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31. 发明申请

WO2012136813A9 AGENTS FOR MEDICAL RADAR DIAGNOSIS 审中-公开
标题翻译：医疗雷达诊断代理
公开(公告)号：WO2012136813A9
公开(公告)日：2013-03-14
申请号：PCT/EP2012056363
申请日：2012-04-05
申请人： UNI I OSLO , KLAVENESS JO
发明人： KLAVENESS JO
IPC分类号： A61K49/00 , A61B5/05 , A61K49/04 , A61K49/10 , A61K49/18 , A61K49/22
CPC分类号： A61K49/0438 , A61B5/0507 , A61K49/00 , A61K49/0404 , A61K49/105 , A61K49/1863 , A61K49/223
摘要： The present invention relates to the use of contrast agents in radar based imaging, particularly in medical imaging. The invention also relates to the use of contrast agents in diagnosis of various diseases using radar-based technology. An apparatus for radar-based imaging comprising a contrast agent is also disclosed.
摘要翻译：本发明涉及造影剂在基于雷达的成像中的应用，特别是在医学成像中。本发明还涉及造影剂在使用基于雷达的技术诊断各种疾病中的用途。还公开了一种包括造影剂的基于雷达的成像设备。

32. 发明申请

WO2012136813A3 AGENTS FOR MEDICAL RADAR DIAGNOSIS 审中-公开
标题翻译：药物雷达诊断代理
公开(公告)号：WO2012136813A3
公开(公告)日：2013-01-17
申请号：PCT/EP2012056363
申请日：2012-04-05
申请人： UNI I OSLO , KLAVENESS JO
发明人： KLAVENESS JO
IPC分类号： A61K49/00 , A61B5/05 , A61K49/04 , A61K49/10 , A61K49/18 , A61K49/22
CPC分类号： A61K49/0438 , A61B5/0507 , A61K49/00 , A61K49/0404 , A61K49/105 , A61K49/1863 , A61K49/223
摘要： The present invention relates to the use of contrast agents in radar based imaging, particularly in medical imaging. The invention also relates to the use of contrast agents in diagnosis of various diseases using radar-based technology. An apparatus for radar-based imaging comprising a contrast agent is also disclosed.
摘要翻译：本发明涉及造影剂在雷达成像中的应用，特别是在医学成像中。本发明还涉及使用造影剂在使用基于雷达的技术诊断各种疾病方面。还公开了一种包括造影剂的雷达成像装置。

33. 发明申请

WO2005030265A3 OPTICAL IMAGING OF ENDOMETRIOSIS 审中-公开
标题翻译：内分泌瘤的光学成像
公开(公告)号：WO2005030265A3
公开(公告)日：2005-07-07
申请号：PCT/NO2004000286
申请日：2004-09-28
申请人： AMERSHAM HEALTH AS , KLAVENESS JO , JOHANNESEN EDVIN , TOLLESHAUG HELGE
发明人： KLAVENESS JO , JOHANNESEN EDVIN , TOLLESHAUG HELGE
IPC分类号： A61K49/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0043 , A61K49/0052
摘要： The invention provides contrast agents for optical imaging of endometriosis in patients. The contrast agent may be used in diagnosis of endometriosis, for follow-up of progress in disease development, and for follow-up of treatment of endometriosis. Further, the invention provides methods for optical imaging of endometriosis. The contrast agent has affinity for an abnormally expressed target associated with endometriosis. By abnormally expressed, is meant that the target is either overexpressed or downregulated. Endometriotic tissue containing a downregulated target may be identified by a low amount of bound contrast agent compared to normal tissue. In this situation, the amount of contrast agent should be less than 50% of that in normal tissue, preferably less than 10%.
摘要翻译：本发明提供了用于患者子宫内膜异位症的光学成像的造影剂。造影剂可用于诊断子宫内膜异位症，用于随访疾病发展进展，以及随访子宫内膜异位症的治疗。此外，本发明提供了用于子宫内膜异位症的光学成像的方法。造影剂对与子宫内膜异位症相关的异常表达的靶标具有亲和力。通过异常表达意味着靶标过表达或下调。与正常组织相比，含有下调靶的子宫内膜异位组织可以通过少量结合的造影剂来鉴定。在这种情况下，造影剂的量应小于正常组织的50％，优选小于10％。

