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31. 发明申请

US20090124004A1 Insect desiccation resistance genes and uses thereof 有权
标题翻译：昆虫干燥抗性基因及其用途
公开(公告)号：US20090124004A1
公开(公告)日：2009-05-14
申请号：US12313645
申请日：2008-11-21
申请人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Kazuei Mita , Keiko Kadono
发明人： Takahiro Kikawada , Takashi Okuda , Masahiko Watanabe , Kazuei Mita , Keiko Kadono
IPC分类号： C12N15/63 , C07H21/04 , C12N5/10
CPC分类号： C07K14/43563
摘要： An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof. cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST database was constructed, and genes encoding LEA proteins were isolated. This resulted in the successful isolation of three types of novel gene encoding LEA-like proteins (PvLEA1, PvLEA2, and PvLEA3.) When secondary structure predictions and motif searches were performed on the proteins deduced from each of the genes, all three proteins had α-helix-rich structures and LEA_4 motifs, which are characteristic of LEA proteins. Moreover, the recombinant proteins synthesized from PvLEA1, 2 and 3 genes were heat soluble even when boiling, so that PvLEA1, 2 and 3 proteins have highly hydrophilic property as well as plant LEA proteins. Therefore, the three isolated genes were found to be novel P. vanderplanki-derived LEA genes. Furthermore, introduction of these PvLEA 1, 2 and 3 genes into animal cells successfully conferred desiccation resistance to the cells. The present invention provides the first example of LEA genes isolated from insects.
摘要翻译：本发明的目的是提供编码昆虫耐干燥性蛋白质的多核苷酸及其用途。在干燥状态下从Polypedilum vanderplanki幼虫生产cDNA文库，构建了P.vanderplanki EST数据库，分离了编码LEA蛋白的基因。这导致了三种类型的编码LEA样蛋白的新基因（PvLEA1，PvLEA2和PvLEA3）的成功分离。当对从每个基因推导的蛋白进行二级结构预测和基序搜索时，所有三种蛋白都具有α 富含螺旋的结构和LEA_4基序，是LEA蛋白的特征。此外，由PvLEA1,2和3基因合成的重组蛋白即使在沸腾时也是热溶性的，因此PvLEA1,2和3蛋白具有高亲水性以及植物LEA蛋白。因此，发现三个分离的基因是新的P. vanderplanki衍生的LEA基因。此外，将这些PvLEA 1,2和3基因引入动物细胞成功地赋予细胞干燥抗性。本发明提供了从昆虫分离的LEA基因的第一个实例。

32. 发明授权

US07478614B2 Variably operated valve system for compression ignition engine 失效
标题翻译：压力点火发动机可变阀门系统
公开(公告)号：US07478614B2
公开(公告)日：2009-01-20
申请号：US11367587
申请日：2006-03-06
申请人： Makoto Nakamura , Seinosuke Hara , Seiji Suga , Masahiko Watanabe , Tomio Hokari
发明人： Makoto Nakamura , Seinosuke Hara , Seiji Suga , Masahiko Watanabe , Tomio Hokari
IPC分类号： F01L1/34
CPC分类号： F01L1/3442 , F01L13/0026 , F01L2001/0537 , F01L2001/34483 , F01L2013/0073 , F01L2800/00 , F01L2820/032
摘要： In a variably operated valve system for a compression ignition engine, an adjustment mechanism is controlled by means of a control section to detach an intake valve closure timing from a bottom dead center in accordance with an engine driving condition, and an engine start securing section guarantees an engine start even at least one of cases during a failure in the control section, during a stop of the engine, and during a start of the engine.
摘要翻译：在用于压缩点火式发动机的可变操作的阀系统中，通过控制部分控制调节机构，以根据发动机驱动条件将进气门关闭定时与下止点分离，并且发动机起动保护部分保证在发动机停止期间和发动机起动期间，发动机甚至启动控制部分故障期间的至少一个情况。

