disrupted. The invention still further provides isolated 18221 proteins, fusion proteins, antigenic peptides and anti-18221 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating the differentiation and proliferation of hematopoietic cells (e.g., erythroid cells) utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing hematopoietic disorders are disclosed.
摘要翻译：本发明提供了分离的核酸分子，命名为18221核酸分子，其编码新的双特异性磷酸酶家族成员。本发明还提供了反义核酸分子，含有18221个核酸分子的重组表达载体，导入了表达载体的宿主细胞和导入或破坏了18221基因的非人转基因动物。本发明还提供了分离的18221蛋白，融合蛋白，抗原肽和抗18221抗体。还提供了利用本发明组合物的诊断方法。本发明还提供了利用本发明的组合物调节造血细胞（例如类红细胞）的分化和增殖的方法。因此，公开了治疗，预防和/或诊断造血疾病的方法。

32. 发明申请

WO0220800A9 16658, 14223, and 16002, NOVEL HUMAN KINASES AND USES THEREFOR 审中-公开
标题翻译： 16658，14223和16002，新的人类激酶和用途
公开(公告)号：WO0220800A9
公开(公告)日：2002-10-17
申请号：PCT/US0124601
申请日：2001-08-03
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
发明人： MEYERS RACHEL E , SILOS-SANTIAGO INMACULADA
IPC分类号： C12N9/12 , C12N15/54 , C07K16/40 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/12
摘要： The invention provides isolated nucleic acids molecules, designated 16658, 14223, and 16002 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16658, 14223, and 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16658, 14223, and 16002 gene has been introduced or disrupted. The invention still further provides isolated 16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, -14223, and -16002 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为16658,14223和16002核酸分子，其编码新的激酶家族成员。本发明还提供了反义核酸分子，含有16658,14223和16002核酸分子的重组表达载体，导入了表达载体的宿主细胞和其中已经存在16658,14223和16002基因的非人转基因动物介绍或中断。本发明还提供了分离的16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和16002蛋白，融合蛋白，抗原肽和抗16658,14223和-16002抗体。还提供了利用本发明组合物的诊断方法。

33. 发明申请

WO0164905A3 2504, 15977, AND 14760, NOVEL PROTEIN KINASE FAMILY MEMBERS AND USES THEREFOR 审中-公开
标题翻译： 2504，15977，AND 14760，新型蛋白激酶家族成员及其用途
公开(公告)号：WO0164905A3
公开(公告)日：2002-08-08
申请号：PCT/US0106525
申请日：2001-02-28
申请人： MILLENNIUM PHARM INC , OLANDT PETER J , KAPELLER-LIBERMANN ROSANA , MEYERS RACHEL E
发明人： OLANDT PETER J , KAPELLER-LIBERMANN ROSANA , MEYERS RACHEL E
IPC分类号： A61K38/00 , C07K16/40 , C12N9/12 , C12N15/54 , C12N5/10 , C12N15/62 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/1205 , A61K38/00 , A61K2039/505 , C07K16/40
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为2504,15977或14760核酸分子，其编码新的蛋白激酶家族成员。本发明还提供反义核酸分子，含有2504,15977或14760核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入了2504,15977或14760基因的非人类转基因动物或中断。本发明还进一步提供分离的2504,15977或14760蛋白，融合蛋白，抗原肽和抗2504,15977或14760抗体。还提供了利用本发明组合物的诊断方法。

34. 发明申请

WO0173059A3 38692 AND 21117: DUAL SPECIFICITY PHOSPHATASE MOLECULES AND USES THEREFOR 审中-公开
标题翻译： 38692 AND 21117：双重特异性磷酸酯酶分子及其用途
公开(公告)号：WO0173059A3
公开(公告)日：2002-06-20
申请号：PCT/US0109477
申请日：2001-03-23
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E
发明人： MEYERS RACHEL E
IPC分类号： A61K38/00 , C12N9/16 , C12N15/55 , A61K31/70 , A61K38/46 , A61K39/395 , C07K16/40 , C12N15/62 , C12Q1/42 , C12Q1/68 , G01N33/53
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 38692 or 21117 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38692 or 21117 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38692 or 21117 proteins, fusion proteins, antigenic peptides and anti-38692 or 21117 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的双特异性磷酸酶家族成员的分离的核酸分子，命名为38692或21117核酸分子。本发明还提供反义核酸分子，含有38692或21117个核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中38692或21117蛋白，融合蛋白，抗原肽和抗体 -38692或21117抗体。还提供了利用本发明组合物的诊断方法。

