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31. 发明授权

US4991977A Smoothing filter for stage position pulses 失效
标题翻译：平滑滤波器用于平台位置脉冲
公开(公告)号：US4991977A
公开(公告)日：1991-02-12
申请号：US173777
申请日：1988-03-25
申请人： William G. Manns , Anthony B. Wood , Ronald S. Drafz , Don J. Weeks
发明人： William G. Manns , Anthony B. Wood , Ronald S. Drafz , Don J. Weeks
IPC分类号： B23K26/04 , G03F7/20
CPC分类号： G03F7/70633 , B23K26/04 , B23K26/043 , B23K26/046 , G03F7/704 , G03F7/70641 , G03F7/70725
摘要： A laser pattern inspection and/or writing system which writes or inspects a pattern on a target on a stage, by raster scanning the target pixels. Inspection can also be done by substage illumination with non-laser light. A database, organized into frames and strips, represents an ideal pattern as one or more polygons. Each polygon's data description is contained within a single data frame. The database is transformed into a turnpoint polygon representation, then a left and right vector representation, then an addressed pixel representation, then a bit-mapped representation of the entire target. Most of the transformations are carried out in parallel pipelines. Guardbands around polygon sides are used for error filtering during inspection. Guardbands are polygons, and frames containing only guardband information are sent down dedicated pipelines. Error filtering also is done at the time of pixel comparisons of ideal with real patterns, and subsequently during defect area consolidation. Defect areas are viewed as color overlays of ideal and actual target areas, from data generated during real time. Defect areas can be de-zoomed to allow larger target areas to be viewed. An autofocus keeps the scanning laser beam in focus on the target. The inspection system is used to find fiducial marks to orient the target prior to raster scanning. IC bars are provided with alignment marks for locating each IC bar. Interferometers or glass scale encoders allow the stage position to be known.
摘要翻译：激光图案检查和/或写入系统，其通过光栅扫描目标像素来写入或检查在舞台上的目标上的图案。检查也可以通过非激光的分层照明进行。组织成框架和条带的数据库表示作为一个或多个多边形的理想模式。每个多边形的数据描述都包含在单个数据帧中。将数据库转换为转折点多边形表示，然后转换为左和右向量表示，然后转换为寻址像素表示，然后是整个目标的位映射表示。大多数转换是在并行管道中进行的。多边形周围的保护带用于检查过程中的错误过滤。保卫带是多边形，仅包含保护带信息的帧被发送到专用管道。在理想与实际图案的像素比较时，随后在缺陷区域合并期间，也进行误差滤波。缺陷区域被视为理想和实际目标区域的颜色叠加，从实时生成的数据。缺陷区域可以去放大，以允许查看较大的目标区域。自动对焦将扫描激光束保持在目标上。检查系统用于在光栅扫描之前找到基准标记来定向目标。 IC条具有用于定位每个IC条的对准标记。干涉仪或玻璃刻度尺可以让舞台位置知道。

32. 发明授权

US4912487A Laser scanner using focusing acousto-optic device 失效
标题翻译：激光扫描仪采用聚焦声光装置
公开(公告)号：US4912487A
公开(公告)日：1990-03-27
申请号：US173775
申请日：1988-03-25
申请人： Vernon R. Porter , William G. Manns , Anthony B. Wood , S. Charles Baber , Thomas C. Penn
发明人： Vernon R. Porter , William G. Manns , Anthony B. Wood , S. Charles Baber , Thomas C. Penn
IPC分类号： B23K26/08 , G01N21/95 , G03F7/20
CPC分类号： G03F7/70633 , B23K26/0853 , G01N21/956 , G03F7/704 , G03F7/70641 , G03F7/70725 , G01N21/9501
摘要： A laser pattern inspection and/or writing system which writes or inspects a pattern on a target on a stage, by raster scanning the target pixels. Inspection can also be done by substage illumination with non-laser light. A database, organized into frames and strips, represents an ideal pattern as one or more polygons. Each polygon's data description is contained within a single data frame. The database is transformed into a turnpoint polygon representation, then a left and right vector representation, then an addressed pixel representation, then a bit-mapped representation of the entire target. Most of the transformations are carried out in parallel pipelines. Guardbands around polygon sides are used for error filtering during inspection. Guardbands are polygons, and frames containing only guardband information are sent down dedicated pipelines. Error filtering also is done at the time of pixel comparisons of ideal with real patterns, and subsequently during defect area consolidation. Defect areas are viewed as color overlays of ideal and actual target areas, from data generated during real time. Defect areas can be de-zoomed to allow larger target areas to be viewed. An autofocus keeps the scanning laser beam in focus on the target. The inspection system is used to find fiducial marks to orient the target prior to raster scanning. IC bars are provided with alignment marks for locating each IC bar. Interferometers or glass scale encoders allow the stage position to be known.
摘要翻译：激光图案检查和/或写入系统，其通过光栅扫描目标像素来写入或检查在舞台上的目标上的图案。检查也可以通过非激光的分层照明进行。组织成框架和条带的数据库表示作为一个或多个多边形的理想模式。每个多边形的数据描述都包含在单个数据帧中。将数据库转换为转折点多边形表示，然后转换为左和右向量表示，然后转换为寻址像素表示，然后是整个目标的位映射表示。大多数转换是在并行管道中进行的。多边形周围的保护带用于检查过程中的错误过滤。保卫带是多边形，仅包含保护带信息的帧被发送到专用管道。在理想与实际图案的像素比较时，随后在缺陷区域合并期间，也进行误差滤波。缺陷区域被视为理想和实际目标区域的颜色叠加，从实时生成的数据。缺陷区域可以去放大，以允许查看较大的目标区域。自动对焦将扫描激光束保持在目标上。检查系统用于在光栅扫描之前找到基准标记来定向目标。 IC条具有用于定位每个IC条的对准标记。干涉仪或玻璃刻度尺可以让舞台位置知道。

