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31. 发明申请

US20090242755A1 LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS 有权
标题翻译：低压电沉积离子系统和有效传输离子的方法
公开(公告)号：US20090242755A1
公开(公告)日：2009-10-01
申请号：US12468645
申请日：2009-05-19
申请人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
发明人： Keqi Tang , Jason S. Page , Ryan T. Kelly , Richard D. Smith
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/0431 , H01J49/066
摘要： Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An “interfaceless” electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.
摘要翻译：提供耦合级之间离子完全传输的系统和方法，具有低有效离子损耗。进一步描述了一种“无接口”电喷雾离子化系统，其以减压的方式操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦和离子传输到质量分析器中的电动离子漏斗中。此外，保持在不同压力的室可以为电喷雾发射器和离子导向器提供更优化的操作条件。

32. 发明授权

US07514676B1 Method and apparatus for selective filtering of ions 有权
标题翻译：选择性过滤离子的方法和装置
公开(公告)号：US07514676B1
公开(公告)日：2009-04-07
申请号：US11251529
申请日：2005-09-30
申请人： Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/066 , G01N27/622
摘要： An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution.
摘要翻译：公开了一种可调节的低质量 - 电荷（m / z）滤波器，其使用电喷雾电离来阻挡与不想要的低m / z物质相关的离子进入质谱仪并且为下游离子累积步骤贡献其空间电荷。低质量过滤器通过使用来自电动离子漏斗的电导限制端子电极的可调势势垒来制造，其阻止具有较高离子迁移率的物质被传输。滤波器提供从大约50到大约500的m / z值的低质量滤波的线性电压调节。也可以执行m / z 500以上的质量过滤; 然而，更高的m / z物种减弱。通过对白蛋白胰蛋白酶消化物的液相色谱 - 质谱分析来评估质量过滤器，并且导致阻断低质量“背景”离子的能力，其占离子源的总离子电流的40-70％峰洗脱。

33. 发明授权

US07491341B2 Method of making tapered capillary tips with constant inner diameters 有权
标题翻译：制造具有恒定内径的锥形毛细管尖端的方法
公开(公告)号：US07491341B2
公开(公告)日：2009-02-17
申请号：US11394840
申请日：2006-03-31
申请人： Ryan T. Kelly , Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Ryan T. Kelly , Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： C03C25/68 , B44C1/22
CPC分类号： H01J49/167
摘要： Methods of forming electrospray ionization emitter tips are disclosed herein. In one embodiment, an end portion of a capillary tube can be immersed into an etchant, wherein the etchant forms a concave meniscus on the outer surface of the capillary. Variable etching rates in the meniscus can cause an external taper to form. While etching the outer surface of the capillary wall, a fluid can be flowed through the interior of the capillary tube. Etching continues until the immersed portion of the capillary tube is completely etched away.
摘要翻译：本文公开了形成电喷雾电离发射器尖端的方法。在一个实施例中，毛细管的端部可以浸入蚀刻剂中，其中蚀刻剂在毛细管的外表面上形成凹弯月面。弯液面中的可变蚀刻速率可能导致形成外部锥度。在蚀刻毛细管壁的外表面时，流体可以流过毛细管的内部。继续蚀刻直到毛细管的浸入部分被完全蚀刻掉。

34. 发明申请

US20070194224A1 Monolithic electrospray ionization emitters and methods of making same 审中-公开
标题翻译：单片电喷雾电离发射器及其制作方法
公开(公告)号：US20070194224A1
公开(公告)日：2007-08-23
申请号：US11346799
申请日：2006-02-02
申请人： Keqi Tang , Jason Page , Quanzhou Luo , Richard Smith
发明人： Keqi Tang , Jason Page , Quanzhou Luo , Richard Smith
IPC分类号： H01J49/10
CPC分类号： H01J49/167 , G01N30/7266
摘要： Electrospray ionization (ESI) apparatuses and methods of making the same are disclosed. In one embodiment, an ESI emitter comprises a capillary tube filled with a porous monolithic material, wherein the end of the emitter is tapered and the tip of the tapered end comprises a protrusion of the porous monolithic material. One embodiment of the method for making ESI emitters comprises filling a capillary tube with a porous monolithic material and tapering the end of the capillary tube, thereby exposing a portion of the porous material. The exposed portion of the porous material at the tapered end, rather than the capillary tube itself, forms the tip of the ESI emitter.
摘要翻译：公开了电喷雾离子化（ESI）装置及其制备方法。在一个实施例中，ESI发射器包括填充有多孔整体材料的毛细管，其中发射器的端部是锥形的，锥形末端包括多孔整体材料的突起。用于制备ESI发射器的方法的一个实施例包括用多孔整体材料填充毛细管并使毛细管的端部逐渐变细，由此暴露多孔材料的一部分。锥形端部的多孔材料的暴露部分而不是毛细管本身形成ESI发射体的尖端。

