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31. 发明授权

US07920670B2 Keyhole computed tomography 有权
标题翻译：钥匙孔计算机断层扫描
公开(公告)号：US07920670B2
公开(公告)日：2011-04-05
申请号：US12412160
申请日：2009-03-26
申请人： James William Hugg , Ravindra Mohan Manjeshwar
发明人： James William Hugg , Ravindra Mohan Manjeshwar
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/469 , A61B6/488 , G06T11/006 , G06T2211/412 , G06T2211/424
摘要： A method of acquiring and reconstructing a computed tomography (CT) image is provided. A first scan of the full field of view (FOV) is acquired. A second scan of a smaller target FOV is then acquired by using a collimator to narrow the X-ray beam width. The CT image is iteratively reconstructed by replacing a key-hole region of the full FOV projection data with the target FOV projection data. An exemplary embodiment comprises imaging a heart (target FOV) within a torso (full FOV) over multiple heart beat cycles. A computer readable medium is further provided, including a program configured to reconstruct a CT image using the key-hole method.
摘要翻译：提供了一种获取和重建计算机断层摄影（CT）图像的方法。获取全视野（FOV）的第一次扫描。然后通过使用准直器来获取较小目标FOV的第二次扫描以使X射线束宽度变窄。通过用目标FOV投影数据替换全FOV投影数据的键孔区域来迭代地重建CT图像。示例性实施例包括在多个心跳周期内在躯干（全FOV）内成像心脏（目标FOV）。还提供了一种计算机可读介质，其包括被配置为使用所述键孔方法重建CT图像的程序。

32. 发明授权

US07756310B2 System and method for segmentation 有权
标题翻译：用于分割的系统和方法
公开(公告)号：US07756310B2
公开(公告)日：2010-07-13
申请号：US11531882
申请日：2006-09-14
申请人： Ravindra Mohan Manjeshwar , James Vradenburg Miller , Thomas Baby Sebastian
发明人： Ravindra Mohan Manjeshwar , James Vradenburg Miller , Thomas Baby Sebastian
IPC分类号： G06K9/00
CPC分类号： G06K9/342 , G06K9/00 , G06K2009/366 , G06K2209/05
摘要： A method and system for segmenting structures such as lesions in an image is provided. The method comprises selecting one seed inside a lesion in an image either by a user or automatically. The method further includes deriving a directionally statistical model based on a background region or a foreground region of the lesion and determining candidate voxels along a radial direction. The candidate voxels represent the lesion. The method further includes segmenting the lesion using the candidate voxels.
摘要翻译：提供了用于分割诸如图像中的病变的结构的方法和系统。该方法包括由用户或自动地选择图像中的病变内的一个种子。该方法还包括基于病变的背景区域或前景区域导出定向统计模型，并沿着径向方向确定候选体素。候选体素代表病变。该方法还包括使用候选体素分割病变。

33. 发明申请

US20100046821A1 MOTION CORRECTION IN TOMOGRAPHIC IMAGES 有权
标题翻译：图像图像中的运动校正
公开(公告)号：US20100046821A1
公开(公告)日：2010-02-25
申请号：US12550773
申请日：2009-08-31
申请人： Ravindra Mohan Manjeshwar , Kris Filip Johan Jules Thielemans , Evren Asma
发明人： Ravindra Mohan Manjeshwar , Kris Filip Johan Jules Thielemans , Evren Asma
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B5/7285 , A61B6/037 , A61B6/5235 , A61B6/5247 , A61B6/541 , G06T5/003 , G06T7/30 , G06T7/33 , G06T11/005 , G06T11/008 , G06T2207/10081 , G06T2207/10084 , G06T2207/10104 , G06T2207/20201 , G06T2207/20221 , G06T2207/30004 , G06T2207/30048 , G06T2207/30061 , G06T2211/412
摘要： An imaging method comprises reconstructing gated emission tomography images for a region of interest, adjusting a mismatch between the gated emission tomography images and a computed tomography image of the region of interest, registering the gated emission tomography images, and combining the registered gated emission tomography images to generate motion corrected images.
摘要翻译：一种成像方法包括重建关注区域的门控发射断层摄影图像，调整门控发射断层摄影图像与感兴趣区域的计算机断层摄影图像之间的失配，登记门控发射断层摄影图像，以及组合登记的门控发射断层摄影图像以产生运动校正图像。

