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31. 发明申请

US20090247584A1 PHENOXY-PIPERIDINES FOR THE TREATMENT OF DISEASES SUCH AS SCHIZOPHRENIA AND DEPRESSION 审中-公开
标题翻译：用于治疗疾病的苯氧基苯丙胺，如抗抑郁药和抑郁症
公开(公告)号：US20090247584A1
公开(公告)日：2009-10-01
申请号：US12393480
申请日：2009-02-26
申请人： Gunter HOLZEMANN , Helmut Prucher , Kai Schiemann , Joachim Leibrock , Hartmut Greiner , Christa Burger , Laurie von Melchner
发明人： Gunter HOLZEMANN , Helmut Prucher , Kai Schiemann , Joachim Leibrock , Hartmut Greiner , Christa Burger , Laurie von Melchner
IPC分类号： A61K31/445 , A61P25/28 , A61P25/18
CPC分类号： C07D211/46 , A61K31/445 , A61K2300/00
摘要： Compounds of the formula (I), in which R1, R2′, R2″, R2′″, R3 and n are as defined in Claim 1, are effectors of the nicotinic and/or muscarinic acetylcholine receptor and are suitable for the prophylaxis or treatment of schizophrenia, depression, anxiety states, dementia, Alzheimer's disease, Lewy bodies dementia, neurodegenerative diseases, Parkinson's disease, Huntington's disease, Tourette's syndrome, learning and memory impairments, age-related memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds.
摘要翻译：式（I）化合物，其中R 1，R 2'，R 2“，R 2”'，R 3和n如权利要求1所定义，是烟碱和/或毒蕈碱性乙酰胆碱受体的作用剂，并且适用于预防或治疗精神分裂症，抑郁症，焦虑状态，痴呆，阿尔茨海默病，路易体痴呆，神经退行性疾病，帕金森病，亨廷顿氏病，杜氏综合征，学习记忆障碍，年龄相关记忆障碍，尼古丁依赖戒断症状改善，中风或脑损伤的有毒化合物。

32. 发明申请

US20090215799A1 HETEROCYCLIC SUBSTITUTED BISARYLUREA DERIVATIVES 有权
标题翻译：杂环取代的双歧杆菌衍生物
公开(公告)号：US20090215799A1
公开(公告)日：2009-08-27
申请号：US11577270
申请日：2005-10-06
申请人： Frank Stieber , Alfred Jonczyk , Guenter Hoelzemann , Hans-Peter Buchstaller , Lars Thore Burgdorf , Wilfried Rautenberg , Hartmut Greiner
发明人： Frank Stieber , Alfred Jonczyk , Guenter Hoelzemann , Hans-Peter Buchstaller , Lars Thore Burgdorf , Wilfried Rautenberg , Hartmut Greiner
IPC分类号： A61K31/519 , C07D401/12 , A61K31/4439 , C07D471/04 , C07D403/12 , A61K31/4192 , A61P35/00
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10
摘要： The present invention relates to heterocyclic substituted bisarylurea derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译：本发明涉及式I的杂环取代的双芳基脲衍生物，式I化合物作为一种或多种激酶抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法，包括向患者施用所述药物组合物。

33. 发明申请

US20080312244A1 Squaric Acid Derivatives as Protein Kinase Inhibitors 审中-公开
标题翻译：方酸衍生物作为蛋白激酶抑制剂
公开(公告)号：US20080312244A1
公开(公告)日：2008-12-18
申请号：US11997036
申请日：2006-06-30
申请人： Werner Mederski , Ulrich Emde , Gerhard Barnickel , Frank Zenke , Hartmut Greiner , Frank Stieber
发明人： Werner Mederski , Ulrich Emde , Gerhard Barnickel , Frank Zenke , Hartmut Greiner , Frank Stieber
IPC分类号： A61K31/4965 , A61K31/4402 , C07D241/10 , A61P35/00 , A61P3/10 , C07D213/38
CPC分类号： C07D213/38 , C07C225/20 , C07C2601/04 , C07D207/323 , C07D207/325 , C07D213/61 , C07D213/85 , C07D215/12 , C07D217/12 , C07D231/12 , C07D233/54 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12
摘要： Compounds of the formula I, in which R, X, R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
摘要翻译：其中R，X，R 1，R 2，R 3，R 4和R 5具有权利要求1所示含义的式I化合物是CHK1 CHK2和SGK激酶的抑制剂，并且可以用于治疗癌症。

