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31. 发明授权

US5041462A Novel substituted acetamide compounds and use as anti-allergic agents 失效
标题翻译：新型取代的乙酰胺化合物，并用作抗过敏剂
公开(公告)号：US5041462A
公开(公告)日：1991-08-20
申请号：US476515
申请日：1990-02-07
申请人： Hiroaki Taguchi , Takeo Katsushima , Masakazu Ban , Mitsuru Takahashi , Kiyotaka Shinoda , Akihiko Watanabe
发明人： Hiroaki Taguchi , Takeo Katsushima , Masakazu Ban , Mitsuru Takahashi , Kiyotaka Shinoda , Akihiko Watanabe
IPC分类号： A61K31/165 , A61K31/275 , A61P37/08 , C07C237/30 , C07C237/42 , C07C237/44 , C07C255/60 , C07D295/155
CPC分类号： C07D295/155 , C07C237/42 , C07C237/44 , C07C255/60
摘要： Novel substituted acetamide compounds of the formula ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a lower acyl group, or an aryl group; R.sup.2 is cyano group or aminocarbonyl group; R.sup.3 is a halogen atom, nitro group, a lower alkoxy group, a group of the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 is hydrogen atom, a lower alkyl group or a group of the formula: --COCH.sub.2 OR.sup.1 ; R.sup.5 is hydrogen atom or a lower alkyl group), or a cyclic amino group of the formula: ##STR2## (wherein R.sup.6 and R.sup.7 are each an alkylene group having 1 to 3 carbon atoms, and X is oxygen atom or methylene), or a pharmaceutically acceptable acid addition salt thereof, which have excellent anti-allergic activity and are useful for the prophylaxis and treatment of various allergic diseases, and a pharmaceutical composition containing the amide compound as set forth above as an active ingredient.

32. 发明授权

US5004567A Process for producing fluorine-containing aliphatic carboxylic acids 失效
标题翻译：含氟脂肪族羧酸的制造方法
公开(公告)号：US5004567A
公开(公告)日：1991-04-02
申请号：US222302
申请日：1988-07-22
申请人： Mitsuru Takahashi , Hideo Shuyama , Osamu Miyano , Yukihiro Tsutsumi
发明人： Mitsuru Takahashi , Hideo Shuyama , Osamu Miyano , Yukihiro Tsutsumi
IPC分类号： C07C51/15
CPC分类号： C07C51/15
摘要： Process for producing fluorine-containing aliphatic carboxylic acids having the general formula of Y--R.sub.f --Y' as defined herein by reaction of fluorine-containing aliphatic halogen compounds having the general formula of X--R.sub.4 --X' as defined herein with carbon dioxide under the presence of zinc in an organic solvent and hydrolysis of the reaction product, wherein the improvement comprises controlling the concentration of carbon dioxide in the organic solvent at a level of 0.3 to 5 mol/l.
摘要翻译：通过如本文定义的具有通式X-R4-X'的含氟脂族卤素化合物与二氧化碳的反应生成具有通式Y-Rf-Y'的含氟脂族羧酸的方法，锌在有机溶剂中的存在和反应产物的水解，其中改进包括控制有机溶剂中二氧化碳的浓度为0.3-5mol / l。