34. 发明申请

WO03011265A3 5-AMINOLEVULINIC ACID AND ESTERS, IN COMBINATION WITH ANOTHER PHTOSENSITIZER, AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY, AND THEIR USES IN TREATING WOUNDS 审中-公开
标题翻译： 5-氨基冰片酸和酯，与另一种光敏剂，作为光敏剂在光化学治疗中的应用，以及它们用于治疗伤口的用途
公开(公告)号：WO03011265A3
公开(公告)日：2003-04-24
申请号：PCT/GB0203386
申请日：2002-07-25
申请人： PHOTOCURE ASA , KLAVENESS JO , HANSSON VIDAR , GOLDING LOUISE
发明人： KLAVENESS JO , HANSSON VIDAR
IPC分类号： A61K31/409 , A61K31/197 , A61K31/22 , A61K31/222 , A61K31/25 , A61K31/27 , A61K31/4406 , A61K41/00 , A61P1/04 , A61P9/00 , A61P17/02
CPC分类号： A61K41/0061
摘要： The method relates to the use of a photosensitizer selected from 5-aminolevulinic acid (5-ALA) and 5-ALA derivatives, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in treating a wound. Examples of wounds which may be treated in accordance with the invention include those resulting from non-physiological processes, e.g. from surgery or from physical injury, abrasions, lacerations, and wounds arising from a thermal injury (e.g. a burn or a wound arising from any cryo-based treatment). Ulcers, e.g. leg ulcers, venous ulcers and gastric ulcers, may also be successfully treated in accordance with the methods of the invention.
摘要翻译：该方法涉及使用选自5-氨基乙酰丙酸（5-ALA）和5-ALA衍生物的光敏剂及其药学上可接受的盐在制备用于治疗伤口的药物中的用途。根据本发明可以治疗的伤口的例子包括由非生理过程产生的伤口，从手术或由于热损伤（例如由任何基于冷冻治疗引起的烧伤或伤口）引起的身体损伤，擦伤，撕裂伤和伤口。溃疡，例如根据本发明的方法也可以成功治疗腿部溃疡，静脉溃疡和胃溃疡。

35. 发明申请

WO9818498A3 Improvements in or relating to diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂的改进或与之相关
公开(公告)号：WO9818498A3
公开(公告)日：1998-07-16
申请号：PCT/GB9702958
申请日：1997-10-28
申请人： MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAL , HOGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , CUTHBERTSON ALAN , LOVHAUG DAGFINN , SOLBAKKEN MAGNE
发明人： KLAVENESS JO , RONGVED PAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , CUTHBERTSON ALAN , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0091 , A61K49/223 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.

36. 发明申请

WO9818495A2 IMPROVEMENTS IN OR RELATING TO DIAGNOSTIC/THERAPEUTIC AGENTS 审中-公开
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：WO9818495A2
公开(公告)日：1998-05-07
申请号：PCT/GB9702955
申请日：1997-10-28
申请人： MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS , KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE , CUTHBERTSON ALAN
发明人： KLAVENESS JO , RONGVED PAAL , HOEGSET ANDERS , TOLLESHAUG HELGE , GODAL ASLAK , LOEVHAUG DAGFINN , SOLBAKKEN MAGNE , CUTHBERTSON ALAN
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12 , A61K51/10
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/55 , A61K47/554 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K49/223 , A61K51/04 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said reporter being conjugated to one or more non-proteinaceous, non-peptide and non-polysaccharide vectors.
摘要翻译：可靶向的诊断和/或治疗活性剂，例如超声造影剂，包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述报道分子与一种或多种非蛋白质，非肽和非多糖载体缀合。

