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31. 发明申请

WO2014095524A1 DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：检测血液加压装置中的压力脉冲
公开(公告)号：WO2014095524A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/076233
申请日：2013-12-11
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/36 , A61B5/00
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04
摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (lb). A pulse detection block (54) processes the filtered signal (y f ) for detection of subject pulses originating from the subject.
摘要翻译：监测装置（7）对来自血液处理装置的压力信号进行操作。透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力来自处理液供给系统中的第二压力传感器（6b）的信号（w）。仿真块（56）根据第二压力信号（w）产生仿真第一压力传感器（6a）的并行信号响应的模拟第一压力信号（y）和滤波块（53），根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y）来自治疗液供应系统（1b）的信号干扰。脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。

32. 发明授权

EP2519280B1 METHOD AND DEVICE FOR DETECTING A CONFIGURATION OF WITHDRAWAL AND RETURN DEVICES 有权
标题翻译：方法和设备检测配置拆除和回器
公开(公告)号：EP2519280B1
公开(公告)日：2015-01-28
申请号：EP10798814.9
申请日：2010-12-22
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61M1/30 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M5/16859 , A61M2205/13 , A61M2205/3331 , A61M2230/04

33. 发明授权

EP2519278B1 METHOD AND DEVICE FOR DETECTING A FAULT CONDITION 有权
标题翻译：方法和设备识别出故障
公开(公告)号：EP2519278B1
公开(公告)日：2015-01-28
申请号：EP10798332.2
申请日：2010-12-22
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： G01N11/02 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3661 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04

34. 发明公开

EP2723419A1 DETECTING BLOOD PATH DISRUPTION IN EXTRACORPOREAL BLOOD PROCESSING 有权
标题翻译：一个BLUTWEGUNTERBRECHUNG在体外血液处理检测
公开(公告)号：EP2723419A1
公开(公告)日：2014-04-30
申请号：EP12722394.9
申请日：2012-05-23
申请人： Gambro Lundia AB
发明人： HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/3331 , A61M2205/3351 , G01N19/00
摘要： A device (7) monitors a blood path from a blood vessel access (3) of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access (3). A pumping device (4) in the blood path is operable to pump blood through the blood path from the blood withdrawal device (2') to the blood return device (2"). The monitoring device (7) obtains pressure data from a pressure sensor (6a) arranged upstream of the pumping device (4) in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device (4), e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor (6a), where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus (80) and have propagated on a propagation path (P2) in a direction downstream of the pumping device (4) through the blood return device (2"), the blood vessel access (3) and the blood withdrawal device (2') to the pressure sensor (6a).

35. 发明公开

EP2519277A1 APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 有权
标题翻译：用于预测快速症状性血压下降的装置和方法
公开(公告)号：EP2519277A1
公开(公告)日：2012-11-07
申请号：EP10796397.7
申请日：2010-12-22
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/0215
CPC分类号： A61B5/0215 , A61M1/3639
摘要： A monitoring device (29) is included in a medical system to implement a method for prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment such as dialysis. To this aim, a pulse shape parameter (p
PS ) with respect to a pulse generator of the subject is registered by means of a pressure sensor (4a, 4b, 4c) arranged in an extracorporeal blood flow circuit coupled to a cardiovascular system of the subject (P). The pressure sensor (4a, 4b, 4c) is adapted to detect pressure variations in blood vessels of the subject (P). It is investigated, during measurement period, whether or not one or more of the pulse shape parameters fulfil a decision criterion. An output signal (α) is generated if the decision criterion is found to be fulfilled, to indicate a predicted rapid symptomatic blood pressure decrease in the subject (P). The decision criterion may operate on pulse magnitude measures calculated for the received pulse shape parameters (p
PS ), or statistical dispersion measures calculated based on the thus-calculated pulse magnitude measures.
摘要翻译：监视设备（29）被包括在医疗系统中以实施用于预测对象的血压的快速症状下降的方法，例如，在透析等医疗过程中。为了这个目的，借助布置在体外血流回路中的压力传感器（4a，4b，4c）来记录关于受试者的脉冲发生器的脉搏形状参数（p PS），该体外血流回路耦合到心血管系统的心血管系统主题（P）。压力传感器（4a，4b，4c）适于检测对象（P）的血管中的压力变化。在测量期间研究一个或多个脉冲形状参数是否满足判定标准。如果发现判定标准被满足，则产生输出信号（α），以指示对象（P）中的预测的快速症状性血压降低。判定标准可以对针对接收到的脉冲形状参数（p PS）计算的脉搏幅度度量或基于如此计算的脉搏幅度度量计算的统计色散度量进行操作。

