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31. 发明申请

US20090211962A1 PROCESSING CHAMBERS FOR USE WITH APHERESIS DEVICES 审中-公开
标题翻译：加工中心与APHERESIS设备一起使用
公开(公告)号：US20090211962A1
公开(公告)日：2009-08-27
申请号：US12392952
申请日：2009-02-25
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D33/74
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/0231 , A61M1/3652 , A61M1/3696 , A61M1/38 , A61M2205/128
摘要： Processing chamber for use with apheresis devices are described herein. An example centrifugal processing chamber includes first and second lateral walls spaced at a distance from one another. Additionally, the example centrifugal processing chamber includes a channel at least partially defined by the first and second lateral walls. Further, the centrifugal processing chamber includes an inlet fluidly coupled to the channel to convey blood to the channel. Further still, the centrifugal processing chamber includes a first outlet fluidly coupled to the channel having a first opening adjacent the first lateral wall. The first outlet is to convey separated plasma from the channel. Additionally, the centrifugal processing chamber includes a second fluid outlet fluidly coupled to the channel having a second opening adjacent the second lateral wall. The second outlet is to convey separated red blood cells from the channel. Additionally, the processing chamber includes a barrier formed along the second lateral wall to intercept platelets. The first and second lateral walls are spaced such that the distance between the first and second lateral walls enables at least one therapeutic unit of single dose platelets to pool adjacent the barrier without spilling into the first outlet or the second outlet.
摘要翻译：本文描述了与分离装置一起使用的处理室。一个示例性离心处理室包括彼此间隔一定距离的第一和第二侧壁。另外，示例性离心处理室包括至少部分地由第一和第二侧壁限定的通道。此外，离心处理室包括流体耦合到通道以将血液输送到通道的入口。此外，离心处理室包括流体耦合到通道的第一出口，其具有与第一侧壁相邻的第一开口。第一个出口是从通道传送分离的等离子体。此外，离心处理室包括流体地联接到通道的第二流体出口，其具有邻近第二侧壁的第二开口。第二个出口是从通道传送分离的红细胞。另外，处理室包括沿着第二侧壁形成的屏障，以拦截血小板。第一和第二侧壁间隔开，使得第一和第二侧壁之间的距离使得单剂量血小板的至少一个治疗单元能够在不渗入第一出口或第二出口的情况下相邻隔离池。

32. 发明授权

US06706008B2 Automated system and method for withdrawing compounds from blood 有权
标题翻译：自动化系统和从血液中提取化合物的方法
公开(公告)号：US06706008B2
公开(公告)日：2004-03-16
申请号：US09800133
申请日：2001-03-06
申请人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
发明人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3687 , A61M1/3692 , A61M1/3696 , A61M2205/12
摘要： Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.
摘要翻译：公开了用于从血液中取出选定化合物的自动化系统和方法。系统和方法利用安装在可重复使用的硬件部件或模块上的一次性流体回路。系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。

33. 发明授权

US06183651B2 Blood processing systems and methods which optically monitor plasma opacity 有权
标题翻译：血液处理系统和光学监测等离子体不透明度的方法
公开(公告)号：US06183651B2
公开(公告)日：2001-02-06
申请号：US09382893
申请日：1999-08-25
申请人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
发明人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
IPC分类号： B01D1712
CPC分类号： B01D17/0217 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , B01D21/003 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/32 , B01D2221/10 , B04B5/0442 , B04B13/00 , A61M2202/0071
摘要： Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates a third output based, at least in part, upon the integrated output, which comprises parameters for storing the platelet volume.
摘要翻译：血液处理系统和方法将血液分成包括血小板体积的血浆成分的成分。系统和方法检测等离子体成分的光密度并产生表示光密度的第一输出。处理元件将第一输出相对于等离子体成分的体积积分并产生积分输出。综合输出与血小板体积相关。第二处理元件至少部分地基于集成输出产生第三输出，其包括用于存储血小板体积的参数。

34. 发明申请

US20090218277A1 SEPARATION APPARATUS AND METHOD 有权
标题翻译：分离装置和方法
公开(公告)号：US20090218277A1
公开(公告)日：2009-09-03
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B01D17/038
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