35. 发明申请

WO0166764A3 16835, A HUMAN PHOSPHOLIPASE C AND USES THEREOF 审中-公开
标题翻译： 16835，人类磷脂酶C及其用途
公开(公告)号：WO0166764A3
公开(公告)日：2002-04-18
申请号：PCT/US0107136
申请日：2001-03-05
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL E
发明人： MEYERS RACHEL E
IPC分类号： A61K38/00 , C12N9/20 , C12N15/55 , C07K16/40 , C12N5/10 , C12Q1/68 , G01N33/53
CPC分类号： C12N9/20 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 16835 nucleic acid molecules, which encode novel phospholipase C members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16835 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16835 gene has been introduced or disrupted. The invention still further provides isolated 16835 proteins, fusion proteins, antigenic peptides and anti-16835 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的磷脂酶C成员的分离的核酸分子，命名为16835个核酸分子。本发明还提供了反义核酸分子，含有16835个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及16835基因被引入或破坏的非人转基因动物。本发明还进一步提供了分离的16835蛋白，融合蛋白，抗原肽和抗-16835抗体。还提供了利用本发明组合物的诊断方法。

36. 发明申请

WO03004989A3 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER 审中-公开
标题翻译：用于乳腺癌的鉴定，评估，预防和治疗的组合物，试剂盒和方法
公开(公告)号：WO03004989A3
公开(公告)日：2003-03-27
申请号：PCT/US0219669
申请日：2002-06-21
申请人： MILLENIUM PHARMACEUTICALS INC , LILLIE JAMES , GANNAVARAPU MANJULA , GLATT KAREN , HOERSH SEBASTIAN , KAMATKAR SHUBHANGI , MERTENS MAUREEN , MONAHAN JOHN E , MYER VICKESH , WANG YOUZHEN , XU YONGYAO , ZHAO XUMEI , MEYERS RACHEL E , BAST ROBERT C JR , HORTOBAGYI GABRIEL N , PUSZTAI LAJOS , MERIC FUNDA , SAHIN AYSEGUL , MILLS GORDON B
发明人： LILLIE JAMES , GANNAVARAPU MANJULA , GLATT KAREN , HOERSH SEBASTIAN , KAMATKAR SHUBHANGI , MERTENS MAUREEN , MONAHAN JOHN E , MYER VICKESH , WANG YOUZHEN , XU YONGYAO , ZHAO XUMEI , MEYERS RACHEL E , BAST ROBERT C JR , HORTOBAGYI GABRIEL N , PUSZTAI LAJOS , MERIC FUNDA , SAHIN AYSEGUL , MILLS GORDON B
IPC分类号： C12Q1/68 , C12Q1/00 , A01N43/04 , A01N61/00 , A61K31/00 , A61K31/07 , A61K35/14 , A61K38/00 , C07H1/00 , C07H5/04 , C07H5/06 , C07H19/00 , C07H21/00 , C07H21/04 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08B37/00 , G01N1/00 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
摘要翻译：本发明涉及新发现的与乳腺癌相关的核酸分子和蛋白质。提供了用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。

37. 发明申请

WO0216568A3 46863, A HUMAN METHYLTRANSFERASE AND USES THEREOF 审中-公开
标题翻译： 46863，人甲状腺素及其用途
公开(公告)号：WO0216568A3
公开(公告)日：2002-09-06
申请号：PCT/US0126556
申请日：2001-08-24
申请人： MILLENIUM PHARMACEUTICALS INC , MEYERS RACHEL E , WILLIAMSON MARK , RUDOLPH-OWEN LAURA A
发明人： MEYERS RACHEL E , WILLIAMSON MARK , RUDOLPH-OWEN LAURA A
IPC分类号： C12N9/10 , C07K16/18 , C12N15/12 , G01N33/50
CPC分类号： C12N9/1007
摘要： The invention provides isolated nucleic acid molecules, designated TPRM nucleic acid molecules, which encode novel methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TPRM nucleic acid molecules, host cells into which the expression vectors have been introduced. The invention still further provides isolated TPRM proteins, fusion proteins, antigenic peptides and anti-TPRM antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TPRM核酸分子，其编码新的甲基转移酶家族成员。本发明还提供了反义核酸分子，含有TPRM核酸分子的重组表达载体，已引入表达载体的宿主细胞。本发明还进一步提供分离的TPRM蛋白，融合蛋白，抗原肽和抗-TPRM抗体。还提供了利用本发明组合物的诊断和治疗方法。