37. 发明申请

WO2012085671A2 ANTIOXIDANTS IN FISH OIL POWDER AND TABLETS 审中-公开
标题翻译：鱼油粉末和片剂中的抗氧化剂
公开(公告)号：WO2012085671A2
公开(公告)日：2012-06-28
申请号：PCT/IB2011003266
申请日：2011-12-21
申请人： OMEGATRI AS , TORGERSEN TRINE-LISE , KLAVENESS JO , MYRSET ASTRID HILDE
发明人： TORGERSEN TRINE-LISE , KLAVENESS JO , MYRSET ASTRID HILDE
IPC分类号： A23L1/30 , A23L1/00 , A23L1/302 , A61K35/60
CPC分类号： C11B5/0092 , A23D7/0053 , A23D7/04 , A23D9/007 , A23D9/05 , A23L3/3508 , A23L33/115 , A23L33/12 , A23L33/15 , A23V2002/00 , A61K9/0007 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/2018 , A61K9/4825 , A61K35/655 , A61K47/6951 , C08B15/00 , C08B37/0015 , C08L1/04 , C08L5/16 , C11B5/0021 , C11B5/0028 , C11B5/005 , A23V2200/02 , A23V2200/214 , A23V2250/1882 , A23V2250/5112 , A23V2250/708 , A61K2300/00
摘要： This invention relates to antioxidants and combinations of antioxidants used to prevent oxidation of pharmaceutical and nutraceutical products in the form of powders, granulates, tablets, emulsions, gels and the like comprising one or more fatty acids and/or fatty acid derivatives and, optionally, at least one carbohydrate carrier alone or together with vitamins, minerals and/or pharmaceuticals. In particular, the invention concerns the use of antioxidants to reduce oxidation of powders, tablets, gels and emulsions comprising high concentrations and high doses of omega-3 fatty acids or derivatives thereof.
摘要翻译：本发明涉及抗氧化剂和抗氧化剂的组合，其用于防止粉末，颗粒，片剂，乳液，凝胶等形式的药物和营养产品的氧化，其包含一种或多种脂肪酸和/或脂肪酸衍生物，以及任选地，至少一种碳水化合物载体单独或与维生素，矿物质和/或药物一起使用。特别地，本发明涉及使用抗氧化剂来减少包含高浓度和高剂量的ω-3脂肪酸或其衍生物的粉末，片剂，凝胶和乳液的氧化。

38. 发明申请

WO2008006607A3 PHARMACEUTICAL AND NUTRACEUTICAL PRODUCTS COMPRISING VITAMIN K2 审中-公开
标题翻译：包含维生素K2的药物和营养产品
公开(公告)号：WO2008006607A3
公开(公告)日：2008-10-23
申请号：PCT/EP2007006241
申请日：2007-07-13
申请人： NATTOPHARMA ASA , VERMEER CEES , SCHURGERS LEON J , KLAVENESS JO , VIK HOGNE , VIK ANNE BJORNEBYE , WESTBYE STEIN
发明人： VERMEER CEES , SCHURGERS LEON J , KLAVENESS JO , VIK HOGNE , VIK ANNE BJORNEBYE , WESTBYE STEIN
IPC分类号： A61K31/122 , A61K31/231 , A61K31/232 , A61K35/60 , A61P9/00 , A61P19/00
CPC分类号： A61K35/60 , A23L33/15 , A23V2002/00 , A61K31/122 , A61K31/231 , A61K31/232 , A61K2300/00 , A23V2250/714
摘要： A pharmaceutical and nutraceutical product is provided comprising vitamin K 2 or a compound within the vitamin K 2 class of compounds, optionally and preferably in combination with one or more polyunsaturated fatty acids, either in purified form or as a marine oil (i.e. fish and/or krill oil). Also provided is the use of vitamin K 2 or a compound within the vitamin K 2 class of compounds, preferably in combination with one or more polyunsaturated fatty acids, either in purified form or as a marine oil, in the treatment or prophylaxis of disorders related to bone, cartilage and the cardiovascular system. Preferred compounds within the vitamin K 2 class of compounds are MK-7, MK-8, MK-9 and MK-10, in particular MK-7 or MK-9. The marine oil is preferably krill oil or fish oil.
摘要翻译：提供了药物和营养品产品，其包含维生素K 2或维生素K 2类化合物内的化合物，任选且优选与一种或多种多不饱和脂肪酸组合，以纯化形式或作为海洋油（即鱼和/或磷虾油）。还提供了维生素K 2或维生素K 2类化合物内的化合物的用途，所述化合物优选与一种或多种多不饱和脂肪酸以纯化形式或作为海洋油，用于治疗或预防与骨，软骨和心血管系统相关的病症。维生素K 2类化合物中优选的化合物是MK-7，MK-8，MK-9和MK-10，特别是MK-7或MK-9。海洋油优选磷虾油或鱼油。