33. 发明申请

US20080058477A1 Polythiourethane 失效
标题翻译：聚硫氨酯
公开(公告)号：US20080058477A1
公开(公告)日：2008-03-06
申请号：US11587362
申请日：2005-04-28
申请人： Masanori Watanabe , Masahiko Watanabe , Atsushi Morikami , Takafumi Hirakawa
发明人： Masanori Watanabe , Masahiko Watanabe , Atsushi Morikami , Takafumi Hirakawa
IPC分类号： C08G18/02
CPC分类号： C08G75/28 , C08G18/4676 , G02B1/04 , C08L75/04
摘要： Disclosed is a polythiourethane having a high refractive index and low dispersion which is obtained through a reaction between a polythiol component containing one or more polythiocarbonate polythiol (preferably one having a —(CO—S—R—S)— structure (wherein R represents a divalent hydrocarbon group) and a number average molecular weight of 200-2,500) and a polyisocyanate component containing a polyisocyanate and/or a polyisothiocyanate. This polythiourethane is useful for plastic lenses, prisms, optical fibers, substrates for information recording, colored filters, infrared absorbing filters and the like.
摘要翻译：公开了通过含有一种或多种聚硫代碳酸酯多硫醇（优选具有 - （CO-SRS） - 结构（其中R表示二价烃基）的多硫醇组分的多硫醇组分之间的反应获得的具有高折射率和低分散性的聚硫氨酯，数均分子量为200-2,500）和含有多异氰酸酯和/或多异氰酸酯的多异氰酸酯组分。该聚硫氨酯可用于塑料透镜，棱镜，光纤，信息记录用基板，彩色滤光片，红外吸收滤光片等。

34. 发明授权

US07228830B2 Valve timing control device for internal combustion engine 有权
公开(公告)号：US07228830B2
公开(公告)日：2007-06-12
申请号：US10765105
申请日：2004-01-28
申请人： Masahiko Watanabe
发明人： Masahiko Watanabe
IPC分类号： F01L1/34
CPC分类号： F01L1/34 , F01L1/34409 , F01L1/352 , F01L1/356 , F01L2101/00 , F01L2105/00 , Y10T74/2102
摘要： A valve timing control device includes a drive pulley driven by a crankshaft of an engine, and a driven camshaft. The camshaft has a cam that serves to open and close an intake port. An engine valve is spring-loaded by a valve spring, whereas the cam opens or closes the engine valve against the bias of the spring. Torque is transmittable between the drive pulley and the camshaft, and a rotation angle adjusting mechanism is provided therebetween. The rotation angle adjusting mechanism has a movable operating member being movable in a substantially radial direction.

35. 发明申请

US20070036717A1 Chemoradiotherapy with TS-1/camptothecins 审中-公开
标题翻译：化疗放疗与TS-1 /喜树碱
公开(公告)号：US20070036717A1
公开(公告)日：2007-02-15
申请号：US11498098
申请日：2006-08-03
申请人： Masahiko Watanabe , Takeo Sato
发明人： Masahiko Watanabe , Takeo Sato
IPC分类号： A61K51/00 , A61K31/4745
CPC分类号： A61K41/0038 , A61K31/4745 , A61K45/06
摘要： An antitumor agent for chemoradiotherapy of rectal cancer comprising a combination of TS-1 (a combination drug of tegafur, gimeracil, and oteracil potassium at a 1:0.4:1 molar ratio) and CPT-11 (irinotecan hydrochloride). The antitumor agent of the invention can achieve marked tumor volume reduction without causing major side effects, especially by coadministering it with preoperative radiation therapy. The volume of even large tumors that are refractory to surgical resection can be reduced by coadministering the antitumor agent of the invention with preoperative radiation therapy, making the subsequent surgical resection of the tumor easier.
摘要翻译：包括TS-1（替加氟组合药物，吉马斯特和1：0.4：1摩尔比的奥特拉西钾）和CPT-11（盐酸伊立替康）的组合的直肠癌放化疗用抗肿瘤剂。本发明的抗肿瘤剂可以显着降低肿瘤体积，而不会引起重大副作用，特别是通过术前放射治疗联合使用。通过用术前放射治疗联合本发明的抗肿瘤药物可以减少手术切除难治的甚至大肿瘤的体积，使随后的肿瘤手术切除更容易。

