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31. 发明授权

US08834544B2 Photodynamic therapy for tumors with localized delivery 有权
标题翻译：具有局部递送的肿瘤的光动力疗法
公开(公告)号：US08834544B2
公开(公告)日：2014-09-16
申请号：US13440715
申请日：2012-04-05
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61N5/06 , A61K41/00 , A61K45/06 , A61N5/10 , A61K31/704
CPC分类号： A61K41/008 , A61K9/1647 , A61K31/195 , A61K31/704 , A61K33/00 , A61K41/00 , A61K41/0038 , A61K45/06 , A61N5/10 , A61N2005/1098 , A61K2300/00
摘要： Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light.
摘要翻译：提供了用于治疗缺氧性肿瘤的方法和系统，包括将递送装置定位在与肿瘤组织相邻的体腔中的步骤，通过递送装置将氧合剂递送至肿瘤组织，并用辐射辐射肿瘤组织。还提供了治疗肿瘤的方法和系统，包括将递送装置定位在与肿瘤组织相邻的体腔中的步骤，通过递送装置将光敏剂递送至肿瘤组织，并用光照射肿瘤组织。

32. 发明申请

US20140194776A1 Precision Directed Medical Instruments 审中-公开
标题翻译：精密定向医疗仪器
公开(公告)号：US20140194776A1
公开(公告)日：2014-07-10
申请号：US13736746
申请日：2013-01-08
申请人： Erhan H. Gunday , Lawrence J. Gerrans
发明人： Erhan H. Gunday , Lawrence J. Gerrans
IPC分类号： A61M25/10 , A61B10/02 , A61B1/018 , A61N5/00
CPC分类号： A61B10/0233 , A61B1/00098 , A61B17/3478 , A61B2017/22071 , A61B2017/22082 , A61M25/0084 , A61M25/0155 , A61M2025/0089 , A61M2025/0092
摘要： A system for delivering a medical instrument into a bodily cavity is provided, including an outer shaft having an aperture in a side wall thereof, wherein the aperture is provided at a distal portion of the outer shaft, an inner shaft positioned inside the outer shaft and having an inflatable balloon disposed at a distal portion thereof, and a needle member movably disposed in the outer shaft, wherein the needle member extends outwardly from the outer shaft through the aperture when the balloon is inflated.
摘要翻译：提供了一种用于将医疗器械输送到身体腔中的系统，包括在其侧壁中具有孔的外轴，其中所述孔设置在外轴的远端部分处，内轴位于外轴内部，具有设置在其远端部分处的可膨胀气囊和可移动地设置在所述外轴中的针构件，其中当所述气囊膨胀时，所述针构件从所述外轴向外延伸穿过所述孔。

33. 发明授权

US08668654B1 Cytological brushing system 有权
标题翻译：细胞刷洗系统
公开(公告)号：US08668654B1
公开(公告)日：2014-03-11
申请号：US13800623
申请日：2013-03-13
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61B5/00
CPC分类号： A61B10/04 , A61B5/08 , A61B5/1459 , A61B10/02 , A61B2010/0216
摘要： A system for gathering biological material in a biological cavity comprising a catheter having a first lumen, a balloon, and a second lumen in fluid communication with said balloon. The balloon has a textured outer surface for collecting biological material. At least one device for sampling a bodily tissue, such as a needle, optic or forceps, is disposed in the first lumen. A fluid source in fluid communication with the balloon supplies fluid to the second lumen to inflate the balloon such that the textured outer surface collects additional biological material. The system is particularly useful for collecting samples in the lungs or bronchial airways, such as at a bronchial junction.
摘要翻译：一种用于在生物腔中收集生物材料的系统，包括具有与所述气囊流体连通的第一腔，气囊和第二腔的导管。气球具有用于收集生物材料的纹理外表面。至少一个用于取样身体组织的装置，例如针，光学或镊子，设置在第一管腔中。与气囊流体连通的流体源将流体提供给第二腔以使气囊膨胀，使得织构化的外表面收集额外的生物材料。该系统特别可用于在肺或支气管气道中收集样品，例如在支气管结合处。

