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31. 发明授权

US08828740B2 Rapid and sensitive biosensing 有权
标题翻译：快速敏感的生物传感
公开(公告)号：US08828740B2
公开(公告)日：2014-09-09
申请号：US11814826
申请日：2006-01-30
申请人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
发明人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
IPC分类号： G01N33/553 , G01N27/74 , G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and includes at least one sensor element (23) for detecting the presence of magnetic particles (13), an element or elements for attracting magnetic structures having at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and an element or elements for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译：用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并且包括用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引具有至少一个磁性颗粒（13）的磁性结构朝向和传递到传感器装置（15）的结合表面（40）上，以及用于重新排列和随机化各个磁性颗粒（13）的位置的元件或元件，相对于结合表面（40）上的结合位点以在所有单个颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。利用这种传感器装置（15），提高了流体中目标分子的检测速度。

32. 发明授权

US08689606B2 Gas sensing using ultrasound 有权
标题翻译：气体传感使用超声波
公开(公告)号：US08689606B2
公开(公告)日：2014-04-08
申请号：US13203987
申请日：2010-03-10
申请人： Martijn Schellekens , Josephus Arnoldus Henricus Maria Kahlman , Martinus Gernardus Van Der Mark , Peter Dirksen
发明人： Martijn Schellekens , Josephus Arnoldus Henricus Maria Kahlman , Martinus Gernardus Van Der Mark , Peter Dirksen
IPC分类号： G01N29/02
CPC分类号： G01N33/497 , G01N29/2406 , G01N29/348 , G01N33/004 , G01N2291/0215 , G01N2291/02809
摘要： A sensor chip (1030) for gas has cells (200) for emitting and receiving ultrasound and is configured for a sufficiently large frequency range and for measuring concentration of at least one of the gas components based on at least two responses within the range. The frequency range can be achieved by varying the size of cell membranes (230), varying bias voltages, and/or varying air pressure for an array (205) of cMUTs or MEMS microphones. The sensor chip can be applied in, for example, capnography. A measurement air chamber (515) is implemented in the respiratory pathway (400), and it and/or the pathway may be designed to reduce turbulence in the exhaled breath (120) subject to ultrasound interrogation. The chip (1030) can be implemented as self-contained in the monitoring of parameters, obviating the need for off-chip sensors.
摘要翻译：用于气体的传感器芯片（1030）具有用于发射和接收超声波的电池（200），并且被配置为足够大的频率范围，并且用于基于该范围内的至少两个响应来测量至少一个气体成分的浓度。频率范围可以通过改变cMUT或MEMS麦克风的阵列（205）的细胞膜（230）的尺寸，改变的偏置电压和/或变化的空气压力来实现。传感器芯片可以应用于例如二氧化碳图谱中。在呼吸路径（400）中实施测量空气室（515），并且其和/或路径可被设计成减少经过超声询问的呼出呼吸（120）中的湍流。芯片（1030）可以被实现为独立于监视参数，从而避免了片外传感器的需要。

