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31. 发明授权

US09316656B2 Lid separation device and methods 有权
标题翻译：盖分离装置及方法
公开(公告)号：US09316656B2
公开(公告)日：2016-04-19
申请号：US12617611
申请日：2009-11-12
申请人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
发明人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
IPC分类号： B01L3/00 , G01N35/04 , G01N21/03 , G01N21/07 , G01N21/25
CPC分类号： G01N35/04 , B01L3/5025 , B01L2200/026 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0409 , G01N21/03 , G01N21/07 , G01N21/253 , G01N2021/0328 , G01N2035/0449
摘要： The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.
摘要翻译：本发明包括一种包括盖和容器的装置，其形成允许将废物从净化室转移到废物室的界面和用于净化分析物的方法，其中将上清液与固相分离，分析物通过装置的盖子离心而结合。本发明还包括使用该装置的方法。

32. 发明授权

US08808647B2 Multi-well plate with tailored chambers 有权
标题翻译：多孔板与定制的房间
公开(公告)号：US08808647B2
公开(公告)日：2014-08-19
申请号：US12556925
申请日：2009-09-10
申请人： Claudio Cherubini , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
发明人： Claudio Cherubini , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
IPC分类号： B01L3/00
CPC分类号： B01L3/50851 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858
摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.
摘要翻译：公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与底部开口小于从上部开口的高度。具有第二横截面积的样品室形成在底部开口和突起之间。在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积。

33. 发明申请

US20120088227A1 Devices and Process for Separating Plasma From a Blood Sample 审中-公开
标题翻译：从血液样品中分离血浆的装置和方法
公开(公告)号：US20120088227A1
公开(公告)日：2012-04-12
申请号：US13082646
申请日：2011-04-08
申请人： Tomas Gruebl , Michael Heinrich , Roger Sandoz , Emad Sarofim , Hans-Peter Wahl
发明人： Tomas Gruebl , Michael Heinrich , Roger Sandoz , Emad Sarofim , Hans-Peter Wahl
IPC分类号： B01D43/00 , C12Q1/70
CPC分类号： G01N33/491 , B01L3/5023 , B01L2200/028 , B01L2300/043 , B01L2300/0681 , B01L2300/069 , B01L2400/0406
摘要： The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member.
摘要翻译：本发明涉及一种用于从血液样品分离血浆的装置，包括层叠结构，该层叠结构设置有包括具有用于施加或接收血液样本的第一表面的分离构件的第一部分，其中分离构件适于允许等离子体通过，但是抑制细胞通过，第二部分包括用于吸收等离子体的吸收部件，该第二部分具有与用于接收等离子体的分离部件接触的第二表面，其中吸收部件适于产生毛细管压力以将等离子体从分离构件吸入吸收构件。第一部分以不被破坏吸收构件的方式被移除而固定到背衬构件上。吸收构件以不会破坏吸收构件的方式被移除而固定到背衬构件上。

34. 发明申请

US20110250695A1 METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES 有权
标题翻译：液体样品自动分析的方法，结构，装置，工具包和系统
公开(公告)号：US20110250695A1
公开(公告)日：2011-10-13
申请号：US12903492
申请日：2010-10-13
申请人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
发明人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
IPC分类号： G01N35/00 , G01N33/00 , C12M1/34 , B01L3/00
CPC分类号： G01N35/00029 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/0673 , B01L2300/0829 , B01L2300/0864 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N2021/0325 , G01N2035/00099 , G01N2035/00495
摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring said sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning said microfluidic structure so as to transport said sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of said sample contained in said one or more dead-end recesses or chambers; and analyzing said sample contained in said one or more dead-end recesses or chambers.
摘要翻译：公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。在一个实施例中，该方法可以包括：将所述样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转所述微流体结构以将所述样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生所述一个或多个死端凹部或室中容纳的所述样品的流动和扩散的阻挡层; 并分析包含在所述一个或多个死端凹部或腔室中的所述样品。