34. 发明授权

US08597239B2 Abrading balloon catheter for extravasated drug delivery 有权
标题翻译：用于外敷药物输送的磨砂球导管
公开(公告)号：US08597239B2
公开(公告)日：2013-12-03
申请号：US13037826
申请日：2011-03-01
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61M29/00
CPC分类号： A61M37/00 , A61B5/0084 , A61B5/6853 , A61B6/12 , A61B6/481 , A61B8/0833 , A61B17/22 , A61B17/22012 , A61B17/22032 , A61B17/320725 , A61B18/1492 , A61B2017/22054 , A61B2017/22061 , A61B2017/22084 , A61B2017/320004 , A61B2018/00214 , A61B2018/00898 , A61M5/007 , A61M25/0108 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/10181 , A61M25/10184 , A61M2025/105 , A61M2025/1086
摘要： A method of extravasated drug delivery is disclosed, including inserting a catheter with a first balloon, a second balloon, and a third balloon positioned between the first and second balloons and having a wall with an abrasive outer surface, into a bodily cavity, inflating the first and second balloons to create a chamber therebetween, stimulating a flow of blood cells by inflating the third balloon until the abrasive outer surface abrades tissue, and delivering the agent to the chamber. A balloon catheter system is also provided including a balloon having a wall with an abrasive outer surface for abrading tissue, a catheter having a first lumen for supplying fluid to the balloon to inflate the balloon such that the abrasive surface stimulates a flow of blood cells, and a second lumen for supplying an agent to tissue.
摘要翻译：公开了一种外渗药物递送的方法，包括将具有第一球囊，第二球囊和第三球囊的导管插入到第一和第二球囊之间并且具有磨料外表面的壁进入体腔，使第第一和第二气球以在其间形成室，通过使第三气囊膨胀直到研磨外表面磨损组织，并将试剂输送到腔室来刺激血细胞流。还提供了一种球囊导管系统，其包括具有用于研磨组织的具有磨料外表面的壁的气囊，具有用于向球囊供应流体以使气囊膨胀以使得研磨表面刺激血细胞流动的第一腔的导管，以及用于向组织供应药剂的第二腔。

35. 发明申请

US20130282173A1 Remotely Controlled Surgical Robots 审中-公开
标题翻译：遥控手术机器人
公开(公告)号：US20130282173A1
公开(公告)日：2013-10-24
申请号：US13867761
申请日：2013-04-22
申请人： Erhan H. Gunday , Lawrence J. Gerrans
发明人： Erhan H. Gunday , Lawrence J. Gerrans
IPC分类号： B25J9/16
CPC分类号： A61B34/30 , A61B34/72 , A61B90/30 , A61B90/361 , A61B2034/302 , B25J5/00 , B25J7/00 , B25J9/1689 , B25J13/006 , G05B2219/45073 , G05B2219/45117 , Y10S901/01 , Y10S901/30 , Y10S901/46
摘要： A surgical robotic system is provided including at least one robotic unit that is mechanically self-contained such that the robotic unit is movable on a bodily surface inside a patient's body independently of any structure positioned outside of the patient's body, and a control device positioned remotely from the at least one robotic unit, wherein said control device transmits commands that manipulate the at least one robotic unit inside the patient's body. A method of performing a robotically assisted medical procedure is also provided, including positioning at least one robotic unit inside a patient's body, moving the robotic unit on a bodily surface inside the patient's body by transmitting commands thereto via a control device that is positioned remotely from the at least one robotic unit, and actuating at least one medical tool positioned on the robotic unit via the control device.
摘要翻译：提供了一种外科手术机器人系统，其包括至少一个机械装置的机器人单元，使得机器人单元可以独立于位于患者身体外部的任何结构在患者身体内的身体表面上移动，以及远程定位的控制装置从所述至少一个机器人单元，其中所述控制装置发送操纵所述至少一个机器人单元在所述患者体内的命令。还提供了一种执行机器人辅助医疗过程的方法，包括将至少一个机器人单元定位在患者体内，通过经由远程远程定位的控制设备传送命令来将机器人单元移动到患者体内的身体表面上所述至少一个机器人单元，以及经由所述控制装置致动定位在所述机器人单元上的至少一个医疗工具。

36. 发明申请

US20120289982A1 Balloon Catheter Mesh 有权
标题翻译：气球导管网
公开(公告)号：US20120289982A1
公开(公告)日：2012-11-15
申请号：US13107426
申请日：2011-05-13
申请人： Erhan H. Gunday , Lawrence J. Gerrans
发明人： Erhan H. Gunday , Lawrence J. Gerrans
IPC分类号： A61B17/22
CPC分类号： A61B18/1492 , A61B17/320725 , A61B18/02 , A61B90/39 , A61B90/98 , A61B2017/00026 , A61B2017/22051 , A61B2018/0022 , A61B2018/00875 , A61B2090/3966 , A61B2218/002 , A61M25/10 , A61M2025/105 , A61M2025/1079 , A61M2025/1081 , A61M2025/1086 , A61M2025/109
摘要： A resector balloon includes an outer wall having a resecting surface that resects biological material. The balloon also includes a woven sleeve including at least one woven thread disposed on at least a portion of the outer wall. The woven sleeve forms at least a portion of the resecting surface. In certain embodiments, the woven sleeve includes weft knit threads including crossover points where the threads overlap. In some embodiments, the woven sleeve includes electrically conductive threads.
摘要翻译：覆盖气囊包括具有切除生物材料的切除表面的外壁。气球还包括编织套筒，其包括设置在外壁的至少一部分上的至少一个编织线。织造套筒形成切割表面的至少一部分。在某些实施例中，编织套管包括纬编针织纱线，其中纱线重叠的交叉点。在一些实施例中，织造套筒包括导电线。