36. 发明公开

EP2445395A2 DEVICES, A COMPUTER PROGRAM PRODUCT AND A METHOD FOR DATA EXTRACTION 有权
标题翻译：装置和方法来进行提取
公开(公告)号：EP2445395A2
公开(公告)日：2012-05-02
申请号：EP10728643.7
申请日：2010-06-24
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61B5/021 , A61B5/08 , A61M1/36 , A61B5/02
CPC分类号： A61B5/02 , A61B5/021 , A61B5/02125 , A61B5/0816 , A61B5/0823 , A61B5/4094 , A61B5/411 , A61B5/4818 , A61M1/3639 , A61M2205/3331 , A61M2205/50 , A61M2230/06 , A61M2230/40 , A61M2230/63
摘要： A monitoring device is arranged to receive (401) at least one measurement signal obtained by at least one pressure sensor in an extracorporeal fluid system. The extracorporeal fluid system is in contact with a vascular system of a subject via a fluid connection. The monitoring device is configured to process (403) the measurement signal to identify pressure data that represents pulses originating from a first physiological phenomenon in the subject, excluding the heart of the subject. The extracorporeal fluid system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine. The first physiological phenomenon may be any one of reflexes, voluntary muscle contractions, non- voluntary muscle contractions, a breathing system of the subject, an autonomous system of the subject for blood pressure regulation, or an autonomous system of the subject for body temperature regulation. The monitoring device may detect, present, track or predict (409) a disordered condition of the subject using the pressure data, or monitor (410) the integrity of the fluid connection based on the pressure data.

37. 发明公开

EP2303356A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OF A FLUID CONNECTION 有权
标题翻译：方法和设备监测流体连接的完整性
公开(公告)号：EP2303356A2
公开(公告)日：2011-04-06
申请号：EP09769023.4
申请日：2009-06-26
申请人： Gambro Lundia AB
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36 , G01M3/28
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.

38. 发明授权

EP0772693B1 METHOD AND DEVICE FOR MEASURING THE CONCENTRATION OF A SUBSTANCE IN A SOLUTION 失效
标题翻译：方法和设备测量物质的浓度在溶液中
公开(公告)号：EP0772693B1
公开(公告)日：2003-06-04
申请号：EP95926583.6
申请日：1995-07-28
申请人： Gambro Lundia AB
发明人： EDGSON, Raymond , OLDE, Bo , OLSSON, Lars-Fride , GOODMAN JONES, Arfon Cambridge Consultants Ltd.
IPC分类号： C12Q1/58 , C12Q1/54 , C12Q1/60 , C12Q1/68 , G01N33/487
CPC分类号： C12Q1/58 , G01N27/021 , G01N33/493 , Y10T436/171538 , Y10T436/25

39. 发明授权

EP2519145B1 MONITORING A PROPERTY OF THE CARDIOVASCULAR SYSTEM OF A SUBJECT 有权
公开(公告)号：EP2519145B1
公开(公告)日：2019-05-15
申请号：EP10799034.3
申请日：2010-12-22
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61B5/0215 , A61M1/36 , A61B5/00

40. 发明授权

EP2519281B2 METHOD AND DEVICE FOR MONITORING THE INTEGRITY OF A CONNECTION SYSTEM 有权
公开(公告)号：EP2519281B2
公开(公告)日：2018-07-25
申请号：EP10799036.8
申请日：2010-12-22
申请人： Gambro Lundia AB
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： G01N19/08 , A61B5/024 , A61B2562/0247 , A61B2562/226 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04 , A61M2230/06
摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time-dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to-pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.

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