35. 发明授权

US07297272B2 Separation apparatus and method 有权
标题翻译：分离装置及方法
公开(公告)号：US07297272B2
公开(公告)日：2007-11-20
申请号：US10827603
申请日：2004-04-19
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur
IPC分类号： B04B3/00 , B04B1/06 , B04B1/12 , B04B7/10 , B01D21/26 , B01D45/12
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

36. 发明授权

US07087177B2 Methods for determining flow rates of biological fluids 有权
标题翻译：确定生物体液流速的方法
公开(公告)号：US07087177B2
公开(公告)日：2006-08-08
申请号：US10826086
申请日：2004-04-16
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D21/26 , G01F1/00 , B01D21/32 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/3696
摘要： A separation method comprises introducing a first fluid comprising first and second components having different density into a centrifugal field and allowing an interface to form between at least portions of such components at a first location. The method also comprises moving the interface from the first location to a second location and further comprises introducing the first fluid and removing one of the first and second components at known controlled flow rates so as to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The flow rate of the first or second component may be determined based, at least in part, on the time interval between the interface moving from and returning to the second location. The flow rate may also be based on the weight of the one component removed during the time interval.
摘要翻译：分离方法包括将包含具有不同密度的第一和第二组分的第一流体引入到离心场中，并允许在第一位置处在这些组分的至少部分之间形成界面。该方法还包括将界面从第一位置移动到第二位置，并且进一步包括引入第一流体并以已知的受控流速移除第一和第二组分中的一个，以便使接口从第二位置朝向第一个位置并将界面返回到第二个位置。至少部分地基于从第二位置移动到返回到第二位置的界面之间的时间间隔来确定第一或第二部件的流量。流量也可以基于在时间间隔期间去除的一个部件的重量。

37. 发明授权

US06582386B2 Multi-purpose, automated blood and fluid processing systems and methods 有权
公开(公告)号：US06582386B2
公开(公告)日：2003-06-24
申请号：US09800129
申请日：2001-03-06
申请人： Kyungyoon Min , Richard I. Brown , Rohit Vishnoi , Tom Westberg , Alan Armer
发明人： Kyungyoon Min , Richard I. Brown , Rohit Vishnoi , Tom Westberg , Alan Armer
IPC分类号： A61M3700
CPC分类号： A61M1/3687 , A61M1/262 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/12
摘要： Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further processes or treats the separated component.

38. 发明授权

US06500107B2 Method for the concentration of fluid-borne pathogens 有权
标题翻译：流体传播病原体浓度的方法
公开(公告)号：US06500107B2
公开(公告)日：2002-12-31
申请号：US09874731
申请日：2001-06-05
申请人： Richard I. Brown , Kyungyoon Min
发明人： Richard I. Brown , Kyungyoon Min
IPC分类号： B01D2126
CPC分类号： B04B5/0428 , A61M1/362 , A61M1/3693 , A61M1/3696 , A61M2202/20 , B04B5/0442 , B04B2005/045 , C12M33/10
摘要： Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).
摘要翻译：公开了从血液以外的流体浓缩和回收病原体的方法和装置。该方法包括通过将流体连续地供给到一个或多个柔性室中并对该室进行离心力来浓缩包含在流体中的病原体。浓缩的病原体可以通过摇动室来重新悬浮。

39. 发明授权

US09603986B2 Device and method for processing and producing autologous platelet-rich plasma 有权
公开(公告)号：US09603986B2
公开(公告)日：2017-03-28
申请号：US14014542
申请日：2013-08-30
申请人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
发明人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
IPC分类号： B01D63/16 , A61M1/34 , A61M1/26 , A61M1/02
CPC分类号： A61M1/3496 , A61M1/0218 , A61M1/265 , A61M2205/103 , A61M2205/75 , B01D63/16 , B01D2317/02 , B01D2319/02 , B01D2319/06
摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.

40. 发明授权

US09408961B2 Membrane separation devices, systems and methods employing same and data management systems and methods 有权
标题翻译：膜分离装置，采用相同的系统和方法以及数据管理系统和方法
公开(公告)号：US09408961B2
公开(公告)日：2016-08-09
申请号：US14003281
申请日：2012-03-09
申请人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
发明人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
IPC分类号： A61M1/34 , A61M1/02 , B01D61/18 , B01D63/06 , B01D63/16 , A61M1/38 , A61M1/26 , A61M1/36
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译：公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。还公开了数据管理系统和方法以及启动方法。

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