33. 发明授权

US4234466A Process for preparation of solid pigment resin dispersion 失效
标题翻译：固体颜料树脂分散体的制备方法
公开(公告)号：US4234466A
公开(公告)日：1980-11-18
申请号：US856803
申请日：1977-12-01
申请人： Mitsuru Takahashi , Yukio Omori , Shuji Ikeda , Hiroyoshi Kataoka
发明人： Mitsuru Takahashi , Yukio Omori , Shuji Ikeda , Hiroyoshi Kataoka
IPC分类号： C08K9/00 , A63F13/70 , A63F13/80 , C08F2/00 , C08F2/20 , C08F2/44 , C08K9/08 , C08L33/00 , C08L33/02 , C08L67/00 , C09C3/00 , C09C3/10 , C09D5/03 , C09D7/00 , C09D11/00 , C09D11/10 , C09D17/00 , G06F21/10 , C08L1/14 , C08L1/28
CPC分类号： C09D17/00
摘要： A process for preparing a solid pigment dispersed composition which comprises subjecting a liquid composition comprising at least one ethylenically unsaturated polymerizable compound, at least one resin dissolved or dispersed therein and at least one pigment dispersed therein to suspension or bulk polymerization, if necessary, with previous color matching.
摘要翻译：一种制备固体颜料分散组合物的方法，其包括将包含至少一种烯键式不饱和可聚合化合物的液体组合物，至少一种溶解或分散在其中的树脂和至少一种分散在其中的颜料进行悬浮或本体聚合，如果需要，颜色匹配。

34. 发明授权

US08835443B2 Pyrimidine compound and medical use thereof 有权
标题翻译：嘧啶化合物及其医疗用途
公开(公告)号：US08835443B2
公开(公告)日：2014-09-16
申请号：US12626443
申请日：2009-11-25
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/519 , C07D239/545 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

35. 发明授权

US08642586B2 1,4-benzothiazepine-1-oxide derivative and pharmaceutical composition utilizing the same 有权
标题翻译： 1,4-苯并硫氮杂-1-氧化物衍生物和利用其的药物组合物
公开(公告)号：US08642586B2
公开(公告)日：2014-02-04
申请号：US13203188
申请日：2010-02-24
申请人： Noboru Kaneko , Mitsuru Takahashi
发明人： Noboru Kaneko , Mitsuru Takahashi
IPC分类号： A61P9/10 , A61K31/554 , C07D417/06
CPC分类号： C07D417/06
摘要： Provided are novel compound that is useful as a treatment agent or a prophylactic agent for cardiac failure, cardiac failure due to dystelectasis, left ventricular diastolic impairment, angina or cardiac infarct, hypertension, ischemic cardiac disease, and myocardial relaxation impairment recognized in cardiac failure, atrial fibrillation or ventricular arrhythmia, and a pharmaceutical composition containing the same. The invention pertains to a 1,4-benzothiazepine-1-oxide derivative represented by general formula [I] (In the formula, R represents a hydrogen atom or a hydroxyl group.) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same [I].
摘要翻译：提供可用作心脏衰竭的治疗剂或预防剂，由于心脏衰竭导致的心包衰竭引起的心脏衰竭，左心室舒张功能障碍，心绞痛或心肌梗塞，高血压，缺血性心脏病和心肌松弛障碍的新化合物，心房颤动或室性心律失常，以及含有它们的药物组合物。本发明涉及由通式[I]（式中，R表示氢原子或羟基）表示的1,4-苯并硫氮杂-1-氧化物衍生物或其药学上可接受的盐，以及含有相同[I]。

36. 发明授权

US08412089B2 Image forming apparatus and guide therefor capable of reducing toner scattered on recording medium 有权
标题翻译：图像形成装置及其导向装置，其能够减少在记录介质上散落的调色剂
公开(公告)号：US08412089B2
公开(公告)日：2013-04-02
申请号：US12986732
申请日：2011-01-07
申请人： Kazuchika Saeki , Mitsuru Takahashi , Kazuosa Kuma , Takeshi Fukao , Tsutomu Kato , Yoshiharu Kishi
发明人： Kazuchika Saeki , Mitsuru Takahashi , Kazuosa Kuma , Takeshi Fukao , Tsutomu Kato , Yoshiharu Kishi
IPC分类号： G03G15/00
CPC分类号： G03G15/657 , G03G2215/00413
摘要： An image forming apparatus includes an image carrier, a transferor, a fixing unit, and a guide. The image carrier carries a toner image. The transferor opposes the image carrier to form a transfer nip and transfers the toner image on the image carrier onto a recording medium at the transfer nip. The fixing unit fixes the toner image on the recording medium. The guide guides the recording medium bearing the toner image from the transferor toward the fixing unit and includes a surface portion directly contacting the recording medium. The surface portion includes a material for charging the recording medium to have a polarity opposite to the polarity of a toner forming the toner image.
摘要翻译：图像形成装置包括图像载体，转印器，定影单元和引导件。图像载体携带调色剂图像。转印器与图像载体相对以形成转印压区，并将转印辊上的图像载体上的调色剂图像转印到记录介质上。定影单元将调色剂图像固定在记录介质上。引导件将从转印器承载调色剂图像的记录介质引向定影单元，并且包括直接接触记录介质的表面部分。表面部分包括用于将记录介质充电以具有与形成调色剂图像的调色剂的极性相反的极性的材料。

