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31. 发明申请

US20080014613A1 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US20080014613A1
公开(公告)日：2008-01-17
申请号：US11800288
申请日：2007-05-04
申请人： Magnus Hook , Slawomir Lukomski , Yi Xu
发明人： Magnus Hook , Slawomir Lukomski , Yi Xu
IPC分类号： C12P21/00 , C07K14/78 , C07K16/12 , C12N1/00 , G01N33/00 , C12N1/21 , C12N15/63
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

32. 发明申请

US20070053925A1 Staphylococcus aureus efb protein and c3 binding region which inhibit complement activation 审中-公开
标题翻译：金黄色葡萄球菌efb蛋白和抑制补体活化的c3结合区
公开(公告)号：US20070053925A1
公开(公告)日：2007-03-08
申请号：US10553225
申请日：2004-04-16
申请人： Eric Brown , Lawrence Lee , Magnus Hook
发明人： Eric Brown , Lawrence Lee , Magnus Hook
IPC分类号： A61K39/02 , G01N33/554 , C07K14/31 , C07K16/12
CPC分类号： C07K14/31 , A61K39/00 , A61K2039/505 , G01N33/564 , G01N33/56938
摘要： The Efb protein from Staphylococcus aureus has now been shown to have the ability to bind to the C3 protein which is a crucial component in the activation of complement, and a specific C3 binding region has been located at the C-terminal end of the Efb protein. Isolated proteins and protein fragments containing the Efb protein C3 binding region are thus provided which have complement inhibiting activity, and these proteins and fragments are particularly useful in therapeutic methods wherein the inhibition of complement is desirable, such as in the treatment of hemolytic anemia, the prevention of graft or implant rejection, and to alleviate complement activation that is associated with kidney dialysis methods such as hemodialysis.
摘要翻译：来自金黄色葡萄球菌的Efb蛋白质已被证明具有结合C3蛋白的能力，C3蛋白是补体活化中的关键成分，特异性C3结合区位于Efb蛋白的C末端。因此提供了含有Efb蛋白C 3结合区的分离的蛋白质和蛋白质片段，其具有补体抑制活性，并且这些蛋白质和片段特别可用于其中需要补体抑制的治疗方法，例如在溶血性贫血的治疗中，预防移植物或植入物排斥，以及减轻与肾透析方法如血液透析相关的补体活化。

33. 发明申请

US20060035336A1 Prokaryotic collagen-like proteins and uses thereof 有权
公开(公告)号：US20060035336A1
公开(公告)日：2006-02-16
申请号：US11245689
申请日：2005-10-07
申请人： Magnus Hook , Slawomir Lukomski , Yi Xu
发明人： Magnus Hook , Slawomir Lukomski , Yi Xu
IPC分类号： C07H21/04 , C12P21/06 , C12N1/21
CPC分类号： C07H21/04 , C07K14/315 , C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

34. 发明授权

US06692739B1 Staphylococcal immunotherapeutics via donor selection and donor stimulation 有权
标题翻译：葡萄球菌免疫治疗通过供体选择和供体刺激
公开(公告)号：US06692739B1
公开(公告)日：2004-02-17
申请号：US09386960
申请日：1999-08-31
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39395
CPC分类号： A61K9/0019 , A61K39/00 , A61K2039/505 , C07K16/1271 , C07K2317/20 , C07K2317/76
摘要： A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host. In either case, the donor plasma pool is preferably purified and concentrated prior to intravenous introduction into the patient, and the present invention is advantageous in that a patient can be immunized against a wide variety of potentially dangerous staphylococcal infections. Kits for identifying potential donor with high titers of the selected adhesins are also provided. The present invention thus provides methods and compositions which can be highly effective against infections associated with Staphylococcus bacteria.
摘要翻译：提供了感染或易感染葡萄球菌如金黄色葡萄球菌和表皮葡萄球菌感染的患者的被动免疫的方法和组合物，其包括选择或制备具有高抗体滴度的供体血浆池以精心选择的葡萄球菌粘附素或MSCRAMM，或其片段或组分，或与其基本上同源的序列。供体血浆池可以通过将具有高于正常滴度的抗体的单个血液或血液成分样品与一种或多种所选择的粘附素或与细胞外基质蛋白结合的其它蛋白质组合，或通过将仔细选择的蛋白质或肽给予诱导所需抗体表达的宿主，随后从被处理的宿主中回收增强的高效价血清或血浆池。在任一情况下，供体血浆池优选在静脉内引入患者体内之前进行纯化和浓缩，本发明的优点在于可以免疫多种潜在危险的葡萄球菌感染。还提供了用于鉴定具有高滴度选择的粘附素的潜在供体的试剂盒。因此，本发明提供了可以高效地抵抗与葡萄球菌细菌相关的感染的方法和组合物。

35. 发明授权

US6086895A Fibronectin binding protein 失效
标题翻译：纤连蛋白结合蛋白
公开(公告)号：US6086895A
公开(公告)日：2000-07-11
申请号：US904179
申请日：1997-08-01
申请人： Magnus Hook , Kjell Martin Lindberg , Per-Eric Lindgren , Lars Christer Signas
发明人： Magnus Hook , Kjell Martin Lindberg , Per-Eric Lindgren , Lars Christer Signas
IPC分类号： C12N15/09 , A61K38/00 , A61K39/09 , A61P31/04 , C07K7/08 , C07K14/00 , C07K14/195 , C07K14/315 , C12N1/21 , C12N7/00 , C12N15/00 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/44 , C12R1/46 , A61K39/085 , C07K17/00
CPC分类号： C07K14/315 , A61K38/00
摘要： The present invention relates to new recombinant DNA-molecules comprising nucleotide sequences of S. dygalactiae encoding for at least one protein or polypeptide having fibronectin binding property.
摘要翻译：本发明涉及包含编码至少一种具有纤连蛋白结合性质的蛋白质或多肽的乳酸半乳糖苷的核苷酸序列的新的重组DNA分子。

