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31. 发明授权

US08445529B2 Indole derivative having, carbamoyl group, ureido group and substituted oxy group 失效
标题翻译：具有氨基甲酰基，脲基和取代氧基的吲哚衍生物
公开(公告)号：US08445529B2
公开(公告)日：2013-05-21
申请号：US13054041
申请日：2009-07-14
申请人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
发明人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
IPC分类号： A61K31/404 , C07D209/40
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/04
摘要： An indole compound having a carbamoyl group, a ureido group and a substituted oxy group having the following formula (1) or a salt thereof: In the formula (1), R1 represents a hydrogen atom, an alkyl group, a hydroxy group, or an alkoxy group; R2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R3 represents a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group, a heterocyclic group an alkoxy group, an alkenyloxy group, an alkynyloxy group, a cycloalkyloxy group, an aryloxy group or a heterocyclic oxy group; m represents 0, 1, 2, or 3.
摘要翻译：具有氨基甲酰基，脲基和具有下式（1）的取代的氧基的吲哚化合物或其盐：在式（1）中，R 1表示氢原子，烷基，羟基或烷氧基 R2表示氢原子，烷基，环烷基，芳基或杂环基; R3表示卤素原子，烷基，烯基，炔基，环烷基，芳基，杂环基，烷氧基，烯氧基，炔氧基，环烷氧基，芳氧基或杂环氧基; m表示0,1,2或3。

32. 发明授权

US08198271B2 Thiophenediamine derivative having urea structure 有权
标题翻译：具有尿素结构的噻吩并二胺衍生物
公开(公告)号：US08198271B2
公开(公告)日：2012-06-12
申请号：US12993452
申请日：2009-05-25
申请人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： A61K31/444 , A61K31/5377 , A61K31/4436 , A61K31/381 , A61K31/496 , A61K31/4439 , C07D409/14 , C07D409/12 , C07D413/12 , C07D333/36 , C07D417/14
CPC分类号： C07D333/36 , C07D409/12
摘要： A compound having the following formula (1) or a salt thereof: wherein R1 and R2 represent hydrogen, a lower alkyl, a lower alkenyl, a lower alkynyl or a group having the following formula (2): (R6)n—{circle around (A)}—Z— (2), R3 represents hydroxy, a lower alkoxy, a lower cycloalkyloxy, an aryloxy, carboxy, a lower alkoxycarbonyl, or —NRaRb having the following formula (3): (R7)o—{circle around (B)}— (3), R4 and R5 represent halogen, a lower alkyl, hydroxy, or a lower alkoxy; R6 represents halogen, a lower alkyl, an aryl group, a heterocyclic, a hydroxy, a lower alkoxy, mercapto, a lower alkylthio, a lower alkylcarbonyl, amino, nitro or cyano; R7 represents a lower alkyl, hydroxy or a lower alkoxy; Ra and Rb represent hydrogen or a lower alkyl; the ring A represents a cyclic hydrocarbon or a heterocyclic ring; the ring B represents a heterocyclic ring having one or more heteroatoms selected from the group consisting of nitrogen and oxygen; X represents a lower alkylene; Y represents a lower alkylene; Z represents a single bond or a lower alkylene; W1-W2 represents N—CH or C—N and l, m, n and o represent 0, 1, 2, or 3.
摘要翻译：具有下式（1）的化合物或其盐：其中R1和R2表示氢，低级烷基，低级烯基，低级炔基或具有下式（2）的基团：（R6）n- {圆（A）} - Z-（2），R3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基或具有下式（3）的-NR aRb：（R 7）（B）} - （3），R4和R5代表卤素，低级烷基，羟基或低级烷氧基; R6表示卤素，低级烷基，芳基，杂环，羟基，低级烷氧基，巯基，低级烷硫基，低级烷基羰基，氨基，硝基或氰基; R7表示低级烷基，羟基或低级烷氧基; Ra和Rb代表氢或低级烷基; 环A表示环状烃或杂环; 环B表示具有一个或多个选自氮和氧的杂原子的杂环; X表示低级亚烷基; Y表示低级亚烷基; Z表示单键或低级亚烷基; W1-W2表示N-CH或C-N，且l，m，n和o表示0,1,2或3。

