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31. 发明申请

US20130022604A1 ANTIBODY AGAINST SEROTYPE B LIPOPOLYSACCHARIDE OF PSEUDOMONAS AERUGINOSA 审中-公开
标题翻译：抗坏血酸乙酰胆碱酯酶抗体
公开(公告)号：US20130022604A1
公开(公告)日：2013-01-24
申请号：US13579826
申请日：2011-02-18
申请人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
发明人： Jiro Tanaka , Peter Sejer Andersen , Takafumi Okutomi , Tsuneyoshi Inaba , Keiko Otsuka , Hirotomo Akabane , Yukari Hoshina , Hiroshi Nagaso , Masashi Kumagai
IPC分类号： A61K39/40 , A61P31/04 , C12N5/16 , C07K16/12 , C12N15/13
CPC分类号： C07K16/1214 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/734 , G01N2333/21
摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.
摘要翻译：提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

32. 发明申请

US20120296005A1 MEDICAL RESIN COMPOSITION, MANUFACTURING PROCESS THEREFOR AND MEDICAL KIT 审中-公开
标题翻译：医用树脂组合物及其制造工艺及医用包装
公开(公告)号：US20120296005A1
公开(公告)日：2012-11-22
申请号：US13574216
申请日：2011-01-19
申请人： Jiro Tanaka
发明人： Jiro Tanaka
IPC分类号： C08L33/12 , C09J133/12
CPC分类号： A61L24/06 , A61L2430/02 , C08L33/12
摘要： A medical resin composition, particularly a dental resin composition is produced by mixing a polymer (A) containing 70% by weight or more of methyl methacrylate units and a liquid of a monomer (B) containing 70% by weight or more of a compound (b1) represented by formula (1): wherein R denotes a methyl group or a hydrogen atom and n is an integer of 2 to 4, in the presence of a polymerization initiator (C) to increase a viscosity. The resin composition can be suitably used in producing a denture base, a mouthpiece or a bone cement. A shaped article formed using such a resin composition exhibits excellent mechanical properties, particularly toughness. Furthermore, such a resin composition can be prepared with ease.
摘要翻译：通过将含有70重量％以上的甲基丙烯酸甲酯单元的聚合物（A）和含有70重量％以上的化合物（B）的单体（B）的液体混合来制造医用树脂组合物，特别是牙科用树脂组合物 b1），其中R表示甲基或氢原子，n表示2〜4的整数，在聚合引发剂（C）的存在下，增加粘度。树脂组合物可以适用于制造假牙基底，口罩或骨水泥。使用这种树脂组合物成型的成型制品表现出优异的机械性能，特别是韧性。此外，可以容易地制备这种树脂组合物。

33. 发明授权

US08084044B2 Pseudomonas aeruginosa outer membrane protein PA0427 失效
标题翻译：铜绿假单胞菌外膜蛋白PA0427
公开(公告)号：US08084044B2
公开(公告)日：2011-12-27
申请号：US12225821
申请日：2007-03-30
申请人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
发明人： Jiro Tanaka , Fukuichi Ohsawa , Takafumi Okutomi , Hiroshi Nagaso , Masashi Kumagai , Takahisa Suzuki , Keiko Otsuka
IPC分类号： A61K39/108
CPC分类号： C07K16/1214 , C07K14/21 , C07K2317/77
摘要： An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA0427 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.
摘要翻译：本发明的目的是提供蛋白质或肽抗原和抗体的抗体，用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。根据本发明，提供了来自绿脓假单胞菌外膜蛋白PA0427的蛋白质或肽，以及用于诊断，预防或治疗与绿脓假单胞菌相关疾病的抗体。

