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31. 发明授权

US5786371A Pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds 失效
标题翻译：吡啶和哒嗪衍生物，其制备方法和含有这些化合物的药剂
公开(公告)号：US5786371A
公开(公告)日：1998-07-28
申请号：US875951
申请日：1997-08-11
申请人： Christos Tsaklakidis , Alfred Mertens , Gerd Zimmermann , Wolfgang Schafer , Liesel Dorge
发明人： Christos Tsaklakidis , Alfred Mertens , Gerd Zimmermann , Wolfgang Schafer , Liesel Dorge
IPC分类号： C07D213/68 , A61K31/4427 , A61K31/445 , A61K31/495 , A61P7/02 , C07D213/74 , C07D213/75 , C07D237/20 , C07D401/12 , A01N43/40
CPC分类号： C07D213/74 , C07D237/20 , C07D401/12 , Y02P20/55
摘要： Compounds of Formula I ##STR1## in which the variables are defined herein, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of diseases which are the result of thromboembolytic events.
摘要翻译： PCT No.PCT / EP96 / 00523 Sec。 371日期1997年8月11日 102（e）日期1997年8月11日PCT提交1996年2月8日PCT公布。 WO96 / 24586 PCT公开号日期：1996年8月15日本文定义变量的式I（I）化合物，其制备方法以及含有这些化合物的药剂，用于治疗由血栓溶解事件引起的疾病。

32. 发明授权

US4361468A Flue housing for a coke oven 失效
标题翻译：焦炉烟道
公开(公告)号：US4361468A
公开(公告)日：1982-11-30
申请号：US177992
申请日：1980-08-15
申请人： Alfred Mertens , Franz Schafer
发明人： Alfred Mertens , Franz Schafer
IPC分类号： C10B29/00 , C10B21/16 , C10B21/10 , C10B21/14
CPC分类号： C10B21/16
摘要： A regulating device for the flue housing of a coke oven for alternately opening and closing channels of the flue housing including a rotatable shaft, frames mounted on the shaft, preferably, 90.degree. relative to each other, in alternating sequence along the shaft, peripheral seals about the frames for sealing a channel when the frame is disposed across it. The seals are arcuate in configuration and lie on a circle having its center at the center axis of the shaft. Rotation of the shaft selectively opens and closes alternate channels of the flue housing.
摘要翻译：一种用于焦炉的烟道壳体的调节装置，用于交替地打开和关闭烟道外壳的通道，包括可旋转的轴，相对于彼此安装在轴上的框架优选地相对于彼此以90°交替顺序地沿着轴，周边密封关于当框架布置在其上时用于密封通道的框架。密封件呈弓形构型并且位于其轴线的中心轴线上的圆形上。轴的旋转选择性地打开和关闭烟道外壳的交替通道。

33. 发明授权

US07572809B2 Isoquinoline aminopyrazole derivatives 失效
标题翻译：异喹啉氨基吡唑衍生物
公开(公告)号：US07572809B2
公开(公告)日：2009-08-11
申请号：US11637733
申请日：2006-12-12
申请人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
发明人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
IPC分类号： C07D403/14 , A61K31/4709
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，这些化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在对照中的用途或预防癌症等疾病。

34. 发明申请

US20130288266A1 DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT 审中-公开
标题翻译：通过一个双向绑定剂检测后置改性的多肽
公开(公告)号：US20130288266A1
公开(公告)日：2013-10-31
申请号：US13923618
申请日：2013-06-21
申请人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
发明人： Michael Gerg , Dieter Heindl , Christian Klein , Alfred Mertens , Volker Schmid , Michael Schraeml , Monika Soukupova , Michael Tacke
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , G01N33/531
摘要： A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures.
摘要翻译：具有结合靶多肽的多肽表位的第一单价结合剂的双价结合剂，与靶多肽上的翻译后多肽修饰结合的第二单价粘合剂和接头。进一步公开的是用于检测翻译后修饰的靶多肽，用于制备所公开的双价结合剂的方法，以及用于所公开的双价结合剂在组织学染色程序中的方法。

35. 发明申请

US20070179151A1 Isoquinoline aminopyrazole derivatives 失效
标题翻译：异喹啉氨基吡唑衍生物
公开(公告)号：US20070179151A1
公开(公告)日：2007-08-02
申请号：US11637733
申请日：2006-12-12
申请人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
发明人： Li Chen , Guy Georges , Alfred Mertens , Xihan Wu
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/4709 , C07D403/14 , C07D409/14 , C07D403/02
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，这些化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在对照中的用途或预防癌症等疾病。