33. 发明授权

US08088817B2 Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent 失效
标题翻译：作为取代基的吡咯衍生物，可以具有取代基的脲基，氨基碳基和双环
公开(公告)号：US08088817B2
公开(公告)日：2012-01-03
申请号：US12737807
申请日：2009-08-25
申请人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
发明人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
IPC分类号： A61K31/4025 , A61K31/401 , C07D207/34 , C07D405/04 , C07D409/04
CPC分类号： C07D207/34 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
摘要翻译：由下式（1）表示的化合物或其盐：该化合物对白细胞介素-6的产生具有抑制活性，因此可用作与白介素-6，眼炎性疾病相关疾病的治疗剂，类似。式中，R 1表示卤素原子，氢原子，可具有取代基的低级烷基，甲酰基或可具有取代基的低级烷基羰基，R 2表示可具有取代基的二环烃基，或可以具有取代基的二环杂环基，R 3表示氢原子，可以具有取代基的低级烷基，可以具有取代基的芳基或酰基。

34. 发明授权

US07906511B2 Cyclic compound having pyrimidinylalkylthio group 有权
标题翻译：具有嘧啶基烷硫基的环状化合物
公开(公告)号：US07906511B2
公开(公告)日：2011-03-15
申请号：US11887308
申请日：2006-03-31
申请人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
发明人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
IPC分类号： C07D239/42 , C07D401/12 , C07D401/14 , A61K31/506 , A61K31/5377
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D409/12
摘要： The present invention has its object to study synthesis of novel cyclic compounds having a pyrimidinylalkylthio group and to find pharmacological actions of the compounds. According to the present invention, a compound represented by the formula (1) or a salt thereof is provided. In the formula, the ring X represents: R1 and R2 independently represent a hydrogen atom, an alkyl group, an aryl group, an aromatic heterocyclic group or the like; R3 represents a hydrogen atom, a halogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino group or the like; A1 represents a sulfur atom or the like; and A2 represents an alkylene group.
摘要翻译：本发明的目的是研究具有嘧啶基烷硫基的新型环状化合物的合成，并找到化合物的药理作用。根据本发明，提供由式（1）表示的化合物或其盐。在该式中，环X表示：R 1和R 2分别表示氢原子，烷基，芳基，芳香族杂环基等， R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基等; A1表示硫原子等; A2表示亚烷基。

35. 发明授权

US07726646B2 Sheet package with recloseable flap 有权
标题翻译：具有可再瓣膜的片材包装
公开(公告)号：US07726646B2
公开(公告)日：2010-06-01
申请号：US10509382
申请日：2003-03-17
申请人： Koji Sugiyama , Hiroshi Taira , Minoru Yamamoto , Keiji Seo , Takashi Okumura , Katsuhiko Shimada , Mutsuo Naoe
发明人： Koji Sugiyama , Hiroshi Taira , Minoru Yamamoto , Keiji Seo , Takashi Okumura , Katsuhiko Shimada , Mutsuo Naoe
IPC分类号： B65H1/00
CPC分类号： B41J29/023 , B41J13/0081 , B65H1/04 , B65H1/266 , B65H2405/311
摘要： A sheet in accordance with the present invention includes sheets as print mediums for a printer and a package member surrounding the sheets which have been stacked up. The sheet package is configured so that the sheets can be set in the printer together with the package member exposing part of the sheets. The package member is integrally provided with a flap part which can expose part of the sheets by being opened when the sheet package is set in the printer and cover the exposed part of the sheets by being closed when the sheet package is not used.
摘要翻译：根据本发明的片材包括作为打印机的打印介质的纸张和围绕已堆叠的纸张的包装件。片材包装被配置为使得片材可以与暴露片材的一部分的包装构件一起设置在打印机中。包装件一体地设置有翼片部件，当片材包装被设置在打印机中时可以使打印部分的片材暴露，并且当不使用片材包装时通过关闭来遮盖片材的暴露部分。