34. 发明授权

US08903152B2 Methods and systems for enhanced tomographic imaging 有权
标题翻译：增强断层成像的方法和系统
公开(公告)号：US08903152B2
公开(公告)日：2014-12-02
申请号：US13539028
申请日：2012-06-29
申请人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
发明人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/424
摘要： Embodiments of methods, systems and non-transitory computer readable media for tomographic imaging are presented. 3D TOF projection data is processed to generate corresponding data in a designated format that allows for computationally cheaper image reconstruction than the 3D TOF projection data. Further, one or more preliminary images are reconstructed from the processed data using a particular image reconstruction technique for one or more iterations. To that end, one or more imaging parameters are iteratively varied every one or more iterations. The imaging parameters, for example, include the designated format, the image reconstruction technique and one or more image quality characteristics. One or more intermediate images are reconstructed from the one or more preliminary images using the iteratively varying imaging parameters. Further, 3D TOF images having the one or more designated image quality characteristics are generated using the one or more intermediate images and the iteratively varying imaging parameters.
摘要翻译：提出了用于断层成像的方法，系统和非暂时计算机可读介质的实施例。 3D TOF投影数据被处理以产生指定格式的相应数据，这允许比3D TOF投影数据更便宜的图像重建。此外，使用用于一次或多次迭代的特定图像重建技术，从经处理的数据重建一个或多个预备图像。为此，每一次或多次迭代迭代地改变一个或多个成像参数。成像参数例如包括指定格式，图像重建技术和一个或多个图像质量特性。使用迭代变化的成像参数，从一个或多个初步图像重建一个或多个中间图像。此外，使用一个或多个中间图像和迭代变化的成像参数来生成具有一个或多个指定图像质量特性的3D TOF图像。

35. 发明申请

US20140079304A1 Method and System for Correction of Lung Density Variation in Positron Emission Tomography Using Magnetic Resonance Imaging 有权
标题翻译：使用磁共振成像校正正电子发射断层扫描肺密度变化的方法和系统
公开(公告)号：US20140079304A1
公开(公告)日：2014-03-20
申请号：US13618079
申请日：2012-09-14
申请人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
发明人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G06T7/11 , G06T7/12 , G06T2207/10088 , G06T2207/10104 , G06T2207/20221 , G06T2207/30061
摘要： Exemplary embodiments of the present disclosure are directed to correcting lung density variations in positron emission tomography (PET) images of a subject using a magnetic resonance (MR) image. A pulmonary vasculature and an outer extent of a lung cavity can be identified in a MR image corresponding to a thoracic region of the subject in response to an intensity associated with pixels in the MR image. The pixels within the outer extent of the lung cavity are classified as corresponding to the pulmonary vasculature or the lung tissue. Exemplary embodiments of the present disclosure can apply attenuation coefficients to a reconstruction of the PET image based on the classification of the pixels within the outer extent of the lung cavity.
摘要翻译：本公开的示例性实施例涉及使用磁共振（MR）图像校正受试者的正电子发射断层摄影（PET）图像中的肺密度变化。响应于与MR图像中的像素相关联的强度，可以在对应于受试者的胸部区域的MR图像中识别肺部脉管系统和肺腔的外部范围。肺腔外部范围内的像素被分类为对应于肺血管或肺组织。本公开的示例性实施例可以基于肺腔外部范围内的像素的分类，将衰减系数应用于PET图像的重建。