36. 发明授权

US07159545B2 Valve timing control apparatus for internal combustion engine and control method thereof 有权
标题翻译：内燃机气门正时控制装置及其控制方法
公开(公告)号：US07159545B2
公开(公告)日：2007-01-09
申请号：US11074768
申请日：2005-03-09
申请人： Ryo Miyakoshi , Kenichi Machida , Masahiko Watanabe , Yoshiyuki Kobayashi
发明人： Ryo Miyakoshi , Kenichi Machida , Masahiko Watanabe , Yoshiyuki Kobayashi
IPC分类号： F01L1/34
CPC分类号： F02D13/08 , F01L1/34 , F01L2001/3522 , F01L2013/103 , F02D13/0219 , F02N19/004 , Y02T10/18
摘要： A valve timing control apparatus for an internal combustion engine which comprises a variable valve timing mechanism which varies an opening-and-closing timing of an intake valve and/or an exhaust valve of an engine, and in which the opening-and-closing timing at a time of starting the engine is set to a starting time timing which is at a further advance side than a maximum retard timing which is retarded at the maximum, said apparatus characterized in that, at a time of stopping the engine, the variable valve timing mechanism is controlled such that the opening-and-closing timing is made to be the starting time timing.
摘要翻译：一种用于内燃机的气门正时控制装置，包括改变发动机的进气门和/或排气门的打开和关闭正时的可变气门正时机构，其中开/关定时在启动发动机时，将发动机设定为比最大延迟的最大延迟定时更进一步的起动时刻，所述装置的特征在于，在停止发动机时，可变阀控制定时机构，使开/关定时成为起动时刻。

37. 发明授权

US06940381B2 Mn-Zn based ferrite, magnetic core for transformer and transformer 失效
标题翻译： Mn-Zn系铁氧体，变压器用磁芯及变压器
公开(公告)号：US06940381B2
公开(公告)日：2005-09-06
申请号：US10732319
申请日：2003-12-11
申请人： Masahiko Watanabe , Katsushi Yasuhara
发明人： Masahiko Watanabe , Katsushi Yasuhara
IPC分类号： C04B35/38 , C04B35/26 , H01F1/34 , H01F1/36 , H01F17/04 , H01F19/08 , H01F27/255 , H01F27/32 , H01F27/02
CPC分类号： H01F1/344 , C04B35/2658 , C04B35/6261 , C04B35/62625 , C04B35/62655 , C04B35/63 , C04B2235/3208 , C04B2235/3251 , C04B2235/3262 , C04B2235/3275 , C04B2235/3284 , C04B2235/42 , C04B2235/604 , C04B2235/658 , C04B2235/786 , C04B2235/94 , H01F1/36 , H01F17/04 , H01F19/08 , H01F27/324
摘要： A Mn—Zn based ferrite having a main component comprised of 51 to 54 mol % of an iron oxide in Fe2O3 conversion, 14 to 21 mol % of a zinc oxide in ZnO conversion and the rest of a manganese oxide, wherein a content (α [ppm]) of cobalt oxide in a CoO conversion with respect to 100 wt % of the main component satisfies a relation formula below. Relation formula: Y1≦α≦Y2 (1) Note that Y1 and Y2 are expressed by the formulas below and CoO>0 [ppm]. Y1=(−0.13·B2+1.5·B−15.6A+850)/(0.0003·B+0.0098)−233 (2) Y2=(−0.40·B2+4.6·B−46.7A+2546)/(0.0003·B+0.0098)+1074 (3) The A and B in the above Y1 and Y2 are A=Fe2O3 (mol %) and B=ZnO (mol %).
摘要翻译：一种主要成分为Fe-2-O 3 3转换成的51〜54摩尔％的铁氧化物的Mn-Zn系铁氧体，14〜21摩尔％的锌 ZnO转化中的氧化物和其余的氧化锰，其中相对于主要成分的100重量％，CoO转化中的氧化钴的含量（α[ppm]）满足以下关系式。 <？in-line-formula description =“In-line Formulas”end =“lead”？>关系公式：Y1 <= alpha <= Y2（1）<？in-line-formula description =“In-line Formulas” end =“tail”？>注意，Y1和Y2由下式表示，CoO> 0 [ppm]。 <？in-line-formula description =“In-line Formulas”end =“lead”？> Y1 =（ - 0.13.B <2> + 1.5.B-15.6A + 850）/（0.0003 .B + 0.0098）-233（2）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end = 导线“> Y2 =（-0.40.B2-2 + 4.6.B-46.7A + 2546）/（0.0003B + 0.0098）+1074（3）<？在线公式描述 =“直线公式”end =“tail”？>上述Y1和Y2中的A和B是A = Fe 2 O 3（摩尔％）和 B = ZnO（mol％）。

