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31. 发明申请

US20050070164A1 Connecting structure for electric cells 失效
标题翻译：电池连接结构
公开(公告)号：US20050070164A1
公开(公告)日：2005-03-31
申请号：US10941830
申请日：2004-09-16
申请人： Yoshinori Mita , Kazuo Ando
发明人： Yoshinori Mita , Kazuo Ando
IPC分类号： H01R24/00 , H01R33/00
CPC分类号： H01M2/204
摘要： A connecting bus bar 12 is formed from a negative opposing section 27 which is smaller in thickness than a closed end of a bottomed cylinder 13, partially has a negative weld plate section 27a to be welded to the closed end of a bottomed cylinder 13, and opposes the closed end of the bottomed cylinder 13; a positive opposing section 28 which is smaller in thickness than a seal plate 14, partially has a positive weld plate section 28a to be welded to the seal plate 14, and opposes the seal plates 14; and the coupling section 29 for connecting together the negative opposing section 27 and the positive opposing section 28. The connecting bus bar 12 is formed such that the connecting bus bar 12, which excludes the negative weld plate section 27a and the positive weld plate section 28a, becomes lower in thickness than a thinner one of the closed end of the bottomed cylinder 13 and the seal plate 14.
摘要翻译：连接汇流条12由与底部圆筒13的封闭端的厚度相比较小的负相对部分27形成，部分地具有焊接到有底圆筒13的封闭端的负焊接板部分27a，与底筒13的封闭端相对; 与密封板14相比厚度小的正相对部分28部分地具有焊接到密封板14的正焊接部分28a，并与密封板14相对; 以及用于将负相对部分27和正相对部分28连接在一起的联接部分29.连接汇流条12形成为使得不包括负焊接部分27a和正焊接部分28a的连接汇流条12 厚度比底层圆筒13和密封板14的封闭端中的较薄的一个薄。

32. 发明授权

US06649636B1 Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents 失效
标题翻译：杂芳基苯基吡唑化合物作为抗炎/止痛剂
公开(公告)号：US06649636B1
公开(公告)日：2003-11-18
申请号：US09723608
申请日：2000-11-28
申请人： Kazuo Ando , Martha L. Minich , Jin Li , Subas M. Sakya , Kristin M. Lundy , Hengmiao Cheng , Brian S. Bronk , Kiyoshi Kawamura , Tomoki Kato
发明人： Kazuo Ando , Martha L. Minich , Jin Li , Subas M. Sakya , Kristin M. Lundy , Hengmiao Cheng , Brian S. Bronk , Kiyoshi Kawamura , Tomoki Kato
IPC分类号： C07D40114
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14
摘要： This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，其中A和R 1各自为任选取代的5至6元杂芳基，其中杂芳基任选地稠合于碳环或5至6个杂芳基 R 2是任选被卤素，氨基或烷基氨基取代的（C 1 -C 4）烷基; R 3和R 4各自为氢，卤素，任选被卤素取代的（C 1 -C 4）烷基等; X 1至X 4各自为氢，卤素，羟基，任选被卤素取代的（C 1 -C 4）烷基等。这些化合物具有COX-2抑制活性，因此可用于治疗或预防炎症或其他COX-2相关疾病。

33. 发明授权

US5753682A Imidazole lipoxygenase inhibitors 失效
标题翻译：咪唑脂氧合酶抑制剂
公开(公告)号：US5753682A
公开(公告)日：1998-05-19
申请号：US553546
申请日：1996-05-06
申请人： Rodney W. Stevens , Takashi Mano , Kazuo Ando
发明人： Rodney W. Stevens , Takashi Mano , Kazuo Ando
IPC分类号： A61K31/415 , A61K31/4178 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D233/54 , C07D233/60 , C07D305/04 , C07D309/02 , C07D405/10 , C07D405/12 , C07D405/14 , C07D521/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14
摘要： Certain novel imidazole derivatives having the ability to inhibit the lipoxygenase enzyme and having formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.8 alkyl, halosubstituted C.sub.1 -C.sub.4 alkyl, phenyl, substituted phenyl, C.sub.7 -C.sub.14 phenylalkyl, C.sub.7 -C.sub.14 (substituted phenyl)alkyl, pyridyl, substituted pyridyl, C.sub.6 -C.sub.13 pyridylalkyl or C.sub.6 -C.sub.13 (substituted pyridyl)alkyl, wherein each substituent is independently halo, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halosubstituted C.sub.1 -C.sub.4 alkyl, halosubstituted C.sub.1 -C.sub.4 alkoxy, NR.sup.4 R.sup.5, CO.sub.2 R.sup.4 or CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or C.sub.1 -C.sub.6 alkyl; Ar.sup.1 and Ar.sup.2 are each, independently, phenylene, mono-substituted phenylene or di-substituted phenylene, wherein the substituents are, independently, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo-substituted C.sub.1 -C.sub.4 alkyl or halo-substituted C.sub.1 -C.sub.4 alkoxy; X and X.sup.1 are each, independently, O, S, SO or SO.sub.2 ; R' is hydrogen or C.sub.1 -C.sub.4 alkyl; and R.sup.2 and R.sup.3 are each, independently, methylene, ethylene or propylene. These compounds are useful for the treatment of disease states such as bronchial asthma, skin disorders and arthritis in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译： PCT No.PCT / JP94 / 00836 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年5月25日PCT公布。第WO94 / 29299号公报日期：1994年12月22日具有抑制脂氧合酶和具有式（I）的能力的新型咪唑衍生物，其中Y为氢，C1-C8烷基，卤代C1-C4烷基，苯基，取代苯基，C7-C14苯基烷基， C7-C14（取代苯基）烷基，吡啶基，取代的吡啶基，C6-C13吡啶基烷基或C6-C13（取代的吡啶基）烷基，其中各取代基独立地为卤素，硝基，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基， C 1 -C 4烷基，卤代C 1 -C 4烷氧基，NR 4 R 5，CO 2 R 4或CONR 4 R 5，其中R 4和R 5各自独立地为氢或C 1 -C 6烷基; Ar 1和Ar 2各自独立地为亚苯基，单取代亚苯基或二取代亚苯基，其中取代基独立地为卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，卤素取代的C 1 -C 4烷基或卤素取代的 C1-C4烷氧基; X和X1各自独立地为O，S，SO或SO 2; R'是氢或C 1 -C 4烷基; 并且R 2和R 3各自独立地为亚甲基，亚乙基或亚丙基。这些化合物可用于治疗疾病状态，例如哺乳动物中的支气管哮喘，皮肤病和关节炎，以及用作治疗这些病症的药物组合物中的活性成分。

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