36. 发明授权

US07534802B2 Compounds having 4-pyridylalkylthio group as substituent 有权
标题翻译：具有4-吡啶基烷硫基作为取代基的化合物
公开(公告)号：US07534802B2
公开(公告)日：2009-05-19
申请号：US10548283
申请日：2004-03-05
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： C07D401/14 , A61K31/444
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R1 and R2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.
摘要翻译：本发明的目的是提供一种新颖的具有4-吡啶基烷硫基作为取代基的五元或六元杂环衍生物或其盐，其可用作药物。由以下通式[I]表示的化合物或其盐可用作涉及血管生成或增加血管通透性的疾病的治疗剂。在该式中，环“A”是可以与环烷烃环稠合的苯环或芳族五元或六元杂环，“B”是亚烷基，R 1和R 2相同或不同，是H，OH 取代或未取代的烷氧基等，X和Y相同或不同，分别为选自H，卤素，OH，取代或未取代的烷氧基等的基团，p为0,1或2，q为0,1或2，q为是0或1。

37. 发明授权

US07415163B2 Method of reducing noise in images 失效
标题翻译：降低图像噪声的方法
公开(公告)号：US07415163B2
公开(公告)日：2008-08-19
申请号：US10996229
申请日：2004-11-23
申请人： Noriyuki Nishi , Hisakazu Kuramoto , Takuma Suzuki , Minoru Yamamoto
发明人： Noriyuki Nishi , Hisakazu Kuramoto , Takuma Suzuki , Minoru Yamamoto
IPC分类号： G06K9/40 , H04N1/32 , H04N1/00 , H04N1/41 , H04N1/413
CPC分类号： H04N19/117 , H04N19/176 , H04N19/186 , H04N19/527 , H04N19/60
摘要： An image noise reducing method that can properly reduce both block noise and mosquito noise without deterioration of the image quality is provided. The method includes creating a first luminance component image data with the boundaries of the blocks thereof smoothened, creating a second luminance component image data with its entirety smoothened from the first luminance component image data, creating edge image data by subtracting the second luminance component image data from the first luminance component image data, creating corrected edge image data by applying correction to the edge image data under given conditions, and creating third luminance component image data by adding the corrected edge image data to the second luminance component image data. For color-difference component image data, first color-difference component image data with its entirety smoothened is created from the color-difference component image data. The third luminance component image data and the first color-difference component image data are finally outputted.
摘要翻译：提供了可以适当地降低块噪声和蚊式噪声而不降低图像质量的图像噪声降低方法。该方法包括：创建其平滑块的边界的第一亮度分量图像数据，创建从第一亮度分量图像数据整体整合的第二亮度分量图像数据，通过减去第二亮度分量图像数据来产生边缘图像数据从第一亮度分量图像数据，通过在给定条件下对边缘图像数据应用校正来创建校正的边缘图像数据，并且通过将校正的边缘图像数据与第二亮度分量图像数据相加来创建第三亮度分量图像数据。对于色差分量图像数据，从色差分量图像数据创建整体平滑化的第一色差分量图像数据。最后输出第三亮度分量图像数据和第一色差分量图像数据。

