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31. 发明申请

US20060073113A1 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US20060073113A1
公开(公告)日：2006-04-06
申请号：US11142678
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08G59/14
CPC分类号： C08G65/333 , C08G65/2609 , C08G65/329
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mu of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R是具有1至24个碳原子的烃基，OA 2是具有2至4个碳原子的氧化烯基，所表示的基团在一个分子中，R彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同，m是氧化烯基的平均摩尔数 m表示10〜1000，X表示能够与生物相关物质发生化学反应的官能团，上述聚亚烷基二醇衍生物的多分散性Mw / Mu在凝胶渗透色谱中满足以下关系：＆lt; 公式描述=“在线公式”end =“lead”？> Mw / Mn <= 1.07 <？in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重量平均分子量，Mn表示数均分子量。

32. 发明申请

US20050288490A1 Modified bio-related substance, process for producing the same, and intermediate 有权
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050288490A1
公开(公告)日：2005-12-29
申请号：US11142255
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K35/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1 和/或O 2各自为具有2〜4个碳原子的氧化烯基，由R表示的基团在一个分子中彼此相同或不同， SUP> 2个在一个分子中彼此相同或不同，n和m各自是加成的氧化烯基的平均摩尔数，n表示0〜1000，m表示10〜1000。

33. 发明申请

US20050058620A1 Modified bio-related substance, process for producing the same, and intermediate 审中-公开
标题翻译：改性生物相关物质，其生产方法和中间体
公开(公告)号：US20050058620A1
公开(公告)日：2005-03-17
申请号：US10716432
申请日：2003-11-20
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , A61K31/765 , C08G59/14
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, R and OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA 1和 OA 2各自为具有2〜4个碳原子的氧化烯基，R 1和OA 2在一个分子中相同或不同，n和m各自是加入的氧化烯基的平均摩尔数，n 表示0〜1000，m表示10〜1000。

34. 发明授权

US06812367B2 Polyethylene glycol and process for producing the same 有权
标题翻译：聚乙二醇及其制造方法
公开(公告)号：US06812367B2
公开(公告)日：2004-11-02
申请号：US10463547
申请日：2003-06-18
申请人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
发明人： Kenji Sakanoue , Kouzoh Sanchika , Tohru Yasukohchi
IPC分类号： C07C4318
CPC分类号： C08G65/2609 , C08L2203/02
摘要： Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢ ⁢ of ⁢ ⁢ ethylene ⁢ ⁢ glycol ⁢ ⁢ and ⁢ ⁢ diethylene ⁢ ⁢ glycol ⁢ ⁢ contents ⁢ ⁢ ( ppm ) = 150 × 2900 × 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.
摘要翻译：聚乙二醇用于应用于生物体的领域，其中聚乙二醇中乙二醇和二甘醇的含量之和小于或等于下式[I]表示的含量：其中x表示平均分子量聚乙二醇的重量，聚乙二醇的平均分子量为190〜1050。

35. 发明授权

US06667292B1 Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex 失效
标题翻译：一氧化氮代谢物 - 聚氧化烯 - 血红蛋白复合物
公开(公告)号：US06667292B1
公开(公告)日：2003-12-23
申请号：US09499758
申请日：2000-02-08
申请人： Akira Kitabatake , Ichiro Sakuma , Kunihiko Nakai , Tohru Yasukohchi
发明人： Akira Kitabatake , Ichiro Sakuma , Kunihiko Nakai , Tohru Yasukohchi
IPC分类号： A61K3514
CPC分类号： A61K47/60
摘要： Disclosed is a nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex having a molecular weight of from 100,000 to 2,000,000 daltons, in which a polyoxyalkylene derivative is bound to from 10 to 30% in total of bindable amino groups in hemoglobin and a nitric monoxide metabolite is bound to from 10 to 100% in total of thiol groups of cysteine residues.
摘要翻译：公开了一种分子量为100,000至2,000,000道尔顿的一氧化氮代谢物 - 聚亚氧烷基 - 血红蛋白复合物，其中聚氧化烯衍生物与血红蛋白中的可结合氨基的总量相结合为10至30％，一氧化氮代谢物被结合至10至100％的半胱氨酸残基的硫醇基团。