39. 发明申请

WO0182724A3 COMPOSITIONS CONTAINING AMINOPOLYSACCHARIDES AND NEGATIVELY CHARGED POLYSACCHARIDES 审中-公开
标题翻译：含有氨基胆甾醇和负价电荷的多糖的组合物
公开(公告)号：WO0182724A3
公开(公告)日：2004-05-13
申请号：PCT/IB0101044
申请日：2001-05-03
申请人： NATURAL AS , REMMEREIT JAN , KLAVENESS JO
发明人： REMMEREIT JAN , KLAVENESS JO
IPC分类号： A23L1/054 , A23L1/056 , A23L1/308 , A23L1/30
CPC分类号： A23L33/21 , A23L29/27 , A23L29/275 , A23V2002/00 , A23V2250/511 , A23V2250/5072 , A23V2250/2482 , A23V2250/5036 , A23V2250/5086 , A23V2250/506 , A23V2250/5432 , A23V2250/5026
摘要： The present invention relates to a readily dispersable composition that includes an aminopolysaccharide and a negatively charged polysaccharide. An aminopolysaccharide and a negatively charged polysaccharide such as xanthan gum, guar gum, alginic acid, carrageenan and pectin are blended together to form particles of chitosan coated with the polysaccharide. The composition may optionally contain food flavorings, dyes, vitamins, minerals, and/or phytonutrients.
摘要翻译：本发明涉及包含氨基多糖和带负电荷的多糖的易分散组合物。将氨基多糖和负电荷多糖如黄原胶，瓜尔胶，藻酸，角叉菜胶和果胶混合在一起形成用多糖包被的壳聚糖颗粒。组合物可任选地含有食品香料，染料，维生素，矿物质和/或植物营养素。

40. 发明申请

WO9805364A3 Improvements in or relating to contrast agents 审中-公开
标题翻译：造影剂的改善或与之相关
公开(公告)号：WO9805364A3
公开(公告)日：1998-06-18
申请号：PCT/GB9702119
申请日：1997-08-04
申请人： JOHNSON DAVID , OSTENSEN JONNY , ERIKSEN MORTEN , TORNES AUDUN , FRIGSTAD SIGMUND , DUGSTAD HARALD , KLAVENESS JO , RONGVED PAL , SKURTVEIT ROALD , BRAENDEN JORUNN , MARSDEN JOHN CHRISTOPHER , NYCOMED IMAGING AS
发明人： JOHNSON DAVID , OESTENSEN JONNY , ERIKSEN MORTEN , TORNES AUDUN , FRIGSTAD SIGMUND , DUGSTAD HARALD , KLAVENESS JO , RONGVED PAL , SKURTVEIT ROALD , BRAENDEN JORUNN
IPC分类号： A61K47/04 , A61K20060101 , A61K47/06 , A61K47/08 , A61K47/24 , A61K49/00 , A61K49/04 , A61K49/22
CPC分类号： A61K49/223
摘要： Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilised by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

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