33. 发明授权

US09523090B2 Compositions and methods for treating inflammation 有权
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：US09523090B2
公开(公告)日：2016-12-20
申请号：US12433825
申请日：2009-04-30
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , C12N13/00
CPC分类号： C12N13/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating inflammation or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（气体富集（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供至少调节细胞膜电位和细胞膜电导率之一，以及用于治疗炎症或其至少一种症状的治疗组合物和方法。电动改变的流体组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白如膜受体，包括但不限于G-蛋白偶联受体（GPCR）和细胞间的细胞膜中的至少一种来调节或调节与炎性反应相关的细胞内信号转导交汇处（紧密连接处，间隙连接处，电子邮件地址和地址）。其他实施方案包括用于电动产生的流体（电动产生的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

34. 发明授权

US08784897B2 Methods of therapeutic treatment of eyes 失效
标题翻译：眼睛治疗方法
公开(公告)号：US08784897B2
公开(公告)日：2014-07-22
申请号：US12769136
申请日：2010-04-28
申请人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
发明人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
IPC分类号： A01N39/00
CPC分类号： A61K33/40 , A01N1/0226 , A61K9/0048 , A61K9/10 , A61K9/5115 , A61K31/573 , A61K33/00 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , A61K2300/00
摘要： Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.
摘要翻译：提供了电动改变的含水流体（例如，富含气体的电动液），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以提供细胞膜电位和细胞膜电导率中的至少一种的调节，以及治疗组合物和用于治疗刺激性，感染性或炎症性眼病症的方法，包括通过使需要的受试者的眼睛接触治疗有效量的电动改变的水性液体来施用。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。其它实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体）的特定施用途径或制剂以及用于治疗眼睛状况的治疗组合物。某些实施方案涉及使用流体处理与眼睛条件和/或疾病相关的化妆品和/或治疗症状的化妆品和/或治疗流体和/或治疗方法。

35. 发明授权

US08449172B2 Mixing device for creating an output mixture by mixing a first material and a second material 有权
公开(公告)号：US08449172B2
公开(公告)日：2013-05-28
申请号：US12945703
申请日：2010-11-12
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： B01F7/12
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.

36. 发明申请

US20120114702A1 COMPOSITIONS AND METHODS FOR TREATING ASTHMA AND OTHER LUNG DISORDERS 审中-公开
标题翻译：用于治疗哮喘和其他肺功能障碍的组合物和方法
公开(公告)号：US20120114702A1
公开(公告)日：2012-05-10
申请号：US13126117
申请日：2009-10-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61P11/06 , A61P11/00 , A61P29/00 , A61P31/04 , A61P11/14 , A61K33/00 , A61P11/02 , A61P11/08 , A61P31/12 , A61P31/06 , A61K39/395 , A61P31/16 , B82Y5/00
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or symptoms thereof (e g, asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (CaPO) and CaPO-associated conditions (e g, bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, in-fluenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) comprising administering a therapeutic composition comprising at least one electrokinetically altered fluid comprising an ionic aqueous solution of charge-stabilized oxygen containing nanostructures as disclosed herein, or comprising administering a nonelectrokinetic superoxygenated aqueous solution The methods preferably comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (e g, membrane receptors, (e g, G protein-coupled receptors, and intercellular junctions)) Additional aspects include therapeutic compositions, and combination treatment methods comprising administration of electrokinetically generated fluid in combination with at least one additional therapeutic agent (e g, albuterol, etc).
摘要翻译：提供用于治疗肺或呼吸系统疾病或由气流阻塞或限制或其症状（例如哮喘，鼻炎，过敏性鼻炎和慢性阻塞性肺疾病（CaPO）和CaPO相关病症（例如支气管炎）的特征的组合物和方法，肺气肿，哮喘），肺气肿，肺炎，支气管炎，流感，SARS，结核病和百日咳（百日咳）等），其包括施用包含至少一种电动改变的流体的治疗组合物，其包含离子水电荷所述方法优选包括通过调节细胞膜，膜电位，膜蛋白（例如，膜受体（例如，G蛋白））中的至少一种来调节细胞内信号转导蛋白偶联受体和细胞间结））另外的方面包括治疗组合物和组合治疗方法，包括与至少一种另外的治疗剂（例如沙丁胺醇等）组合施用电动产生的流体。