36. 发明授权

US5332523A Dispersion-stabilizing agent for inorganic powder in oily material 失效
标题翻译：油性材料中无机粉末的分散稳定剂
公开(公告)号：US5332523A
公开(公告)日：1994-07-26
申请号：US869057
申请日：1992-04-15
申请人： Taizo Igarashi , Susumu Honda , Tohru Yasukohchi , Show Onodera
发明人： Taizo Igarashi , Susumu Honda , Tohru Yasukohchi , Show Onodera
IPC分类号： B01F17/52 , B01F17/00 , B01F17/42 , C08F216/12 , C08F290/00 , C08F290/06 , C08F299/00 , C09D17/00 , C09D155/00 , B01J13/00 , C08F122/04
CPC分类号： C09D17/004 , B01F17/0028 , C08F216/12 , Y10S516/01 , Y10S526/91
摘要： A dispersion stabilizing agent for inorganic powder in an oily material, comprising a copolymer of (i) a polyoxyalkylene derivative represented by the general formula [I] below with (ii) one or more of maleic acid and the derivatives thereof selected from the group of maleic anhydride, maleic acid, maleic acid salts, maleic acid amides, and maleic acid esters, ##STR1## where Z is a residue of a compound having 2-8 hydroxyl groups, AO is an oxyalkylene group having 2-18 carbon atoms, R.sup.1 is an unsaturated hydrocarbon group having 2-5 carbon atoms, R.sup.2 is a hydrocarbon group having 1-40 carbon atoms, a=0 to 1000, b=0 to 1000, c=0 to 1000, l=1 to 8, m=0 to 2, n=0 to 7, (l+m+n)=2 to 8, (al+bm+cn)=1 to 1000, m/(l+n).ltoreq.1/2.
摘要翻译：一种油性材料中无机粉末的分散稳定剂，其包含（i）由下列通式[I]表示的聚氧化烯衍生物与（ii）一种或多种马来酸及其衍生物的共聚物的共聚物，所述马来酸及其衍生物选自马来酸酐，马来酸，马来酸盐，马来酸酰胺和马来酸酯，其中Z是具有2-8个羟基的化合物的残基，AO是具有2-18个碳原子的氧化烯基原子，R 1是具有2-5个碳原子的不饱和烃基，R 2是具有1-40个碳原子的烃基，a = 0至1000，b = 0至1000，c = 0至1000，l = 1至8 ，m = 0〜2，n = 0〜7，（1 + m + n）= 2〜8，（a1 + bm + cn）= 1〜1000，m /（1 + n）。

37. 发明申请

US20110082277A1 MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权
标题翻译：改良的生物相关物质，其生产方法和中间体
公开(公告)号：US20110082277A1
公开(公告)日：2011-04-07
申请号：US12942554
申请日：2010-11-09
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yammamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yammamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： C08G65/28 , C08G63/06
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

38. 发明授权

US07531604B2 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US07531604B2
公开(公告)日：2009-05-12
申请号：US10529692
申请日：2003-09-30
申请人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
发明人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
IPC分类号： C08F8/32 , C08F8/40 , A61K9/127 , A61K47/32 , A61P35/00
CPC分类号： C08F8/40 , A61K8/14 , A61K8/8164 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/795 , A61Q19/00 , C08F220/28 , C08F222/06 , C08L53/00 , C08F222/04 , C08L2666/02
摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.
摘要翻译：可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式式（2B）和式（3）表示的成分单元C [R1和R2表示氢原子或甲基，条件是R1和R2不同时表示甲基; R3表示碳原子数为1〜3的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，为4≤m≤100的范围内的数; R4表示氢原子，碳原子数为1〜20的烃基或酰基， R5CO和R6CO表示碳原子数为8〜24的酰基， R 7表示碳原子数为2〜4的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。

39. 发明授权

US07198945B2 Cell having modified cell membrane 有权
标题翻译：细胞具有改变的细胞膜
公开(公告)号：US07198945B2
公开(公告)日：2007-04-03
申请号：US10211587
申请日：2002-08-05
申请人： Teruyuki Nagamune , Chika Itoh , Tohru Yasukohchi , Syunsuke Ohhashi , Kazuhiro Kubo
发明人： Teruyuki Nagamune , Chika Itoh , Tohru Yasukohchi , Syunsuke Ohhashi , Kazuhiro Kubo
IPC分类号： C12N5/00
CPC分类号： C12N5/0006
摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).
摘要翻译：其中待修饰物质和两亲性化合物的反应产物与细胞膜非共价结合的细胞，其中所述化合物具有以下特征

40. 发明授权

US06455639B1 Oxirane derivative and process for the preparation thereof 有权
标题翻译：环氧乙烷衍生物及其制备方法
公开(公告)号：US06455639B1
公开(公告)日：2002-09-24
申请号：US09367642
申请日：1999-08-19
申请人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
发明人： Tohru Yasukohchi , Kouzoh Sanchika , Chika Itoh , Kei-ichi Maruyama
IPC分类号： C08G6528
CPC分类号： C08G65/2609 , C08G65/30 , G01N30/90
摘要： An oxirane derivative and process for preparation of the same, having a high purity characterized in terms of gel permeation chromatography and thin layer chromatography. The oxirane derivative is useful as a starting material for medical purposes, and mainly drug delivery systems.
摘要翻译：一种环氧乙烷衍生物及其制备方法，具有以凝胶渗透色谱和薄层色谱为特征的高纯度。环氧乙烷衍生物可用作医疗用途的原料，主要用于药物输送系统。

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