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31. 发明申请

US20050260667A1 Schizophrenia associated genes, proteins and biallelic markers 失效
标题翻译：精神分裂症相关基因，蛋白质和双重标记物
公开(公告)号：US20050260667A1
公开(公告)日：2005-11-24
申请号：US11145703
申请日：2005-06-06
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C07H21/04 , C07K14/47 , C07K14/705 , C12N5/08 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

32. 发明授权

US06346381B1 Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US06346381B1
公开(公告)日：2002-02-12
申请号：US09218207
申请日：1998-12-22
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention provides polynucleotides including biallelic markers derived from PG1 and from flanking genomic regions. Primers hybridizing to these biallelic markers and regions flanking are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and prostate cancer and between a haplotype and prostate cancer. The invention also relates to diagnostic methods of determining whether an individual is at risk for developing prostate cancer, and whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明提供了多核苷酸，其包括衍生自PG1和来自侧翼基因组区域的双重标记。还提供了与这些双重标记和侧翼区域杂交的引物。本发明提供了适用于对本发明的一种或多种双重标记的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了检测双重标记等位基因与前列腺癌之间以及单倍型与前列腺癌之间的统计学相关性的方法。本发明还涉及确定个体是否处于发展中的前列腺癌风险的诊断方法以及PG1基因突变导致个体患有前列腺癌的诊断方法。

33. 发明授权

US5945522A Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US5945522A
公开(公告)日：1999-08-31
申请号：US996306
申请日：1997-12-22
申请人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld , Lydie Bougueleret
发明人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld , Lydie Bougueleret
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , A61K38/00 , C12Q2600/136 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention also relates to methods of determining whether an individual is at risk for developing prostate cancer at a later date or whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明还涉及确定个体是否处于晚期发展中的前列腺癌风险的方法，还是由于PG1基因突变导致个体患有前列腺癌的方法。

34. 发明申请

US20080254451A1 Compositions and Methods for Treating Schizophrenia and Related Disorders 审中-公开
标题翻译：治疗精神分裂症和相关疾病的组合物和方法
公开(公告)号：US20080254451A1
公开(公告)日：2008-10-16
申请号：US11575844
申请日：2005-12-12
申请人： Ilya Chumakov , Daniel Cohen , Fabio Macciardi
发明人： Ilya Chumakov , Daniel Cohen , Fabio Macciardi
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/566 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates, generally, to methods and compositions for detecting or treating mental disorders, such as schizophrenia. The present invention more particularly discloses the identification of human genes which can be used for the diagnosis, prevention and treatment of schizophrenia and related disorders, as well as for the screening of therapeutically active drugs. The invention further discloses specific polymorphisms or alleles of the CNTFR gene that are related to schizophrenia, as well as diagnostic tools and kits based on these markers. The invention can be used in the diagnosis of or predisposition to, detection, prevention and/or treatment of schizophrenia and related disorders.
摘要翻译：本发明一般涉及用于检测或治疗精神障碍如精神分裂症的方法和组合物。本发明更具体地公开了可用于诊断，预防和治疗精神分裂症及相关病症以及用于筛选治疗活性药物的人类基因的鉴定。本发明还公开了与精神分裂症相关的CNTFR基因的特异性多态性或等位基因，以及基于这些标记的诊断工具和试剂盒。本发明可用于诊断或倾向于检测，预防和/或治疗精神分裂症及相关疾病。

35. 发明申请

US20080182268A1 SCHIZOPHRENIA ASSOCIATED GENES, PROTEINS AND BIALLELIC MARKERS 审中-公开
标题翻译： SCHIZOPHRENIA相关基因，蛋白质和BIALLELIC标记
公开(公告)号：US20080182268A1
公开(公告)日：2008-07-31
申请号：US12056900
申请日：2008-03-27
申请人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C12Q1/68 , C07K14/00 , C07H21/00 , C40B40/06 , C12N15/63 , C12N5/10 , C07K16/00
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

36. 发明授权

US07105353B2 Methods of identifying individuals for inclusion in drug studies 失效
标题翻译：识别个人包括在药物研究中的方法
公开(公告)号：US07105353B2
公开(公告)日：2006-09-12
申请号：US10367438
申请日：2003-02-14
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov
IPC分类号： G01N33/00 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q1/6827 , C12Q1/6837 , C12Q1/6841 , Y10T436/143333
摘要： The present invention relates to genomic maps comprising biallelic markers, new biallelic markers, and methods of using biallelic markers.
摘要翻译：本发明涉及包含双重标记，新的双重标记的基因组图谱和使用双重标记的方法。