34. 发明授权

US5495790A Piston catcher for a pyrotechnic linear piston and cylinder drive 失效
标题翻译：用于烟火线性活塞和气缸驱动的活塞捕手
公开(公告)号：US5495790A
公开(公告)日：1996-03-05
申请号：US373985
申请日：1995-01-18
申请人： Hartmut Greiner
发明人： Hartmut Greiner
IPC分类号： B60R22/46 , F01B11/02
CPC分类号： F15B15/19 , B60R22/4619 , Y10T74/2045 , Y10T74/20462
摘要： In a pyrotechnic linear piston and cylinder drive in a belt pretensioner, the cylinder (10) has a frustoconical free end (12) and the piston (14) is attached to the end of a cable (16). The piston (14) is tapered frustoconically at its end adjacent to the free end (12) of the cylinder (10). An annular piston member (22) is slipped over and frictionally engaged with the tapered end portion (20) of the piston (14). When the annular piston member (22) reaches the frustoconical free end (12) of the cylinder (10), the piston (14) is forced further into the annular piston member, deforming both parts and dissipating energy.
摘要翻译：在带状预张紧器中的烟火线性活塞和气缸驱动器中，气缸（10）具有截头圆锥形自由端（12），并且活塞（14）附接到电缆（16）的端部。活塞（14）在其与气缸（10）的自由端（12）相邻的端部处具有锥形锥形锥形。环形活塞构件（22）滑动并与活塞（14）的锥形端部（20）摩擦接合。当环形活塞构件（22）到达气缸（10）的截头圆锥形自由端（12）时，活塞（14）被进一步压入环形活塞构件，使两部分变形并消耗能量。

35. 发明申请

US20130158005A1 PYRIMIDINE DERIVATIVES AS FAK INHIBITORS 有权
标题翻译：吡啶衍生物作为FAK抑制剂
公开(公告)号：US20130158005A1
公开(公告)日：2013-06-20
申请号：US13817251
申请日：2011-07-19
申请人： Timo Heinrich , Christina Esdar , Hartmut Greiner
发明人： Timo Heinrich , Christina Esdar , Hartmut Greiner
IPC分类号： C07D239/42 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/04 , C07D413/12 , C07D417/12 , C07D403/04 , C07D405/04 , C07D401/12 , C07D401/06
CPC分类号： C07D239/42 , C07D233/88 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12
摘要： Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.
摘要翻译：其中R1，R2和R3具有权利要求1所述含义的式（I）化合物是激酶抑制剂，尤其可用于治疗肿瘤。

36. 发明申请

US20090131506A1 Oxindoles as Kinase Inhibitors 有权
标题翻译： Oxindoles作为激酶抑制剂
公开(公告)号：US20090131506A1
公开(公告)日：2009-05-21
申请号：US11916902
申请日：2006-05-11
申请人： Lars Thore Burgdorf , David Bruge , Hartmut Greiner , Maria Kordowicz , Christian Sirrenberg , Frank Zenke
发明人： Lars Thore Burgdorf , David Bruge , Hartmut Greiner , Maria Kordowicz , Christian Sirrenberg , Frank Zenke
IPC分类号： A61K31/404 , C07D209/34 , A61P35/00
CPC分类号： C07D209/34
摘要： The present invention relates to oxindoles of the formula I, their use as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases and their use for the manufacture of a pharmaceutical composition.
摘要翻译：本发明涉及式I的羟吲哚，其用作蛋白激酶激活剂或抑制剂，其制备方法，其用于制备用于治疗疾病的药物及其用于制备药物组合物的用途。

37. 发明申请

US20070299065A1 Tetrahydropyran Derivatives as Antidiabetics 审中-公开
标题翻译：四氢吡喃衍生物作为抗糖尿病药
公开(公告)号：US20070299065A1
公开(公告)日：2007-12-27
申请号：US11792133
申请日：2005-11-07
申请人： Werner Mederski , Christoph Van Amsterdam , Christa Burger , Hartmut Greiner
发明人： Werner Mederski , Christoph Van Amsterdam , Christa Burger , Hartmut Greiner
IPC分类号： A61K31/5355 , A61K31/351 , A61K31/4433 , A61K31/453 , A61P3/10 , C07D315/00 , C07D413/12 , C07D405/12 , C07D239/36 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号： C07H15/203
摘要： Novel compounds of the formula (I), in which T, E, R, R′, R″, R1, R2 and R2′ have the meanings indicated in patent Claim 1, are suitable as antidiabetics.
摘要翻译：式（I）的新型化合物，其中T，E，R，R'，R“，R”，R“2和R”2“ 具有专利权利要求1中所示的含义，适合作为抗糖尿病药。