33. 发明授权

US08486689B2 Microelectronic sensor device for the detection of target particles 有权
标题翻译：用于检测目标颗粒的微电子传感器装置
公开(公告)号：US08486689B2
公开(公告)日：2013-07-16
申请号：US12747529
申请日：2008-10-31
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen , Josephus Arnoldus Henricus Maria Kahlman , Menno Willem Jose Prins
IPC分类号： C12M1/00
CPC分类号： G01N21/1717 , G01N21/552 , G01N21/648 , G01N2021/1721 , G01N2021/1727 , G01N2201/0691
摘要： The invention relates to a microelectronic sensor device for the examination of target particles (1) that are bound to binding sites (3) at the binding surface (12) of a carrier (11). In a preferred embodiment, an input light beam (L1) is transmitted into the carrier (11), where a frustrated total internal reflection (FTIR) takes place at the binding surface (12). The amount of light in a resulting output light beam (L2) is detected by a light detector (31) and provides information about the presence of target particles at the binding surface. Moreover, an actuation unit (50) induces movements of the bound target particles (1) by an interaction with a magnetic field (B) or an electric field, particularly with a given modulation frequency (COIn), such that by a demodulation of the detector signal (S) effects of the target particles can be distinguished from background.
摘要翻译：本发明涉及一种用于检查在载体（11）的结合表面（12）处结合到结合位点（3）的靶颗粒（1）的微电子传感器装置。在优选实施例中，输入光束（L1）被传输到载体（11）中，其中在结合表面（12）处发生挫败的全内反射（FTIR）。通过光检测器（31）检测所得到的输出光束（L2）中的光量，并提供关于在结合表面处存在目标颗粒的信息。此外，致动单元（50）通过与磁场（B）或电场的相互作用（特别是给定的调制频率（COIn））的相互作用来诱导结合的目标颗粒（1）的运动，使得通过解调目标颗粒的检测器信号（S）效应可以与背景区分开。

34. 发明申请

US20120262565A1 SENSOR DEVICE WITH IMAGING OPTICS 有权
标题翻译：具有成像光学的传感器设备
公开(公告)号：US20120262565A1
公开(公告)日：2012-10-18
申请号：US13498347
申请日：2010-09-27
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： H04N7/18
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP) onto an image sensor (53). In order to increase the spatial resolution of the microscope(50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateral displacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的颗粒（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将结合颗粒（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可相对于图像传感器（53）移动载体（11）的位移单元（60,70,80）。因此，可以高精度地确定结合粒子（MP）与结合面（12）的距离和/或其与力的反应的横向位移。这允许通过来自非特异性直接结合的较小靶颗粒来区分与结合表面（12）结合的大磁性颗粒（MP）的特异性结合。

35. 发明申请

US20120203126A1 METHOD AND APPARATUS FOR MEASURING THE CONCENTRATION OF A GAS IN EXHALED AIR 有权
标题翻译：用于测量排气中气体浓度的方法和装置
公开(公告)号：US20120203126A1
公开(公告)日：2012-08-09
申请号：US13500922
申请日：2010-10-18
申请人： Josephus Arnoldus Henricus Maria Kahlman , Teunis Johannes Vink
发明人： Josephus Arnoldus Henricus Maria Kahlman , Teunis Johannes Vink
IPC分类号： A61B5/08
CPC分类号： A61B5/082 , A61B5/097 , A61B5/412 , A61B2562/028 , G01N33/497
摘要： There is provided an apparatus for monitoring the respiration of a subject, the apparatus comprising a sensor for measuring the concentration of a specified gas in air exhaled by the subject and a processor configured to provide an output indicating the concentration of the specified gas in a selected portion of the exhaled air, the selected portion of the exhaled air corresponding to air from a specific part of the respiratory system of the subject.
摘要翻译：提供了一种用于监测对象的呼吸的装置，该装置包括用于测量由被摄体呼出的空气中的特定气体的浓度的传感器，以及处理器，其被配置为提供指示所选择的特定气体的浓度的输出呼出空气的一部分，呼出空气的选定部分对应于来自受试者的呼吸系统的特定部分的空气。

36. 发明申请

US20120197610A1 ANALYZING TOOL FOR AMPLIFICATION REACTIONS 有权
标题翻译：分析反应分析工具
公开(公告)号：US20120197610A1
公开(公告)日：2012-08-02
申请号：US13500431
申请日：2010-10-14
申请人： Josephus Arnoldus Henricus Maria Kahlman , Tamara Mathea Elisabeth Nijsen , Bin Yin
发明人： Josephus Arnoldus Henricus Maria Kahlman , Tamara Mathea Elisabeth Nijsen , Bin Yin
IPC分类号： G06F19/12 , G06F17/10 , G06G7/48
CPC分类号： G06F19/24
摘要： The invention relates to a method and apparatus for obtaining information from an amplification curve of a target nucleic acid sequence or sequences by defining at least one model function that describes the amplification curve and that contains at least one parameter that is related to a physical quantity that influences the signals recorded, fitting said model function to the amplification curve, and obtaining information with respect to said physical quantity by identifying the value of said parameter that results in the best fit of the model function.
摘要翻译：本发明涉及一种通过定义描述扩增曲线的至少一个模型函数并且包含与物理量相关的至少一个参数来从靶核酸序列或序列的扩增曲线获得信息的方法和装置，影响记录的信号，将所述模型函数拟合到放大曲线，并通过识别导致模型函数的最佳拟合的所述参数的值来获得关于所述物理量的信息。

