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31. 发明申请

US20150201958A1 Cutting Devices and Methods 有权
标题翻译：切割装置和方法
公开(公告)号：US20150201958A1
公开(公告)日：2015-07-23
申请号：US14600336
申请日：2015-01-20
申请人： Joshua F. Krieger , Ram H. Paul , Zachary Berwick
发明人： Joshua F. Krieger , Ram H. Paul , Zachary Berwick
IPC分类号： A61B17/32 , B21F45/00
CPC分类号： A61B17/320016 , A61B17/32 , A61B2017/00526 , B21F45/008
摘要： Cutting devices useful for cutting objects or materials are described. Examples of cutting devices useful for creating avulsions in animals, such as human beings, are described. A cutting device includes an elongate main body having proximal and distal ends. A first portion of the main body has a cross-sectional shape that substantially lacks flat surfaces and a second portion of the main body has a cross-sectional shape having one, two or more flat surfaces. The distal end defines a hook having one or more sharpened edges disposed within the notch of the hook. Methods of making cutting devices are also described.
摘要翻译：描述用于切割物体或材料的切割装置。描述了用于在动物（例如人）中产生撕裂的切割装置的实例。切割装置包括具有近端和远端的细长主体。主体的第一部分具有基本上缺少平坦表面的横截面形状，并且主体的第二部分具有具有一个，两个或更多个平坦表面的横截面形状。远端限定具有设置在钩的凹口内的一个或多个锋利边缘的钩。还描述了制造切割装置的方法。

32. 发明申请

US20130079867A1 Valve Frame 审中-公开
公开(公告)号：US20130079867A1
公开(公告)日：2013-03-28
申请号：US13681362
申请日：2012-11-19
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

33. 发明授权

US08366761B2 Delivery system with medical device release by evertable sleeve 有权
标题翻译：带可拆卸套管释放医疗器械的输送系统
公开(公告)号：US08366761B2
公开(公告)日：2013-02-05
申请号：US13562674
申请日：2012-07-31
申请人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
发明人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61B17/12109 , A61B17/12131 , A61B2017/12054 , A61B2017/3435 , A61F2/966
摘要： A medical device delivery system has a tubular member defining a passageway and an inner member slideably disposed within the passageway. An expandable intraluminal medical device is disposed on a chamber of the inner member, and an evertable sleeve is attached to the inner member proximal to the chamber and to an inner surface of the tubular member. Relative movement between the tubular and outer members moves the evertable sleeve from a first position substantially overlying the expandable intraluminal medical device to a second position substantially proximal to the chamber.
摘要翻译：医疗装置输送系统具有限定通道的管状构件和可滑动地设置在通道内的内部构件。可扩展的管腔内医疗装置设置在内部构件的腔室上，并且可翻转套筒附接到靠近腔室的内部构件和管状构件的内表面。管状和外部构件之间的相对运动将可翻转套管从基本上覆盖可膨胀管腔内医疗装置的第一位置移动到基本上靠近腔室的第二位置。

34. 发明授权

US07780647B2 Medical device with therapeutic agents 有权
标题翻译：带治疗剂的医疗器械
公开(公告)号：US07780647B2
公开(公告)日：2010-08-24
申请号：US11930722
申请日：2007-10-31
申请人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
发明人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
IPC分类号： A61M25/00
CPC分类号： A61M25/00 , A61M25/0017 , A61M2025/0057
摘要： A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.
摘要翻译：医疗装置适于至少部分植入体内，并且包括沿着装置长度的第一和第二部分。第一治疗剂与第一部分相关联，第二治疗剂与第二部分相关联。第一种治疗剂可以是一种或多种抗增殖剂，例如紫杉醇，紫杉醇衍生物或紫杉醇前药，抗凝血剂，抗血栓形成剂，溶栓剂，纤维蛋白溶解剂或其组合。第二治疗剂可以是一种或多种抗微生物剂，例如一种或多种抗生素。第一和第二治疗剂中的每一个可以被放置在相应部分的一个或多个表面上，或浸渍在该部分内。该装置可以包括用于分隔第一和第二部分的分离器。还提供了制造医疗装置的方法和建立对体内容器的通路的方法。

35. 发明申请

US20100023114A1 VALVE DEVICE WITH BIASED LEAFLETS 审中-公开
标题翻译：具有偏心叶片的阀装置
公开(公告)号：US20100023114A1
公开(公告)日：2010-01-28
申请号：US12508606
申请日：2009-07-24
申请人： Sean Chambers , Ram H. Paul
发明人： Sean Chambers , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0067 , A61F2230/008
摘要： Valve devices useful in the treatment of various valve-related disorders and/or conditions are described. A valve device includes a leaflet and a means for biasing the leaflet in an open configuration. A method of making a valve device comprises the steps of determining a desired closing pressure; determining a desired opening pressure, selecting one or more valve leaflets; selecting an appropriate means for biasing the leaflet in an open configuration based on the determined closing and opening pressures; and attaching the one or more valve leaflets to the means for biasing the leaflet in an open configuration.
摘要翻译：描述了可用于治疗各种与瓣膜相关的疾病和/或病症的瓣膜装置。阀装置包括传单和用于将开口偏压在打开构型中的装置。制造阀装置的方法包括以下步骤：确定期望的关闭压力; 确定期望的打开压力，选择一个或多个瓣膜传单; 基于所确定的关闭和打开压力，选择适当的装置以将所述传单偏置在打开构型中; 以及将所述一个或多个瓣膜小叶附接到用于将所述小叶偏压成打开构型的装置。