35. 发明申请

US20110189785A1 PROCESSING UNITS AND METHODS FOR THE PROCESSING OF LIQUID SAMPLES 失效
标题翻译：处理单元和液体样品加工方法
公开(公告)号：US20110189785A1
公开(公告)日：2011-08-04
申请号：US12850949
申请日：2010-08-05
申请人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
发明人： Oliver Gutmann , Edwin Oosterbroek , Michael Glauser , Michael Andreas Heinrich , Jean-Pierre Bolliger , Emad Sarofim , Rainer D. Jaeggi
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N35/1072 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0621 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0677 , G01N2035/00158 , Y10T436/2575
摘要： A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.
摘要翻译：公开了用于液体样品的自动处理的微流体处理单元及其方法。在一个实施例中，该单元包括连接到泵的用于在其中产生负压或正压的第一和第二主通道; 提供液体样品的样品通道可连接到包含液体样品的样品容器，样品通道与第一主通道连通并且配备有开关阀; 一个或多个用于供应一种或多种试剂的试剂通道，所述试剂通道可连接到含有用于与液体样品反应的试剂的试剂容器，每个试剂通道与第一或第二主通道连通并且装备有开/关阀; 以及用于使样品和试剂反应的反应室，所述反应室经由至少一个开/关阀连接到所述第一和第二主通道。

36. 发明申请

US20090291505A1 Analytical Device for Thermally Treating a Fluid and/or Monitoring a Property Thereof 审中-公开
标题翻译：用于热处理流体和/或监测流体的分析装置
公开(公告)号：US20090291505A1
公开(公告)日：2009-11-26
申请号：US12373519
申请日：2007-07-13
申请人： Emad Sarofim
发明人： Emad Sarofim
IPC分类号： G01N33/00 , G01N21/01 , B32B37/02
CPC分类号： B01L3/50851 , Y10T436/143333
摘要： A device having a protrusion in one of the large side walls of a chamber thereof is disclosed. The device can be used advantageously in reliable analyses in automate procedures.
摘要翻译：公开了一种在其室的大侧壁之一上具有突起的装置。该设备可以有效地用于自动化程序中的可靠分析。

37. 发明申请

US20070299365A1 Sampling system for sample fluid 审中-公开
标题翻译：样品液采样系统
公开(公告)号：US20070299365A1
公开(公告)日：2007-12-27
申请号：US11746386
申请日：2007-05-09
申请人： Irio Calasso , Emad Sarofim
发明人： Irio Calasso , Emad Sarofim
IPC分类号： A61B5/00
CPC分类号： A61B5/150503 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/15105 , A61B5/15142
摘要： The invention generally relates to a sampling system for sample liquid having a support, a lancing element arranged thereon and a semi-open channel for the capillary transport of the sample liquid from the lancing element to a collecting site on the support. A receiving structure is provided for receiving excess sample liquid escaping from the side of the channel.
摘要翻译：本发明一般涉及一种用于样品液体的采样系统，其具有支撑件，布置在其上的穿刺元件和用于将样品液体从穿刺元件毛细管输送到支撑体上的收集位置的半开口通道。提供接收结构，用于接收从通道侧排出的多余的样品液体。