34. 发明申请

US20100330100A1 PSEUDOMONAS AERUGINOSA-OUTER MEMBRANE PROTEIN PA4710 审中-公开
标题翻译： PSEUDOMONAS AERUGINOSA-OTER膜蛋白PA4710
公开(公告)号：US20100330100A1
公开(公告)日：2010-12-30
申请号：US12666805
申请日：2008-06-30
申请人： Jiro Tanaka , Hiroshi Nagaso , Masashi Kumagai , Keiko Otsuka , Hirotomo Akabane , Takahisa Suzuki
发明人： Jiro Tanaka , Hiroshi Nagaso , Masashi Kumagai , Keiko Otsuka , Hirotomo Akabane , Takahisa Suzuki
IPC分类号： A61K39/40 , C07K14/21 , C07K7/08 , C07K7/06 , C07K16/12 , C07K16/00 , C12N5/16 , A61K39/104 , A61P31/04
CPC分类号： C07K16/1214 , A61K39/104 , A61K2039/505 , C07K14/21 , C12Q1/04 , G01N33/569 , G01N2333/445
摘要： An object is to provide: a protein antigen or a peptide antigen usable as a vaccine composition which has an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients with a Pseudomonas aeruginosa infection; and an antibody directed against the antigen. The present invention provides a protein antigen or a peptide antigen and an antibody directed against these, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa. According to the present invention, a protein or a peptide derived from a Pseudomonas aeruginosa-outer membrane protein PA4710, and an antibody directed against these are provided, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa.
摘要翻译：目的是提供：可用作疫苗组合物的蛋白质抗原或肽抗原，其具有实际预防或治疗绿脓假单胞菌感染的能力，并且其可以应对来自铜绿假单胞菌感染患者的临床分离物的多样性 ; 和针对抗原的抗体。本发明提供蛋白质抗原或肽抗原和针对这些的抗原的抗体，其用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。根据本发明，提供了来自绿脓假单胞菌 - 外膜蛋白PA4710的蛋白质或肽，以及针对这些蛋白质的抗体，其用于诊断，预防或治疗与铜绿假单胞菌相关的疾病。

35. 发明申请

US20100291070A1 TYPE III SECRETION SYSTEM COMPONENT PROTEIN PA1698 OF PSEUDOMONAS AERUGINOSA 审中-公开
标题翻译： PSEUDOMONAS AERUGINOSA型III型分泌系统组分蛋白PA1698
公开(公告)号：US20100291070A1
公开(公告)日：2010-11-18
申请号：US12810459
申请日：2008-12-24
申请人： Masashi Kumagai , Jiro Tanaka , Hiroshi Nagaso , Tomohisa Ninomiya , Keiko Otsuka , Hirotomo Akabane , Takahisa Suzuki
发明人： Masashi Kumagai , Jiro Tanaka , Hiroshi Nagaso , Tomohisa Ninomiya , Keiko Otsuka , Hirotomo Akabane , Takahisa Suzuki
IPC分类号： A61K39/40 , C07K16/12 , C07K16/44 , C12N5/20 , A61K39/104 , A61K39/395 , A61P31/04 , A61P37/04
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K14/21 , C07K2317/76 , G01N33/56911 , G01N2333/21
摘要： An object is to provide an antibody and a vaccine composition which have an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients infected with Pseudomonas aeruginosa. According to the present invention, an antibody against a PA1698 protein that is a type III secretion system component protein of Pseudomonas aeruginosa or against a peptide of the protein, and a vaccine composition comprising the protein or the peptide are provided.
摘要翻译：目的是提供具有实际预防或治疗铜绿假单胞菌感染能力的抗体和疫苗组合物，其可以应付源自感染铜绿假单胞菌的患者的临床分离物的多样性。根据本发明，提供了针对PA1698蛋白的抗体，其是铜绿假单胞菌的III型分泌系统组分蛋白或针对蛋白质的肽，以及包含所述蛋白质或肽的疫苗组合物。