38. 发明授权

US07409103B2 Method of reducing noise in images 失效
标题翻译：降低图像噪声的方法
公开(公告)号：US07409103B2
公开(公告)日：2008-08-05
申请号：US10996243
申请日：2004-11-23
申请人： Noriyuki Nishi , Hisakazu Kuramoto , Takuma Suzuki , Minoru Yamamoto
发明人： Noriyuki Nishi , Hisakazu Kuramoto , Takuma Suzuki , Minoru Yamamoto
IPC分类号： G06K9/40 , G06K9/00 , H04N5/217 , H04B1/66
CPC分类号： H04N9/646 , G06T5/002 , G06T2207/10024 , G06T2207/20192 , H04N9/045 , H04N19/117 , H04N19/186 , H04N19/527
摘要： An image noise reducing method that can properly reduce CCD noise which emerges in an image imported from a digital camera is provided. The method includes applying a first filtering step to luminance component image data of the image with each pixel of the luminance component image data being designated as a target pixel, thereby creating luminance component image data with its entirety smoothened, and applying a second filtering step to color-difference component image data of the image with each pixel of the color-difference component image data being designated as a target pixel, thereby creating color-difference component image data with its entirety smoothened.
摘要翻译：提供了可以适当地减少从数字照相机导入的图像中出现的CCD噪声的图像噪声降低方法。该方法包括：将亮度分量图像数据的每个像素指定为目标像素，对图像的亮度分量图像数据应用第一滤波步骤，从而创建整体平滑的亮度分量图像数据，并将第二滤波步骤应用于将色差分量图像数据的每个像素指定为目标像素的图像的色差分量图像数据，从而产生整体平滑的色差分量图像数据。

39. 外观设计

USD562887S1 Paper cartridge having detachable cover portions for printer 失效
标题翻译：纸盒具有用于打印机的可拆卸的盖部分
公开(公告)号：USD562887S1
公开(公告)日：2008-02-26
申请号：US29167846
申请日：2002-09-23
申请人： Keiji Seo , Motoaki Yamanashi , Minoru Yamamoto
设计人： Keiji Seo , Motoaki Yamanashi , Minoru Yamamoto

40. 发明授权

US07257877B2 Grating forming method and manufacturing method for master member for manufacturing molding die 失效
标题翻译：用于制造成型模具的主元件的光栅形成方法和制造方法
公开(公告)号：US07257877B2
公开(公告)日：2007-08-21
申请号：US10876912
申请日：2004-06-25
申请人： Masashi Hanaoka , Kenichi Hayashi , Minoru Yamamoto
发明人： Masashi Hanaoka , Kenichi Hayashi , Minoru Yamamoto
IPC分类号： B23P13/04 , G02B6/34
CPC分类号： G02B1/11 , G02B5/1852 , Y10T29/49995
摘要： A grating forming method for forming a fine grating with a grating period of at most 1 μm on a surface of a blank material including (1) feeding realatively a diamond cutting tool and the blank material in a groove extended direction while rotating the diamond cutting tool about the axial line and (2) cutting the surface of the blank material with a blade tip part of the diamond cutting tool to form the grooves while rotating and feeding the diamond cutting tool. When the fine grating with the grating period of “P” μm is formed and the feed amount per revolution of the diamond cutting tool is set to be “S” μm, the feed amount per revolution “S”, with which the diamond cutting tool is fed in the groove extended direction while rotating the diamond cutting tool about the axial line, is set to satisfy the following conditional expression: S
摘要翻译：一种光栅形成方法，用于在坯料的表面上形成光栅周期至多为1um的精细光栅，包括（1）在使金刚石切割工具旋转的同时实际上进给金刚石切削工具和坯料，沿着槽延伸方向围绕轴线和（2）用金刚石切割工具的刀片尖部切割坯料的表面，以在旋转和馈送金刚石切割工具的同时形成凹槽。当形成光栅周期为“P”mum的精细光栅时，金刚石切削刀具的每转进给量设定为“S”mum，每转“S”的进给量，金刚石刀具在金刚石切削工具绕轴线旋转的同时沿槽延伸方向进给，设定为满足以下条件表达式：S <2.9P 3。这种条件是将表达式应用于坯料，成型模具，模制产品和用于制造成型模具的主构件。

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