36. 发明申请

US20140003689A1 METHODS AND SYSTEMS FOR ENHANCED TOMOGRAPHIC IMAGING 有权
标题翻译：用于增强图像成像的方法和系统
公开(公告)号：US20140003689A1
公开(公告)日：2014-01-02
申请号：US13539028
申请日：2012-06-29
申请人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
发明人： Evren Asma , Ravindra Mohan Manjeshwar , Steven Gerard Ross , Sangtae Ahn , David Erik Chevalier
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/424
摘要： Embodiments of methods, systems and non-transitory computer readable media for tomographic imaging are presented. 3D TOF projection data is processed to generate corresponding data in a designated format that allows for computationally cheaper image reconstruction than the 3D TOF projection data. Further, one or more preliminary images are reconstructed from the processed data using a particular image reconstruction technique for one or more iterations. To that end, one or more imaging parameters are iteratively varied every one or more iterations. The imaging parameters, for example, include the designated format, the image reconstruction technique and one or more image quality characteristics. One or more intermediate images are reconstructed from the one or more preliminary images using the iteratively varying imaging parameters. Further, 3D TOF images having the one or more designated image quality characteristics are generated using the one or more intermediate images and the iteratively varying imaging parameters.
摘要翻译：提出了用于断层成像的方法，系统和非暂时计算机可读介质的实施例。 3D TOF投影数据被处理以产生指定格式的相应数据，这允许比3D TOF投影数据更便宜的图像重建。此外，使用用于一次或多次迭代的特定图像重建技术，从经处理的数据重建一个或多个预备图像。为此，每一次或多次迭代迭代地改变一个或多个成像参数。成像参数例如包括指定格式，图像重建技术和一个或多个图像质量特性。使用迭代变化的成像参数，从一个或多个初步图像重建一个或多个中间图像。此外，使用一个或多个中间图像和迭代变化的成像参数来生成具有一个或多个指定图像质量特性的3D TOF图像。

37. 发明授权

US08158951B2 Apparatus and methods for evaluating operation of pixelated detectors 有权
标题翻译：用于评估像素化检测器的操作的装置和方法
公开(公告)号：US08158951B2
公开(公告)日：2012-04-17
申请号：US12365100
申请日：2009-02-03
申请人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
发明人： Girish Bal , Floribertus Heukensfeldt Jansen , Osnat Zak , Gideon Berlad , Yaron Hefetz , Sergei Dolinsky , Brian D. Yanoff , John Eric Tkaczyk , Yanfeng Du , Ravindra Mohan Manjeshwar , Evren Asma , Qian Hua
IPC分类号： G01T1/00
CPC分类号： G01T1/249 , G01T1/247
摘要： An apparatus and methods for evaluating the operation of pixelated detectors are provided. The method includes obtaining data values for each of a plurality of pixels of a pixelated detector and determining a data consistency metric for each of the plurality of detector pixels. The method further includes identifying, using the determined data consistency metric, any detector pixels that exceed an acceptance criterion as noisy pixels.
摘要翻译：提供了一种用于评估像素化检测器的操作的装置和方法。该方法包括获得像素化检测器的多个像素中的每一个的数据值，并确定多个检测器像素中的每一个的数据一致性度量。该方法还包括使用所确定的数据一致性度量来识别超过接受标准的任何检测器像素作为噪声像素。

38. 发明授权

US07006677B2 Semi-automatic segmentation algorithm for pet oncology images 失效
公开(公告)号：US07006677B2
公开(公告)日：2006-02-28
申请号：US10122892
申请日：2002-04-15
申请人： Ravindra Mohan Manjeshwar , Harvey Ellis Cline
发明人： Ravindra Mohan Manjeshwar , Harvey Ellis Cline
IPC分类号： G06K9/00
CPC分类号： G06K9/342 , G06K2009/366 , G06T7/11 , G06T7/187 , G06T2207/10104 , G06T2207/20104 , G06T2207/20156 , G06T2207/30016 , Y10S128/922
摘要： An apparatus and method for segmenting three-dimensional (3D) medical images containing a region of interest is provided that identifies a first set of seed points within the region of interest and a second set of seed points outside the region of interest. A first sphere is constructed within the region of interest. Voxels contained within the medical image are classified using a spatial constrained fuzzy clustering algorithm. A plurality of second spheres is generated. Ones of the plurality of second spheres are accepted that satisfy the homogeneity function threshold as defined by the spatial constricted fuzzy clustering algorithm. A three-dimensional area is grown that defines the region of interest. The region of interest defined by the three-dimensional area is displayed.