36. 发明授权

US07445611B2 Hemostasis cannula 有权
标题翻译：止血套管
公开(公告)号：US07445611B2
公开(公告)日：2008-11-04
申请号：US10737313
申请日：2003-12-16
申请人： Thomas A. Osborne , Ram H. Paul
发明人： Thomas A. Osborne , Ram H. Paul
IPC分类号： A61M39/06 , A61M5/36
CPC分类号： A61M39/0606 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , A61M2039/0653
摘要： A medical instrument includes a housing having a housing member with a passage through which a catheter is inserted. A valve body is mounted in the housing and abuts the housing member at an end of the passage, and, as the catheter penetrates through the valve body, the valve body conforms to the outer wall of the catheter to maintain a fluid tight seal between the valve body and the catheter. When the valve body is unstressed before being mounted in the passage, the valve body has a first planar dimension and a second planar dimension that is less than the first planar dimension.
摘要翻译：医疗器械包括具有壳体构件的壳体，该壳体具有插入导管的通道。阀体安装在壳体中并且在通道的端部处邻接壳体构件，并且当导管穿过阀体时，阀体与导管的外壁相一致，以保持流体密封阀体和导管。当阀体在安装在通道中之前不受应力时，阀体具有第一平面尺寸和小于第一平面尺寸的第二平面尺寸。

37. 发明申请

US20080183279A1 Prosthetic Valve with Slanted Leaflet Design 有权
标题翻译：假体瓣与倾斜小叶设计
公开(公告)号：US20080183279A1
公开(公告)日：2008-07-31
申请号：US12019987
申请日：2008-01-25
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

38. 发明授权

US07306580B2 Medical device with therapeutic agents 失效
标题翻译：带治疗剂的医疗器械
公开(公告)号：US07306580B2
公开(公告)日：2007-12-11
申请号：US10414939
申请日：2003-04-16
申请人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
发明人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
IPC分类号： A61M5/00 , A61M5/32 , A61M25/00
CPC分类号： A61M25/00 , A61M25/0017 , A61M2025/0057
摘要： A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.
摘要翻译：医疗装置适于至少部分植入体内，并且包括沿着装置长度的第一和第二部分。第一治疗剂与第一部分相关联，第二治疗剂与第二部分相关联。第一种治疗剂可以是一种或多种抗增殖剂，例如紫杉醇，紫杉醇衍生物或紫杉醇前药，抗凝血剂，抗血栓形成剂，溶栓剂，纤维蛋白溶解剂或其组合。第二治疗剂可以是一种或多种抗微生物剂，例如一种或多种抗生素。第一和第二治疗剂中的每一个可以被放置在相应部分的一个或多个表面上，或浸渍在该部分内。该装置可以包括用于分隔第一和第二部分的分离器。还提供了制造医疗装置的方法和建立对体内容器的通路的方法。

39. 发明授权

US08663320B2 Storage and loading system for implantable medical devices 有权
标题翻译：可植入医疗器械的储存和装载系统
公开(公告)号：US08663320B2
公开(公告)日：2014-03-04
申请号：US12328273
申请日：2008-12-04
申请人： Sean D. Chambers , Ram H. Paul
发明人： Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/0095 , A61F2/2427 , A61F2/95 , A61F2002/9522 , A61F2002/9528
摘要： Storage and loading systems for expandable intraluminal medical devices are described. The systems include a container that defines an opening that tapers from a relatively large first diameter to a relatively small second diameter. A neck region includes structure adapted to engage an outer sheath of a delivery system such that an intraluminal medical device within the chamber of the container can be advanced through the tapered opening to effect compression of the intraluminal medical device and, ultimately, loading of the device into the delivery system. Methods of preparing and intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了可扩展管腔内医疗器械的储存和装载系统。该系统包括限定从相对大的第一直径逐渐变细到相对小的第二直径的开口的容器。颈部区域包括适于接合输送系统的外护套的结构，使得容器腔室内的管腔内医疗装置可以推进穿过锥形开口以实现腔内医疗装置的压缩，并且最终装载装置进入送货系统。还描述了用于植入患者的制备方法和管腔内医疗装置以及在这些方法中有用的试剂盒。

40. 发明授权

US08608795B2 Tapered loading system for implantable medical devices 有权
标题翻译：用于可植入医疗器械的锥形加载系统
公开(公告)号：US08608795B2
公开(公告)日：2013-12-17
申请号：US12328157
申请日：2008-12-04
申请人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
发明人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

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