36. 发明申请

US20100086738A1 LEATHER-LIKE SHEET BEARING GRAIN FINISH AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：用于生产其类似表面的皮革表面粗粒料及其制造方法
公开(公告)号：US20100086738A1
公开(公告)日：2010-04-08
申请号：US12593399
申请日：2008-03-28
申请人： Jiro Tanaka , Tsuyoshi Yamasaki , Yoshiyuki Ando , Norio Makiyama , Kimio Nakayama
发明人： Jiro Tanaka , Tsuyoshi Yamasaki , Yoshiyuki Ando , Norio Makiyama , Kimio Nakayama
IPC分类号： D06N3/08 , B29C67/00 , A63B41/08
CPC分类号： D06N3/0004 , D06N3/042 , D06N3/14 , Y10S428/904 , Y10T428/24438 , Y10T442/2893 , Y10T442/614 , Y10T442/621 , Y10T442/626 , Y10T442/64 , Y10T442/671
摘要： A (semi)grain-finished leather-like sheet composed of an entangled nonwoven fabric of three-dimensionally entangled fiber bundles containing microfine long fibers and an elastic polymer contained in the entangled nonwoven fabric. When dividing the (semi)grain-finished leather-like sheet to five layers with equal thickness, i.e., surface layer, substrate layer 1, substrate layer 2, substrate layer 3 and back layer in this order along the thickness direction, part of the microfine long fibers forming the surface layer and/or the back layer are fuse-bonded to each other and the microfine long fibers forming the intermediate layer are not fuse-bonded. With such a fuse-bonding state of the microfine long fibers, the (semi)grain-finished leather-like sheet combines a low compression resistance and a dense feel each comparable to natural leathers, has a sufficient practical strength, and are excellent in properties which are required according to its use.
摘要翻译：由缠绕在无纺织物中的包含微细长纤维的三维缠结纤维束的缠结非织造织物和弹性聚合物组成的（半）粒状皮革状片材。当将（半）粒状皮革样片材沿着厚度方向依次划分为相同厚度的五层，即表面层，基底层1，基底层2，基底层3和背层时，部分形成表面层和/或背层的微细长纤维彼此熔合，并且形成中间层的微细长纤维不熔合。通过这种超细长纤维的熔断状态，（半）粒状皮革样片材具有低天然皮革相当的低抗压性和致密感，具有足够的实用强度，并具有优异的性能这是根据其使用需要的。

37. 发明申请

US20090053948A1 BASE FOR SYNTHETIC LEATHER AND SYNTHETIC LEATHERS MADE BY USING THE SAME 有权
标题翻译：使用合成皮革和合成皮革的基础
公开(公告)号：US20090053948A1
公开(公告)日：2009-02-26
申请号：US12097659
申请日：2006-12-13
申请人： Michinori Fujisawa , Jiro Tanaka , Tsuyoshi Yamasaki , Norio Makiyama , Yoshiyuki Ando
发明人： Michinori Fujisawa , Jiro Tanaka , Tsuyoshi Yamasaki , Norio Makiyama , Yoshiyuki Ando
IPC分类号： B32B27/04 , D01F8/04
CPC分类号： D06N3/0004 , Y10S428/904 , Y10T442/2861 , Y10T442/614 , Y10T442/682 , Y10T442/689
摘要： A substrate for artificial leathers, comprising a nonwoven fabric body made of microfine fiber bundles and an elastic polymer impregnated therein. The substrate for artificial leathers simultaneously satisfies the following requirements 1 to 4: (1) each of the microfine fiber bundles contains 6 to 150 bundled microfine long fibers in average; (2) a cross-sectional area of the microfine long fibers constituting the microfine fiber bundles is 27 μm2 or less, and 80% or more of the microfine long fibers has a cross-sectional area of from 0.9 to 25 μm2; (3) an average cross-sectional area of the microfine fiber bundles is from 15 to 150 μm2; and (4) on a cross section parallel to a thickness direction of the nonwoven fabric body, cross sections of the microfine fiber bundles exist in a density of from 1000 to 3000/mm2 in average. The raised artificial leathers and grain-finished artificial leathers made from the substrate for artificial leathers are excellent in the properties which are hitherto difficult to be combined.
摘要翻译：一种人造革用基材，其特征在于，包括由超细纤维束构成的无纺布体和浸渍在其中的弹性聚合物。人造革用基材同时满足以下要求1〜4：（1）每个超细纤维束平均含有6〜150个捆束的超细长纤维; （2）构成超细纤维束的微细长纤维的截面积为27mum2以下，超微细长纤维的80％以上的截面积为0.9〜25mum2; （3）超细纤维束的平均截面积为15〜150μm2; 和（4）在与无纺布体的厚度方向平行的截面上，超细纤维束的截面的平均密度为1000〜3000 / mm 2。由人造革用基材制成的人造革和人造革人造皮革，迄今为止难以组合的性能优异。