39. 发明授权

US08942445B2 Method and system for correction of lung density variation in positron emission tomography using magnetic resonance imaging 有权
标题翻译：使用磁共振成像校正正电子发射断层扫描中肺密度变化的方法和系统
公开(公告)号：US08942445B2
公开(公告)日：2015-01-27
申请号：US13618079
申请日：2012-09-14
申请人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
发明人： Thomas Kwok-Fah Foo , Christopher Judson Hardy , Albert Henry Roger Lonn , Ravindra Mohan Manjeshwar , Dattesh Dayanand Shanbhag , Sheshadri Thiruvenkadam
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G06T7/11 , G06T7/12 , G06T2207/10088 , G06T2207/10104 , G06T2207/20221 , G06T2207/30061
摘要： Exemplary embodiments of the present disclosure are directed to correcting lung density variations in positron emission tomography (PET) images of a subject using a magnetic resonance (MR) image. A pulmonary vasculature and an outer extent of a lung cavity can be identified in a MR image corresponding to a thoracic region of the subject in response to an intensity associated with pixels in the MR image. The pixels within the outer extent of the lung cavity are classified as corresponding to the pulmonary vasculature or the lung tissue. Exemplary embodiments of the present disclosure can apply attenuation coefficients to a reconstruction of the PET image based on the classification of the pixels within the outer extent of the lung cavity.
摘要翻译：本公开的示例性实施例涉及使用磁共振（MR）图像校正受试者的正电子发射断层摄影（PET）图像中的肺密度变化。响应于与MR图像中的像素相关联的强度，可以在对应于受试者的胸部区域的MR图像中识别肺部脉管系统和肺腔的外部范围。肺腔外部范围内的像素被分类为对应于肺血管或肺组织。本公开的示例性实施例可以基于肺腔外部范围内的像素的分类，将衰减系数应用于PET图像的重建。

40. 发明授权

US08809793B2 System and method for pixelated detector calibration 有权
标题翻译：用于像素化检测器校准的系统和方法
公开(公告)号：US08809793B2
公开(公告)日：2014-08-19
申请号：US13360381
申请日：2012-01-27
申请人： Ashwin Ashok Wagadarikar , Ravindra Mohan Manjeshwar , Sergei Ivanovich Dolinsky
发明人： Ashwin Ashok Wagadarikar , Ravindra Mohan Manjeshwar , Sergei Ivanovich Dolinsky
IPC分类号： G01T1/166
CPC分类号： G01T1/1648
摘要： Present embodiments relate to the calibration of detectors having one or more arrays of pixelated detectors. According to an embodiment, a method includes detecting optical outputs generated by a plurality of scintillation crystals of a detector with an array of pixelated detectors, generating, with the array of pixelated detectors, respective signals indicative of the optical outputs, generating, from the respective signals, a unique energy spectrum correlated to each of the plurality of scintillation crystals, grouping subsets of the plurality of scintillation crystals into macrocrystals, determining a representative energy spectrum peak for each macrocrystal based on the respective energy spectra of the scintillation crystals in the macrocrystal, comparing a value of the representative energy spectrum peak for each macrocrystal with a target peak value, and adjusting an operating parameter of at least one pixelated detector in the array of pixelated detectors as a result of the comparison.
摘要翻译：本实施例涉及具有一个或多个像素化检测器阵列的检测器的校准。根据实施例，一种方法包括检测由具有像素化检测器阵列的检测器的多个闪烁晶体产生的光输出，利用像素化检测器阵列产生指示光输出的相应信号，从相应的信号，与多个闪烁晶体中的每一个相关的独特的能量谱，将多个闪烁晶体的子集分组为大的晶体，基于宏晶中的闪烁晶体的各自的能谱确定每个宏晶的代表性能谱峰，将每个宏晶的代表性能谱峰值与目标峰值进行比较，并且作为比较的结果，调整像素化检测器阵列中的至少一个像素化检测器的操作参数。

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