38. 发明申请

US20050157555A1 NONVOLATILE SEMICONDUCTOR MEMORY DEVICE 有权
标题翻译：非易失性半导体存储器件
公开(公告)号：US20050157555A1
公开(公告)日：2005-07-21
申请号：US10760351
申请日：2004-01-21
申请人： Tsuyoshi Ono , Yasuaki Hirano , Masahiko Watanabe , Sau Wong
发明人： Tsuyoshi Ono , Yasuaki Hirano , Masahiko Watanabe , Sau Wong
IPC分类号： G11C16/02 , G11C11/56 , G11C16/04 , G11C16/06 , G11C16/10 , G11C16/34 , H01L21/8247 , H01L27/115 , H01L29/788 , H01L29/792
CPC分类号： G11C16/3459 , G11C11/5628 , G11C16/10 , G11C16/3454 , G11C2211/5621
摘要： In a nonvolatile floating-gate semiconductor memory device, a word line voltage supply circuit is configured to be able to apply gate voltages to the same memory cells such that the gate voltage applied at and after the second time is different from the gate voltage applied at the first time. At least one of the word line voltage supply circuit and the bit line voltage supply circuit is set to be able to apply a voltage to the same memory cells for a longer application period at the first time than at and after the second time. With this configuration, the threshold voltage distribution of the memory cells is controlled to be narrow.
摘要翻译：在非易失性浮栅半导体存储器件中，字线电压供给电路被配置为能够向相同的存储单元施加栅极电压，使得在第二时间施加的栅极电压与施加在第二时间的栅极电压不同第一次。字线电压供给电路和位线电压供给电路中的至少一个被设置为能够在第一时间比在第二时间和之后向相同存储器单元施加电压较长的施加周期。利用这种配置，将存储单元的阈值电压分布控制得很窄。

39. 发明授权

US06805081B2 Valve timing control device for internal combustion engine 有权
标题翻译：内燃机气门正时控制装置
公开(公告)号：US06805081B2
公开(公告)日：2004-10-19
申请号：US10455531
申请日：2003-06-06
申请人： Masahiko Watanabe , Tamotsu Todo , Kazuhiko Takayanagi
发明人： Masahiko Watanabe , Tamotsu Todo , Kazuhiko Takayanagi
IPC分类号： F01L134
CPC分类号： F01L1/344 , F01L1/34 , Y10T464/30
摘要： A valve timing control device for an internal combustion engine, comprises a drive rotary member rotated by a crankshaft of the engine, a driven rotary member to rotate a camshaft of the engine upon rotation of the drive rotary member; a rotational phase control mechanism having an intermediate rotary member rotated relative to the drive and driven rotary members to cause relative rotation between the drive and driven rotary members and an braking mechanism having a hysteresis brake that generates a braking force to cause the intermediate rotary member to rotate relative to the drive and driven rotary members.
摘要翻译：一种用于内燃机的气门正时控制装置，包括由发动机的曲轴旋转的驱动旋转构件，驱动旋转构件，用于在驱动旋转构件旋转时使发动机的凸轮轴旋转; 旋转相位控制机构，其具有相对于驱动旋转构件旋转的中间旋转构件，以及驱动旋转构件和从动旋转构件之间的相对旋转;以及具有滞后制动器的制动机构，该制动机构产生制动力以使中间旋转构件相对于驱动和驱动旋转构件旋转。

40. 发明授权

US06752480B2 Integrated-circuit apparatus and ink jet recording apparatus using the same 失效
标题翻译：集成电路装置和使用其的喷墨记录装置
公开(公告)号：US06752480B2
公开(公告)日：2004-06-22
申请号：US09919902
申请日：2001-08-02
申请人： Masahiko Watanabe
发明人： Masahiko Watanabe
IPC分类号： B41J2938
CPC分类号： B41J2/04541 , B41J2/0457 , B41J2/04586
摘要： A large-scale integrated-circuit apparatus includes a CPU and a plurality of circuit blocks to be operated in accordance with clock signals. The circuit blocks receive reset signals to perform initialization and output reset completion signals. The CPU logic-operates the initialization completion signals output from the circuit blocks and outputs a signal for canceling resetting to the circuit blocks in accordance with the logic-operation result.
摘要翻译：大型集成电路装置包括CPU和多个根据时钟信号进行操作的电路块。电路块接收复位信号以执行初始化并输出复位完成信号。 CPU逻辑 - 操作从电路块输出的初始化完成信号，并且根据逻辑运算结果输出用于取消对电路块的复位的信号。

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