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    • 32. 发明授权
    • Method for assaying endotoxin in serum or plasma using limulus
amoebocyte lysate
    • 使用鲎变形细胞裂解液测定血清或血浆中的内毒素的方法
    • US5378610A
    • 1995-01-03
    • US859398
    • 1992-05-28
    • Shigenori TanakaHiroshi Tamura
    • Shigenori TanakaHiroshi Tamura
    • G01N33/579C12Q1/34C12Q1/00C12Q1/02
    • G01N33/579
    • The present invention has been made in order to solve the problems in conventional methods of assaying an endotoxin in a specimen such as plasma or serum by the limulus test, which requires a complicated pretreatment procedure such as centrifugation for removing denatured precipitates formed with an acid treatment. According to the assay method of the present invention, an endotoxin adsorbed by proteins, lipids and platelets can be efficiently liberated simply by adding a mixed aqueous solution having a specific composition according to the present invention without any separation procedure and thus a sample solution of good qualities can be prepared. After adding the mixed aqueous solution containing a specific surfactant, a compound having an imidazolyl group or an amino group and an alkaline earth metal salt and an alkaline metal hydroxide to the specimen, followed by addition of the limulus amoebocyte lysate components, the endotoxin can be easily, quickly and precisely assayed. In particular, gram-negative bacterial septicemia, which can be hardly diagnosed, can be quickly assayed thereby.
    • PCT No.PCT / JP91 / 01309 Sec。 371日期:1992年5月28日 102(e)日期1992年5月28日PCT 1991年9月27日PCT公布。 出版物WO92 / 06382 日期为1992年4月16日。本发明是为了解决通过鲎试验来测定血浆或血清等标本中的内毒素的常规方法中的问题,需要复杂的预处理步骤,例如离心分离 用酸处理形成变性沉淀。 根据本发明的测定方法,可以简单地通过添加根据本发明的具有特定组成的混合水溶液而无需任何分离程序,有效地释放被蛋白质,脂质和血小板吸附的内毒素,因此,可以有良好的样品溶液 品质可以做好准备。 将含有特定表面活性剂的混合水溶液,具有咪唑基或氨基的化合物和碱土金属盐和碱金属氢氧化物加入到样品中,然后加入鲎变形细胞裂解物组分,内毒素可以是 容易,快速和准确地测定。 特别地,可以快速测定可以很难诊断的革兰氏阴性细菌性败血症。
    • 35. 发明授权
    • Backlight unit and liquid crystal display device
    • 背光单元和液晶显示装置
    • US08891040B2
    • 2014-11-18
    • US13642893
    • 2011-02-23
    • Yoshinobu HirayamaShigenori TanakaRyoh Araki
    • Yoshinobu HirayamaShigenori TanakaRyoh Araki
    • G02F1/1335F21S2/00
    • F21S2/00G02B6/0045G02F1/133605
    • A liquid crystal display device (100) of the present invention includes an edge light type backlight unit (10) and a liquid crystal panel (20). The backlight unit (10) includes a light guide plate (2) and a light source (1) that emits light to a light entrance end surface (2a) of the light guide plate (2). An opposite end surface (2b), of the light guide plate (2), which is opposite to the light entrance end surface (2a), is shaped to have one or more triangular shape(s) or one or more rounded shape(s) in a cross section both in a thickness direction of the light guide plate (2) and in a peak luminance direction of light from the light source (1). Light parallel to the peak luminance direction, which light is from the light source (1), is suitably reflected without being scattered by an inclined surface of the opposite end surface (2b).