37. 发明授权

US08059514B2 Optical disc comprising a watermark and a method and recorder for recording such a disc 失效
标题翻译：包括水印的光盘和用于记录这种盘的方法和记录器
公开(公告)号：US08059514B2
公开(公告)日：2011-11-15
申请号：US12674446
申请日：2008-08-22
申请人： Jacobus Maarten Den Hollander , Josephus Arnoldus Henricus Maria Kahlman
发明人： Jacobus Maarten Den Hollander , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G11B7/00
CPC分类号： G11B20/00086 , G11B7/24094 , G11B20/00579 , G11B20/00884 , G11B20/1426 , G11B23/284 , G11B23/36 , G11B23/40 , G11B2020/1453 , G11B2020/1457 , G11B2220/2541
摘要： A visible pattern is obtained by modulating the digital sum value. Because the digital sum value modulation allows the choice of several different channel bits groups between DC control points, the selection of a group of channel bits resulting in a change of reflection. This creation of a visible pattern is highly suitable for Blueray as the parity preserving property of the channel code guarantees disparity inversion by the DC-control bit, which keeps the DSV excursions between hard limits. As a result only small DSV deliberate variations are required to produce a grating, which will not deteriorate the bit-detection margin of the optical disc.
摘要翻译：通过调制数字和值获得可视图案。由于数字和值调制允许在DC控制点之间选择几个不同的信道位组，所以选择一组通道位导致反射变化。这种可见图案的创建非常适合于Blueray，因为通道代码的奇偶校验保留属性保证DC控制位的视差反转，这保持DSV在硬限制之间的偏移。因此，仅需要小的DSV有意的变化来产生光栅，这不会劣化光盘的位检测余量。

38. 发明授权

US07990837B2 Optical disc comprising a watermark and a method and recorder for recording such a disc 失效
标题翻译：包括水印的光盘和用于记录这种盘的方法和记录器
公开(公告)号：US07990837B2
公开(公告)日：2011-08-02
申请号：US12519538
申请日：2007-12-14
申请人： Josephus Arnoldus Henricus Maria Kahlman , Jacobus Maarten Den Hollander
发明人： Josephus Arnoldus Henricus Maria Kahlman , Jacobus Maarten Den Hollander
IPC分类号： G11B7/24
CPC分类号： G11B20/00086 , G11B7/24094 , G11B20/0013 , G11B20/00173 , G11B20/00579 , G11B20/00884 , G11B20/14 , G11B23/281 , G11B23/40 , G11B2220/2541
摘要： A visible pattern is obtained by modulating the digital sum value. Because the digital sum value modulation allows the choice of several different channel bits groups between DC control points, the selection of a group of channel bits resulting in a change of reflection. This creation of a visible pattern is highly suitable for Blueray as the parity preserving property of the channel code guarantees disparity inversion by the DC-control bit, which keeps the DSV excursions between hard limits. As a result only small DSV deliberate variations are required to produce a visual watermark, which will not deteriorate the bit-detection margin of the optical disc.
摘要翻译：通过调制数字和值获得可视图案。由于数字和值调制允许在DC控制点之间选择几个不同的信道位组，所以选择一组通道位导致反射变化。这种可见图案的创建非常适合于Blueray，因为通道代码的奇偶校验保留属性保证DC控制位的视差反转，这保持DSV在硬限制之间的偏移。因此，仅需要小的DSV有意的变化来产生视觉水印，这不会使光盘的位检测边缘劣化。