36. 发明授权

US5599826A Thiazolidinediones and drugs containing them 失效
标题翻译：噻唑烷二酮类和含有它们的药物
公开(公告)号：US5599826A
公开(公告)日：1997-02-04
申请号：US578561
申请日：1995-11-21
申请人： Alfred Mertens , Hans-Peter Wolff , Peter Freund
发明人： Alfred Mertens , Hans-Peter Wolff , Peter Freund
IPC分类号： C07D277/20 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/427 , A61P3/06 , A61P3/10 , C07D277/34 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12
摘要： Compounds of formula I ##STR1## in which A denotes a carbocyclic ring with 5 or 6 carbon atoms or a heterocyclic ring with a maximum of 4 heteroatoms in which the heteroatoms can be the same or different and denote oxygen, nitrogen or sulphur and the heterocycles can if desired carry an oxygen atom on one or several nitrogen atoms,B denotes --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N--, O or S,W denotes CH.sub.2, O, CH(OH), CO or --CH.dbd.CH--,X denotes S, O or NR.sup.2 in which the residue R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl,Y is CH or N,R denotes naphthyl, pyridyl, furyl, thienyl or phenyl which if desired is mono- or disubstituted with C.sub.1 -C.sub.3 alkyl, CF.sub.3, C.sub.1 -C.sub.3 alkoxy, F, Cl or bromine,R.sup.1 denotes hydrogen or C.sub.1 -C.sub.6 alkyl andn equals 1-3as well as their tautomers, enantiomers, diastereomers and physiologically tolerated salts,processes for their production as well as pharmaceutical agents that contain these compounds for the treatment of diabetes.
摘要翻译： PCT No.PCT / EP94 / 01619 Sec。 371日期：1995年11月21日 102（e）日期1995年11月21日PCT 1994年5月19日PCT PCT。第WO94 / 27995号公报日期1994年12月8日，式I的化合物（I）其中A表示碳原子数5或6的碳环或最多有4个杂原子的杂环，其中杂原子可以相同或不同，表示氧，氮或硫，如果需要，可以在一个或多个氮原子上带有氧原子，B表示-CH = CH-，-N = CH-，-CH = N-，O或S，W表示CH 2， O，CH（OH），CO或-CH = CH-，X表示残基R2为氢或C1-C6烷基，Y为CH或N的S，O或NR2，R为萘基，吡啶基，呋喃基，噻吩基或苯基，如果需要，可以被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴单取代或被二取代，R 1表示氢或C 1 -C 6烷基，n等于1-3，以及它们的互变异构体，对映异构体，非对映异构体和生理上耐受的盐，其生产方法以及含有这些化合物用于治疗糖尿病的药剂。

37. 发明授权

US08980063B2 Air proportioning system for secondary air in coke ovens depending on the vault vs. sole temperature ratio 有权
标题翻译：焦炉中二次空气的空气配比系统取决于穹顶与唯一的温度比
公开(公告)号：US08980063B2
公开(公告)日：2015-03-17
申请号：US12998222
申请日：2009-08-25
申请人： Ronald Kim , Alfred Mertens
发明人： Ronald Kim , Alfred Mertens
IPC分类号： C10B5/06 , C10B15/02 , C10B21/22 , C10B21/10 , C10B41/00
CPC分类号： C10B15/02 , C10B5/06 , C10B21/10 , C10B21/22 , C10B41/00
摘要： A device for proportioning of secondary combustion air into the secondary air soles of coke oven chamber ovens is shown. The device is formed by a slide gate or a parallelepiped device or by plates moved by means of a thrust bar, the thrust bar being moved longitudinally in parallel to the coke oven chamber wall so that the plates move away from the secondary air apertures and open or close these. The thrust bar is moved by means of a positioning motor, with the power transmission being effected hydraulically or pneumatically. Via suitable measuring parameters, it is thus possible to optimize secondary heating so that heating is provided evenly from all sides, thus achieving an improvement in coke quality.
摘要翻译：示出了用于将二次燃烧空气配入焦炉室炉的二次空气底壳的装置。该装置由滑动门或平行六面体装置或通过推杆移动的板形成，推力杆平行于焦炉室壁纵向移动，使得板移动离开二次空气孔并打开或关闭这些。推力杆通过定位电机移动，动力传动通过液压或气动方式进行。通过适当的测量参数，因此可以优化二次加热，使得从所有侧面均匀地提供加热，从而实现焦炭质量的提高。