37. 发明申请

US20120034696A1 Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures 有权
标题翻译：包含电荷稳定的含气体纳米结构的电动改性流体
公开(公告)号：US20120034696A1
公开(公告)日：2012-02-09
申请号：US13016659
申请日：2011-01-28
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： C12N5/07 , C12N1/20 , A23L2/38 , B01F5/06 , C12N5/04 , C12N1/14 , B82Y30/00
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.
摘要翻译：具体方面提供了包含电动改变的含氧水溶液的组合物，其中流体中的氧以至少25ppm的量存在。在某些方面，电动改变的含氧水性流体包含以至少0.5ppm的量存在的电动改性或带电的氧物质。在某些方面，电动改变的含氧水性流体包含由分子氧稳定的溶剂化电子，并且其中溶剂化电子以至少0.01ppm的量存在。在某些方面，流体有助于在辣根过氧化物酶（HRP）存在下将连苯三酚氧化成紫罗卜糖苷，其量高于由产生的对照压力罐或具有等效溶解氧水平的微小气泡产生的水性流体所提供的量，并且其中在电动性富氧水溶液中不存在过氧化氢或少于0.1ppm的过氧化氢。

38. 发明申请

US20110104804A1 MIXING DEVICE 有权
标题翻译：混合装置
公开(公告)号：US20110104804A1
公开(公告)日：2011-05-05
申请号：US12945703
申请日：2010-11-12
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： B01F5/06 , B01F15/02 , C12M1/02 , C12N5/02 , C12M3/00 , C09K3/00
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.
摘要翻译：一种用于将第一和第二材料混合在一起以产生输出混合物的混合装置。该装置包括第一室，该第一室包含耦合到限定在转子和定子之间的混合室的第一材料。转子设置在定子内部并绕其旋转轴线旋转。第一室容纳内部泵，其构造成将第一材料从第一室泵送到混合室中。泵可以构造成在其进入混合室之前将圆周速度赋予第一材料。转子和定子中的至少一个具有多个通孔，第二材料通过该通孔提供给混合室。可选地，第二室耦合到混合室。第二室可以容纳内部泵，其构造成将输出材料从混合室泵入第二室。

39. 发明授权

US07919534B2 Mixing device 有权
标题翻译：混合装置
公开(公告)号：US07919534B2
公开(公告)日：2011-04-05
申请号：US11924595
申请日：2007-10-25
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： B01F3/04
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.
摘要翻译：具体方面提供了包含电动改变的含氧水溶液的组合物，其中流体中的氧以至少25ppm的量存在。在某些方面，电动改变的含氧水性流体包含以至少0.5ppm的量存在的电动改性或带电的氧物质。在某些方面，电动改变的含氧水性流体包含由分子氧稳定的溶剂化电子，并且其中溶剂化电子以至少0.01ppm的量存在。在某些方面，流体有助于在辣根过氧化物酶（HRP）存在下将连苯三酚氧化成紫罗卜糖醇，其量高于由产生的对照压力罐或具有等效溶解氧水平的微小气泡产生的含水流体所提供的量，并且其中在电动性富氧水溶液中不存在过氧化氢或少于0.1ppm的过氧化氢。

40. 发明申请

US20100316723A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION 审中-公开
公开(公告)号：US20100316723A1
公开(公告)日：2010-12-16
申请号：US12772028
申请日：2010-04-30
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K31/56 , A61K31/58 , A61K31/135 , A61K31/573 , A61K39/395 , A61K38/02 , A61P29/00 , A61P43/00 , C12N5/07 , C12N5/078 , C12N5/0783 , C12N5/0787
CPC分类号： C12N13/00 , G01N33/6872
摘要： Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating inflammation or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.

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