39. 发明申请

US20110057651A1 OXYGEN CONCENTRATION MEASUREMENT WITH GMR 有权
标题翻译：氧气浓度测量与GMR
公开(公告)号：US20110057651A1
公开(公告)日：2011-03-10
申请号：US12990986
申请日：2009-05-04
申请人： Haris Duric , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen
发明人： Haris Duric , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Veen
IPC分类号： G01R33/02
CPC分类号： G01N27/74 , G01R33/091
摘要： In an embodiment, an oxygen sensor comprises a giant magnetoresistance device (10), and a magnetic field generator (14, 14a, 14b) arranged to generate a magnetic field (12, 12a, 12b) overlapping the giant magnetoresistance device and an examination region (20). A component (Bx) of the magnetic field detected by the giant magnetoresistance device is dependent upon an oxygen concentration in the examination region. In an embodiment, a chip (40) includes one or more electrically conductive traces (14a, 14b) disposed on or in the chip and a giant magnetoresistance device (10) disposed on or in the chip such that electrical current flowing in the trace or traces generates a magnetic field (12a, 12b) that overlaps the magnetic field sensor, said magnetic field being perturbed (Bx) by ambient oxygen (24) such that a signal output by the magnetic field sensor indicates ambient oxygen concentration.
摘要翻译：在一个实施例中，氧传感器包括巨磁电阻装置（10）和布置成产生与巨磁电阻装置重叠的磁场（12,12a，12b）的磁场发生器（14,14a，14b）和检查区（20）。由巨磁电阻装置检测的磁场的分量（Bx）取决于检查区域中的氧浓度。在一个实施例中，芯片（40）包括设置在芯片上或芯片中的一个或多个导电迹线（14a，14b）和设置在芯片上或芯片上的巨磁电阻器件（10），使得流过迹线或轨迹产生与磁场传感器重叠的磁场（12a，12b），所述磁场被环境氧（24）扰动（Bx），使得由磁场传感器输出的信号表示环境氧浓度。

40. 发明申请

US20110007178A1 CORRECTION OF SPOT AREA IN MEASURING BRIGHTNESS OF SAMPLE IN BIOSENSING DEVICE 审中-公开
标题翻译：校正装置中样品亮度测量点
公开(公告)号：US20110007178A1
公开(公告)日：2011-01-13
申请号：US12919513
申请日：2009-03-05
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H04N5/228
CPC分类号： G06T7/0012 , G01N21/6456 , G01N2021/1765 , G06T7/12 , G06T2207/10016 , G06T2207/10056 , G06T2207/30072
摘要： A biosensing device for sensing brightness of a bio sample from frames of a video signal, has circuitry (40) arranged to receive the video signal and determine a brightness of a given area (110) of one or more of the frames in real time. A controller (50) adjusts boundaries of the given area, and uses the measures of brightness for different boundaries, to determine location of edges of the sample, then sets the boundaries according to the edges for subsequent measurements of brightness. By determining the brightness in real time, the given area can be adjusted in real time. By adjusting the given area based on real time assessments of brightness, various common errors or tolerances in sample shapes and locations can be compensated without the need for the software to carry out operations at pixel rates.
摘要翻译：一种用于从视频信号的帧中感测生物样本的亮度的生物传感装置，具有布置成接收视频信号并实时确定一个或多个帧的给定区域（110）的亮度的电路（40）。控制器（50）调整给定区域的边界，并且使用不同边界的亮度测量来确定样本边缘的位置，然后根据边缘设置边界用于随后的亮度测量。通过实时确定亮度，可以实时调整给定的面积。通过基于亮度的实时评估来调整给定面积，可以补偿样本形状和位置中的各种常见误差或公差，而不需要软件以像素速率执行操作。

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