38. 发明授权

US06316711B2 Musical sound signal generation apparatus 失效
标题翻译：音乐声音信号发生装置
公开(公告)号：US06316711B2
公开(公告)日：2001-11-13
申请号：US09771055
申请日：2001-01-26
申请人： Eiji Matsuda , Jiro Tanaka , Tsutomu Saito
发明人： Eiji Matsuda , Jiro Tanaka , Tsutomu Saito
IPC分类号： G01H118
CPC分类号： G10H7/02 , G10H1/186 , G10H2210/305
摘要： A musical sound signal generation apparatus for producing a sound corresponding to an operated key can produce a sound of a newly-operated key even if all the musical sound signal generation means for generating a musical sound signal are in use. On producing the new sound, the apparatus prevents the players and the audience from having a sense of incongruity derived from the change in sound production. Especially, when a chord has been produced, it can maintain the state of chord production normally.
摘要翻译：即使用于生成音乐声音信号的所有音乐声音信号产生装置都在使用时，产生与被操作的键对应的声音的音乐声音信号产生装置也可以产生新操作的键的声音。在产生新的声音时，该装置可防止玩家和观众从声音产生的变化中产生不协调的感觉。特别是在和弦生成时，可以保持和弦的正常生成状态。

39. 发明授权

US06247912B1 Powder molding device for forming spiral bevel gear 失效
标题翻译：用于形成螺旋锥齿轮的粉末成型装置
公开(公告)号：US06247912B1
公开(公告)日：2001-06-19
申请号：US09444558
申请日：1999-11-19
申请人： Mamoru Sugimoto , Jiro Tanaka
发明人： Mamoru Sugimoto , Jiro Tanaka
IPC分类号： B22F0303
CPC分类号： B22F5/085 , B21K1/30 , B22F5/08 , B22F2998/00 , B30B11/02 , B30B11/027 , Y10S425/058
摘要： A spiral bevel gear having right and left tooth flanks having such a small pitch angle that either right or left ones are not seen in plan from the apex side of cone is molded by a powder molding device so as not to interfere with a die of the device when removed from the die. The die has teeth for molding and is rotatably supported. A fixed guide mechanism for guiding the die is provided. Guide portions of the guide mechanism have a predetermined lead so that the die is rotated guided by the guide portions when the molded article is punched out of the die. Thus, the teeth formed on the molded article reliably disengage from the teeth for molding. This makes it possible to reliably punch the molded article out of the die.
摘要翻译：具有左右齿面的螺旋锥齿轮由粉末成形装置模制而成，其具有从锥体的顶点侧的平面中看不到右侧或左侧的左右齿面，从而不会干扰设备从模具中取出时。模具具有用于模制的齿并被可旋转地支撑。提供了用于引导模具的固定引导机构。引导机构的引导部分具有预定的引线，使得当模制品冲压出模具时，模具被引导部分引导。因此，形成在模制品上的齿可以与用于模制的齿可靠地脱开。这使得可以将模制品可靠地冲压出模具。

40. 发明授权

US06198035B1 Musical sound signal generation apparatus 有权
标题翻译：音乐声音信号发生装置
公开(公告)号：US06198035B1
公开(公告)日：2001-03-06
申请号：US09504647
申请日：2000-02-14
申请人： Tsutomu Saito , Jiro Tanaka
发明人： Tsutomu Saito , Jiro Tanaka
IPC分类号： G10H700
CPC分类号： G10H7/02 , G10H1/186 , G10H7/002 , G10H2210/305 , G10H2250/621
摘要： There is disclosed a musical sound signal generation apparatus for creating vacant channels by monaural sounding, in which a left/right balance is maintained and the total sound volume can be increased. When there is a key-on, and there is no vacant channel, a pair of channels for stereo sounding are selected, one channel of the pair of channels is released at a high rate, the panning coefficient of the other channel is changed, and a monaural sound is outputted from left and right output systems. Similarly, another pair of channels are selected, one channel of the pair of channels is released at the high rate, the panning coefficient of the other channel is changed, and the monaural sound is outputted from the left and right output systems. The L and R channels of the new key-on are assigned to two vacant channels.
摘要翻译：公开了一种用于通过单声道声音创建空闲频道的音乐声音信号产生装置，其中保持左/右平衡并且可以增加总音量。当存在按键，并且没有空闲频道时，选择用于立体声的一对声道，一对通道的一个通道以高速率释放，另一个通道的摇摄系数改变，从左右输出系统输出单声道声音。类似地，选择另一对通道，一对通道的一个通道以高速率被释放，另一个通道的摇摄系数改变，并且从左右输出系统输出单声道声音。新密钥的L和R信道被分配给两个空闲信道。

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