    • 本发明的液晶显示装置(100)包括边缘光型背光单元(10)和液晶面板(20)。 背光单元(10)包括向导光板(2)的光入射端面(2a)发光的导光板(2)和光源(1)。 导光板(2)的与光入射端面(2a)相对的相对端面(2b)成形为具有一个或多个三角形形状或一个或多个圆形(s) )在导光板(2)的厚度方向和来自光源(1)的光的峰值亮度方向的截面中。 平行于来自光源(1)的光的峰值亮度方向的光被适当地反射而不被相对端面(2b)的倾斜表面散射。
    • 37. 发明申请
    • SURFACE LIGHT SOURCE DEVICE AND LIQUID CRYSTAL DISPLAY DEVICE EQUIPPED WITH SAME
    • 表面光源装置和液晶显示装置
    • US20120300154A1
    • 2012-11-29
    • US13576499
    • 2010-11-16
    • Shigenori Tanaka
    • Shigenori Tanaka
    • G02F1/13357F21V8/00
    • G02B6/0055
    • The surface light source device (1) includes a light guide plate (2), a resin frame (3), an optical frame (4), a reflecting film (5), and a light source (not illustrated). The light guide plate (2) and the optical frame (4) are provided within the resin frame (3) on the reflecting film (5). At least part, of at least a side surface of the resin frame (3) which faces a side surface of the light guide plate (2), is (i) a inclined surface which is inclined with respect to a direction perpendicular to a light exit surface or (ii) a curved surface which is curved with respect to a direction perpendicular to the light exit surface. Further, the inclined surface or the curved surface looks towards the light exit surface. The light, which has leaked out of the side surface of the light guide plate (2), is reflected from the inclined surface or the curved surface of the resin frame (3) so as to be directed towards a liquid crystal panel. This allows the light, which has leaked out of the side surface of the light guide plate (2), to be reflected towards the liquid crystal panel.
    • 表面光源装置(1)包括导光板(2),树脂框架(3),光学框架(4),反射膜(5)和光源(未示出)。 导光板(2)和光学框架(4)设置在反射膜(5)上的树脂框架(3)内。 树脂框架(3)的与导光板(2)的侧表面相对的至少一个侧表面的至少一部分是(i)相对于垂直于光的方向倾斜的倾斜表面 出口表面或(ii)相对于垂直于光出射表面的方向弯曲的曲面。 此外,倾斜表面或弯曲表面朝向光出射表面。 从导光板(2)的侧面漏出的光从树脂框架(3)的倾斜面或曲面反射,朝向液晶面板。 这允许从导光板(2)的侧表面泄漏的光朝向液晶面板反射。
    • 40. 发明申请
    • Method of measuring lipoarabinomannan and application thereof
    • 测量脂多巴胺甘露聚糖的方法及其应用
    • US20070154979A1
    • 2007-07-05
    • US10584071
    • 2004-12-22
    • Shigenori TanakaShoji Takahashi
    • Shigenori TanakaShoji Takahashi
    • C12Q1/04
    • G01N33/579G01N33/56911G01N2400/50
    • A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample, a method for removing reactivity of LAM with a Limulus reagent, which comprises at least a step of allowing a predetermined substance to coexist with a LAM-containing sample; a method for measuring Et in a LAM-containing sample and a method for detecting an Et-related disease, which each is a method for measuring an endotoxin using a Limulus reagent, which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the above-described removing method; a method for measuring BG in a LAM-containing sample and a method for detecting mycosis, which is a method for measuring BG using a Limulus reagent which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the described-described removing method; and the like.
    • 一种用于测量LAM的方法和一种用于检测耐酸细菌的方法,其包括使鲎试剂与含LAM的样品接触的步骤,用于除去LAM与鲎试剂的反应性的方法,所述方法包括 至少一个允许预定物质与含LAM的样品共存的步骤; 用于测量含LAM的样品中的Et的方法和用于检测Et相关疾病的方法,其各自是使用鲎试剂测量内毒素的方法,该方法至少包括除去LAM与鲎的反应性的步骤 试剂通过上述去除方法; 用于测量含有LAM的样品中的BG的方法和用于检测真菌病的方法,其是使用鲎试剂测量BG的方法,所述方法至少包括通过所述除去的方法除去LAM与鲎试剂的反应性的步骤 方法; 等等。