38. 发明申请

WO0240674A9 "67118", "67067" AND "62092", HUMAN PROTEINS AND METHODS OF USE THEREOF 审中-公开
标题翻译： “67118”，“67067”AND“62092”，人类蛋白质及其使用方法
公开(公告)号：WO0240674A9
公开(公告)日：2004-05-21
申请号：PCT/US0145789
申请日：2001-11-14
申请人： MILLENIUM PHARMACEUTICALS INC , MEYERS RACHEL E , CURTIS RORY A J
发明人： MEYERS RACHEL E , CURTIS RORY A J
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C12N9/16 , C12N15/12 , G01N33/50 , G01N33/68 , C07K14/435 , C07K16/18 , C12N5/10 , C12N9/14 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/502 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/705 , C07K2319/00 , C12N9/16 , C12N2310/3181 , C12N2310/351 , G01N33/5008 , G01N33/6872 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： The invention provides isolated nucleic acid molecules, designated 67118, 67067, and 62092 nucleic acid molecules, which encode novel transporter family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 67118, 67067, and 62092 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 67118, 67067, gene has been introduced or disrupted. The invention still further provides isolated 67118, 67067, and/or 62092 polypeptides, fusion polypeptides, antigenic peptides and anti-67118, anti 67067, and anti-62092 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型转运蛋白家族分子的分离的核酸分子，命名为67118,67067和62092核酸分子。本发明还提供了反义核酸分子，含有67118,67067和62092核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入了67118,67067个基因的非人类转基因动物，破坏。本发明还进一步提供分离的67118,67067和/或62092多肽，融合多肽，抗原肽和抗-67118，抗67067和抗-62092抗体。还提供了利用本发明组合物的诊断方法。

39. 发明申请

WO0244356A3 25206, A NOVEL HUMAN SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY MEMBER AND USES THEREOF 审中-公开
标题翻译： 25206，一个新的人类短链脱氧核糖核酸/减少家族成员及其用途
公开(公告)号：WO0244356A3
公开(公告)日：2003-05-08
申请号：PCT/US0145040
申请日：2001-11-29
申请人： MILLENIUM PHARMACEUTICALS INC , MEYERS RACHEL E , MACBETH KYLE J
发明人： MEYERS RACHEL E , MACBETH KYLE J
IPC分类号： A61K38/00 , C12N9/04 , C12N9/00 , C07K16/40 , C12N5/10 , C12N15/52 , C12N15/62 , C12Q1/68 , G01N33/50 , G01N33/573
CPC分类号： C12N9/0006 , A61K38/00
摘要： The indication provides isolated nucleic acids molecules, designated 25206 nucleic acid molecules, which encode novel short-chain dehydrogenase/reductase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25206 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25206 gene has been introduced or disrupted. The invention still further provides isolated 25206 proteins, fusion proteins, antigenic peptides and anti-25206 antibodies. Diagnostic methods utilizing composition of the invention are also provided.
摘要翻译：该指示提供分离的核酸分子，命名为25206核酸分子，其编码新的短链脱氢酶/还原酶成员。本发明还提供了反义核酸分子，含有25206个核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏25206基因的非人转基因动物。本发明还进一步提供分离的25206蛋白，融合蛋白，抗原肽和抗-25206抗体。还提供了利用本发明组合物的诊断方法。

40. 发明公开

EP1497797A4 2150, A HUMAN PROTEIN KINASE FAMILY MEMBER AND USES THEREFOR 有权
标题翻译： 2150对人体的蛋白激酶家族之成员及其用途
公开(公告)号：EP1497797A4
公开(公告)日：2005-08-10
申请号：EP02752124
申请日：2002-06-27
申请人： MILLENNIUM PHARM INC
发明人： MEYERS RACHEL E , LORA JOSE M
IPC分类号： C12N9/12 , C12Q1/48 , G01N33/68
CPC分类号： C12N9/12 , C07K2319/00 , C12N9/1205
摘要： The invention provides isolated nucleic acids molecules, designated 2150 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2150 nucleic acid molecules, host cells into which the expression vectors have been introduced, ands nonhuman transgenic animals in which a 2150 gene has been introduced or disrupted. The invention still further provides isolated 2150 proteins, fusion, antigenic peptides and anti-2150 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

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