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31. 发明授权

US07095014B2 Mass spectrometer 有权
公开(公告)号：US07095014B2
公开(公告)日：2006-08-22
申请号：US11002423
申请日：2004-12-03
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： B01D59/44
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42 , H01J49/429
摘要： A mass spectrometer is disclosed wherein ions having a particular desired charge state are selected by operating an ion mobility spectrometer in combination with a quadrupole mass filter. Precursor ions are fragmented or reacted to form product ions in a collision cell ion trap and sent back upstream to an upstream ion trap. The fragment or product ions are then passed through the ion mobility spectrometer wherein they become temporally separated according to their ion mobility. Fragment or product ions are then re-trapped in the collision cell ion trap before being released therefrom in packets. A pusher electrode of a time of flight mass analyser is energised a predetermined period of time after a packet of ions is released from the collision cell ion trap. Accordingly, it is possible to select multiply charged precursor ions from a background of singly charged ions, fragment them, and mass analyse the fragment ions with a near 100% duty cycle across the whole mass range.

32. 发明授权

US07071467B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07071467B2
公开(公告)日：2006-07-04
申请号：US10633702
申请日：2003-08-05
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
摘要翻译：公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。

33. 发明授权

US06791078B2 Mass spectrometer 有权
公开(公告)号：US06791078B2
公开(公告)日：2004-09-14
申请号：US10603824
申请日：2003-06-26
申请人： Kevin Giles , John Brian Hoyes , Steve Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , John Brian Hoyes , Steve Pringle , Jason Lee Wildgoose
IPC分类号： H01J4940
CPC分类号： G01N27/622
摘要： A mass spectrometer comprising an ion mobility separator for separating ions according to their ion mobility is disclosed. The ion mobility separator comprises a plurality of electrodes and one or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain ion mobility are separated from other ions having different ion mobilities.

34. 发明授权

US06586727B2 Methods and apparatus for mass spectrometry 有权
标题翻译：质谱方法和仪器
公开(公告)号：US06586727B2
公开(公告)日：2003-07-01
申请号：US09796544
申请日：2001-03-02
申请人： Robert Harold Bateman , John Brian Hoyes
发明人： Robert Harold Bateman , John Brian Hoyes
IPC分类号： H01J4940
CPC分类号： H01J49/0045 , H01J49/4215
摘要： An improved method of parent ion scanning is disclosed. In one embodiment a quadrupole mass filter 3 upstream of a collision cell 4 is arranged to operate in a highpass mode. Parent ions transmitted by the mass filter 3 are fragmented in the collision cell 4 and detected by an orthogonal time of flight analyser 5 which obtains a daughter ion mass spectrum. Ions having a mass to charge ratio below the cutoff of the mass filter 3 are identified as daughter ions, and candidate parent ions may then be discovered and their identity confirmed by obtaining corresponding daughter ion spectra. In a second embodiment, the collision cell 4 alternates between high and low fragmentation and candidate parent ions can additionally be identified on the basis of the loss of a predetermined ion or neutral particle.
摘要翻译：公开了改进的亲离子扫描方法。在一个实施例中，碰撞单元4上游的四极质量过滤器3布置成以高通模式操作。由质量过滤器3传递的亲本离子在碰撞池4中被分段，并且通过获得子离子质谱的飞行分析仪5的正交时间检测。具有低于质量过滤器3的截止值的质荷比的离子被鉴定为子离子，然后可以通过获得相应的子离子光谱来发现候选母体离子并且确定它们的身份。在第二实施例中，碰撞单元4在高和低碎片之间交替，并且候选母离子可以另外根据预定离子或中性粒子的损失来识别。