38. 发明授权

US07084164B2 Triazole derivative 失效
公开(公告)号：US07084164B2
公开(公告)日：2006-08-01
申请号：US11232011
申请日：2005-09-22
申请人： Takahiko Tobe , Takashi Sugane , Wataru Hamaguchi , Itsuro Shimada , Kyoichi Maeno , Junji Miyata , Tetsuya Kimizuka , Takeshi Suzuki , Atsuyuki Kohara , Takuma Morita , Michael Arlt , Hartmut Greiner
发明人： Takahiko Tobe , Takashi Sugane , Wataru Hamaguchi , Itsuro Shimada , Kyoichi Maeno , Junji Miyata , Tetsuya Kimizuka , Takeshi Suzuki , Atsuyuki Kohara , Takuma Morita , Michael Arlt , Hartmut Greiner
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D249/08 , A61K31/41 , A61K31/4155 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D495/04
摘要： The invention relates to a triazole derivative with an activity inhibiting glycine transporter and for use as a pharmaceutical drug, and a novel triazole derivative. The inventive triazole derivative has an excellent activity inhibiting glycine transporter and is useful as a therapeutic agent of dementia, schizophrenia, cognitive disorders, or cognitive disorders involved in various diseases such as Alzheimer disease, Parkinson's disease, or Huntington disease or the like, or spasm involved in diseases such as nerve degenerative diseases and cerebrovascular disorders, or the like. Particularly, the pharmaceutical drug is useful for the amelioration of learning disability of dementia and the like.

39. 发明授权

US06737426B1 Sulfonyloxazoleamines 失效
标题翻译：磺酰基恶唑胺
公开(公告)号：US06737426B1
公开(公告)日：2004-05-18
申请号：US10148078
申请日：2002-05-28
申请人： Rolf Gericke , Henning Böttcher , Michael Gassen , Hartmut Greiner
发明人： Rolf Gericke , Henning Böttcher , Michael Gassen , Hartmut Greiner
IPC分类号： A61K31496
CPC分类号： C07D213/81 , C07D213/82 , C07D307/68 , C07D333/38 , C07D413/04
摘要： The invention relates to compounds of the general formula (I) where R1 and R2 independently of one another are H, —R6, C3-C8-cycloalkyl, —(CH2)n—R7, —(CH2)n—O—R6, —(CH2)n—NH2, —(CH2)n—NHR6, —(CH2)—N(R6)2, C2-C6-alkenyl or, where appropriate, together form a mononuclear saturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms, R3 and R4 independently of one another are H, —R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, R5 is a 5- or 6-membered, saturated or unsaturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms which may be mono- or disubstituted by R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, and R6 is C1-C6-alkyl, R7 is R3- and/or R4-substituted phenyl, n is 0 to 2, and physiologically acceptable salts or solvates thereof. The invention also relates to the use of the compounds of the general formula I as medicaments.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 2彼此独立地为H，-R 6，C 3 -C 8 - 环烷基， - （CH 2）n -R 7， - （CH 2）n O-R 6， - （CH 2 ）n-NH 2， - （CH 2）n -NHR 6， - （CH 2）-N（R 6）2，C 2 -C 6 - 烯基或在适当的情况下一起形成具有一个或两个氮，氧和/ 硫原子，R3和R4彼此独立地是H，-R6，-CF3，-NO2，-Hal，-OH，-O-R6，-NH2，-NH-R6或-N（R6）2，R5是具有一个或两个可被R 6，-CF 3，-NO 2，-Hal，-OH，-O-R 6单价或二取代的氮，氧和/或硫原子的5-或6-元饱和或不饱和杂环，-NH 2，-NH-R 6或-N（R 6）2，R 6为C 1 -C 6烷基，R 7为R 3 - 和/或R 4取代的苯基，n为0至2，以及其生理上可接受的盐或溶剂化物。本发明还涉及通式I的化合物作为药物的用途。

40. 发明授权

US06333339B1 3-Benzylpiperidine 失效
标题翻译： 3-苄基哌啶
公开(公告)号：US06333339B1
公开(公告)日：2001-12-25
申请号：US09445587
申请日：2000-04-17
申请人： Henning Boettcher , Helmut Pruecher , Hartmut Greiner , Christoph Seyfried , Andrew Barber , Joseph Maria Martinez
发明人： Henning Boettcher , Helmut Pruecher , Hartmut Greiner , Christoph Seyfried , Andrew Barber , Joseph Maria Martinez
IPC分类号： A61K31445
CPC分类号： C07D401/06
摘要： The invention relates to piperidine derivatives of the formula I in which R1, R2, m and k have the meanings indicated in claim 1, and their salts, novel intermediates and processes for the preparation of the compounds according to the invention. The compounds of the formula I are potent a receptor ligands and show 5-HT reuptake-inhibiting actions and can be used for the production of medicaments, for example for the treatment of disorders of the central nervous system, of strokes, brain or bone marrow traumata or of ischaemic states.
摘要翻译：本发明涉及式Iin的哌啶衍生物，其中R1，R2，m和k具有权利要求1所示的含义，以及它们的盐，新的中间体和制备本发明化合物的方法。我是有效的受体配体并显示出5-HT再摄取抑制作用，可以用于制备药物，例如用于治疗中枢神经系统疾病，脑卒中，脑或骨髓创伤或缺血状态。

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