35. 发明授权

US06528784B1 Mass spectrometer system including a double ion guide interface and method of operation 有权
标题翻译：质谱系统包括双离子导向界面和操作方法
公开(公告)号：US06528784B1
公开(公告)日：2003-03-04
申请号：US09715815
申请日：2000-11-16
申请人： Keqi Tang , Alan E. Schoen , Jean-Jacques Dunyach
发明人： Keqi Tang , Alan E. Schoen , Jean-Jacques Dunyach
IPC分类号： B01D5944
CPC分类号： H01J49/063 , H01J49/044 , H01J49/067
摘要： There is described an interface for delivering ions generated in an ion source into a mass analyzer in a chamber under vacuum pressure. In particular, the interface employs two consecutive ion guides operated to dissociate adduct ions formed in the ion source or high pressure regions of the interface between the ion source and the mass analyzer, thus improving the limit of detection or limit of quantitation of the mass analyzer by increasing the analyte ion current.
摘要翻译：描述了在真空压力下将在离子源中产生的离子输送到室中的质量分析器的界面。特别地，界面使用两个连续的离子导向器来操作以离解形成在离子源中的加合离子或离子源和质量分析器之间的界面的高压区域，从而提高质量分析器的检测限度或定量限度通过增加分析物离子电流。

36. 发明申请

US20060219889A1 Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD) 有权
标题翻译：用于偶极方向对准的离子迁移光谱法的方法和装置（IMS-ADD）
公开(公告)号：US20060219889A1
公开(公告)日：2006-10-05
申请号：US11097855
申请日：2005-03-31
申请人： Alexandre Shvartsburg , Keqi Tang , Richard Smith
发明人： Alexandre Shvartsburg , Keqi Tang , Richard Smith
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/004 , H01J49/40
摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that “locks” the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ˜3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.
摘要翻译：描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。通过以特定的角度对漂移场施加更强的交变电场来实现对准，所述交变电场通过超过一定值的力矩“锁定”离子偶极子。该值取决于缓冲气体组成，压力和温度，但在某些条件下可能低至〜3德拜。目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。

37. 再颁专利

USRE40632E1 Mass spectrometer system including a double ion guide interface and method of operation 有权
标题翻译：质谱系统包括双离子导向界面和操作方法
公开(公告)号：USRE40632E1
公开(公告)日：2009-02-03
申请号：US11073394
申请日：2005-03-04
申请人： Keqi Tang , Jean-Jacques Dunyach , Alan E. Schoen
发明人： Keqi Tang , Jean-Jacques Dunyach , Alan E. Schoen
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/063 , H01J49/044 , H01J49/067
摘要： There is described an interface for delivering ions generated in an ion source into a mass analyzer in a chamber under vacuum pressure. In particular, the interface employs two consecutive ion guides operated to dissociate adduct ions formed in the ion source or high pressure regions of the interface between the ion source and the mass analyzer, thus improving the limit of detection or limit of quantitation of the mass analyzer by increasing the analyte ion current.The questions raised in reexamination request no. 90/007,724, filed Sep. 16, 2005 have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e), for ex parte reexaminations, or the reexamination certificate required by 35 U.S.C. 316 as provided in 37 CFR 1.997(e) for inter partes reexaminations.
摘要翻译：描述了在真空压力下将在离子源中产生的离子输送到室中的质量分析器的界面。特别地，界面使用两个连续的离子导向器来操作以离解形成在离子源中的加合离子或离子源和质量分析器之间的界面的高压区域，从而提高质量分析器的检测限度或定量限度通过增加分析物离子电流。复审请求中提出的问题已经考虑了2005年9月16日提交的第90 / 007,724号，其结果反映在构成35U.S.C所要求的复审证书的该再发行专利中。根据第37 CFR 1.570（e）条规定，单方面复审或35 U.S.C.所要求的复审证书。按照第37 CFR 1.997（e）条的规定进行跨部门重新审查。