35. 发明授权

US06570152B1 Time of flight mass spectrometer with selectable drift length 有权
标题翻译：飞行时间质谱仪具有可选择的漂移长度
公开(公告)号：US06570152B1
公开(公告)日：2003-05-27
申请号：US09594022
申请日：2000-06-15
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： B01D5944
CPC分类号： H01J49/406
摘要： A time of flight mass analyzer having a drift region, an ion package generator, first and second ion reflectors and at least one ion detector. The drift region has an axis, an entrance and an exit and provides for a place wherein ions may be temporarily separated according to their mass-to-charge ratios. The ion package generator injects packets of ions into the drift region at the region's entrance from a beam of ions by intermittently applying an electrostatic field such that the packets of ions enter the drift region in an initial direction which is inclined to the direction of said beam of ions. The first ion reflector is disposed at the exit of the drift region to reflect, back towards the entrance, ions which are traveling towards the reflector in the drift region. The second ion reflector is disposed in juxtaposition to the first ion reflector to reflect packets of ions back towards the first ion reflector through at least a portion of the drift region so that the packet of ions may be reflected to and fro between said first and second ion reflectors and undergo a number n of reflections at the second ion reflector. A detector is disposed to detect at least some packets of ions reflected by the first ion reflector which do not enter the second ion reflector. The number of reflections at the second ion reflector may be selected by adjustment of an inclination of the initial direction to the axis.
摘要翻译：具有漂移区的飞行时间质量分析器，离子封装发生器，第一和第二离子反射器以及至少一个离子检测器。漂移区域具有轴线，入口和出口，并提供可以根据其质荷比临时分离离子的地方。离子包装发生器通过间歇地施加静电场将离子包从离子束注入到区域入口处的漂移区域中，使得离子包在初始方向进入漂移区域，该初始方向倾斜于所述束的方向的离子。第一离子反射器设置在漂移区的出口处，以朝向入口反射在漂移区域中向着反射器行进的离子。第二离子反射器与第一离子反射器并置设置，以通过漂移区的至少一部分将离子分组反射回第一离子反射器，使得离子束可以在所述第一和第二离子反射器之间反射离子反射器并且在第二离子反射器处经历数量n的反射。设置检测器以检测由第一离子反射器反射的离子的至少一些分组，其不进入第二离子反射器。可以通过调整初始方向相对于轴的倾斜度来选择第二离子反射器处的反射次数。

36. 发明授权

US6107623A Methods and apparatus for tandem mass spectrometry 有权
标题翻译：串联质谱法的方法和装置
公开(公告)号：US6107623A
公开(公告)日：2000-08-22
申请号：US138152
申请日：1998-08-21
申请人： Robert Harold Bateman , John Brian Hoyes
发明人： Robert Harold Bateman , John Brian Hoyes
IPC分类号： H01J49/26 , H01J49/40 , H01J49/42 , B01D59/44
CPC分类号： H01J49/004 , H01J49/4215
摘要： The invention provides methods and apparatus for tandem mass spectrometry (MS/MS) in which parent ions generated from a sample are passed through a mass filter (2) and are fragmented into daughter ions in fragmentation means (3), the daughter ions being passed through a discontinuous output mass analyser, such as a time-of-flight analyzer (16) or an ion storage device (29). The range of possible parent mass-to-charge ratios is split into a plurality of smaller ranges, and the mass filter (2) is set to pass ions of each smaller range in turn. A flag is set for each smaller range which produces daughter ions of interest, and the mass filter (2) is set to pass each mass-to-charge ratio of the flagged ranges so that the mass-to-charge ratios of the fragmented ions produced for each of the mass-to-charge ratios passed may be determined using the discontinuous analyser (16, 29). The flagged ranges may be themselves split into a plurality of still smaller ranges, which are correspondingly flagged.
摘要翻译：本发明提供串联质谱法（MS / MS）的方法和装置，其中从样品产生的亲本离子通过质量过滤器（2），并在碎片装置（3）中碎裂成子离子，子离子通过通过不连续输出质量分析器，例如飞行时间分析器（16）或离子存储装置（29）。可能的母体质荷比的范围被分成多个较小的范围，并且质量过滤器（2）被设置为依次通过每个较小范围的离子。对于产生感兴趣的子离子的每个较小的范围设置标志，并且质量过滤器（2）被设置为通过标记范围的每个质荷比，使得碎裂离子的质荷比可以使用不连续分析仪（16,29）来确定通过的每个质荷比。标记的范围本身可以分成多个相应标记的较小范围。

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