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31. 发明申请

US20050214352A1 Patch and process for producing the same 审中-公开
标题翻译：补丁和生产过程相同
公开(公告)号：US20050214352A1
公开(公告)日：2005-09-29
申请号：US10511061
申请日：2003-04-11
申请人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
发明人： Mitsuhiko Hori , Keiji Yamamoto , Kensuke Matsuoka , Yoshihisa Nakano , Kenjirou Mimomi , Masashi Yamada , Masaru Otsuka , Yasunori Suzuki , Akihiro Kawashima
IPC分类号： A61K9/70 , A61K31/137 , A61K47/10 , A61K47/14 , A61P9/02 , A61K31/138
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing DMAE or a pharmacologically acceptable salt thereof laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of DMAE or a pharmacologically acceptable salt thereof can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.
摘要翻译：本发明涉及层叠在基材的一面上的含有基材，含有DMAE的非交联型粘合剂层（A）或其药理学上可接受的盐的贴剂和层叠在粘合剂层（A）上的交联粘合剂层）。根据本发明，可以提高DMAE或其药理学上可接受的盐的经皮吸收性，并且可以提供没有粘合剂残留和粘合剂渗色等问题的贴剂。

32. 发明授权

US6146656A Percutaneous absorption preparation 失效
标题翻译：经皮吸收制剂
公开(公告)号：US6146656A
公开(公告)日：2000-11-14
申请号：US232684
申请日：1999-01-19
申请人： Mitsuhiko Hori , Kenjiro Minomi , Yoshihisa Nakano
发明人： Mitsuhiko Hori , Kenjiro Minomi , Yoshihisa Nakano
IPC分类号： A61K9/70 , A61F13/02 , A61K31/445
CPC分类号： A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneous absorption preparation which comprises a skin contact base containing therein at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salts thereof in an amount of from 0.5 to 60% by weight. The percutaneous absorption preparation makes it possible to permit the percutaneous absorption of biperiden, trihexyphenidyl or pharmacologically acceptable salt thereof as an active ingredient so that the medicament can be used effectively and at the same time, pharmacological effects can be sustained long and administration can be carried out conveniently. In addition, the active ingredient contained in it can be maintained stably.
摘要翻译：本发明提供了一种经皮吸收制剂，其包含皮肤接触基质，其中含有至少一种活性成分，所述至少一种活性成分选自双倍哌啶，三己烯基及其药理学上可接受的盐，其量为0.5至60重量％。经皮吸收制剂使得双倍哌啶，三己苯醌或其药理学上可接受的盐的经皮吸收作为活性成分成为可能，可以有效地使用药物，同时可以持续长时间的药理作用，可以进行给药方便的此外，其中包含的活性成分可以稳定地保持。

33. 发明授权

US4740374A Anti-inflammatory analgesic adhesive preparation 失效
标题翻译：消炎止痛胶制剂
公开(公告)号：US4740374A
公开(公告)日：1988-04-26
申请号：US917136
申请日：1986-10-09
申请人： Yoshihisa Nakano , Kazuhisa Ninomiya , Tetuo Horiuchi , Yuichi Inoue
发明人： Yoshihisa Nakano , Kazuhisa Ninomiya , Tetuo Horiuchi , Yuichi Inoue
IPC分类号： A61K31/19 , A61K9/70 , A61K31/195 , A61K47/12 , A61L15/58 , A61P29/00 , A61F13/02
CPC分类号： A61K9/7053 , A61K47/12 , A61K9/7061 , A61L15/58
摘要： An anti-inflammatory analgesic adhesive preparation is disclosed, comprising a flexible support having laminated thereon a pressure-sensitive adhesive material layer which contains a non-steroidal anti-inflammatory analgesic agent having salt form and an organic acid. This adhesive preparation has excellent percutaneous absorption properties.
摘要翻译：公开了一种消炎镇痛粘合剂制剂，其包括在其上层叠有压敏粘合剂材料层的柔性载体，其包含具有盐形式的非甾体抗炎止痛剂和有机酸。该粘合剂具有优异的经皮吸收性能。

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