38. 发明申请

US20070235408A1 Method of making tapered capillary tips with constant inner diameters 有权
标题翻译：制造具有恒定内径的锥形毛细管尖端的方法
公开(公告)号：US20070235408A1
公开(公告)日：2007-10-11
申请号：US11394840
申请日：2006-03-31
申请人： Ryan Kelly , Jason Page , Keqi Tang , Richard Smith
发明人： Ryan Kelly , Jason Page , Keqi Tang , Richard Smith
IPC分类号： B32B1/08 , B44C1/22
CPC分类号： H01J49/167
摘要： Methods of forming electrospray ionization emitter tips are disclosed herein. In one embodiment, an end portion of a capillary tube can be immersed into an etchant, wherein the etchant forms a concave meniscus on the outer surface of the capillary. Variable etching rates in the meniscus can cause an external taper to form. While etching the outer surface of the capillary wall, a fluid can be flowed through the interior of the capillary tube. Etching continues until the immersed portion of the capillary tube is completely etched away.
摘要翻译：本文公开了形成电喷雾电离发射器尖端的方法。在一个实施例中，毛细管的端部可以浸入蚀刻剂中，其中蚀刻剂在毛细管的外表面上形成凹弯月面。弯液面中的可变蚀刻速率可能导致形成外部锥度。在蚀刻毛细管壁的外表面时，流体可以流过毛细管的内部。继续蚀刻直到毛细管的浸入部分被完全蚀刻掉。

39. 发明申请

US20070200059A1 Interface and process for enhanced transmission of non-circular ion beams between stages at unequal pressure 有权
标题翻译：用于在不同压力的阶段之间增强非圆形离子束传输的界面和过程
公开(公告)号：US20070200059A1
公开(公告)日：2007-08-30
申请号：US11361264
申请日：2006-02-24
申请人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
发明人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
IPC分类号： H01J49/06
CPC分类号： H01J49/067
摘要： The invention discloses a new interface with non-circular conductance limit aperture(s) useful for effective transmission of non-circular ion beams between stages with different gas pressure. In particular, the invention provides an improved coupling of field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of planar or side-to-side geometry to downstream stages such as mass spectrometry or ion mobility spectrometry. In this case, the non-circular aperture is rectangular; other geometries may be optimum in other applications. In the preferred embodiment, the non-circular aperture interface is followed by an electrodynamic ion funnel that may focus wide ion beams of any shape into tight circular beams with virtually no losses. The jet disrupter element of the funnel may also have a non-circular geometry, matching the shape of arriving ion beam. The improved sensitivity of planar FAIMS/MS has been demonstrated in experiments using a non-contiguous elongated aperture but other embodiments (e.g., with a contiguous slit aperture) may be preferable, especially in conjunction with an ion funnel operated at high pressures.
摘要翻译：本发明公开了一种具有非圆形电导限制孔径的新界面，其可用于在具有不同气体压力的级之间有效地传输非圆形离子束。特别地，本发明提供了平面或侧对面几何的场非对称波形离子淌度光谱（FAIMS）分析仪与诸如质谱或离子淌度光谱法的下游阶段的改进的耦合。在这种情况下，非圆形孔是矩形的; 其他几何形状在其他应用中可能是最佳的。在优选实施例中，非圆形孔径界面之后是电动离子漏斗，其可将任何形状的宽离子束聚焦成紧密的圆形梁，实际上没有损失。漏斗的喷射破坏器元件也可以具有与到达的离子束的形状匹配的非圆形几何形状。已经在使用不连续的细长孔的实验中证明了平面FAIMS / MS的改进的灵敏度，但是其它实施例（例如，具有连续的狭缝孔）可能是优选的，特别是与在高压下操作的离子漏斗相结合。

40. 发明申请

US20060226353A1 DEVICE FOR TWO-DIMENSIONAL GAS-PHASE SEPARATION AND CHARACTERIZATION OF ION MIXTURES 有权
标题翻译：用于二维气相分离和离子混合特征的装置
公开(公告)号：US20060226353A1
公开(公告)日：2006-10-12
申请号：US11103984
申请日：2005-04-11
申请人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
发明人： Keqi Tang , Alexandre Shvartsburg , Richard Smith
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译：本发明涉及气相离子的分离和表征装置。该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

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