37. 发明授权

US08571804B2 Disease treatment by predicting drug association 有权
标题翻译：预防药物协会的疾病治疗
公开(公告)号：US08571804B2
公开(公告)日：2013-10-29
申请号：US12744363
申请日：2008-11-28
申请人： Daniel Cohen , Ilya Chumakov
发明人： Daniel Cohen , Ilya Chumakov
IPC分类号： G06F19/00 , G06F19/12 , G06F17/10
CPC分类号： G16H50/50 , G06F19/00 , G06F19/18 , G06F19/326 , G06F19/3456 , Y02A90/26
摘要： The present invention relates to methods for drug repositioning. More particularly, this invention relates to methods for selecting approved drugs or combinations of approved drugs for use in new therapeutic indications. This approach is situated in a cross section between drug repositioning and disease treatment by combinations of drugs with additive or synergistic action. The invention also allows to define drugs or drug combinations for treating the unmet medical need in diseases neglected by majority of Pharma companies, such as orphan diseases.
摘要翻译：本发明涉及药物重新定位的方法。更具体地，本发明涉及用于选择用于新的治疗适应症的批准药物或批准药物的组合的方法。该方法位于药物重新定位和疾病治疗之间的横截面，其中药物与添加剂或协同作用的组合。本发明还允许定义药物或药物组合来治疗大多数Pharma公司忽视的疾病，例如孤儿疾病。

38. 发明申请

US20070249518A1 Compositions and Methods for Treating Mental Disorders 审中-公开
标题翻译：治疗精神疾病的组成和方法
公开(公告)号：US20070249518A1
公开(公告)日：2007-10-25
申请号：US11575838
申请日：2005-12-09
申请人： Ilya Chumakov , Daniel Cohen , Fabio Macciardi
发明人： Ilya Chumakov , Daniel Cohen , Fabio Macciardi
IPC分类号： A61K38/00 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates, generally, to methods and compositions for detecting or treating mental disorders, such as schizophrenia or bipolar disorder. The present invention more particularly discloses the identification of human genes that can be used for the diagnosis, prevention and treatment of schizophrenia, bipolar disorder and related disorders, as well as for the screening of therapeutically active drugs to treat said disorders. The invention further discloses specific polymorphisms or alleles of the KCNQ3 gene that are related to schizophrenia or bipolar disorder, as well as diagnostic tools and kits based on these markers. The invention can be used in the diagnosis of or predisposition to, detection, prevention and/or treatment of schizophrenia, bipolar disorder and related disorders.
摘要翻译：本发明一般涉及用于检测或治疗精神障碍如精神分裂症或双相情感障碍的方法和组合物。本发明更具体地公开了可用于诊断，预防和治疗精神分裂症，双相性精神障碍和相关病症以及用于筛选治疗性活性药物以治疗所述疾病的人类基因的鉴定。本发明还公开了与精神分裂症或双相性精神障碍相关的KCNQ3基因的特异性多态性或等位基因，以及基于这些标记的诊断工具和试剂盒。本发明可用于诊断或倾向于检测，预防和/或治疗精神分裂症，双相情感障碍和相关疾病。

39. 发明申请

US20060234221A1 Biallelic markers of d-amino acid oxidase and uses thereof 审中-公开
标题翻译： d氨基酸氧化酶的双相标记物及其用途
公开(公告)号：US20060234221A1
公开(公告)日：2006-10-19
申请号：US10497268
申请日：2002-10-29
申请人： Daniel Cohen , Ilya Chumakov
发明人： Daniel Cohen , Ilya Chumakov
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention concerns the human DAO gene, polynucleotides, and biallelic markers. The invention also concerns the association established between schizophrenia and the biallelic markers. The invention provides means to determine the predisposition of individuals to schizophrenia or related CNS disorder, as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人DAO基因，多核苷酸和双重标记。本发明还涉及精神分裂症与双重标记之间建立的关联。本发明提供了确定个体对精神分裂症或相关CNS障碍的倾向的手段，以及用于疾病诊断和预后的手段。

40. 发明授权

US06537751B1 Biallelic markers for use in constructing a high density disequilibrium map of the human genome 失效
标题翻译：用于构建人类基因组高密度不平衡图的双相标记
公开(公告)号：US06537751B1
公开(公告)日：2003-03-25
申请号：US09422978
申请日：1999-10-20
申请人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld
发明人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld
IPC分类号： C07H2104
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6841 , C12Q1/6876 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to genomic maps comprising biallelic markers, new biallelic markers, and methods of using biallelic markers. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides a number of methods utilizing the biallelic markers of the invention including methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
摘要翻译：本发明涉及包含双重标记，新的双重标记的基因组图谱和使用双重标记的方法。还提供了与这些双重标记物侧翼的区域杂交的引物。本发明提供了适用于对本发明的一种或多种双重标记的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了利用本发明的双重标记物的多种方法，包括检测双标记等位基因和表型之间和/或双标记单倍型和表型之间的统计学相关性的方法。

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