38. 发明申请

US20060081600A1 Method and apparatus for performing rapid thermo cycling as well as micro fabricated system 审中-公开
标题翻译：执行快速热循环的方法和装置以及微制造系统
公开(公告)号：US20060081600A1
公开(公告)日：2006-04-20
申请号：US11226637
申请日：2005-09-13
申请人： Martin Kopp , Emad Sarofim
发明人： Martin Kopp , Emad Sarofim
IPC分类号： F27D11/04
CPC分类号： G05D23/19 , B01L7/52 , B01L2300/1822 , B01L2300/1833
摘要： A method to adjust a temperature of a fluid is disclosed, the method comprising the steps of providing a heat sink taking effect on the fluid, heating the fluid by Joule heating, and adjusting the heat provided by Joule heating in order to reach a desired temperature of the fluid. Furthermore, an apparatus to carry out the method is also disclosed. Therewith, a very efficient temperature change of the fluid can very quickly be obtained since the temperature of the surrounding is not substantially changed by heat diffusion. While a temperature increase is carried out by Joule heating, a temperature decrease is carried out by simply deactivating Joule heating. As soon as Joule heating is deactivated, the heat is extracted from the fluid by the heat sink, thereby initiating a high speed temperature change towards lower temperatures.
摘要翻译：公开了一种调节流体温度的方法，该方法包括以下步骤：提供散热器对流体的作用，通过焦耳加热加热流体，并调节由焦耳加热提供的热量以达到所需温度的流体。此外，还公开了一种执行该方法的装置。因此，由于通过热扩散基本上不改变周围的温度，所以可以非常快速地获得流体的非常有效的温度变化。当通过焦耳加热进行温度升高时，通过简单地停用焦耳加热来进行温度降低。一旦焦耳加热被停用，热量通过散热器从流体中提取，从而开始向较低温度的高速温度变化。

39. 发明授权

US06649896B2 Method and a device for measuring the spatially averaged intensity of a light beam and a method and a device for regulating a light source 有权
公开(公告)号：US06649896B2
公开(公告)日：2003-11-18
申请号：US10168790
申请日：2002-06-21
申请人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
发明人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
IPC分类号： H01L3100
CPC分类号： G01J1/4228 , G01J1/04 , G01J1/0429 , G01J1/1626 , G01J1/32 , G01J1/4257
摘要： A photoelectric module (1) comprises an electrically non-conducting support (2) and a photoelectric element including an array of spatially distributed photoelectric members applied to a surface of the support (2). High simplicity and efficiency is obtained by the double function of module (1) for light transmission or reflection, and spatially averaged light measurement. In a preferred application of module (1) a light source (8, LED) is energized by a driving circuit (9) controlled by an electronic circuit (11). The input of this circuit (11) is connected to the photoelectric module (1), the power delivered to the light source (8) and the intensity of the light beam emitted by the light source being regulated preferably to a constant value by the feedback loop consisting of module (1), electronic circuit (11) and driving circuit (9).

40. 发明授权

US08808648B2 Disposable for analyzing a liquid sample by nucleic acid amplification 有权
标题翻译：一次性用于通过核酸扩增分析液体样品
公开(公告)号：US08808648B2
公开(公告)日：2014-08-19
申请号：US12373513
申请日：2007-07-05
申请人： Emad Sarofim
发明人： Emad Sarofim
IPC分类号： B01L3/00 , B01L7/00 , B01L3/02
CPC分类号： B01L3/502715 , B01L3/0275 , B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0816 , B01L2300/087
摘要： The invention refers to a disposable sample holding and processing device (1) for being used in an apparatus for analyzing a liquid sample by nucleic acid amplification, especially polymerase chain reaction technique, comprising a device body (2) having a structured surface and a sealing cover (4) which covers the structured surface thereby forming a wall of an amplification chamber (5)), which amplification chamber (5) is designed and intended for performing nucleic acid amplification for analyzing the liquid sample, and a wall of an inlet channel (6) connected to the amplification chamber (5) for providing the amplification chamber (5) with liquid. According to the invention the device body (2) comprises a sheet (20) on which the structured surface forming the inlet channel (6) is arranged, and that the sheet (20) carries at least one rib (34, 35, 36) for increasing the stiffness of the device body (2).
摘要翻译：本发明涉及一种用于通过核酸扩增特别是聚合酶链反应技术分析液体样品的装置中的一次性样品保持和处理装置（1），其包括具有结构化表面的装置体（2）和密封覆盖结构化表面的盖（4），从而形成扩散室（5）的壁），该扩散室（5）被设计并用于进行用于分析液体样品的核酸扩增，以及入口通道（6），其连接到用于向所述放大室（5）提供液体的所述放大室（5）。根据本发明，装置主体（2）包括其上布置有形成入口通道（6）的结构化表面的片（20），并且片（20）承载至少一个肋（34,35,36）以增加装置主体（2）的刚度。

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