37. 发明授权

US08249468B2 Image forming apparatus 有权
标题翻译：图像形成装置
公开(公告)号：US08249468B2
公开(公告)日：2012-08-21
申请号：US12434009
申请日：2009-05-01
申请人： Kazuosa Kuma , Shinichi Kawahara , Mitsuru Takahashi , Tsutomu Katoh , Takeshi Fukao , Kazuhisa Sudo
发明人： Kazuosa Kuma , Shinichi Kawahara , Mitsuru Takahashi , Tsutomu Katoh , Takeshi Fukao , Kazuhisa Sudo
IPC分类号： G03G15/00
CPC分类号： G03G15/167 , B65H5/062 , B65H2403/512 , B65H2404/1442 , B65H2511/514 , B65H2701/1313 , B65H2801/06 , G03G15/6561 , G03G2215/00409 , G03G2215/00599 , B65H2220/01
摘要： An image forming apparatus includes at least one image carrier and a recording medium conveyor forming a transfer nip therebetween, a conveyance member disposed closest to the transfer nip on an upstream side of the transfer nip to convey the recording medium to the transfer nip, and a conveyance control mechanism to deactivate the conveyance member to stop providing a conveyance force to the recording medium after the leading edge of the recording medium has entered the transfer nip and before the trailing edge of the recording medium passes a point of force application and remaining in the inactive state until the recording medium passes the point of force application. The conveyance force remains unapplied to the recording medium from when the conveyance control mechanism deactivates the conveyance member to when the trailing edge of the recording medium passes the transfer nip.
摘要翻译：图像形成装置包括至少一个图像载体和在其之间形成转印夹持器的记录介质输送器，在转印夹持部的上游侧最靠近转印夹持部布置的输送部件，将记录介质输送到转印压区，输送控制机构，用于在记录介质的前缘进入转印辊隙之后并且在记录介质的后缘通过施加点之前停止输送构件停止向记录介质提供传送力，并保留在记录介质中直到记录介质通过施加点为止。当输送控制机构使传送部件停止运动到记录介质的后端通过传送辊隙时，输送力保持不会对记录介质施加。

38. 发明授权

US08101774B2 Ester derivatives and medicinal use thereof 有权
标题翻译：酯衍生物及其药用
公开(公告)号：US08101774B2
公开(公告)日：2012-01-24
申请号：US11250636
申请日：2005-10-17
申请人： Atsushi Hagiwara , Taku Ikenogami , Kazunori Kurihara , Toshio Taniguchi , Mitsuru Takahashi , Akio Iida
发明人： Atsushi Hagiwara , Taku Ikenogami , Kazunori Kurihara , Toshio Taniguchi , Mitsuru Takahashi , Akio Iida
IPC分类号： C07D213/56 , A61K31/44
CPC分类号： C07D295/192 , C07C237/42 , C07C255/55
摘要： The present invention relates to an ester represented by the formula [1]: or its pharmaceutically acceptable salt, or use of the same. The compound represented by the formula [1] or its pharmaceutically acceptable salt is useful as an agent for the treatment or prophylaxis of hyperlipidemia or the like, since it disappears very rapidly in the living body and has an excellent MTP inhibitory activity.
摘要翻译：本发明涉及由式[1]表示的酯：或其药学上可接受的盐或其用途。由式[1]表示的化合物或其药学上可接受的盐可用作治疗或预防高脂血症等的药剂，因为其在生物体中消失非常迅速，具有优异的MTP抑制活性。

