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31. 发明授权

US06379698B1 Fusogenic lipids and vesicles 失效
标题翻译：融合脂质和囊泡
公开(公告)号：US06379698B1
公开(公告)日：2002-04-30
申请号：US09287175
申请日：1999-04-06
申请人： Christopher Paul Leamon
发明人： Christopher Paul Leamon
IPC分类号： A61K9127
CPC分类号： C12N15/1135 , A61K9/1271 , A61K48/00 , C12N15/88 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , Y10S977/907 , C12N2310/3525
摘要： Novel lipid compounds are provided that may be termed “pro-cationic” in that they are neutral or negatively charged until they are either brought into contact with cellular membranes or are internalized by cells. The lipids have a hydrophobic tail group and a hydrophilic head group, the head group incorporating both a positively and negatively charged region at physiological pH. The hydrophobic tail group is stably connected to the positive region of the head group which in turn is connected to the negative region by a disulfide bond that is susceptible to cleavage by membrane-bound and intracellular factors. Cleavage of the disulfide bond removes the negatively charged region from the head group resulting in a lipid that is cationic and therefor fusogenic with negatively charged cell membranes. Consequently, lipids of the invention are useful as components of liposomes that serve as vehicles for delivering pharmaceutical agents into cells with reduced toxicity.
摘要翻译：提供了可以称为“阳离子阳离子”的新型脂质化合物，因为它们是中性的或带负电荷的，直到它们与细胞膜接触或被细胞内化。脂质具有疏水性尾巴基团和亲水性头部基团，头部基团在生理pH下既带有带正电荷又带负电荷的区域。疏水性尾基稳定地连接到头基的正区域，该基团又通过易受膜结合和胞内因子切割的二硫键连接到负区。二硫键的切割从头部基团中除去带负电荷的区域，导致一种阳离子脂质，并带有带负电荷的细胞膜。因此，本发明的脂质可用作脂质体的组分，其作为用于将药剂递送到具有降低的毒性的细胞中的载体。

32. 发明申请

US20130330326A1 METHODS OF TREATING CANCER 有权
标题翻译：癌症治疗方法
公开(公告)号：US20130330326A1
公开(公告)日：2013-12-12
申请号：US13884842
申请日：2011-11-11
申请人： Joseph Anand Reddy , Christopher Paul Leamon
发明人： Joseph Anand Reddy , Christopher Paul Leamon
IPC分类号： A61K38/08 , A61K33/24 , A61K31/4745 , A61K39/395 , A61K31/7068 , A61K31/517 , A61K31/519 , A61K31/282 , A61K31/704
CPC分类号： A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.
摘要翻译：描述了用叶酸 - 长春花碱缀合物与至少一种其他化学治疗剂联合治疗上皮肿瘤的方法和组合物，其中肿瘤包括卵巢，子宫内膜或非小细胞肺癌肿瘤，包括耐铂性卵巢肿瘤和铂 - 敏感的卵巢肿瘤。

33. 发明申请

US20090081710A1 Method for Cancer Prognosis Using Cellular Folate Vitamin Receptor Quantification 审中-公开
标题翻译：使用细胞叶酸维生素受体定量的癌症预后的方法
公开(公告)号：US20090081710A1
公开(公告)日：2009-03-26
申请号：US11887438
申请日：2006-03-30
申请人： Philip Stewart Low , Lynn C. Hartmann , Christopher Paul Leamon , Phil Ronald Ellis
发明人： Philip Stewart Low , Lynn C. Hartmann , Christopher Paul Leamon , Phil Ronald Ellis
IPC分类号： G01N33/574
CPC分类号： G01N33/57492
摘要： The invention relates to a method for determining a prognosis for a cancer by quantifying vitamin receptor expression on the cancer cells. The method comprises the steps of quantifying vitamin receptor expression on the cancer cells, and determining a prognosis for the cancer. The invention also relates to methods and kits for determining the presence of vitamin receptors on cancer cells to select patients that should be treated with a therapy that utilizes vitamin receptor targeting and to develop a treatment regimen for such patients. The invention further relates to kits for performing the methods.
摘要翻译：本发明涉及通过量化癌细胞上的维生素受体表达来确定癌症预后的方法。该方法包括以下步骤：定量对癌细胞的维生素受体表达，并确定癌症的预后。本发明还涉及用于确定癌细胞上维生素受体存在的方法和试剂盒，以选择应该用利用维生素受体靶向治疗的患者进行治疗，并开发这种患者的治疗方案。本发明还涉及用于执行所述方法的试剂盒。

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