36. 发明授权

US5840846A Fibronectin binding protein as well as its preparation 失效
标题翻译：纤连蛋白结合蛋白及其制备
公开(公告)号：US5840846A
公开(公告)日：1998-11-24
申请号：US725492
申请日：1996-10-04
申请人： Magnus Hook , Klas Jonsson , Kjell Martin Lindberg , Christer Signas
发明人： Magnus Hook , Klas Jonsson , Kjell Martin Lindberg , Christer Signas
IPC分类号： C12P21/02 , A61K38/00 , A61K39/00 , A61K39/385 , A61P17/00 , A61P43/00 , C07K1/22 , C07K14/195 , C07K14/31 , C07K14/41 , C07K14/705 , C12N1/21 , C12N15/09 , C12N15/31 , C12R1/19 , C12R1/445 , C07K14/00
CPC分类号： C07K14/31 , C07K14/70546 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.
摘要翻译：本发明涉及包含编码具有纤连蛋白结合特性的蛋白质或多肽的来自金黄色葡萄球菌的核苷酸序列的新的重组杂交DNA分子。

37. 发明授权

US5789549A Fibronectin binding protein 失效
标题翻译：纤连蛋白结合蛋白
公开(公告)号：US5789549A
公开(公告)日：1998-08-04
申请号：US729766
申请日：1996-10-07
申请人： Magnus Hook , Kjell Martin Lindberg , Per-Eric Lindgren , Lars Christer Signas
发明人： Magnus Hook , Kjell Martin Lindberg , Per-Eric Lindgren , Lars Christer Signas
IPC分类号： A61K38/00 , A61P31/04 , C07K14/315 , C12N15/31 , C07K5/00 , C07H21/04 , C07K14/00 , C12N15/11
CPC分类号： C07K14/315 , A61K38/00 , Y10S530/825
摘要： The present invention relates to new recombinant DNA-molecules comprising nucleotide sequences of S. dysgalactiae encoding for at least one protein or polypeptide having fibronectin binding property.
摘要翻译：本发明涉及包含编码至少一种具有纤连蛋白结合性质的蛋白质或多肽的白念珠菌的核苷酸序列的新的重组DNA分子。

38. 发明授权

US5416021A Fibronectin binding protein-encoding DNA 失效
标题翻译：纤连蛋白结合蛋白编码DNA
公开(公告)号：US5416021A
公开(公告)日：1995-05-16
申请号：US125222
申请日：1993-09-23
申请人： Magnus Hook , Kjell M. Lindberg , Per-Eric Lindgren , Lars C. Signas
发明人： Magnus Hook , Kjell M. Lindberg , Per-Eric Lindgren , Lars C. Signas
IPC分类号： C12N15/09 , A61K38/00 , A61K39/09 , A61P31/04 , C07K7/08 , C07K14/00 , C07K14/195 , C07K14/315 , C12N1/21 , C12N7/00 , C12N15/00 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/44 , C12R1/46 , C07H21/04 , C12N15/70
CPC分类号： C07K14/315 , A61K38/00
摘要： The present invention relates to new recombinant DNA-molecules comprising nucleotide sequences of S. dysgalactiae encoding for at least one protein or polypeptide having fibronectin binding property.
摘要翻译：本发明涉及包含编码至少一种具有纤连蛋白结合性质的蛋白质或多肽的白念珠菌的核苷酸序列的新的重组DNA分子。

39. 发明授权

US5320951A Fibronectin binding protein as well as its preparation 失效
标题翻译：纤连蛋白结合蛋白及其制备
公开(公告)号：US5320951A
公开(公告)日：1994-06-14
申请号：US7817
申请日：1993-01-22
申请人： Magnus Hook , Martin K. Lindberg , Lars C. Signas , Torkel M. Wadstrom , Gunnar Froman
发明人： Magnus Hook , Martin K. Lindberg , Lars C. Signas , Torkel M. Wadstrom , Gunnar Froman
IPC分类号： C07K14/31 , C12N1/21 , C12N15/31 , C07K7/00 , C07K13/00
CPC分类号： C07K14/31
摘要： The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.
摘要翻译：本发明涉及包含编码具有纤连蛋白结合特性的蛋白质或多肽的来自金黄色葡萄球菌的核苷酸序列的新的重组杂交DNA分子。

40. 发明授权

US08618250B2 Designer collagens and use thereof 有权
标题翻译：设计者胶原和使用
公开(公告)号：US08618250B2
公开(公告)日：2013-12-31
申请号：US12804306
申请日：2010-07-19
申请人： Brooke H. Russell , Magnus Hook , Mariah S. Hahn , Elizabeth M. Cosgriff-Hernandez , Neungseon Seo , Marvin Xuejun Xu
发明人： Brooke H. Russell , Magnus Hook , Mariah S. Hahn , Elizabeth M. Cosgriff-Hernandez , Neungseon Seo , Marvin Xuejun Xu
IPC分类号： C07K14/00
CPC分类号： C07K14/78
摘要： The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one ‘inserted’ biologically active sequence(s).
摘要翻译：本发明鉴定了含有在原核表达系统中产生的三螺旋骨架蛋白的重组合成胶原蛋白，其中蛋白质含有至少一个“插入”生物活性序列。

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