39. 发明申请

US20100061752A1 IMAGE FORMING APPARATUS AND CONTROL METHOD FOR SAME 失效
标题翻译：图像形成装置及其控制方法
公开(公告)号：US20100061752A1
公开(公告)日：2010-03-11
申请号：US12557997
申请日：2009-09-11
申请人： Kazuhisa SUDO , Mitsuru Takahashi , Kazuosa Kuma , Tsutomu Katoh , Takeshi Fukao , Shinichi Kawahara
发明人： Kazuhisa SUDO , Mitsuru Takahashi , Kazuosa Kuma , Tsutomu Katoh , Takeshi Fukao , Shinichi Kawahara
IPC分类号： G03G15/16
CPC分类号： G03G15/0178 , G03G15/0131 , G03G15/50 , G03G2215/0132
摘要： An image forming apparatus includes first and second belt members, at least one color image carrier, a separate image carrier, a primary transfer member, a secondary transfer mechanism, a direct transfer member, a first image detector to detect positional deviation of transferred images from reference pattern images, and a controller to transfer the reference pattern images formed on the at least one color image carrier and the separate image carrier onto the first belt member or onto the second belt member, convey the reference pattern images to the first image detector, cause the first image detector to detect the reference pattern images, and adjust one or more image forming conditions of the image forming apparatus to prevent positional deviation of the transferred images from the reference pattern images based on detection results obtained by the first image detector.
摘要翻译：图像形成装置包括第一和第二带构件，至少一个彩色图像载体，分离的图像载体，一次转印构件，二次转印机构，直接转印构件，第一图像检测器，用于检测转印图像的位置偏差参考图案图像，以及控制器，将形成在所述至少一个彩色图像载体和所述分离图像载体上的参考图案图像转印到所述第一带构件上或所述第二带构件上，将所述参考图案图像传送到所述第一图像检测器，使得第一图像检测器检测参考图案图像，并且基于由第一图像检测器获得的检测结果来调整图像形成装置的一个或多个图像形成条件以防止所转印的图像与参考图案图像的位置偏差。

40. 发明授权

US07609998B2 Transfer unit and image forming apparatus 失效
标题翻译：转印单元和图像形成装置
公开(公告)号：US07609998B2
公开(公告)日：2009-10-27
申请号：US11759657
申请日：2007-06-07
申请人： Tsutomu Katoh , Mitsuru Takahashi , Kazuchika Saeki , Nobuto Yokokawa , Kazuosa Kuma , Takeshi Fukao
发明人： Tsutomu Katoh , Mitsuru Takahashi , Kazuchika Saeki , Nobuto Yokokawa , Kazuosa Kuma , Takeshi Fukao
IPC分类号： G03G15/16
CPC分类号： G03G21/168 , G03G15/1615 , G03G2215/0119 , G03G2221/1642 , G03G2221/1657 , G03G2221/1684
摘要： A transfer belt is driven by a plurality of supporting rollers. A unit frame supports the supporting rollers in a rotatable manner. At least one of the supporting rollers includes a cylindrical member having a substantially same outer diameter over an entire length thereof. Each end portion of the cylindrical member in a longitudinal direction is supported by the unit frame via a bearing in a rotatable manner.
摘要翻译：转印带由多个支撑辊驱动。单元框架以可旋转的方式支撑支撑辊。支撑辊中的至少一个包括在其整个长度上具有基本上相同的外径的圆柱形构件。圆柱形构件的纵向方向的每个端部通过轴承以可旋转的方式由单元框架支撑。

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