37. 发明申请

US20120259238A1 Anatomical Visualization With Electrically Conductive Balloon Catheter 有权
标题翻译：导电气球导管解剖视觉
公开(公告)号：US20120259238A1
公开(公告)日：2012-10-11
申请号：US13440853
申请日：2012-04-05
申请人： Erhan H. Gunday , Lawrence J. Gerrans , Lon Chu
发明人： Erhan H. Gunday , Lawrence J. Gerrans , Lon Chu
IPC分类号： A61B5/053
CPC分类号： A61B5/6853 , A61B5/1076 , A61B2562/046 , F04C2270/041 , Y10T29/49124
摘要： A balloon catheter for providing a 3-dimensional rendering of the interior of a cavity, the catheter system including a controller, a catheter connected to the controller and a balloon positioned on the catheter. The balloon includes a mesh having members extending longitudinally and circumferentially about the balloon where each member of the mesh has an electrical characteristic that changes as the member is deformed. The controller uses a measurement of the variable electrical characteristic to generate a three-dimensional rendering of an interior surface of the cavity, which can be rotating to different viewing angles.
摘要翻译：一种用于提供空腔内部的三维渲染的气囊导管，所述导管系统包括控制器，连接到所述控制器的导管和位于所述导管上的气囊。气囊包括具有围绕球囊纵向和周向延伸的构件的网，其中网的每个构件具有随着构件变形而改变的电特性。控制器使用可变电特性的测量来产生可以旋转到不同视角的空腔的内表面的三维渲染。

38. 发明申请

US20110152683A1 Abrading Balloon Catheter for Extravasated Drug Delivery 有权
标题翻译：用于外推药物输送的磨砂气球导管
公开(公告)号：US20110152683A1
公开(公告)日：2011-06-23
申请号：US13037826
申请日：2011-03-01
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61M37/00 , A61B6/00
CPC分类号： A61M37/00 , A61B5/0084 , A61B5/6853 , A61B6/12 , A61B6/481 , A61B8/0833 , A61B17/22 , A61B17/22012 , A61B17/22032 , A61B17/320725 , A61B18/1492 , A61B2017/22054 , A61B2017/22061 , A61B2017/22084 , A61B2017/320004 , A61B2018/00214 , A61B2018/00898 , A61M5/007 , A61M25/0108 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/10181 , A61M25/10184 , A61M2025/105 , A61M2025/1086
摘要： A method of extravasated drug delivery is disclosed, including inserting a catheter with a first balloon, a second balloon, and a third balloon positioned between the first and second balloons and having a wall with an abrasive outer surface, into a bodily cavity, inflating the first and second balloons to create a chamber therebetween, stimulating a flow of blood cells by inflating the third balloon until the abrasive outer surface abrades tissue, and delivering the agent to the chamber. A balloon catheter system is also provided including a balloon having a wall with an abrasive outer surface for abrading tissue, a catheter having a first lumen for supplying fluid to the balloon to inflate the balloon such that the abrasive surface stimulates a flow of blood cells, and a second lumen for supplying an agent to tissue.
摘要翻译：公开了一种外渗药物递送的方法，包括将具有第一球囊，第二球囊和第三球囊的导管插入到第一和第二球囊之间并且具有磨料外表面的壁进入体腔，使第第一和第二气球以在其间形成室，通过使第三气囊膨胀直到研磨外表面磨损组织，并将试剂输送到腔室来刺激血细胞流。还提供了一种球囊导管系统，其包括具有用于研磨组织的具有磨料外表面的壁的气囊，具有用于向球囊供应流体以使气囊膨胀以使得研磨表面刺激血细胞流动的第一腔的导管，以及用于向组织供应药剂的第二腔。

39. 发明授权

US10098693B2 Balloon catheter mesh 有权
公开(公告)号：US10098693B2
公开(公告)日：2018-10-16
申请号：US14520024
申请日：2014-10-21
申请人： Erhan H. Gunday , Lawrence J. Gerrans
发明人： Erhan H. Gunday , Lawrence J. Gerrans
IPC分类号： A61B18/12 , A61B18/14 , A61B17/3207 , A61M25/10 , A61B90/98 , A61B90/00 , A61B18/02 , A61B17/00 , A61B17/22 , A61B18/00
摘要： A resector balloon includes an outer wall having a resecting surface that resects biological material. The balloon also includes a woven sleeve including at least one woven thread disposed on at least a portion of the outer wall. The woven sleeve forms at least a portion of the resecting surface. In certain embodiments, the woven sleeve includes weft knit threads including crossover points where the threads overlap. In some embodiments, the woven sleeve includes electrically conductive threads.

40. 发明授权

US09694075B2 Treatment of hypoxic tumors with localized oxygenation 有权
公开(公告)号：US09694075B2
公开(公告)日：2017-07-04
申请号：US13440695
申请日：2012-04-05
申请人： Lawrence J. Gerrans , Erhan H. Gunday
发明人： Lawrence J. Gerrans , Erhan H. Gunday
IPC分类号： A61N5/10 , A61K41/00 , A61K45/06 , A61K31/704 , A61K31/195 , A61K33/00 , A61K9/16
CPC分类号： A61K41/008 , A61K9/1647 , A61K31/195 , A61K31/704 , A61K33/00 , A61K41/00 , A61K41/0038 , A61K45/06 , A61N5/10 , A61N2005/1098 , A61K2300/00
摘要： Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light.

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