38. 发明授权

US08409405B2 Device and method for dosing or shutting off primary combustion air in the primary heating room of horizontal coke-oven chambers 有权
标题翻译：在卧式焦炉室的主加热室中配量或关闭主燃烧空气的装置和方法
公开(公告)号：US08409405B2
公开(公告)日：2013-04-02
申请号：US13255422
申请日：2010-02-13
申请人： Ronald Kim , Alfred Mertens
发明人： Ronald Kim , Alfred Mertens
IPC分类号： C10B9/00 , C10B15/02 , C10B21/10
CPC分类号： C10B15/02 , C10B21/10
摘要： Dosed proportioning and cutoff of combustion air into the primary heating space of a horizontal coke oven is provided by apertures in the ceiling of the coke oven chamber, the apertures covered with a withdrawable cover device which controls the amount of air admitted, manually or in an automatic mode. By way of this device, ventilation of a coke oven chamber with primary air can be so controlled that primary air is introduced in an exactly dosed manner and, depending on its place of installation, exactly distributed into the primary heating space of a coke oven chamber.
摘要翻译：通过焦炉室的天花板中的孔提供燃烧空气向卧式焦炉的初级加热空间的配量配料和切断，所述孔被可抽出的盖装置覆盖，所述抽出式盖装置可手动地或以自动模式。通过该装置，可以控制具有一次空气的焦炉室的通风，以使一次空气以精确计量的方式引入，并且根据其安装位置精确地分配到焦炉室的主加热空间。

39. 发明授权

US4824835A Isoquinolinedione derivatives, pharmaceutical compositions and methods of use 失效
标题翻译：异喹啉二酮衍生物，药物组合物和使用方法
公开(公告)号：US4824835A
公开(公告)日：1989-04-25
申请号：US42300
申请日：1987-04-24
申请人： Alfred Mertens , Bernd Muller-Beckmann
发明人： Alfred Mertens , Bernd Muller-Beckmann
IPC分类号： C07D401/12 , A61K31/47 , A61K31/472 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/12 , C07D217/24 , C07D221/20 , C07D401/04
CPC分类号： C07D221/20 , C07D217/24 , C07D401/04
摘要： The present invention provides isoquinolinedione derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical which is optionally interrupted by a heteroatom or by a heteroatom substituted with an alkyl radical, R.sub.2 is a hydrogen atom or an alkyl or alkenyl radical, or together with R.sub.1, represents a cycloalkylene, alkylidene or cycloalkylidene radical which is optionally interrupted by a heteroatom or by a heteroatom substituted by an alkyl radical and R.sub.3 is a radical of the general formula: ##STR2## which can be in the 5- 6-, 7- or 8-position of the isoquinoline-1,3-dione and in which R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms or alkyl, trihaloalkyl, cycloalkyl, cycloalkenyl, dealkylaminoalkyl, alkoxycarbonylalkyl, alkylcarbonyl, aryl or heterayl radicals and X is an oxygen or sulphur atom or a radical of the general formula .dbd.N--R.sub.6, in which R.sub.6 is a hydrogen atom, a cyano group of an alkyl radical; and the physiologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. These new compounds have a blood pressure lowering effect and/or influence thrombocyte aggregation, improve the microcirculation, and exert a positive intropic effect, thus having therapeutic and prophylactic effects.
摘要翻译：本发明提供以下通式的异喹啉二酮衍生物：其中R 1是氢原子或任选地被杂原子或被烷基取代的杂原子间隔的烷基，烯基或环烷基，R2是氢原子或烷基或链烯基，或与R 1一起表示亚环烷基，亚烷基或环亚烷基，其任选地被杂原子或被烷基取代的杂原子中断，并且R 3是以下通式的基团：其可以在异喹啉-1,3-二酮的5-6，7-或8-位，其中可以相同或不同的R 4和R 5是氢原子或烷基，三卤代烷基，环烷基，环烯基，脱烷基氨基烷基，烷氧基羰基烷基，烷基羰基，芳基或杂原子，X是氧或硫原子或通式= N-R6的基团，其中R6是氢原子，烷基的氰基; 及其生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。这些新化合物具有降血压作用和/或影响血栓细胞聚集，改善微循环，并发挥阳性的临床效果，具有治疗和预防作用。

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